ATE120746T1 - Recematspaltung von trans-2-(2-pyrimidinyl)-7- (hydroxymethyl)octahydro-2h-pyrido(1,2-a>- pyrazin. - Google Patents

Recematspaltung von trans-2-(2-pyrimidinyl)-7- (hydroxymethyl)octahydro-2h-pyrido(1,2-a>- pyrazin.

Info

Publication number: ATE120746T1
Authority: AT; Austria
Prior art keywords: octahydro; pyrido; pyrimidinyl; hydroxymethyl; trans
Prior art date: 1991-01-31

Application number

AT92902650T

Other languages

English (en)

Inventor

Charles W Murtiashaw

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-01-31

Filing date

1991-12-05

Publication date

1995-04-15

1991-12-05 Application filed by Pfizer filed Critical Pfizer

1995-04-15 Application granted granted Critical

1995-04-15 Publication of ATE120746T1 publication Critical patent/ATE120746T1/de

Links

238000003776 cleavage reaction Methods 0.000 title 1
230000007017 scission Effects 0.000 title 1
FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
ONHPOXROAPYCGT-UHFFFAOYSA-N 2,3,4,6,7,8,9,9a-octahydro-1h-pyrido[1,2-a]pyrazine Chemical compound C1CNCC2CCCCN21 ONHPOXROAPYCGT-UHFFFAOYSA-N 0.000 abstract 1
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 abstract 1
235000011002 L(+)-tartaric acid Nutrition 0.000 abstract 1
239000001358 L(+)-tartaric acid Substances 0.000 abstract 1
FEWJPZIEWOKRBE-LWMBPPNESA-N L-(+)-Tartaric acid Natural products OC(=O)[C@@H](O)[C@H](O)C(O)=O FEWJPZIEWOKRBE-LWMBPPNESA-N 0.000 abstract 1
AUONNNVJUCSETH-UHFFFAOYSA-N icosanoyl icosanoate Chemical compound CCCCCCCCCCCCCCCCCCCC(=O)OC(=O)CCCCCCCCCCCCCCCCCCC AUONNNVJUCSETH-UHFFFAOYSA-N 0.000 abstract 1
150000003892 tartrate salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT92902650T 1991-01-31 1991-12-05 Recematspaltung von trans-2-(2-pyrimidinyl)-7- (hydroxymethyl)octahydro-2h-pyrido(1,2-a>- pyrazin. ATE120746T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US64868691A	1991-01-31	1991-01-31

Publications (1)

Publication Number	Publication Date
ATE120746T1 true ATE120746T1 (de)	1995-04-15

Family

ID=24601808

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92902650T ATE120746T1 (de)	1991-01-31	1991-12-05	Recematspaltung von trans-2-(2-pyrimidinyl)-7- (hydroxymethyl)octahydro-2h-pyrido(1,2-a>- pyrazin.

Country Status (12)

Country	Link
EP (1)	EP0569387B1 (de)
JP (1)	JP2609410B2 (de)
AT (1)	ATE120746T1 (de)
CA (1)	CA2099563C (de)
DE (1)	DE69108743T2 (de)
DK (1)	DK0569387T3 (de)
ES (1)	ES2072141T3 (de)
FI (1)	FI100400B (de)
GR (1)	GR3015726T3 (de)
IE (1)	IE67777B1 (de)
PT (1)	PT100061B (de)
WO (1)	WO1992013858A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE185565T1 (de) *	1992-06-16	1999-10-15	Pfizer	Verfahren und zwischenprodukte zur herstellung von bis-aza-bicyclischen anxiolytica
US5731307A (en) *	1994-09-30	1998-03-24	Pfizer, Inc.	Neuroleptic 2,7-disubtituted perhydro-1h-pyrido 1, 2-A!pyrazines
PL180899B1 (pl) *	1994-09-30	2001-04-30	Pfizer	Nowe pochodne 2,7-podstawionej oktahydro-1H-pirydo[1,2-a]pirazyny i środek farmaceutyczny je zawierający
TR199802743T2 (xx) *	1996-07-01	1999-03-22	Pfizer Inc.	(7S, trans)-2-(2-Primidinil)-7- (hidroksimetil) oktahidro-2H- pirido $1,2-A] pirazin'in haz�rlan��.
DE19821039A1 (de) *	1998-05-11	1999-11-18	Bayer Ag	Verfahren zur Herstellung von (S,S)-Benzyl-2,8-diazabicyclo[4.3.0]nonan
US6670476B2 (en)	2000-11-29	2003-12-30	Pfizer Inc.	Resolution of trans-7-(hydroxy-methyl)octa-hydro-2H-pyrido[1,2-a]pyrazine
WO2002044177A2 (en) *	2000-11-29	2002-06-06	Pfizer Products Inc.	Resolution of trans-7-(hydroxy-methyl)octa-hydro-2h-pyrido-1,2a)pyrazine

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MX19222A (es) *	1989-01-23	1993-12-01	Pfizer	Agentes ansioliticos bis-aza-biciclicos

1991
- 1991-12-05 CA CA002099563A patent/CA2099563C/en not_active Expired - Fee Related
- 1991-12-05 EP EP92902650A patent/EP0569387B1/de not_active Expired - Lifetime
- 1991-12-05 AT AT92902650T patent/ATE120746T1/de not_active IP Right Cessation
- 1991-12-05 WO PCT/US1991/008314 patent/WO1992013858A1/en not_active Ceased
- 1991-12-05 DK DK92902650.8T patent/DK0569387T3/da active
- 1991-12-05 JP JP4502803A patent/JP2609410B2/ja not_active Expired - Fee Related
- 1991-12-05 ES ES92902650T patent/ES2072141T3/es not_active Expired - Lifetime
- 1991-12-05 DE DE69108743T patent/DE69108743T2/de not_active Expired - Fee Related
1992
- 1992-01-29 PT PT100061A patent/PT100061B/pt not_active IP Right Cessation
- 1992-01-30 IE IE920303A patent/IE67777B1/en not_active IP Right Cessation
1993
- 1993-07-30 FI FI933422A patent/FI100400B/fi active
1995
- 1995-04-10 GR GR950400858T patent/GR3015726T3/el unknown

Also Published As

Publication number	Publication date
PT100061B (pt)	1999-06-30
GR3015726T3 (en)	1995-07-31
IE920303A1 (en)	1992-07-29
FI933422A0 (fi)	1993-07-30
EP0569387A1 (de)	1993-11-18
DE69108743D1 (de)	1995-05-11
PT100061A (pt)	1993-03-31
CA2099563A1 (en)	1992-08-01
FI100400B (fi)	1997-11-28
FI933422L (fi)	1993-07-30
CA2099563C (en)	1998-09-29
IE67777B1 (en)	1996-04-17
JP2609410B2 (ja)	1997-05-14
DK0569387T3 (da)	1995-07-03
ES2072141T3 (es)	1995-07-01
DE69108743T2 (de)	1995-08-17
JPH06502181A (ja)	1994-03-10
EP0569387B1 (de)	1995-04-05
WO1992013858A1 (en)	1992-08-20

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Legal Events

Date	Code	Title	Description
1995-11-15	UEP	Publication of translation of european patent specification
2008-09-15	REN	Ceased due to non-payment of the annual fee