ATE49969T1 - Verfahren zur herstellung von pteridinderivaten. - Google Patents

Verfahren zur herstellung von pteridinderivaten.

Info

Publication number: ATE49969T1
Authority: AT; Austria
Prior art keywords: production; image; pteridine derivatives; pteridine; derivatives
Prior art date: 1985-11-19

Application number

AT86402544T

Other languages

English (en)

Inventor

Pierre Zimmermann

Original Assignee

Rhone Poulenc Sante

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-11-19

Filing date

1986-11-17

Publication date

1990-02-15

1986-11-17 Application filed by Rhone Poulenc Sante filed Critical Rhone Poulenc Sante

1990-02-15 Application granted granted Critical

1990-02-15 Publication of ATE49969T1 publication Critical patent/ATE49969T1/de

Links

CPNGPNLZQNNVQM-UHFFFAOYSA-N pteridine Chemical class N1=CN=CC2=NC=CN=C21 CPNGPNLZQNNVQM-UHFFFAOYSA-N 0.000 title 1
150000003195 pteridines Chemical class 0.000 abstract 2
TVZGACDUOSZQKY-LBPRGKRZSA-N 4-aminofolic acid Chemical compound C1=NC2=NC(N)=NC(N)=C2N=C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 TVZGACDUOSZQKY-LBPRGKRZSA-N 0.000 abstract 1
FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 abstract 1
229960003896 aminopterin Drugs 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
229960000485 methotrexate Drugs 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
- C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT86402544T 1985-11-19 1986-11-17 Verfahren zur herstellung von pteridinderivaten. ATE49969T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR8517057A FR2590255B1 (fr)	1985-11-19	1985-11-19	Procede de preparation de derives de la pteridine
EP86402544A EP0225823B1 (de)	1985-11-19	1986-11-17	Verfahren zur Herstellung von Pteridinderivaten

Publications (1)

Publication Number	Publication Date
ATE49969T1 true ATE49969T1 (de)	1990-02-15

Family

ID=9324943

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT86402544T ATE49969T1 (de)	1985-11-19	1986-11-17	Verfahren zur herstellung von pteridinderivaten.

Country Status (7)

Country	Link
US (1)	US4767859A (de)
EP (1)	EP0225823B1 (de)
JP (1)	JPS62120386A (de)
AT (1)	ATE49969T1 (de)
CA (1)	CA1261324A (de)
DE (1)	DE3668621D1 (de)
FR (1)	FR2590255B1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5382582A (en) *	1993-03-26	1995-01-17	Chan; Carcy L.	Methotrexate analogs and methods of using same
US5698556A (en) *	1995-06-07	1997-12-16	Chan; Carcy L.	Methotrexate analogs and methods of using same
CA2273852C (en)	1996-12-06	2009-09-29	Amgen Inc.	Combination therapy using an il-1 inhibitor for treating il-1 mediated diseases
AU1095799A (en) *	1997-10-17	1999-05-10	Philip L. Fuchs	Folic acid derivatives
WO2004060911A2 (en) *	2002-12-30	2004-07-22	Amgen Inc.	Combination therapy with co-stimulatory factors
US6921667B2 (en)	2003-03-07	2005-07-26	Prometheus Laboratories, Inc.	Methods for direct detection of individual methotrexate metabolites
US7582282B2 (en)	2003-08-29	2009-09-01	Prometheus Laboratories Inc.	Methods for optimizing clinical responsiveness to methotrexate therapy using metabolite profiling and pharmacogenetics
US7612071B2 (en)	2004-03-12	2009-11-03	Syntrix Biosystems, Inc.	Compositions and methods employing aminopterin
WO2006031614A2 (en) *	2004-09-10	2006-03-23	Tosk, Inc.	Reduced toxicity methotrexate formulations and methods for using the same
US7312217B2 (en)	2005-03-11	2007-12-25	Syntrix Biosystems, Inc.	Aminopterin dosage forms and methods for inflammatory disorders
US20060286571A1 (en)	2005-04-28	2006-12-21	Prometheus Laboratories, Inc.	Methods of predicting methotrexate efficacy and toxicity
PT1954292E (pt)	2005-11-28	2014-08-04	Verrow Pharmaceuticals Inc	Composições úteis para reduzir a nefrotoxicidade e métodos para a sua utilização
US7235660B1 (en)	2007-01-02	2007-06-26	Zebala John A	Facile process for the preparation of high-purity aminopterin
US7998967B2 (en)	2008-03-03	2011-08-16	Tosk, Incorporated	Methotrexate adjuvants to reduce toxicity and methods for using the same
US9261509B2 (en)	2010-09-13	2016-02-16	Thierry Dervieux	Methods for monitoring methotrexate therapy
CN111954529A (zh)	2018-02-07	2020-11-17	L.E.A.F.控股集团公司	α聚谷氨酸化氨甲蝶呤及其用途
CN111936145A (zh)	2018-02-14	2020-11-13	L.E.A.F.控股集团公司	γ聚谷氨酸化氨甲蝶呤及其用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2122991C2 (de) *	1971-05-04	1982-06-09	Schering Ag, 1000 Berlin Und 4619 Bergkamen	Verfahren zur Herstellung von Cytosin- und 6-Azacytosinnucleosiden
BE792914A (fr) *	1971-12-18	1973-06-18	Schering Ag	Derives amino de n-heterocycles et leur procede de preparation
DE2621645C3 (de) *	1976-05-13	1981-08-06	Schering Ag Berlin Und Bergkamen, 1000 Berlin	Verfahren zur Herstellung von Aminoderivaten von N-Heterocyclen
FI68400C (fi) *	1980-09-12	1985-09-10	Farmos Oy	Foerfarande foer framstaellning av n-(4-(((2,4-diamino-6-pteridinyl)-metyl)metylamino)bensoyl)glutaminsyra

1985
- 1985-11-19 FR FR8517057A patent/FR2590255B1/fr not_active Expired
1986
- 1986-11-17 US US06/931,053 patent/US4767859A/en not_active Expired - Fee Related
- 1986-11-17 EP EP86402544A patent/EP0225823B1/de not_active Expired - Lifetime
- 1986-11-17 AT AT86402544T patent/ATE49969T1/de not_active IP Right Cessation
- 1986-11-17 DE DE8686402544T patent/DE3668621D1/de not_active Expired - Fee Related
- 1986-11-18 CA CA000523250A patent/CA1261324A/fr not_active Expired
- 1986-11-18 JP JP61273040A patent/JPS62120386A/ja active Pending

Also Published As

Publication number	Publication date
FR2590255A1 (fr)	1987-05-22
EP0225823B1 (de)	1990-01-31
FR2590255B1 (fr)	1987-12-24
CA1261324A (fr)	1989-09-26
JPS62120386A (ja)	1987-06-01
US4767859A (en)	1988-08-30
DE3668621D1 (de)	1990-03-08
EP0225823A1 (de)	1987-06-16

Similar Documents

Publication	Publication Date	Title
DE3668621D1 (de)	1990-03-08	Verfahren zur herstellung von pteridinderivaten.
DE68906705D1 (de)	1993-07-01	Verfahren zur herstellung von baccatin-iii-derivaten und von desacetyl-10-baccatin-iii.
DE59209643D1 (de)	1999-04-08	Verfahren zur trennung von 5-methyl-tetrahydrofolsäure
DE68910718D1 (de)	1993-12-23	Verfahren zur Herstellung von Taxol.
ATA64985A (de)	1990-01-15	Verfahren zur herstellung von neuen 1-fluorphenylbutyl-4-(2-pyrimidinyl)-piperazinderivaten
AT383130B (de)	1987-05-25	Verfahren zur herstellung von an c1 und c2 verschieden substituierten phosphatidylcholinen und phosphatidylethanolaminen ueber die neuen verbindungen 1-0-tritylglycerophosphocholin beziehungsweise (1-0,n-ditrityl)-glycerophosphoethanolamin
DE69122866D1 (de)	1996-11-28	Herstellung von substituierten piperidinen
DE69103192D1 (de)	1994-09-08	Verfahren zur Herstellung von integrierten optischen Geräten mit feldunterstütztem Ionenaustausch.
DE69207429D1 (de)	1996-02-15	Verfahren zur herstellung von substituierten piperidinen
ATE14597T1 (de)	1985-08-15	Verfahren zur enzymatischen herstellung von l-2- amino-4-methylphosphinobuttersaeure.
ATE86978T1 (de)	1993-04-15	Verfahren zur herstellung von 3,5-dimethyl-4methoxypyridinderivaten sowie neues zwischenprodukt hierfuer.
ATE51617T1 (de)	1990-04-15	Verfahren zur herstellung von 4-phenyl-pyrrolderivaten.
DE59001820D1 (de)	1993-07-29	Verfahren zur herstellung von indolcarbonsaeurederivaten.
DE3881091D1 (de)	1993-06-24	Verfahren zur herstellung von phosphatidsaeurederivaten.
DE59005334D1 (de)	1994-05-19	Verfahren zur Herstellung von reinem Guanin.
ATE191476T1 (de)	2000-04-15	Verfahren zur herstellung von indolderivaten
ATE86619T1 (de)	1993-03-15	Verfahren zur herstellung von nitroethenderivaten.
ES2054755T3 (es)	1994-08-16	Un proceso para la produccion de 2,4,5-trifluoroisoftalonitrilo.
DE3578862D1 (de)	1990-08-30	Verfahren zur herstellung von 5,6,7,8-tetrahydrofolsaeure.
ATE88476T1 (de)	1993-05-15	Verfahren zur herstellung von 7-aca-derivaten.
DE69109207D1 (de)	1995-06-01	Verfahren zur Herstellung von kleinen röhrenförmigen Lampen.
ATA313780A (de)	1982-11-15	Verfahren zur herstellung von 4-(substituierten) thio-1-b-d-ribofuranosylpyrazolo(3,4-d)pyrimidinderivaten
ATE31928T1 (de)	1988-01-15	Acylamino-4-aza-1-adamantane, verfahren zu ihrer herstellung und ihre anwendung in der therapeutik.
DE69015907D1 (de)	1995-02-23	Verfahren zur optischen Trennung von Dropropizin.
ATE111093T1 (de)	1994-09-15	Verfahren zur herstellung von enantiomeren von 3- aminchromanderivaten.

Legal Events

Date	Code	Title	Description
1990-08-15	UEP	Publication of translation of european patent specification
1993-08-15	REN	Ceased due to non-payment of the annual fee