ATE120747T1 - Pro-drugs von 6-mercaptopurin und 6-thioguanin. - Google Patents

Pro-drugs von 6-mercaptopurin und 6-thioguanin.

Info

Publication number: ATE120747T1
Authority: AT; Austria
Prior art keywords: thioguanine; mercaptopurine; prodrugs; pro; drugs
Prior art date: 1989-11-03

Application number

AT90311961T

Other languages

English (en)

Inventor

Adnan Elfarra

Original Assignee

Wisconsin Alumni Res Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-11-03

Filing date

1990-11-01

Publication date

1995-04-15

1990-11-01 Application filed by Wisconsin Alumni Res Found filed Critical Wisconsin Alumni Res Found

1995-04-15 Application granted granted Critical

1995-04-15 Publication of ATE120747T1 publication Critical patent/ATE120747T1/de

Links

WYWHKKSPHMUBEB-UHFFFAOYSA-N tioguanine Chemical compound N1C(N)=NC(=S)C2=C1N=CN2 WYWHKKSPHMUBEB-UHFFFAOYSA-N 0.000 title abstract 6
GLVAUDGFNGKCSF-UHFFFAOYSA-N mercaptopurine Chemical compound S=C1NC=NC2=C1NC=N2 GLVAUDGFNGKCSF-UHFFFAOYSA-N 0.000 title abstract 4
229940002612 prodrug Drugs 0.000 title abstract 4
239000000651 prodrug Substances 0.000 title abstract 4
229960003087 tioguanine Drugs 0.000 title abstract 3
229960001428 mercaptopurine Drugs 0.000 title abstract 2
102000004190 Enzymes Human genes 0.000 abstract 1
108090000790 Enzymes Proteins 0.000 abstract 1
208000008839 Kidney Neoplasms Diseases 0.000 abstract 1
125000003368 amide group Chemical group 0.000 abstract 1
150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
210000003734 kidney Anatomy 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/36—Sulfur atom
- C07D473/38—Sulfur atom attached in position 6
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

AT90311961T 1989-11-03 1990-11-01 Pro-drugs von 6-mercaptopurin und 6-thioguanin. ATE120747T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US43209889A	1989-11-03	1989-11-03
US07/542,664 US5120740A (en)	1989-11-03	1990-06-25	Prodrugs of 6-mercaptopurine and 6-thioguanine

Publications (1)

Publication Number	Publication Date
ATE120747T1 true ATE120747T1 (de)	1995-04-15

Family

ID=27029358

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90311961T ATE120747T1 (de)	1989-11-03	1990-11-01	Pro-drugs von 6-mercaptopurin und 6-thioguanin.

Country Status (5)

Country	Link
US (1)	US5120740A (de)
EP (1)	EP0426467B1 (de)
JP (1)	JPH03240789A (de)
AT (1)	ATE120747T1 (de)
DE (1)	DE69018375T2 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5502037A (en) *	1993-07-09	1996-03-26	Neuromed Technologies, Inc.	Pro-cytotoxic drug conjugates for anticancer therapy
US6491905B1 (en) *	1993-09-14	2002-12-10	The Uab Research Foundation	Recombinant bacterial cells for delivery of PNP to tumor cells
DE19953414A1 (de)	1999-11-06	2001-05-10	Merck Patent Gmbh	Imidazopyridinderivate als Phospodiesterase VII-Hemmer
US20040023994A1 (en) *	2002-06-04	2004-02-05	Elfarra Adnan A.	Glutathione-activated anti-tumor prodrugs of 6-mercaptopurine and 6-thioguanine
JP2007518697A (ja) *	2003-09-26	2007-07-12	ニトロメッドインコーポレーティッド	ニトロソ化グルタミン酸化合物、組成物、および使用方法
AU2005232583B2 (en) *	2004-04-01	2009-03-12	Teva Pharmaceutical Industries Ltd.	Delayed release formulations of 6-mercaptopurine
US8188067B2 (en)	2004-04-01	2012-05-29	Teva Pharmaceutical Industries Ltd.	Formulations of 6-mercaptopurine
EP2110130A1 (de) *	2008-04-18	2009-10-21	Teva Pharmaceutical Industries Ltd.	Pharmazeutische Verwendung von 6-Mercaptopurin
EP3362053A4 (de)	2015-10-16	2019-04-17	Hadasit Medical Research Services and Development Ltd.	Behandlung von nicht alkoholbedingter fettleber oder nicht alkoholbedingter steatohepatitis mit 6-mercaptopurin mit verzögerter freisetzung

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2875203A (en) *	1958-03-03	1959-02-24	Shive William	Alkylthiopurines
US2952539A (en) *	1958-10-23	1960-09-13	Gen Aniline & Film Corp	Photographic emulsions and developers stabilized with purine compounds
US3238207A (en) *	1960-03-01	1966-03-01	Burroughs Wellcome Co	6-oxyorganopurines and method of preparing them
US3149111A (en) *	1961-09-29	1964-09-15	Burroughs Wellcome Co	Dinitrophenylmercaptopurines
US3232938A (en) *	1962-08-02	1966-02-01	Burroughs Wellcome Co	6-alkylmercaptopurines
US3232937A (en) *	1962-08-02	1966-02-01	Burroughs Wellcome Co	6-benzylmercaptopurines
CH501652A (de) *	1966-07-01	1971-01-15	Spofa Vereinigte Pharma Werke	Verfahren zur Herstellung von N-( -(6-Purinylthio)-valeryl)-aminosäureestern
US4169948A (en) *	1977-05-20	1979-10-02	The Dow Chemical Company	Pyrazolopyrimidines
US4139705A (en) *	1977-05-20	1979-02-13	The Dow Chemical Company	Pyrazolopyrimidines
GR75219B (de) *	1980-04-21	1984-07-13	Merck & Co Inc
IL78643A0 (en) *	1985-05-02	1986-08-31	Wellcome Found	Purine derivatives,their preparation and pharmaceutical compositions containing them
JPS62240663A (ja) *	1986-04-11	1987-10-21	Mitsubishi Chem Ind Ltd	複素環チオアラニン誘導体
DE3730542A1 (de) *	1987-09-11	1989-04-06	Hoechst Ag	Arzneimittel mit einem gehalt an bestimmten 6-mercaptopurin-derivaten, verwendung dieser 6-mercaptopurin-derivate, verfahren zur herstellung der arzneimittel sowie einige neue 6-mercaptopurin-derivate und verfahren zu deren herstellung
DE3823345A1 (de) *	1988-07-09	1990-01-25	Hoechst Ag	6-merkaptopurin-derivate, ihre herstellung und ihre verwendung zur bekaempfung von retrovirusinfektionen

1990
- 1990-06-25 US US07/542,664 patent/US5120740A/en not_active Expired - Lifetime
- 1990-11-01 AT AT90311961T patent/ATE120747T1/de not_active IP Right Cessation
- 1990-11-01 DE DE69018375T patent/DE69018375T2/de not_active Expired - Fee Related
- 1990-11-01 EP EP90311961A patent/EP0426467B1/de not_active Expired - Lifetime
- 1990-11-05 JP JP2297354A patent/JPH03240789A/ja active Pending

Also Published As

Publication number	Publication date
DE69018375D1 (de)	1995-05-11
JPH03240789A (ja)	1991-10-28
EP0426467B1 (de)	1995-04-05
DE69018375T2 (de)	1996-01-04
US5120740A (en)	1992-06-09
EP0426467A1 (de)	1991-05-08

Legal Events

Date	Code	Title	Description
1995-10-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
IL96790A0 (en)	1991-09-16	A-nor-steroid-3-carboxylic acid derivatives
NO166589C (no)	1991-08-14	Selv-tverrbindbar akrylpolymerer.
DE69132435D1 (de)	2000-11-09	Inhibitoren retroviraler Proteasen
SE8302694D0 (sv)	1983-05-10	Immunomodulating agent
DE69018375D1 (de)	1995-05-11	Pro-drugs von 6-Mercaptopurin und 6-Thioguanin.
BE1002151A5 (fr)	1990-08-07	Nouveaux derives de l'acide furannuronique, leur preparation et leur utilisation comme medicaments.
DE68929227D1 (de)	2000-08-10	Antimikrobielle Quinolonyllactamester
NO930830L (no)	1993-09-13	Nye beta-aminosyrederivater
ATE41773T1 (de)	1989-04-15	4,5-dihydro-4-oxo-2((2-transphenylcyclopropyl)amino>-3-furancarbonsaeuren und derivate davon.
MY132057A (en)	2007-09-28	Quinoxalinones, a process for their preparation and their use
DK464586D0 (da)	1986-09-29	Phosphorforbindelser
DK0407212T3 (da)	1996-06-17	Enantioselektiv syntese af antifolater
ATE46518T1 (de)	1989-10-15	Sialosylcerebroside und verfahren zu ihrer herstellung.
DE3876712D1 (de)	1993-01-28	Antianaerobe naphthyridinverbindungen.
PT90584A (pt)	1989-11-30	Processo de preparacao de agentes diureticos de glutaramidas enantiomericas
BG32418A3 (en)	1982-07-15	Method for obtaining of amid derivatives of 1, 2, 3- thiadiazol- 5- carbonic acid
OA08746A (fr)	1989-03-31	Dérivés d'acide hydrocinnamique.
ATE84220T1 (de)	1993-01-15	Injektionszusammensetzung, die modifiziertes tpa enthaelt.
IT1251202B (it)	1995-05-04	6-amminochinoloni, sintesi ed impiego come antibatterici
IL93197A0 (en)	1990-11-05	Derivatives of 3-pyroglutamyl-thia-zolidine-4-carboxylic acid
GB2104073B (en)	1985-02-06	Fluorinated diamino-heptene and -heptyne derivatives
ATE35981T1 (de)	1988-08-15	Harnstoffacrylderivate.
ATE66216T1 (de)	1991-08-15	Die verbindung 1,4-diisopropyl-2,5diketopiperazin.
DE3863492D1 (de)	1991-08-08	Stabile 5-fluorouracil-formulierungen.
ES2164087T3 (es)	2002-02-16	Ester de hidrolasa tipo norbornane.