ATE120747T1 - Pro-drugs von 6-mercaptopurin und 6-thioguanin. - Google Patents

Pro-drugs von 6-mercaptopurin und 6-thioguanin.

Info

Publication number: ATE120747T1
Authority: AT; Austria
Prior art keywords: thioguanine; mercaptopurine; prodrugs; pro; drugs
Prior art date: 1989-11-03

Application number

AT90311961T

Other languages

English (en)

Inventor

Adnan Elfarra

Original Assignee

Wisconsin Alumni Res Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-11-03

Filing date

1990-11-01

Publication date

1995-04-15

1990-11-01 Application filed by Wisconsin Alumni Res Found filed Critical Wisconsin Alumni Res Found

1995-04-15 Application granted granted Critical

1995-04-15 Publication of ATE120747T1 publication Critical patent/ATE120747T1/de

Links

WYWHKKSPHMUBEB-UHFFFAOYSA-N tioguanine Chemical compound N1C(N)=NC(=S)C2=C1N=CN2 WYWHKKSPHMUBEB-UHFFFAOYSA-N 0.000 title abstract 6
GLVAUDGFNGKCSF-UHFFFAOYSA-N mercaptopurine Chemical compound S=C1NC=NC2=C1NC=N2 GLVAUDGFNGKCSF-UHFFFAOYSA-N 0.000 title abstract 4
229940002612 prodrug Drugs 0.000 title abstract 4
239000000651 prodrug Substances 0.000 title abstract 4
229960003087 tioguanine Drugs 0.000 title abstract 3
229960001428 mercaptopurine Drugs 0.000 title abstract 2
102000004190 Enzymes Human genes 0.000 abstract 1
108090000790 Enzymes Proteins 0.000 abstract 1
208000008839 Kidney Neoplasms Diseases 0.000 abstract 1
125000003368 amide group Chemical group 0.000 abstract 1
150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
210000003734 kidney Anatomy 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/36—Sulfur atom
- C07D473/38—Sulfur atom attached in position 6
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

AT90311961T 1989-11-03 1990-11-01 Pro-drugs von 6-mercaptopurin und 6-thioguanin. ATE120747T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US43209889A	1989-11-03	1989-11-03
US07/542,664 US5120740A (en)	1989-11-03	1990-06-25	Prodrugs of 6-mercaptopurine and 6-thioguanine

Publications (1)

Publication Number	Publication Date
ATE120747T1 true ATE120747T1 (de)	1995-04-15

Family

ID=27029358

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90311961T ATE120747T1 (de)	1989-11-03	1990-11-01	Pro-drugs von 6-mercaptopurin und 6-thioguanin.

Country Status (5)

Country	Link
US (1)	US5120740A (de)
EP (1)	EP0426467B1 (de)
JP (1)	JPH03240789A (de)
AT (1)	ATE120747T1 (de)
DE (1)	DE69018375T2 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5502037A (en) *	1993-07-09	1996-03-26	Neuromed Technologies, Inc.	Pro-cytotoxic drug conjugates for anticancer therapy
US6491905B1 (en) *	1993-09-14	2002-12-10	The Uab Research Foundation	Recombinant bacterial cells for delivery of PNP to tumor cells
DE19953414A1 (de)	1999-11-06	2001-05-10	Merck Patent Gmbh	Imidazopyridinderivate als Phospodiesterase VII-Hemmer
US20040023994A1 (en) *	2002-06-04	2004-02-05	Elfarra Adnan A.	Glutathione-activated anti-tumor prodrugs of 6-mercaptopurine and 6-thioguanine
AU2004275809A1 (en) *	2003-09-26	2005-04-07	Nitromed, Inc.	Nitrosated glutamic acid compounds, compositions and methods of use
CA2560654A1 (en) *	2004-04-01	2006-09-20	Teva Pharmaceutical Industries Ltd.	Imroved formulations of 6-mercaptopurine
US8188067B2 (en)	2004-04-01	2012-05-29	Teva Pharmaceutical Industries Ltd.	Formulations of 6-mercaptopurine
EP2110130A1 (de) *	2008-04-18	2009-10-21	Teva Pharmaceutical Industries Ltd.	Pharmazeutische Verwendung von 6-Mercaptopurin
US20170105996A1 (en)	2015-10-16	2017-04-20	Teva Pharmaceutical Industries, Ltd.	Treatment of non-alcoholic fatty liver disease or non-alcoholic steatohepatitis with delayed-release 6-mercaptopurine

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2875203A (en) *	1958-03-03	1959-02-24	Shive William	Alkylthiopurines
US2952539A (en) *	1958-10-23	1960-09-13	Gen Aniline & Film Corp	Photographic emulsions and developers stabilized with purine compounds
US3238207A (en) *	1960-03-01	1966-03-01	Burroughs Wellcome Co	6-oxyorganopurines and method of preparing them
US3149111A (en) *	1961-09-29	1964-09-15	Burroughs Wellcome Co	Dinitrophenylmercaptopurines
US3232938A (en) *	1962-08-02	1966-02-01	Burroughs Wellcome Co	6-alkylmercaptopurines
US3232937A (en) *	1962-08-02	1966-02-01	Burroughs Wellcome Co	6-benzylmercaptopurines
CH501652A (de) *	1966-07-01	1971-01-15	Spofa Vereinigte Pharma Werke	Verfahren zur Herstellung von N-( -(6-Purinylthio)-valeryl)-aminosäureestern
US4139705A (en) *	1977-05-20	1979-02-13	The Dow Chemical Company	Pyrazolopyrimidines
US4169948A (en) *	1977-05-20	1979-10-02	The Dow Chemical Company	Pyrazolopyrimidines
DK172081A (da) *	1980-04-21	1981-10-22	Merck & Co Inc	Mercaptoforbindelse og fremgangsmaade til fremstilling deraf
IL78643A0 (en) *	1985-05-02	1986-08-31	Wellcome Found	Purine derivatives,their preparation and pharmaceutical compositions containing them
JPS62240663A (ja) *	1986-04-11	1987-10-21	Mitsubishi Chem Ind Ltd	複素環チオアラニン誘導体
DE3730542A1 (de) *	1987-09-11	1989-04-06	Hoechst Ag	Arzneimittel mit einem gehalt an bestimmten 6-mercaptopurin-derivaten, verwendung dieser 6-mercaptopurin-derivate, verfahren zur herstellung der arzneimittel sowie einige neue 6-mercaptopurin-derivate und verfahren zu deren herstellung
DE3823345A1 (de) *	1988-07-09	1990-01-25	Hoechst Ag	6-merkaptopurin-derivate, ihre herstellung und ihre verwendung zur bekaempfung von retrovirusinfektionen

1990
- 1990-06-25 US US07/542,664 patent/US5120740A/en not_active Expired - Lifetime
- 1990-11-01 DE DE69018375T patent/DE69018375T2/de not_active Expired - Fee Related
- 1990-11-01 EP EP90311961A patent/EP0426467B1/de not_active Expired - Lifetime
- 1990-11-01 AT AT90311961T patent/ATE120747T1/de not_active IP Right Cessation
- 1990-11-05 JP JP2297354A patent/JPH03240789A/ja active Pending

Also Published As

Publication number	Publication date
EP0426467A1 (de)	1991-05-08
JPH03240789A (ja)	1991-10-28
US5120740A (en)	1992-06-09
DE69018375T2 (de)	1996-01-04
EP0426467B1 (de)	1995-04-05
DE69018375D1 (de)	1995-05-11

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Legal Events

Date	Code	Title	Description
1995-10-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties