ATE120758T1 - Peptide, deren verwendung als hemmer gegen entwicklung von t-lymphocyten und wirksamkeit von makrophagen und verfahren zu deren herstellung. - Google Patents

Peptide, deren verwendung als hemmer gegen entwicklung von t-lymphocyten und wirksamkeit von makrophagen und verfahren zu deren herstellung.

Info

Publication number
ATE120758T1
ATE120758T1 AT90300355T AT90300355T ATE120758T1 AT E120758 T1 ATE120758 T1 AT E120758T1 AT 90300355 T AT90300355 T AT 90300355T AT 90300355 T AT90300355 T AT 90300355T AT E120758 T1 ATE120758 T1 AT E120758T1
Authority
AT
Austria
Prior art keywords
lys
asp
arg
thr
val
Prior art date
Application number
AT90300355T
Other languages
English (en)
Inventor
Istvan Dr Schoen
Nee Kuprina Olga Nyeki
Lajos Dr Kisfaludy
Denes Dr Laszlo
Gyorgy Dr Hajos
Laszlo Dr Szporny
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Application granted granted Critical
Publication of ATE120758T1 publication Critical patent/ATE120758T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1019—Tetrapeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/081—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Transplantation (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT90300355T 1989-01-13 1990-01-12 Peptide, deren verwendung als hemmer gegen entwicklung von t-lymphocyten und wirksamkeit von makrophagen und verfahren zu deren herstellung. ATE120758T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU89116A HU201964B (en) 1989-01-13 1989-01-13 Process for producing peptides inhibiting maturation of t-lymphocytes and activity of macrophages, as well as pharmaceutical compositions comprising same

Publications (1)

Publication Number Publication Date
ATE120758T1 true ATE120758T1 (de) 1995-04-15

Family

ID=10948008

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90300355T ATE120758T1 (de) 1989-01-13 1990-01-12 Peptide, deren verwendung als hemmer gegen entwicklung von t-lymphocyten und wirksamkeit von makrophagen und verfahren zu deren herstellung.

Country Status (12)

Country Link
US (1) US5093320A (de)
EP (1) EP0378432B1 (de)
JP (1) JPH02270895A (de)
CN (1) CN1031344C (de)
AT (1) ATE120758T1 (de)
AU (1) AU632526B2 (de)
CA (1) CA2008438A1 (de)
DE (1) DE69018275T2 (de)
DK (1) DK0378432T3 (de)
ES (1) ES2071004T3 (de)
HU (1) HU201964B (de)
IL (1) IL93107A (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU201964B (en) * 1989-01-13 1991-01-28 Richter Gedeon Vegyeszet Process for producing peptides inhibiting maturation of t-lymphocytes and activity of macrophages, as well as pharmaceutical compositions comprising same
WO1991004746A1 (en) * 1989-09-29 1991-04-18 Rhone-Poulenc Rorer International (Holdings) Inc. Anti-thrombotic peptides and pseudopeptides
US5332726A (en) * 1989-09-29 1994-07-26 Rhone-Poulenc Rorer Pharmaceuticals Inc. Antithrombotic peptides and pseudopeptides
US6197529B1 (en) * 1990-11-21 2001-03-06 Torrey Pines Institute For Molecular Studies Linear substituted oligoalkyleneimine libraries
MX9201416A (es) * 1991-03-28 1992-10-01 Rhone Poulenc Rorer Int Peptidos y pseudopeptidos antitromboticos.
WO1995003067A1 (en) * 1993-07-21 1995-02-02 Khavinson Vladimir Khatskelevi Pharmaceutical with immunomodulating activity
FR2788058B1 (fr) * 1998-12-30 2002-01-25 Sederma Sa Compositions cosmetiques amincissantes
KR100464787B1 (ko) * 2002-03-20 2005-01-06 박용석 글루탐산염을 이용한 양전하 지질의 제조방법
CN107021996B (zh) * 2017-05-24 2020-02-14 中国海洋大学 一种短肽、其应用以及由其得到的抗菌组合物

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4190646A (en) * 1975-11-11 1980-02-26 Sloan-Kettering Institute For Cancer Research Polypeptide compositions and methods
US4215112A (en) * 1979-03-14 1980-07-29 Ortho Pharmaceutical Corporation Tripeptides and methods
CA1157466A (en) * 1979-04-12 1983-11-22 Gideon Goldstein Peptides having thymopoietin-like activity
EP0033384B1 (de) * 1980-01-18 1984-02-15 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Thymosin-alpha-1-Fragmente enthaltende Arzneimittel mit immunstimulierender Wirkung, und Thymosin-alpha-1-Fragmente
HU185263B (en) * 1981-06-12 1984-12-28 Richter Gedeon Vegyeszet Process for producing peptides effective on the immuncontroll analogous with the tp5
US4442031A (en) * 1981-10-15 1984-04-10 Hoffmann-La Roche Inc. Immunopotentiating peptides
US4395404A (en) * 1982-05-14 1983-07-26 George Washington University Synthetic thymosin β3 and β4 analogues
DE3421614A1 (de) * 1984-06-09 1985-12-12 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von pentapeptiden mit wirkung auf das immunsystem und zwischenprodukte dieses verfahrens
AU602483B2 (en) * 1985-01-18 1990-10-18 Immunetech Pharmaceuticals Immunoregulatory peptides
HU201964B (en) * 1989-01-13 1991-01-28 Richter Gedeon Vegyeszet Process for producing peptides inhibiting maturation of t-lymphocytes and activity of macrophages, as well as pharmaceutical compositions comprising same

Also Published As

Publication number Publication date
DE69018275T2 (de) 1995-08-03
HUT53123A (en) 1990-09-28
US5093320A (en) 1992-03-03
IL93107A0 (en) 1990-11-05
CN1044102A (zh) 1990-07-25
ES2071004T3 (es) 1995-06-16
HU201964B (en) 1991-01-28
EP0378432A3 (de) 1991-04-24
DE69018275D1 (de) 1995-05-11
EP0378432B1 (de) 1995-04-05
JPH02270895A (ja) 1990-11-05
IL93107A (en) 1994-04-12
CA2008438A1 (en) 1991-07-24
EP0378432A2 (de) 1990-07-18
CN1031344C (zh) 1996-03-20
AU4792290A (en) 1990-09-20
AU632526B2 (en) 1993-01-07
DK0378432T3 (da) 1995-05-01

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee