DK0378432T3 - Peptider, deres anvendelse til inhibering af modningen af T-lymfocytter og aktiviteten af makrofager samt fremgangsmåder til deres fremstilling - Google Patents

Peptider, deres anvendelse til inhibering af modningen af T-lymfocytter og aktiviteten af makrofager samt fremgangsmåder til deres fremstilling

Info

Publication number: DK0378432T3
Authority: DK; Denmark
Prior art keywords: lys; asp; arg; thr; val
Prior art date: 1989-01-13

Application number

DK90300355.6T

Other languages

English (en)

Inventor

Istvan Dr Schon

Laszlo Dr Szporny

Nee Kuprina Olga Nyeki

Lajos Dr Kisfaludy

Denes Dr Laszlo

Gyorgy Dr Hajos

Original Assignee

Richter Gedeon Vegyeszet

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-01-13

Filing date

1990-01-12

Publication date

1995-05-01

1990-01-12 Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet

1995-05-01 Application granted granted Critical

1995-05-01 Publication of DK0378432T3 publication Critical patent/DK0378432T3/da

Links

108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
210000001744 T-lymphocyte Anatomy 0.000 title 1
230000000694 effects Effects 0.000 title 1
230000002401 inhibitory effect Effects 0.000 title 1
210000002540 macrophage Anatomy 0.000 title 1
230000035800 maturation Effects 0.000 title 1
JQFZHHSQMKZLRU-IUCAKERBSA-N Arg-Lys Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)[C@@H](N)CCCN=C(N)N JQFZHHSQMKZLRU-IUCAKERBSA-N 0.000 abstract 2
WGLAORUKDGRINI-WDCWCFNPSA-N Lys-Glu-Thr Chemical compound [H]N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O WGLAORUKDGRINI-WDCWCFNPSA-N 0.000 abstract 2
XUDRHBPSPAPDJP-SRVKXCTJSA-N Ser-Lys-Leu Chemical compound CC(C)C[C@@H](C(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CO XUDRHBPSPAPDJP-SRVKXCTJSA-N 0.000 abstract 2
108010062796 arginyllysine Proteins 0.000 abstract 2
210000000987 immune system Anatomy 0.000 abstract 1
108010048397 seryl-lysyl-leucine Proteins 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1019—Tetrapeptides with the first amino acid being basic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/081—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0815—Tripeptides with the first amino acid being basic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Transplantation (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DK90300355.6T 1989-01-13 1990-01-12 Peptider, deres anvendelse til inhibering af modningen af T-lymfocytter og aktiviteten af makrofager samt fremgangsmåder til deres fremstilling DK0378432T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
HU89116A HU201964B (en)	1989-01-13	1989-01-13	Process for producing peptides inhibiting maturation of t-lymphocytes and activity of macrophages, as well as pharmaceutical compositions comprising same

Publications (1)

Publication Number	Publication Date
DK0378432T3 true DK0378432T3 (da)	1995-05-01

Family

ID=10948008

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK90300355.6T DK0378432T3 (da)	1989-01-13	1990-01-12	Peptider, deres anvendelse til inhibering af modningen af T-lymfocytter og aktiviteten af makrofager samt fremgangsmåder til deres fremstilling

Country Status (12)

Country	Link
US (1)	US5093320A (da)
EP (1)	EP0378432B1 (da)
JP (1)	JPH02270895A (da)
CN (1)	CN1031344C (da)
AT (1)	ATE120758T1 (da)
AU (1)	AU632526B2 (da)
CA (1)	CA2008438A1 (da)
DE (1)	DE69018275T2 (da)
DK (1)	DK0378432T3 (da)
ES (1)	ES2071004T3 (da)
HU (1)	HU201964B (da)
IL (1)	IL93107A (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU201964B (en) *	1989-01-13	1991-01-28	Richter Gedeon Vegyeszet	Process for producing peptides inhibiting maturation of t-lymphocytes and activity of macrophages, as well as pharmaceutical compositions comprising same
EP0494248A4 (en) *	1989-09-29	1992-08-26	Rhone-Poulenc Rorer International (Holdings) Inc.	Anti-thrombotic peptides and pseudopeptides
US5332726A (en) *	1989-09-29	1994-07-26	Rhone-Poulenc Rorer Pharmaceuticals Inc.	Antithrombotic peptides and pseudopeptides
US6197529B1 (en) *	1990-11-21	2001-03-06	Torrey Pines Institute For Molecular Studies	Linear substituted oligoalkyleneimine libraries
MX9201416A (es) *	1991-03-28	1992-10-01	Rhone Poulenc Rorer Int	Peptidos y pseudopeptidos antitromboticos.
WO1995003067A1 (en) *	1993-07-21	1995-02-02	Khavinson Vladimir Khatskelevi	Pharmaceutical with immunomodulating activity
FR2788058B1 (fr) *	1998-12-30	2002-01-25	Sederma Sa	Compositions cosmetiques amincissantes
KR100464787B1 (ko) *	2002-03-20	2005-01-06	박용석	글루탐산염을 이용한 양전하 지질의 제조방법
CN107021996B (zh) *	2017-05-24	2020-02-14	中国海洋大学	一种短肽、其应用以及由其得到的抗菌组合物

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4190646A (en) *	1975-11-11	1980-02-26	Sloan-Kettering Institute For Cancer Research	Polypeptide compositions and methods
US4215112A (en) *	1979-03-14	1980-07-29	Ortho Pharmaceutical Corporation	Tripeptides and methods
CA1157466A (en) *	1979-04-12	1983-11-22	Gideon Goldstein	Peptides having thymopoietin-like activity
EP0033384B1 (de) *	1980-01-18	1984-02-15	Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.	Thymosin-alpha-1-Fragmente enthaltende Arzneimittel mit immunstimulierender Wirkung, und Thymosin-alpha-1-Fragmente
HU185263B (en) *	1981-06-12	1984-12-28	Richter Gedeon Vegyeszet	Process for producing peptides effective on the immuncontroll analogous with the tp5
US4442031A (en) *	1981-10-15	1984-04-10	Hoffmann-La Roche Inc.	Immunopotentiating peptides
US4395404A (en) *	1982-05-14	1983-07-26	George Washington University	Synthetic thymosin β3 and β4 analogues
DE3421614A1 (de) *	1984-06-09	1985-12-12	Hoechst Ag, 6230 Frankfurt	Verfahren zur herstellung von pentapeptiden mit wirkung auf das immunsystem und zwischenprodukte dieses verfahrens
AU602483B2 (en) *	1985-01-18	1990-10-18	Immunetech Pharmaceuticals	Immunoregulatory peptides
HU201964B (en) *	1989-01-13	1991-01-28	Richter Gedeon Vegyeszet	Process for producing peptides inhibiting maturation of t-lymphocytes and activity of macrophages, as well as pharmaceutical compositions comprising same

1989
- 1989-01-13 HU HU89116A patent/HU201964B/hu not_active IP Right Cessation
- 1989-12-30 CN CN89109713A patent/CN1031344C/zh not_active Expired - Fee Related
1990
- 1990-01-09 US US07/462,219 patent/US5093320A/en not_active Expired - Fee Related
- 1990-01-12 DE DE69018275T patent/DE69018275T2/de not_active Expired - Fee Related
- 1990-01-12 AU AU47922/90A patent/AU632526B2/en not_active Ceased
- 1990-01-12 EP EP90300355A patent/EP0378432B1/en not_active Expired - Lifetime
- 1990-01-12 AT AT90300355T patent/ATE120758T1/de not_active IP Right Cessation
- 1990-01-12 DK DK90300355.6T patent/DK0378432T3/da active
- 1990-01-12 JP JP2003712A patent/JPH02270895A/ja active Pending
- 1990-01-12 ES ES90300355T patent/ES2071004T3/es not_active Expired - Lifetime
- 1990-01-18 IL IL9310790A patent/IL93107A/en not_active IP Right Cessation
- 1990-01-24 CA CA002008438A patent/CA2008438A1/en not_active Abandoned

Also Published As

Publication number	Publication date
HU201964B (en)	1991-01-28
IL93107A0 (en)	1990-11-05
ES2071004T3 (es)	1995-06-16
DE69018275D1 (de)	1995-05-11
CA2008438A1 (en)	1991-07-24
HUT53123A (en)	1990-09-28
AU4792290A (en)	1990-09-20
CN1044102A (zh)	1990-07-25
EP0378432A2 (en)	1990-07-18
ATE120758T1 (de)	1995-04-15
EP0378432A3 (en)	1991-04-24
JPH02270895A (ja)	1990-11-05
EP0378432B1 (en)	1995-04-05
DE69018275T2 (de)	1995-08-03
AU632526B2 (en)	1993-01-07
US5093320A (en)	1992-03-03
IL93107A (en)	1994-04-12
CN1031344C (zh)	1996-03-20

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IT8812558A0 (it)	1988-09-28	Poltrona per abbronzatura
DK0733067T3 (da)	1999-11-01	N-terminalt kemisk modificerede proteinpræparater og fremgangsmåder
IE891136L (en)	1989-10-11	2-substituted-4-substituted-1,3-dioxolanes, synthesis and use thereof
ATE152172T1 (de)	1997-05-15	Herstellung eines rekombinanten menschlichen interleukin-1-hemmers
DK20690D0 (da)	1990-01-25	Alkoxy-1,2,4-triazolo(1,5-c)pyrimidin-2-sulfonamider, fremgangsmaade til deres fremstilling og mellemprodukter
DK0547932T3 (da)	1997-02-10	Fremgangsmåde til fremstilling af et koncentrat af aktiveret faktor VII med høj renhed
DE3766533D1 (de)	1991-01-17	Kinderlaufstuhl.
FI896157A0 (fi)	1989-12-20	Mikrobinen menetelmä syklosporiinien valmistamiseksi
FI91961C (fi)	1994-09-12	Menetelmä (S)- -etyyli-2-okso-1-pyrrolidiiniasetamidin valmistamiseksi
FI894546A7 (fi)	1990-03-28	Menetelmä uusien 2'-halogeenimetylideeni-, 2'-etenylideeni- ja 2'-etynyyliadenosiinijohdannaisten valmistamiseksi
IT1230068B (it)	1991-10-05	Procedimento per la preparazione di n sulfoniluree.
EP0378432A3 (en)	1991-04-24	Novel peptides, their use to inhibit the maturation of t-lymphocytes and the activity of macrophages, and processes for their preparation
DK494589A (da)	1990-04-09	Substituerede 1,3,5-triazintrioner og deres anvendelse samt mellemprodukter til deres fremstilling
FI890186A7 (fi)	1989-07-16	Menetelmä 1-hydroksialkyyli-5-nitroimidatsolien valmistamiseksi
FI890188A7 (fi)	1989-07-16	Menetelmä 1-hydroksialkyyli-2-metyyli-5-nitroimidatsolien valmistamiseksi
DK642687D0 (da)	1987-12-08	N,n'-disubstituerede urinstoffer samt fremgangsmaade til fremstilling deraf
DE69016693D1 (de)	1995-03-23	Züchtung von transformierten Mikroorganismen.
DK35088A (da)	1988-07-28	Cycloalkan oe1,2-c:4,3-c'aa dipyrazoler samt fremgangsmaade til fremstilling deraf
ES2096559T3 (es)	1997-03-16	Interferon gamma humano, procedimiento para la preparacion de dicho interferon gamma humano, y su uso.
IT8920747A0 (it)	1989-06-02	Procedimento per la preparazione di metil 3 amminocrotonato.
DK355289A (da)	1990-01-20	2,2-dihalogencyclopropyl-hydroxy-ethyltriazoler, fremgangsmaader og mellemprodukter til deres fremstilling samt deres anvendelse
IT1228559B (it)	1991-06-21	Procedimento per la preparazione di enzima mieloperossidasi.
IT1188043B (it)	1987-12-30	Procedimento per il fissaggio di pietre preziose o non prezionse sugicielli in genere
IL106275A0 (en)	1993-11-15	Non-reverting rna viruses
DK376089D0 (da)	1989-07-31	Vaekstoegende praeparater