ATE121066T1 - Verfahren zur herstellung von 6,12-dihydro-6- hydroxy-cannabidiol und dessen anwendung zur herstellung von trans-delta-9- tetrahydrocannabinol. - Google Patents
Verfahren zur herstellung von 6,12-dihydro-6- hydroxy-cannabidiol und dessen anwendung zur herstellung von trans-delta-9- tetrahydrocannabinol.Info
- Publication number
- ATE121066T1 ATE121066T1 AT92100258T AT92100258T ATE121066T1 AT E121066 T1 ATE121066 T1 AT E121066T1 AT 92100258 T AT92100258 T AT 92100258T AT 92100258 T AT92100258 T AT 92100258T AT E121066 T1 ATE121066 T1 AT E121066T1
- Authority
- AT
- Austria
- Prior art keywords
- producing
- cannabidiol
- tetrahydrocannabinol
- dihydro
- delta
- Prior art date
Links
- 229950011318 cannabidiol Drugs 0.000 title abstract 2
- CYQFCXCEBYINGO-IAGOWNOFSA-N delta1-THC Chemical compound C1=C(C)CC[C@H]2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3[C@@H]21 CYQFCXCEBYINGO-IAGOWNOFSA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- IRMPFYJSHJGOPE-UHFFFAOYSA-N olivetol Chemical compound CCCCCC1=CC(O)=CC(O)=C1 IRMPFYJSHJGOPE-UHFFFAOYSA-N 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing six-membered aromatic rings and other rings, with unsaturation outside the aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
- C07C37/11—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions increasing the number of carbon atoms
- C07C37/14—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions increasing the number of carbon atoms by addition reactions, i.e. reactions involving at least one carbon-to-carbon unsaturated bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pyrane Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4100441A DE4100441A1 (de) | 1991-01-09 | 1991-01-09 | Verfahren zur herstellung von 6,12-dihydro-6-hydroxy-cannabidiol und dessen verwendung zur herstellung von trans-delta-9-tetrahydrocannabinol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE121066T1 true ATE121066T1 (de) | 1995-04-15 |
Family
ID=6422735
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92100258T ATE121066T1 (de) | 1991-01-09 | 1992-01-09 | Verfahren zur herstellung von 6,12-dihydro-6- hydroxy-cannabidiol und dessen anwendung zur herstellung von trans-delta-9- tetrahydrocannabinol. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US5227537A (de) |
| EP (1) | EP0494665B1 (de) |
| JP (1) | JP2637659B2 (de) |
| AT (1) | ATE121066T1 (de) |
| DE (2) | DE4100441A1 (de) |
| DK (1) | DK0494665T3 (de) |
| ES (1) | ES2071351T3 (de) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5342971A (en) * | 1992-12-29 | 1994-08-30 | The Australian National University | Process for the preparation of dibenzo[b,d]pyrans |
| US6630507B1 (en) | 1998-04-21 | 2003-10-07 | The United States Of America As Represented By The Department Of Health And Human Services | Cannabinoids as antioxidants and neuroprotectants |
| AU3910700A (en) | 1999-03-22 | 2000-10-09 | Immugen Pharmaceuticals, Inc. | Treatment of immune diseases |
| US6566560B2 (en) | 1999-03-22 | 2003-05-20 | Immugen Pharmaceuticals, Inc. | Resorcinolic compounds |
| WO2002026224A2 (en) * | 2000-09-28 | 2002-04-04 | Immugen Pharmaceuticals, Inc. | Methods and compounds for inhibiting eicosanoid metabolism and platelet aggregation |
| US6541510B2 (en) * | 2000-09-28 | 2003-04-01 | Immugen Pharmaceuticals, Inc. | Antiviral methods and compounds |
| DE10051427C1 (de) * | 2000-10-17 | 2002-06-13 | Adam Mueller | Verfahren zur Herstellung eines Tetrahydrocannabinol- und Cannabidiol-haltigen Extraktes aus Cannabis-Pflanzenmaterial sowie Cannabis-Extrakte |
| AU2008200935B2 (en) * | 2001-02-05 | 2010-02-04 | Thc Pharm The Health Concept Gmbh | Method for the Production of Dronabinol |
| DE10106024B4 (de) * | 2001-02-09 | 2004-10-14 | Thc Pharm Gmbh | Verfahren zur Herstellung von Dronabinol |
| GB0112752D0 (en) * | 2001-05-25 | 2001-07-18 | Johnson Matthey Plc | Synthesis of cannabinoids |
| GB0112748D0 (en) * | 2001-05-25 | 2001-07-18 | Johnson Matthey Plc | Uncatalysed addition reactions |
| AU2002331595A1 (en) * | 2001-08-15 | 2003-03-03 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of | Novel vasoconstrictor cannabinoid analogs |
| WO2003080043A1 (en) * | 2002-03-18 | 2003-10-02 | Immugen Pharmaceuticals, Inc. | Topical formulations of resorcinols and cannibinoids and methods of use |
| KR101113162B1 (ko) * | 2002-08-14 | 2012-06-20 | 지더블유 파마 리미티드 | 식물물질로부터 약제학적 활성성분의 추출의 개량 |
| US7344736B2 (en) * | 2002-08-14 | 2008-03-18 | Gw Pharma Limited | Extraction of pharmaceutically active components from plant materials |
| AU2004230871A1 (en) * | 2003-04-10 | 2004-10-28 | Mallinckrodt Inc. | Olivetol-cyclodextrin complexes and regio-selective process for preparing delta 9-tetrahydrocannabinol |
| CN1809552A (zh) * | 2003-05-20 | 2006-07-26 | 田纳西大学研究基金会 | 大麻素衍生物、其制备方法和用途 |
| US20070287843A1 (en) * | 2004-04-07 | 2007-12-13 | Cabaj John E | Methods and Intermediates for the Synthesis of Delta-9 Tetrahydrocannabinol |
| US7323576B2 (en) | 2004-10-01 | 2008-01-29 | Alphora Research Inc. | Synthetic route to dronabinol |
| TWI369203B (en) | 2004-11-22 | 2012-08-01 | Euro Celtique Sa | Methods for purifying trans-(-)-△9-tetrahydrocannabinol and trans-(+)-△9-tetrahydrocannabinol |
| TWI366460B (en) | 2005-06-16 | 2012-06-21 | Euro Celtique Sa | Cannabinoid active pharmaceutical ingredient for improved dosage forms |
| DE102005028937B4 (de) * | 2005-06-22 | 2009-07-23 | Bionorica Ag | Verfahren zur Herstellung von Dronabinol |
| CA2623723A1 (en) * | 2005-09-29 | 2007-04-12 | Amr Technology, Inc. | Process for production of delta-9-tetrahydrocannabinol |
| US8323211B2 (en) * | 2006-06-01 | 2012-12-04 | Daniel Larkin | Sexually transmitted infection sampling device |
| ES2995732T3 (en) | 2014-07-21 | 2025-02-11 | Pharmaceutical Productions Inc | Solid dosage form composition for buccal or sublingual administration of cannabinoids |
| US10059683B2 (en) | 2015-07-10 | 2018-08-28 | Noramco, Inc. | Process for the production of cannabidiol and delta-9-tetrahydrocannabinol |
| US10239808B1 (en) | 2016-12-07 | 2019-03-26 | Canopy Holdings, LLC | Cannabis extracts |
| BR112019019966A2 (pt) | 2017-03-24 | 2020-04-28 | Trait Biosciences Inc | biossíntese in vivo de alto nível e isolamento de canabinoides solúveis em água em sistemas de plantas |
| CN111465700A (zh) | 2017-07-11 | 2020-07-28 | 特征生物科学公司 | 在酵母和植物细胞悬浮培养物中产生水溶性大麻素化合物和材料组合物 |
| US10640482B2 (en) | 2017-07-21 | 2020-05-05 | University Of South Florida | Synthesis of cannabinoids |
| AU2019212486A1 (en) | 2018-01-24 | 2019-08-29 | Trait Biosciences, Inc. | Systems and methods for enhancing trichome formation and density in |
| CA3089994A1 (en) | 2018-01-31 | 2019-08-08 | Canopy Holdings, LLC | Hemp powder |
| CA3112583A1 (en) | 2018-07-09 | 2020-01-16 | New Age Nanotech Llc | Stabilized formulations of cannabinoid compositions |
| WO2020031179A1 (en) | 2018-08-06 | 2020-02-13 | Beetlebung Pharma Ltd. | Methods for synthesis of cannabinoid compounds |
| WO2020051371A2 (en) | 2018-09-05 | 2020-03-12 | Noramco, Inc. | Cannabidiol compositions having modified cannabinoid profiles |
| WO2020077153A1 (en) | 2018-10-10 | 2020-04-16 | Canopy Holdings, LLC | Synthesis of cannabigerol |
| JP2022507668A (ja) * | 2018-11-14 | 2022-01-18 | エンバイオ リミテッド | カンナビノイドを調製するための方法および化合物 |
| CA3140290A1 (en) | 2019-05-16 | 2020-11-19 | Technion Research & Development Foundation Limited | Cannabinoids and uses thereof |
| CN111943813B (zh) | 2019-05-17 | 2023-04-14 | 上海特化医药科技有限公司 | 大麻二酚类化合物的制备方法 |
| CA3148950A1 (en) | 2019-07-30 | 2021-02-04 | The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (A.R.O.), Volcani Center | Methods of controlling cannabinoid synthesis in plants or cells and plants and cells produced thereby |
| CA3159112A1 (en) | 2019-11-21 | 2021-05-27 | Shinkei Therapeutics, Inc. | Cannabidiol and/or cobicistat combination drug therapy |
| WO2021139739A1 (zh) | 2020-01-08 | 2021-07-15 | 成都百裕制药股份有限公司 | 大麻二酚衍生物及其制备方法和在医药上的应用 |
| CN113087599A (zh) * | 2020-01-08 | 2021-07-09 | 成都百裕制药股份有限公司 | 大麻二酚衍生物及其制备方法和在医药上的应用 |
| EP4089081B1 (de) | 2020-01-08 | 2025-07-23 | Chengdu Baiyu Pharmaceutical Co., Ltd. | Tetrahydrocannabinol-derivat, und herstellungsverfahren dafür und medizinische verwendung davon |
| US12029718B2 (en) | 2021-11-09 | 2024-07-09 | Cct Sciences, Llc | Process for production of essentially pure delta-9-tetrahydrocannabinol |
| US20230414639A1 (en) * | 2020-11-15 | 2023-12-28 | Technion Research And Development Foundation Limited | Cannabinoids, pharmaceutical compositions comprising same and uses thereof |
| CA3200651A1 (en) | 2020-12-04 | 2022-06-09 | Joel Ernest George HARDY | Antiinflammatory compositions comprising cannabidiol, delta-9- tetrahydrocannabinol and linalool |
| US11242328B1 (en) * | 2021-02-25 | 2022-02-08 | Acid Neutral Alkaline Laboratory | Heterogeneous catalyst and method for preparation of aromatic tricyclic pyrans |
| US12029719B2 (en) | 2021-04-16 | 2024-07-09 | Allen Morgan | Compounds comprising cannabinoids and other natural ingredients for alieving premenstrual, menstrual and menopausal symptoms |
| US11352337B1 (en) * | 2021-06-02 | 2022-06-07 | Acid Neutral Alkaline Laboratory | Zeolite catalyst and method for preparation of aromatic tricyclic pyrans |
| PL4124336T3 (pl) | 2021-07-30 | 2024-02-26 | Cannamedical Pharma Gmbh | Plaster przezśluzówkowy obejmujący kannabinoid i/lub opioid |
| US12103950B2 (en) | 2022-01-27 | 2024-10-01 | University Of Connecticut | Transgenic plants that overexpress a R2R3-MYB transcription factor gene and methods for producing the same |
| WO2024160792A1 (en) | 2023-01-30 | 2024-08-08 | Cannamedical Pharma Gmbh | Improved transmucosal patch comprising a cannabinoid and/or an opioid |
| WO2024231543A1 (en) | 2023-05-10 | 2024-11-14 | Gb Lab | Cannabinoid derivatives for treating autism spectrum disorder |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3656906A (en) * | 1970-04-13 | 1972-04-18 | Little Inc A | Method for detecting and quantitating the presence of cannabinoids and analogs thereof in biological materials and resulting products |
| US4116979A (en) * | 1975-06-23 | 1978-09-26 | Sheehan Institute For Research, Inc. | Process for the preparation of (-)-6a,10a-trans-6a,7,8,10a-tetrahydrodibenzo[b,d]-pyrans |
| HU194858B (en) * | 1982-12-03 | 1988-03-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing dibenzo/b,d/pirane derivatives and pharmaceutical compositions containing them |
| US4758597A (en) * | 1987-05-15 | 1988-07-19 | University Patents, Inc. | Carenadiol and derivatives |
-
1991
- 1991-01-09 DE DE4100441A patent/DE4100441A1/de not_active Withdrawn
-
1992
- 1992-01-08 US US07/818,040 patent/US5227537A/en not_active Expired - Fee Related
- 1992-01-09 AT AT92100258T patent/ATE121066T1/de not_active IP Right Cessation
- 1992-01-09 ES ES92100258T patent/ES2071351T3/es not_active Expired - Lifetime
- 1992-01-09 EP EP92100258A patent/EP0494665B1/de not_active Expired - Lifetime
- 1992-01-09 DK DK92100258.0T patent/DK0494665T3/da active
- 1992-01-09 JP JP4002315A patent/JP2637659B2/ja not_active Expired - Fee Related
- 1992-01-09 DE DE69201959T patent/DE69201959T2/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE69201959D1 (de) | 1995-05-18 |
| DK0494665T3 (da) | 1995-08-28 |
| JP2637659B2 (ja) | 1997-08-06 |
| EP0494665B1 (de) | 1995-04-12 |
| ES2071351T3 (es) | 1995-06-16 |
| DE4100441A1 (de) | 1992-07-16 |
| EP0494665A1 (de) | 1992-07-15 |
| US5227537A (en) | 1993-07-13 |
| DE69201959T2 (de) | 1995-08-24 |
| JPH06340650A (ja) | 1994-12-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |