ATE121066T1 - Verfahren zur herstellung von 6,12-dihydro-6- hydroxy-cannabidiol und dessen anwendung zur herstellung von trans-delta-9- tetrahydrocannabinol. - Google Patents
Verfahren zur herstellung von 6,12-dihydro-6- hydroxy-cannabidiol und dessen anwendung zur herstellung von trans-delta-9- tetrahydrocannabinol.Info
- Publication number
- ATE121066T1 ATE121066T1 AT92100258T AT92100258T ATE121066T1 AT E121066 T1 ATE121066 T1 AT E121066T1 AT 92100258 T AT92100258 T AT 92100258T AT 92100258 T AT92100258 T AT 92100258T AT E121066 T1 ATE121066 T1 AT E121066T1
- Authority
- AT
- Austria
- Prior art keywords
- producing
- cannabidiol
- tetrahydrocannabinol
- dihydro
- delta
- Prior art date
Links
- 229950011318 cannabidiol Drugs 0.000 title abstract 2
- CYQFCXCEBYINGO-IAGOWNOFSA-N delta1-THC Chemical compound C1=C(C)CC[C@H]2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3[C@@H]21 CYQFCXCEBYINGO-IAGOWNOFSA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- IRMPFYJSHJGOPE-UHFFFAOYSA-N olivetol Chemical compound CCCCCC1=CC(O)=CC(O)=C1 IRMPFYJSHJGOPE-UHFFFAOYSA-N 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing six-membered aromatic rings and other rings, with unsaturation outside the aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
- C07C37/11—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions increasing the number of carbon atoms
- C07C37/14—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions increasing the number of carbon atoms by addition reactions, i.e. reactions involving at least one carbon-to-carbon unsaturated bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pyrane Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4100441A DE4100441A1 (de) | 1991-01-09 | 1991-01-09 | Verfahren zur herstellung von 6,12-dihydro-6-hydroxy-cannabidiol und dessen verwendung zur herstellung von trans-delta-9-tetrahydrocannabinol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE121066T1 true ATE121066T1 (de) | 1995-04-15 |
Family
ID=6422735
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92100258T ATE121066T1 (de) | 1991-01-09 | 1992-01-09 | Verfahren zur herstellung von 6,12-dihydro-6- hydroxy-cannabidiol und dessen anwendung zur herstellung von trans-delta-9- tetrahydrocannabinol. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US5227537A (de) |
| EP (1) | EP0494665B1 (de) |
| JP (1) | JP2637659B2 (de) |
| AT (1) | ATE121066T1 (de) |
| DE (2) | DE4100441A1 (de) |
| DK (1) | DK0494665T3 (de) |
| ES (1) | ES2071351T3 (de) |
Families Citing this family (54)
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| US5342971A (en) * | 1992-12-29 | 1994-08-30 | The Australian National University | Process for the preparation of dibenzo[b,d]pyrans |
| EP1071419B1 (de) | 1998-04-21 | 2007-07-25 | THE UNITED STATES GOVERNMENT as represented by THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | Cannabinoiden als antioxidantien und neuroschützende mittel |
| CN1377261A (zh) | 1999-03-22 | 2002-10-30 | 免疫力药品有限公司 | 治疗免疫疾病 |
| US6566560B2 (en) | 1999-03-22 | 2003-05-20 | Immugen Pharmaceuticals, Inc. | Resorcinolic compounds |
| AU2001296402A1 (en) * | 2000-09-28 | 2002-04-08 | Immugen Pharmaceuticals, Inc. | Methods and compounds for inhibiting eicosanoid metabolism and platelet aggregation |
| US6541510B2 (en) * | 2000-09-28 | 2003-04-01 | Immugen Pharmaceuticals, Inc. | Antiviral methods and compounds |
| DE10051427C1 (de) | 2000-10-17 | 2002-06-13 | Adam Mueller | Verfahren zur Herstellung eines Tetrahydrocannabinol- und Cannabidiol-haltigen Extraktes aus Cannabis-Pflanzenmaterial sowie Cannabis-Extrakte |
| AU2008200935B2 (en) * | 2001-02-05 | 2010-02-04 | Thc Pharm The Health Concept Gmbh | Method for the Production of Dronabinol |
| DE10106024B4 (de) * | 2001-02-09 | 2004-10-14 | Thc Pharm Gmbh | Verfahren zur Herstellung von Dronabinol |
| GB0112752D0 (en) * | 2001-05-25 | 2001-07-18 | Johnson Matthey Plc | Synthesis of cannabinoids |
| GB0112748D0 (en) * | 2001-05-25 | 2001-07-18 | Johnson Matthey Plc | Uncatalysed addition reactions |
| WO2003015700A2 (en) * | 2001-08-15 | 2003-02-27 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Novel vasoconstrictor cannabinoid analogs |
| WO2003080043A1 (en) * | 2002-03-18 | 2003-10-02 | Immugen Pharmaceuticals, Inc. | Topical formulations of resorcinols and cannibinoids and methods of use |
| US7344736B2 (en) * | 2002-08-14 | 2008-03-18 | Gw Pharma Limited | Extraction of pharmaceutically active components from plant materials |
| MXPA05001621A (es) * | 2002-08-14 | 2005-08-19 | Gw Pharma Ltd | Extraccion de cannabinoides farmaceuticamente activos de materiales vegetales. |
| CA2521920A1 (en) * | 2003-04-10 | 2004-10-28 | Mallinckrodt Inc. | Olivetol-cyclodextrin complexes and regio-selective process for preparing delta 9-tetrahydrocannabinol |
| US7169942B2 (en) * | 2003-05-20 | 2007-01-30 | University Of Tennessee Research Foundation | Cannabinoid derivatives, methods of making, and use thereof |
| EP1732908A1 (de) * | 2004-04-07 | 2006-12-20 | Cedarburg Pharmaceuticals, Inc. | Verfahren und zwischenprodukte zur synthese von delta-9-tetrahydrocannabinol |
| US7323576B2 (en) | 2004-10-01 | 2008-01-29 | Alphora Research Inc. | Synthetic route to dronabinol |
| TWI369203B (en) | 2004-11-22 | 2012-08-01 | Euro Celtique Sa | Methods for purifying trans-(-)-△9-tetrahydrocannabinol and trans-(+)-△9-tetrahydrocannabinol |
| TWI366460B (en) | 2005-06-16 | 2012-06-21 | Euro Celtique Sa | Cannabinoid active pharmaceutical ingredient for improved dosage forms |
| DE102005028937B4 (de) * | 2005-06-22 | 2009-07-23 | Bionorica Ag | Verfahren zur Herstellung von Dronabinol |
| EP2578561A1 (de) * | 2005-09-29 | 2013-04-10 | Albany Molecular Research, Inc. | Verfahren zur Herstellung von Cannavbidiolderivaten und deren Intermediaten |
| US8323211B2 (en) * | 2006-06-01 | 2012-12-04 | Daniel Larkin | Sexually transmitted infection sampling device |
| CA2992923C (en) | 2014-07-21 | 2021-06-29 | Pharmaceutical Productions, Inc. | Solid dosage form composition for buccal and sublingual administration of cannabinoids |
| US20170008869A1 (en) | 2015-07-10 | 2017-01-12 | Noramco, Inc. | Process for the production of cannabidiol and delta-9-tetrahydrocannabinol |
| US10239808B1 (en) | 2016-12-07 | 2019-03-26 | Canopy Holdings, LLC | Cannabis extracts |
| WO2018176055A2 (en) | 2017-03-24 | 2018-09-27 | Trait Biosciences, Inc. | High level in vivo biosynthesis and isolation of water-soluble cannabinoids in plant systems |
| EP3679153A4 (de) | 2017-07-11 | 2021-01-06 | Trait Biosciences, Inc. | Erzeugung von wasserlöslichen cannabinoid-verbindungen in hefe- und pflanzenzellsuspensionskulturen und stoffzusammensetzungen |
| US10640482B2 (en) | 2017-07-21 | 2020-05-05 | University Of South Florida | Synthesis of cannabinoids |
| AU2019212486A1 (en) | 2018-01-24 | 2019-08-29 | Trait Biosciences, Inc. | Systems and methods for enhancing trichome formation and density in |
| US11202771B2 (en) | 2018-01-31 | 2021-12-21 | Treehouse Biotech, Inc. | Hemp powder |
| US20200138772A1 (en) | 2018-07-09 | 2020-05-07 | Volker Berl | Stabilized formulations of cannabinoid compositions |
| WO2020031179A1 (en) | 2018-08-06 | 2020-02-13 | Beetlebung Pharma Ltd. | Methods for synthesis of cannabinoid compounds |
| US12144795B2 (en) | 2018-09-05 | 2024-11-19 | Purisys Llc | Cannabidiol compositions having modified cannabinoid profiles |
| EP3864000A4 (de) | 2018-10-10 | 2022-08-10 | Treehouse Biosciences, Inc. | Synthese von cannabigerol |
| US20220009899A1 (en) * | 2018-11-14 | 2022-01-13 | Embio Limited | Process and compounds for preparation of cannabinoids |
| CN114096241A (zh) | 2019-05-16 | 2022-02-25 | 技术研究及发展基金有限公司 | 大麻素及其用途 |
| CN111943813B (zh) | 2019-05-17 | 2023-04-14 | 上海特化医药科技有限公司 | 大麻二酚类化合物的制备方法 |
| CA3148950A1 (en) | 2019-07-30 | 2021-02-04 | The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (A.R.O.), Volcani Center | Methods of controlling cannabinoid synthesis in plants or cells and plants and cells produced thereby |
| CN115003289B (zh) | 2019-11-21 | 2025-01-10 | 新凯治疗有限公司 | 大麻二酚和/或考比司他联合药物疗法 |
| CN113087743B (zh) | 2020-01-08 | 2023-04-28 | 成都百裕制药股份有限公司 | 四氢大麻酚衍生物及其制备方法和在医药上的应用 |
| EP4089084A4 (de) * | 2020-01-08 | 2024-03-13 | Chengdu Baiyu Pharmaceutical Co., Ltd. | Cannabidiolderivat, verfahren zu seiner herstellung und medizinische verwendung davon |
| US12545694B2 (en) | 2020-01-08 | 2026-02-10 | Chengdu Baiyu Pharmaceutical Co., Ltd. | Cannabidiol derivatives, preparation method thereof and use thereof |
| US12029718B2 (en) | 2021-11-09 | 2024-07-09 | Cct Sciences, Llc | Process for production of essentially pure delta-9-tetrahydrocannabinol |
| WO2022101917A1 (en) * | 2020-11-15 | 2022-05-19 | Technion Research And Development Foundation Limited | Cannabinoids, pharmaceutical compositions comprising same and uses thereof |
| CA3200651A1 (en) | 2020-12-04 | 2022-06-09 | Joel Ernest George HARDY | Antiinflammatory compositions comprising cannabidiol, delta-9- tetrahydrocannabinol and linalool |
| US11242328B1 (en) * | 2021-02-25 | 2022-02-08 | Acid Neutral Alkaline Laboratory | Heterogeneous catalyst and method for preparation of aromatic tricyclic pyrans |
| US12029719B2 (en) | 2021-04-16 | 2024-07-09 | Allen Morgan | Compounds comprising cannabinoids and other natural ingredients for alieving premenstrual, menstrual and menopausal symptoms |
| US11352337B1 (en) * | 2021-06-02 | 2022-06-07 | Acid Neutral Alkaline Laboratory | Zeolite catalyst and method for preparation of aromatic tricyclic pyrans |
| EP4124336B1 (de) | 2021-07-30 | 2023-10-25 | Cannamedical Pharma GmbH | Transmukosales pflaster mit einem cannabinoid und/oder einem opioid |
| US12103950B2 (en) | 2022-01-27 | 2024-10-01 | University Of Connecticut | Transgenic plants that overexpress a R2R3-MYB transcription factor gene and methods for producing the same |
| WO2024160792A1 (en) | 2023-01-30 | 2024-08-08 | Cannamedical Pharma Gmbh | Improved transmucosal patch comprising a cannabinoid and/or an opioid |
| WO2024231543A1 (en) | 2023-05-10 | 2024-11-14 | Gb Lab | Cannabinoid derivatives for treating autism spectrum disorder |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3656906A (en) * | 1970-04-13 | 1972-04-18 | Little Inc A | Method for detecting and quantitating the presence of cannabinoids and analogs thereof in biological materials and resulting products |
| US4116979A (en) | 1975-06-23 | 1978-09-26 | Sheehan Institute For Research, Inc. | Process for the preparation of (-)-6a,10a-trans-6a,7,8,10a-tetrahydrodibenzo[b,d]-pyrans |
| HU194858B (en) * | 1982-12-03 | 1988-03-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing dibenzo/b,d/pirane derivatives and pharmaceutical compositions containing them |
| US4758597A (en) * | 1987-05-15 | 1988-07-19 | University Patents, Inc. | Carenadiol and derivatives |
-
1991
- 1991-01-09 DE DE4100441A patent/DE4100441A1/de not_active Withdrawn
-
1992
- 1992-01-08 US US07/818,040 patent/US5227537A/en not_active Expired - Fee Related
- 1992-01-09 ES ES92100258T patent/ES2071351T3/es not_active Expired - Lifetime
- 1992-01-09 AT AT92100258T patent/ATE121066T1/de not_active IP Right Cessation
- 1992-01-09 EP EP92100258A patent/EP0494665B1/de not_active Expired - Lifetime
- 1992-01-09 JP JP4002315A patent/JP2637659B2/ja not_active Expired - Fee Related
- 1992-01-09 DK DK92100258.0T patent/DK0494665T3/da active
- 1992-01-09 DE DE69201959T patent/DE69201959T2/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE4100441A1 (de) | 1992-07-16 |
| US5227537A (en) | 1993-07-13 |
| JPH06340650A (ja) | 1994-12-13 |
| DE69201959T2 (de) | 1995-08-24 |
| EP0494665A1 (de) | 1992-07-15 |
| DK0494665T3 (da) | 1995-08-28 |
| ES2071351T3 (es) | 1995-06-16 |
| EP0494665B1 (de) | 1995-04-12 |
| DE69201959D1 (de) | 1995-05-18 |
| JP2637659B2 (ja) | 1997-08-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |