ATE121130T1 - Monoklonaler antikörper, spezifisch gegen den funktionellen adhäsionsbereich des oberflächenproteins einer phagocyten-zelle. - Google Patents

Monoklonaler antikörper, spezifisch gegen den funktionellen adhäsionsbereich des oberflächenproteins einer phagocyten-zelle.

Info

Publication number
ATE121130T1
ATE121130T1 AT88904354T AT88904354T ATE121130T1 AT E121130 T1 ATE121130 T1 AT E121130T1 AT 88904354 T AT88904354 T AT 88904354T AT 88904354 T AT88904354 T AT 88904354T AT E121130 T1 ATE121130 T1 AT E121130T1
Authority
AT
Austria
Prior art keywords
monoclonal antibodies
surface protein
adhesion area
antibodies specifically
monoclonal antibody
Prior art date
Application number
AT88904354T
Other languages
English (en)
Inventor
Stuart F Schlossman
James D Griffin
Original Assignee
Dana Farber Cancer Inst Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dana Farber Cancer Inst Inc filed Critical Dana Farber Cancer Inst Inc
Application granted granted Critical
Publication of ATE121130T1 publication Critical patent/ATE121130T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2845—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta2-subunit-containing molecules, e.g. CD11, CD18
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/828—Cancer

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT88904354T 1987-07-06 1988-05-02 Monoklonaler antikörper, spezifisch gegen den funktionellen adhäsionsbereich des oberflächenproteins einer phagocyten-zelle. ATE121130T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7025787A 1987-07-06 1987-07-06
US07/165,024 US5019648A (en) 1987-07-06 1988-03-07 Monoclonal antibody specific for the adhesion function domain of a phagocyte cell surface protein

Publications (1)

Publication Number Publication Date
ATE121130T1 true ATE121130T1 (de) 1995-04-15

Family

ID=26750961

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88904354T ATE121130T1 (de) 1987-07-06 1988-05-02 Monoklonaler antikörper, spezifisch gegen den funktionellen adhäsionsbereich des oberflächenproteins einer phagocyten-zelle.

Country Status (15)

Country Link
US (1) US5019648A (de)
EP (1) EP0357672B1 (de)
JP (1) JPH03501560A (de)
KR (1) KR960009013B1 (de)
CN (1) CN1028114C (de)
AT (1) ATE121130T1 (de)
AU (1) AU616182B2 (de)
CA (1) CA1340015C (de)
DE (1) DE3853588T2 (de)
DK (1) DK3390A (de)
ES (1) ES2013338A6 (de)
IE (1) IE61392B1 (de)
IL (1) IL86676A (de)
MX (1) MX9203245A (de)
WO (1) WO1989000190A1 (de)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
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US5219997A (en) * 1987-07-06 1993-06-15 Dana-Farber Cancer Institute Monoclonal antibody which inhibits the adhesion functions of the β integrin, CR3
US5019648A (en) * 1987-07-06 1991-05-28 Dana-Farber Cancer Institute Monoclonal antibody specific for the adhesion function domain of a phagocyte cell surface protein
AU625454B2 (en) * 1988-03-31 1992-07-09 Biomedical Systems Limited Therapeutic murine monoclonal antibody
US5272263A (en) * 1989-04-28 1993-12-21 Biogen, Inc. DNA sequences encoding vascular cell adhesion molecules (VCAMS)
US5217870A (en) * 1989-04-28 1993-06-08 Biogen, Inc. Monoclonal antibodies against CDX
GB9115364D0 (en) * 1991-07-16 1991-08-28 Wellcome Found Antibody
CA2135390A1 (en) * 1992-05-11 1993-11-25 Matthew Moyle Novel neutrophil inhibitors
US5708141A (en) * 1992-05-11 1998-01-13 Corvas International, Inc. Neutrophil inhibitors
EP1340811A3 (de) * 1992-05-22 2003-11-19 Montana State University Antikörper mit Spezifizität gegen mehrere Adhäsionsmoleküle
AU674556B2 (en) * 1992-10-09 1997-01-02 Center For Blood Research, Inc., The A subpopulation of MAC-1 molecules which mediate neutrophil adhesion to ICAM-1 and fibrinogen
US7083979B1 (en) * 1994-03-25 2006-08-01 Indiana University Foundation Methods for enhanced retroviral-mediated gene transfer
US5656441A (en) * 1994-04-19 1997-08-12 Trustees Of Boston University Methods for determining cellular adhesion
US5834889A (en) * 1995-09-22 1998-11-10 Gl Displays, Inc. Cold cathode fluorescent display
US6001356A (en) * 1995-09-29 1999-12-14 Rush-Presbyterian-St. Luke's Medical Center Method of inhibiting tissue destruction in autoimmune disease using anti-CD44 antibodies
DE19739879A1 (de) * 1996-09-19 1998-03-26 Zeiss Carl Fa Kippvorrichtung
JP2003527439A (ja) 2000-03-17 2003-09-16 ミレニアム・ファーマシューティカルズ・インコーポレイテッド 抗ｃｄ１８抗体と抗ｃｃｒ２抗体の混合物を用いる狭窄および再狭窄を抑制する方法
US8914114B2 (en) 2000-05-23 2014-12-16 The Feinstein Institute For Medical Research Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation
JP2005522457A (ja) * 2002-02-26 2005-07-28 ノース ショア−ロング アイランド ジューイッシュ リサーチ インスティチュート 脳ムスカリン性レセプターの刺激による炎症性サイトカイン産生の阻害
US10912712B2 (en) 2004-03-25 2021-02-09 The Feinstein Institutes For Medical Research Treatment of bleeding by non-invasive stimulation
JP2007530586A (ja) 2004-03-25 2007-11-01 ザ ファインスタイン インスティテュート フォー メディカル リサーチ 神経性止血法
US11207518B2 (en) 2004-12-27 2021-12-28 The Feinstein Institutes For Medical Research Treating inflammatory disorders by stimulation of the cholinergic anti-inflammatory pathway
CN101124012B (zh) 2004-12-27 2012-09-05 范因斯坦医学研究院 通过电刺激迷走神经治疗炎症性疾病的装置
US8391970B2 (en) * 2007-08-27 2013-03-05 The Feinstein Institute For Medical Research Devices and methods for inhibiting granulocyte activation by neural stimulation
US9662490B2 (en) 2008-03-31 2017-05-30 The Feinstein Institute For Medical Research Methods and systems for reducing inflammation by neuromodulation and administration of an anti-inflammatory drug
WO2009146030A1 (en) * 2008-03-31 2009-12-03 The Feinstein Institute For Medical Research Methods and systems for reducing inflammation by neuromodulation of t-cell activity
US8412338B2 (en) 2008-11-18 2013-04-02 Setpoint Medical Corporation Devices and methods for optimizing electrode placement for anti-inflamatory stimulation
US8996116B2 (en) 2009-10-30 2015-03-31 Setpoint Medical Corporation Modulation of the cholinergic anti-inflammatory pathway to treat pain or addiction
US8788034B2 (en) 2011-05-09 2014-07-22 Setpoint Medical Corporation Single-pulse activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation
US9211410B2 (en) 2009-05-01 2015-12-15 Setpoint Medical Corporation Extremely low duty-cycle activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation
CN102573986B (zh) 2009-06-09 2016-01-20 赛博恩特医疗器械公司 用于无导线刺激器的具有袋部的神经封套
WO2011028763A2 (en) * 2009-09-01 2011-03-10 Setpoint Medical Corporation Prescription pad for treatment of inflammatory disorders
US11051744B2 (en) 2009-11-17 2021-07-06 Setpoint Medical Corporation Closed-loop vagus nerve stimulation
US9833621B2 (en) 2011-09-23 2017-12-05 Setpoint Medical Corporation Modulation of sirtuins by vagus nerve stimulation
CN102821814B (zh) 2009-12-23 2015-07-15 赛博恩特医疗器械公司 用于治疗慢性炎症的神经刺激设备和系统
US12172017B2 (en) 2011-05-09 2024-12-24 Setpoint Medical Corporation Vagus nerve stimulation to treat neurodegenerative disorders
US9572983B2 (en) 2012-03-26 2017-02-21 Setpoint Medical Corporation Devices and methods for modulation of bone erosion
US11311725B2 (en) 2014-10-24 2022-04-26 Setpoint Medical Corporation Systems and methods for stimulating and/or monitoring loci in the brain to treat inflammation and to enhance vagus nerve stimulation
WO2016126807A1 (en) 2015-02-03 2016-08-11 Setpoint Medical Corporation Apparatus and method for reminding, prompting, or alerting a patient with an implanted stimulator
US10596367B2 (en) 2016-01-13 2020-03-24 Setpoint Medical Corporation Systems and methods for establishing a nerve block
US11471681B2 (en) 2016-01-20 2022-10-18 Setpoint Medical Corporation Batteryless implantable microstimulators
EP3405107B1 (de) 2016-01-20 2023-04-12 Setpoint Medical Corporation Steuerung der vagalstimulierung
EP3405255B1 (de) 2016-01-20 2025-12-31 Setpoint Medical Corporation Implantierbare mikrostimulatoren und induktive ladesysteme
US10583304B2 (en) 2016-01-25 2020-03-10 Setpoint Medical Corporation Implantable neurostimulator having power control and thermal regulation and methods of use
EP3554257B1 (de) 2016-12-15 2023-07-12 Société des Produits Nestlé S.A. Zusammensetzungen und verfahren zur modulation von weissen blutkörperchen oder neutrophilen in einem haustier
WO2019036470A1 (en) 2017-08-14 2019-02-21 Setpoint Medical Corporation TESTING TEST FOR STIMULATION OF NERVE WAVE
US11260229B2 (en) 2018-09-25 2022-03-01 The Feinstein Institutes For Medical Research Methods and apparatuses for reducing bleeding via coordinated trigeminal and vagal nerve stimulation
AU2020272128B9 (en) 2019-04-12 2025-11-20 Setpoint Medical Corporation Vagus nerve stimulation to treat neurodegenerative disorders
JP2023512447A (ja) 2020-01-13 2023-03-27 ザ ファインスタイン インスティチューツ フォー メディカル リサーチ 脾臓への高密度集束超音波刺激による出血及び出血性疾患の治療
WO2021236977A1 (en) 2020-05-21 2021-11-25 The Feinstein Institutes For Medical Research Systems and methods for vagus nerve stimulation
WO2022245878A1 (en) 2021-05-17 2022-11-24 Setpoint Medical Corporation Neurostimulation parameter authentication and expiration system for neurostimulation
US20250229086A1 (en) 2022-01-20 2025-07-17 Setpoint Medical Corporation Treatment of inflammatory disorders

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4935234A (en) * 1987-06-11 1990-06-19 Dana-Farber Cancer Institute Method of reducing tissue damage at an inflammatory site using a monoclonal antibody
US4840793A (en) * 1987-06-11 1989-06-20 Dana-Farber Cancer Institute Method of reducing tissue damage at an inflammatory site using a monoclonal antibody
US5019648A (en) * 1987-07-06 1991-05-28 Dana-Farber Cancer Institute Monoclonal antibody specific for the adhesion function domain of a phagocyte cell surface protein

Also Published As

Publication number Publication date
ES2013338A6 (es) 1990-05-01
AU1721888A (en) 1989-01-30
DE3853588D1 (de) 1995-05-18
EP0357672A4 (de) 1990-06-05
US5019648A (en) 1991-05-28
JPH03501560A (ja) 1991-04-11
IE61392B1 (en) 1994-11-02
MX9203245A (es) 1992-07-01
CN1030611A (zh) 1989-01-25
WO1989000190A1 (en) 1989-01-12
AU616182B2 (en) 1991-10-24
CA1340015C (en) 1998-08-25
KR890701734A (ko) 1989-12-21
DE3853588T2 (de) 1995-11-23
DK3390A (da) 1990-03-05
EP0357672A1 (de) 1990-03-14
IE881357L (en) 1989-01-06
KR960009013B1 (ko) 1996-07-10
IL86676A (en) 1992-06-21
IL86676A0 (en) 1988-11-30
DK3390D0 (da) 1990-01-05
EP0357672B1 (de) 1995-04-12
CN1028114C (zh) 1995-04-05

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REN Ceased due to non-payment of the annual fee