ATE121414T1 - Verfahren zur herstellung von erythromcin a-oxim oder eines salzes davon. - Google Patents
Verfahren zur herstellung von erythromcin a-oxim oder eines salzes davon.Info
- Publication number
- ATE121414T1 ATE121414T1 AT89305066T AT89305066T ATE121414T1 AT E121414 T1 ATE121414 T1 AT E121414T1 AT 89305066 T AT89305066 T AT 89305066T AT 89305066 T AT89305066 T AT 89305066T AT E121414 T1 ATE121414 T1 AT E121414T1
- Authority
- AT
- Austria
- Prior art keywords
- oxime
- salt
- erythromcin
- producing
- erythromycin
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- KYTWXIARANQMCA-PGYIPVOXSA-N (3r,4s,5s,6r,7r,9r,10z,11s,12r,13s,14r)-6-[(2s,3r,4s,6r)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-7,12,13-trihydroxy-10-hydroxyimino-4-[(2r,4r,5s,6s)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradec Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=N\O)/[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 KYTWXIARANQMCA-PGYIPVOXSA-N 0.000 abstract 2
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 abstract 1
- 229930006677 Erythromycin A Natural products 0.000 abstract 1
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 229960003276 erythromycin Drugs 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000003120 macrolide antibiotic agent Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12272388 | 1988-05-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE121414T1 true ATE121414T1 (de) | 1995-05-15 |
Family
ID=14842996
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT89305066T ATE121414T1 (de) | 1988-05-19 | 1989-05-18 | Verfahren zur herstellung von erythromcin a-oxim oder eines salzes davon. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5274085A (de) |
| EP (1) | EP0342990B1 (de) |
| JP (1) | JP2751385B2 (de) |
| KR (1) | KR0123935B1 (de) |
| AT (1) | ATE121414T1 (de) |
| CA (1) | CA1321787C (de) |
| DE (1) | DE68922241T2 (de) |
| ES (1) | ES2074077T3 (de) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3782994T2 (de) | 1986-09-18 | 1993-04-08 | Taisho Pharma Co Ltd | Erythromycin-a-derivate und verfahren zu ihrer herstellung. |
| US5210235A (en) * | 1992-08-26 | 1993-05-11 | Merck & Co., Inc. | Methods of elaborating erythromycin fragments into amine-containing fragments of azalide antibiotics |
| US5332807A (en) * | 1993-04-14 | 1994-07-26 | Merck & Co., Inc. | Process of producing 8A- and 9A-azalide antibiotics |
| US5872229A (en) | 1995-11-21 | 1999-02-16 | Abbott Laboratories | Process for 6-O-alkylation of erythromycin derivatives |
| US5808017A (en) * | 1996-04-10 | 1998-09-15 | Abbott Laboratories | Process for preparing erythromycin A oxime |
| RU2144924C1 (ru) * | 1996-06-21 | 2000-01-27 | Зинченко Евгений Яковлевич | Способ получения азитромицина и способы получения промежуточных соединений |
| US5945405A (en) * | 1997-01-17 | 1999-08-31 | Abbott Laboratories | Crystal form O of clarithromycin |
| US5864023A (en) * | 1997-02-13 | 1999-01-26 | Abbott Laboratories | 3'-N'oxide, 3'-n-dimethylamine, 9-oxime erythromycin a derivatives |
| GB9705323D0 (en) * | 1997-03-14 | 1997-04-30 | Biochemie Sa | Organic compounds |
| ES2224425T3 (es) * | 1997-07-08 | 2005-03-01 | Sandoz Ag | Compuestos organicos. |
| US5929219A (en) * | 1997-09-10 | 1999-07-27 | Abbott Laboratories | 9-hydrazone and 9-azine erythromycin derivatives and a process of making the same |
| US5852180A (en) * | 1997-11-17 | 1998-12-22 | Abbott Laboratories | Chemical synthesis of 6-O-alkyl erythromycin A |
| IL135792A0 (en) * | 1997-12-01 | 2001-05-20 | Abbott Lab | 6-o-alkyl derivatives of erythronolide b |
| US6437106B1 (en) | 1999-06-24 | 2002-08-20 | Abbott Laboratories | Process for preparing 6-o-substituted erythromycin derivatives |
| KR100322313B1 (ko) * | 1999-10-21 | 2002-02-06 | 민경윤 | 클라리스로마이신 결정형 2의 제조방법 및 이에 사용되는 클라리스로마이신 포르메이트 |
| US6627743B1 (en) | 1999-12-03 | 2003-09-30 | Abbott Laboratories | 6-O-methylerythromycin A crystal form III |
| SK8322002A3 (en) | 1999-12-16 | 2003-02-04 | Teva Pharma | Processes for preparing clarithromycin polymorphs and novel polymorph IV |
| EP1280535B1 (de) * | 2000-01-11 | 2005-02-09 | Teva Pharmaceutical Industries Ltd. | Verfahren zur herstellung von polymorphen des clarithromycins |
| US6565882B2 (en) | 2000-02-24 | 2003-05-20 | Advancis Pharmaceutical Corp | Antibiotic composition with inhibitor |
| US6544555B2 (en) | 2000-02-24 | 2003-04-08 | Advancis Pharmaceutical Corp. | Antibiotic product, use and formulation thereof |
| EP1313486A1 (de) * | 2000-02-29 | 2003-05-28 | Teva Pharmaceutical Industries Ltd. | Verfahren zur herstellung des clarithromycins und eines clarithromycin-zwischenprodukt; clarithromycin wesentlich frei von oxime; und pharmazeutische zusammensetzung die sie enthalten |
| AU2001280000A1 (en) | 2000-08-23 | 2002-03-04 | Jaweed Mukarram, Siddiqui Mohammed | Process for preparation of anhydrous azithromycin |
| US6541014B2 (en) | 2000-10-13 | 2003-04-01 | Advancis Pharmaceutical Corp. | Antiviral product, use and formulation thereof |
| US20020068078A1 (en) | 2000-10-13 | 2002-06-06 | Rudnic Edward M. | Antifungal product, use and formulation thereof |
| US6455680B1 (en) | 2000-12-21 | 2002-09-24 | Abbott Laboratories | Methods utilizing aryl thioimines in synthesis of erythromycin derivatives |
| RU2199546C2 (ru) * | 2001-03-27 | 2003-02-27 | Открытое акционерное общество "Биосинтез" | Способ получения гидрохлорида оксима эритромицина а |
| US6843854B2 (en) | 2002-05-31 | 2005-01-18 | Purdue Research Foundation | Method and apparatus for separating a component from a mixture |
| EP1648418A4 (de) | 2003-07-21 | 2011-11-16 | Middlebrook Pharmaceuticals Inc | Antibiotisches produkt, seine verwendung und formulierung |
| JP2006528190A (ja) | 2003-07-21 | 2006-12-14 | アドバンシス ファーマスーティカル コーポレイション | 抗生物質製剤、その使用法及び作成方法 |
| EP1648415A4 (de) | 2003-07-21 | 2011-11-16 | Middlebrook Pharmaceuticals Inc | Antibiotisches produkt, seine verwendung und formulierung |
| AU2004264939A1 (en) | 2003-08-11 | 2005-02-24 | Middlebrook Pharmaceuticals, Inc. | Robust pellet |
| AU2004264356B2 (en) | 2003-08-12 | 2011-01-27 | Shionogi, Inc. | Antibiotic product, use and formulation thereof |
| JP5686494B2 (ja) | 2003-08-29 | 2015-03-18 | シオノギ インコーポレイテッド | 抗生物質製剤、その使用法及び作成方法 |
| WO2005027877A1 (en) | 2003-09-15 | 2005-03-31 | Advancis Pharmaceutical Corporation | Antibiotic product, use and formulation thereof |
| CA2572292A1 (en) | 2004-07-02 | 2006-02-09 | Advancis Pharmaceutical Corporation | Tablet for pulsed delivery |
| US8357394B2 (en) | 2005-12-08 | 2013-01-22 | Shionogi Inc. | Compositions and methods for improved efficacy of penicillin-type antibiotics |
| US8778924B2 (en) | 2006-12-04 | 2014-07-15 | Shionogi Inc. | Modified release amoxicillin products |
| US7595300B2 (en) | 2005-12-13 | 2009-09-29 | Kosan Biosciences Incorporated | 7-quinolyl ketolide antibacterial agents |
| US8299052B2 (en) | 2006-05-05 | 2012-10-30 | Shionogi Inc. | Pharmaceutical compositions and methods for improved bacterial eradication |
| WO2009023191A2 (en) * | 2007-08-09 | 2009-02-19 | Teva Pharmaceutical Industries Ltd. | An improved process for the preparation of clarithromycin |
| CN103923142B (zh) * | 2014-04-30 | 2017-01-11 | 浙江震元制药有限公司 | 一种罗红霉素中间体的制备方法 |
| FR3021373B1 (fr) | 2014-05-21 | 2016-12-09 | Snecma | Dispositif d'articulation a rotule pour une turbomachine. |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1100504A (en) * | 1967-08-16 | 1968-01-24 | Pliva Pharm & Chem Works | Erythromycin oxime and 9-amino-3-o-cladinosyl-5-o-desosaminyl-6,11,12-trihydroxy-2,4,6,8,10,12-hexamethylpentadecane-13-olide |
| FR2473525A1 (fr) * | 1980-01-11 | 1981-07-17 | Roussel Uclaf | Nouvelles oximes derivees de l'erythromycine, leur procede de preparation et leur application comme medicaments |
| PH19293A (en) * | 1982-11-15 | 1986-03-04 | Pfizer | Epimeric azahomoerythromycin,pharmaceutical composition containing the same and method of use thereof |
| US4526889A (en) * | 1982-11-15 | 1985-07-02 | Pfizer Inc. | Epimeric azahomoerythromycin A derivative, intermediates and method of use |
| JPS60214796A (ja) * | 1984-04-06 | 1985-10-28 | Taisho Pharmaceut Co Ltd | ６−０−メチルエリスロマイシン類の製法 |
| JPS6281399A (ja) * | 1985-10-04 | 1987-04-14 | Taisho Pharmaceut Co Ltd | エリスロマイシン類のオキシム誘導体の製造法 |
| JPS6287599A (ja) * | 1985-10-14 | 1987-04-22 | Taisho Pharmaceut Co Ltd | エリスロマイシン類のオキシム誘導体の製造法 |
-
1989
- 1989-05-10 JP JP1116936A patent/JP2751385B2/ja not_active Expired - Lifetime
- 1989-05-12 US US07/350,789 patent/US5274085A/en not_active Expired - Lifetime
- 1989-05-18 AT AT89305066T patent/ATE121414T1/de not_active IP Right Cessation
- 1989-05-18 EP EP89305066A patent/EP0342990B1/de not_active Expired - Lifetime
- 1989-05-18 CA CA000600050A patent/CA1321787C/en not_active Expired - Lifetime
- 1989-05-18 ES ES89305066T patent/ES2074077T3/es not_active Expired - Lifetime
- 1989-05-18 DE DE68922241T patent/DE68922241T2/de not_active Expired - Lifetime
- 1989-05-18 KR KR1019890006605A patent/KR0123935B1/ko not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| KR900018132A (ko) | 1990-12-20 |
| EP0342990A3 (de) | 1991-09-18 |
| JP2751385B2 (ja) | 1998-05-18 |
| US5274085A (en) | 1993-12-28 |
| EP0342990B1 (de) | 1995-04-19 |
| DE68922241D1 (de) | 1995-05-24 |
| JPH0249797A (ja) | 1990-02-20 |
| CA1321787C (en) | 1993-08-31 |
| ES2074077T3 (es) | 1995-09-01 |
| KR0123935B1 (ko) | 1997-11-25 |
| DE68922241T2 (de) | 1995-08-31 |
| EP0342990A2 (de) | 1989-11-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| EELA | Cancelled due to lapse of time |