ATE121415T1 - Durch acetylen, cyan oder allen substituierte aristeromycin- oder adenosin-derivate. - Google Patents

Durch acetylen, cyan oder allen substituierte aristeromycin- oder adenosin-derivate.

Info

Publication number: ATE121415T1
Authority: AT; Austria
Prior art keywords: aristeromycin; cyane; acetylene; derivatives substituted; adenosine derivatives
Prior art date: 1988-03-25

Application number

AT89105254T

Other languages

English (en)

Inventor

Michael L Edwards

Nellikunja J Prakash

James R Mccarthy

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-03-25

Filing date

1989-03-23

Publication date

1995-05-15

1989-03-23 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1995-05-15 Application granted granted Critical

1995-05-15 Publication of ATE121415T1 publication Critical patent/ATE121415T1/de

Links

HSFWRNGVRCDJHI-UHFFFAOYSA-N Acetylene Chemical group C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 title 2
UGRNVLGKAGREKS-GCXDCGAKSA-N (1r,2s,3r,5r)-3-(6-aminopurin-9-yl)-5-(hydroxymethyl)cyclopentane-1,2-diol Chemical group C1=NC=2C(N)=NC=NC=2N1[C@@H]1C[C@H](CO)[C@@H](O)[C@H]1O UGRNVLGKAGREKS-GCXDCGAKSA-N 0.000 title 1
229930186232 Aristeromycin Natural products 0.000 title 1
150000003835 adenosine derivatives Chemical group 0.000 title 1
XUGWUUDOWNZAGW-UHFFFAOYSA-N neplanocin A Natural products C1=NC=2C(N)=NC=NC=2N1C1C=C(CO)C(O)C1O XUGWUUDOWNZAGW-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/052—Imidazole radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/056—Triazole or tetrazole radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/167—Purine radicals with ribosyl as the saccharide radical

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biotechnology (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT89105254T 1988-03-25 1989-03-23 Durch acetylen, cyan oder allen substituierte aristeromycin- oder adenosin-derivate. ATE121415T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/173,782 US4996308A (en)	1988-03-25	1988-03-25	Derivatives with unsaturated substitutions for the 5'-hydroxymethyl group

Publications (1)

Publication Number	Publication Date
ATE121415T1 true ATE121415T1 (de)	1995-05-15

Family

ID=22633462

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT89105254T ATE121415T1 (de)	1988-03-25	1989-03-23	Durch acetylen, cyan oder allen substituierte aristeromycin- oder adenosin-derivate.

Country Status (21)

Country	Link
US (1)	US4996308A (de)
EP (1)	EP0334361B1 (de)
JP (1)	JP2829737B2 (de)
KR (1)	KR0135529B1 (de)
CN (1)	CN1023804C (de)
AR (1)	AR247403A1 (de)
AT (1)	ATE121415T1 (de)
AU (1)	AU606792B2 (de)
CA (1)	CA1322195C (de)
DE (1)	DE68922235T2 (de)
DK (1)	DK171645B1 (de)
ES (1)	ES2074060T3 (de)
FI (1)	FI90877C (de)
HU (1)	HU203561B (de)
IE (1)	IE67543B1 (de)
IL (1)	IL89689A0 (de)
NO (1)	NO171856C (de)
NZ (1)	NZ228422A (de)
PH (1)	PH26776A (de)
PT (1)	PT90080B (de)
ZA (1)	ZA892105B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3924424A1 (de) *	1989-07-24	1991-01-31	Boehringer Mannheim Gmbh	Nucleosid-derivate, verfahren zu deren herstellung, deren verwendung als arzneimittel sowie deren verwendung bei der nucleinsaeure-sequenzierung
CA2027023C (en) *	1989-10-11	2001-12-25	Esa T. Jarvi	Inosine/guanosine derivatives
AU629988B2 (en) *	1989-10-11	1992-10-15	Merrell Dow Pharmaceuticals Inc.	Inosine/guanosine derivatives as antineoplastic agents
GB8926417D0 (en) *	1989-11-22	1990-01-10	Wellcome Found	Heterocyclic compounds
JPH0421682A (ja) *	1990-05-11	1992-01-24	Asahi Chem Ind Co Ltd	２―フルオロネプラノシンａおよびその製造法
GB9205071D0 (en) *	1992-03-09	1992-04-22	Wellcome Found	Therapeutic nucleosides
US5399580A (en) *	1993-03-08	1995-03-21	Burroughs Wellcome Co.	Therapeutic nucleosides-uses
WO1994021659A1 (fr) *	1993-03-18	1994-09-29	Yamasa Corporation	Nouveau compose de 2'-methylidenenucleotide, procede d'obtention de ce compose et son utilisation pharmaceutique
FI971413L (fi) *	1994-10-05	1997-04-04	Chiroscience Ltd	Puriini- ja guaniiniyhdisteet PNP:n estäjinä
GB9600142D0 (en) *	1996-01-05	1996-03-06	Wellcome Found	Chemical compounds
CZ9901996A3 (cs) *	1999-06-04	2001-01-17	Ústav organické chemie a biochemie AV ČR	Nové 6-fenylpurinové 9-ß-D-ribonukleosidy s antineoplastickým účinkem, jejich použití k přípravě farmaceutických preparátů a farmaceutické přípravky, které je obsahují
ATE310524T1 (de)	1999-06-09	2005-12-15	Anticancer Inc	Modulatoren der methylierung zur kontrolle von bakterieller virulenz
US6579857B1 (en)	1999-06-11	2003-06-17	Evanston Northwestern Healthcare Research Institute	Combination cancer therapy comprising adenosine and deaminase enzyme inhibitors
EP1736478B1 (de) *	2000-05-26	2015-07-22	IDENIX Pharmaceuticals, Inc.	Verfahren und Zusammensetzungen zur Behandlung von Flaviviren und Pestiviren
US20040162422A1 (en) *	2001-03-20	2004-08-19	Adrian Hall	Chemical compounds
KR20040036417A (ko) *	2002-10-25	2004-04-30	정낙신	항암 활성을 갖는 티오뉴클레오시드 유도체 및 이를함유하는 약학적 조성물
JP5002851B2 (ja) *	2005-01-20	2012-08-15	独立行政法人理化学研究所	イミダゾピリジン誘導体
CN102746304B (zh) *	2012-06-21	2014-03-19	成都苑东药业有限公司	一种嘌呤胺类化合物及其制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1113851A (en) *	1965-05-29	1968-05-15	Upjohn Co	Decoyinine derivatives
US3472837A (en) *	1966-10-10	1969-10-14	Syntex Corp	Unsaturated nucleosides and process for their preparation
US3575959A (en) *	1969-05-13	1971-04-20	Merck & Co Inc	5'-substituted ribofuranosyl nucleosides
US3585189A (en) *	1969-06-27	1971-06-15	Syntex Corp	Unsaturated nucleosides and processes for their preparation
US3910885A (en) *	1974-03-12	1975-10-07	Syntex Inc	4-Alkoxy nucleosides and intermediates therefore
EP0184365B1 (de) *	1984-12-04	1993-08-04	Eli Lilly And Company	Tumorbehandlung bei Säugetieren
GB8708050D0 (en) *	1987-04-03	1987-05-07	Wellcome Found	Therapeutic nucleosides
NZ225906A (en) *	1987-08-26	1990-10-26	Merrell Dow Pharma	Aristeromycin/adenosine derivatives and pharmaceutical compositions

1988
- 1988-03-25 US US07/173,782 patent/US4996308A/en not_active Expired - Lifetime
1989
- 1989-03-20 ZA ZA892105A patent/ZA892105B/xx unknown
- 1989-03-20 CA CA000594206A patent/CA1322195C/en not_active Expired - Fee Related
- 1989-03-21 NZ NZ228422A patent/NZ228422A/en unknown
- 1989-03-21 FI FI891339A patent/FI90877C/fi not_active IP Right Cessation
- 1989-03-21 NO NO891248A patent/NO171856C/no unknown
- 1989-03-21 IL IL89689A patent/IL89689A0/xx not_active IP Right Cessation
- 1989-03-22 AR AR89313479A patent/AR247403A1/es active
- 1989-03-22 PT PT90080A patent/PT90080B/pt not_active IP Right Cessation
- 1989-03-22 DK DK145289A patent/DK171645B1/da not_active IP Right Cessation
- 1989-03-23 EP EP89105254A patent/EP0334361B1/de not_active Expired - Lifetime
- 1989-03-23 ES ES89105254T patent/ES2074060T3/es not_active Expired - Lifetime
- 1989-03-23 IE IE95389A patent/IE67543B1/en not_active IP Right Cessation
- 1989-03-23 AT AT89105254T patent/ATE121415T1/de not_active IP Right Cessation
- 1989-03-23 DE DE68922235T patent/DE68922235T2/de not_active Expired - Fee Related
- 1989-03-24 CN CN89101682A patent/CN1023804C/zh not_active Expired - Fee Related
- 1989-03-24 HU HU891526A patent/HU203561B/hu unknown
- 1989-03-24 JP JP1070752A patent/JP2829737B2/ja not_active Expired - Fee Related
- 1989-03-24 KR KR1019890003722A patent/KR0135529B1/ko not_active Expired - Fee Related
- 1989-03-27 PH PH38380A patent/PH26776A/en unknown
- 1989-03-28 AU AU31737/89A patent/AU606792B2/en not_active Ceased

Also Published As

Publication number	Publication date
EP0334361A3 (de)	1991-04-03
IE67543B1 (en)	1996-04-17
KR0135529B1 (ko)	1998-04-23
DE68922235D1 (de)	1995-05-24
FI891339A7 (fi)	1989-09-26
PT90080A (pt)	1989-11-10
KR890014573A (ko)	1989-10-24
JPH01283285A (ja)	1989-11-14
NO891248D0 (no)	1989-03-21
EP0334361B1 (de)	1995-04-19
DK171645B1 (da)	1997-03-03
DK145289A (da)	1989-09-26
US4996308A (en)	1991-02-26
PT90080B (pt)	1994-06-30
EP0334361A2 (de)	1989-09-27
FI90877C (fi)	1994-04-11
JP2829737B2 (ja)	1998-12-02
NO171856B (no)	1993-02-01
IE890953L (en)	1989-09-25
CA1322195C (en)	1993-09-14
AU3173789A (en)	1989-09-28
CN1036579A (zh)	1989-10-25
IL89689A0 (en)	1989-09-28
CN1023804C (zh)	1994-02-16
ZA892105B (en)	1989-11-29
FI90877B (fi)	1993-12-31
DK145289D0 (da)	1989-03-22
HUT49367A (en)	1989-09-28
ES2074060T3 (es)	1995-09-01
FI891339A0 (fi)	1989-03-21
HU203561B (en)	1991-08-28
NZ228422A (en)	1991-04-26
PH26776A (en)	1992-10-13
AR247403A1 (es)	1994-12-29
NO171856C (no)	1993-05-12
DE68922235T2 (de)	1995-08-31
NO891248L (no)	1989-09-26
AU606792B2 (en)	1991-02-14

Legal Events

Date	Code	Title	Description
1995-11-15	UEP	Publication of translation of european patent specification
2004-12-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE121415T1 (de)	1995-05-15	Durch acetylen, cyan oder allen substituierte aristeromycin- oder adenosin-derivate.
NO892892D0 (no)	1989-07-13	Substituerte aminometyltetraliner, samt deres heterocykliske analoger.
NL192782B (nl)	1997-10-01	Hoekslagboormachine, alsmede hoekvoorzetstuk hiervoor.
ATE110271T1 (de)	1994-09-15	3'-azido-2',3'-dideoxyuridin anti-retrovirale zusammensetzung.
ATE90072T1 (de)	1993-06-15	3,5-disubstituierte pyrocatecholderivate.
NO902629D0 (no)	1990-06-13	Hellingskompensator for hurtigkjoerende kjoeretoey, saerlig skinnekjoeretoey.
FI850275A0 (fi)	1985-01-22	Nya 6-susbtituerade furo-(3,4-c) -pyridinderivat.
NO881537L (no)	1988-10-10	Fremgangsmaate for fremstilling av 6-substituert-2',3'-dideoksynukleosider.
DK197990D0 (da)	1990-08-20	Oploesningsmiddelmodstandsdygtige, straalingshaerdelige belaegninger
FI844383L (fi)	1985-05-18	Foerfarande foer framstaellning av nya 7-karboximetoxi-furo-(3,4-c)-pyridinderivat.
FI891713L (fi)	1989-10-14	Slangskal, speciellt konstgjort korvskal med limband i laengsaxelriktningen.
FI884138A0 (fi)	1988-09-08	3,7-diazabicyklo (3,3,1) nonanfoereningar, foerfaranden foer deras framstaellning samt dessa foereningar innehaollande laekemedel.
FI873626A0 (fi)	1987-08-21	Derivat av 2,5-dihydrofuran med en triazol- eller imidazolgrupp, framstaellningsfoerfarande anvaendning som fungicid.
NO863744L (no)	1987-03-23	Fremgangsmaate for anrikning av kull ved skumflotasjon.
DE3889281D1 (de)	1994-06-01	6-Substituierte Alkoxy-2-oxo-1,2-dihydro-chinoxalin-Derivate.
FI883778L (fi)	1989-02-20	Antikropp foer en propeptid av prokollagen av typ iii samt bestaemningsmetod vari den anvaends.
FI881612A7 (fi)	1988-10-12	Nya pyrrolidin-2-(1,3-dikarbonyl) -derivat, foerfaranden foer deras framstaellning, dessa innehaollande aemnen saovael som deras anvaendning.
IT7819037A0 (it)	1978-01-05	Bloccasterzo, particolarmente per motocicli.
AT380534B (de)	1986-06-10	Drehschlag-, dreh- oder schlagwerk
DE3682244D1 (de)	1991-12-05	Substituierte dihydroimidazo(1,2-a)chinoxalinderivate.
FI893276L (fi)	1990-01-07	Parkitusmenetelmä, jossa kromin imeytyminen parkituskylvystä on suuri
FI842538A0 (fi)	1984-06-21	Bicyklo(3.2.1)oktankarboxylsyraderivat, foerfarande foer deras framstaellning samt deras terapeutiska anvaendning.
Clair-Tisdall	1980	The Sources of Islam
FI854370A7 (fi)	1985-11-06	Foerfarande foer redigering, s.k. klippning, av videogram i faerg.
IT8420179A0 (it)	1984-03-22	Deriva, timone o chiglia.