ATE121622T1 - Verfahren zur sensibilisierung von tumorzellen. - Google Patents

Verfahren zur sensibilisierung von tumorzellen.

Info

Publication number
ATE121622T1
ATE121622T1 AT91902395T AT91902395T ATE121622T1 AT E121622 T1 ATE121622 T1 AT E121622T1 AT 91902395 T AT91902395 T AT 91902395T AT 91902395 T AT91902395 T AT 91902395T AT E121622 T1 ATE121622 T1 AT E121622T1
Authority
AT
Austria
Prior art keywords
tumor cells
sensitizing tumor
sensitizing
cells
treatment
Prior art date
Application number
AT91902395T
Other languages
English (en)
Inventor
Wayne Daniel Klohs
Avner Ramu
Original Assignee
Warner Lambert Co
Hadasit Med Res Service
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co, Hadasit Med Res Service filed Critical Warner Lambert Co
Application granted granted Critical
Publication of ATE121622T1 publication Critical patent/ATE121622T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT91902395T 1990-02-13 1991-01-10 Verfahren zur sensibilisierung von tumorzellen. ATE121622T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47932090A 1990-02-13 1990-02-13
US07/497,049 US5160727A (en) 1990-02-13 1990-03-21 Tumor cell sensitization method using quinazolinedione derivatives

Publications (1)

Publication Number Publication Date
ATE121622T1 true ATE121622T1 (de) 1995-05-15

Family

ID=27046201

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91902395T ATE121622T1 (de) 1990-02-13 1991-01-10 Verfahren zur sensibilisierung von tumorzellen.

Country Status (11)

Country Link
US (1) US5160727A (de)
EP (1) EP0524931B1 (de)
JP (1) JPH05509290A (de)
KR (1) KR927003058A (de)
AT (1) ATE121622T1 (de)
AU (1) AU646837B2 (de)
CA (1) CA2076032A1 (de)
DE (1) DE69109283T2 (de)
IE (1) IE910476A1 (de)
IL (1) IL97055A0 (de)
WO (1) WO1991012006A2 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6150398A (en) * 1991-05-08 2000-11-21 The United States Of America As Represented By The Department Of Health And Human Services Methods for the treatment of cancer
US5491234A (en) * 1992-03-30 1996-02-13 Pfizer Inc. Pyrimidine derivatives for enhancing antitumor activity
US5684169A (en) * 1992-11-27 1997-11-04 Ensuiko Sugar Refining Co., Ltd. Cyclodextrin inclusion complex of taxol, and method for its production and its use
US5436243A (en) * 1993-11-17 1995-07-25 Research Triangle Institute Duke University Aminoanthraquinone derivatives to combat multidrug resistance
DE19512484A1 (de) * 1995-04-04 1996-10-17 Bayer Ag Kohlenhydratmodifizierte Cytostatika
US5767113A (en) * 1995-05-10 1998-06-16 The Salk Institute For Biological Studies Compounds useful for concurrently activating glucocorticoid-induced response and reducing multidrug resistance
US6376514B1 (en) 2000-10-17 2002-04-23 The Procter & Gamble Co. Substituted six-membered heterocyclic compounds useful for treating multidrug resistance and compositions and methods thereof
US6693099B2 (en) 2000-10-17 2004-02-17 The Procter & Gamble Company Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance
CA2546002C (en) 2003-11-20 2012-09-18 Janssen Pharmaceutica N.V. 7-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(adp-ribose) polymerase inhibitors
BRPI0416206A (pt) 2003-11-20 2006-12-26 Janssen Pharmaceutica Nv 2-quinolinonas e 2-quinoxalinonas substituìdas por 6-alquenila e 6-fenilalquila como inibidores de polimerase de poli(adp-ribose)
EA011552B1 (ru) 2004-06-30 2009-04-28 Янссен Фармацевтика Н.В. Производные хиназолиндиона в качестве ингибиторов parp
SG154433A1 (en) 2004-06-30 2009-08-28 Janssen Pharmaceutica Nv Phthalazine derivatives as parp inhibitors
ATE540936T1 (de) 2004-06-30 2012-01-15 Janssen Pharmaceutica Nv Substituierte 2-alkyl-chinazolinonderivate als parp-hemmer
KR101188688B1 (ko) 2004-06-30 2012-10-09 얀센 파마슈티카 엔.브이. Ｐａｒｐ 저해제로서의 퀴나졸린디온 유도체
US8299256B2 (en) 2007-03-08 2012-10-30 Janssen Pharmaceutica Nv Quinolinone derivatives as PARP and TANK inhibitors
US8404713B2 (en) 2007-10-26 2013-03-26 Janssen Pharmaceutica Nv Quinolinone derivatives as PARP inhibitors
CN101981013B (zh) 2008-03-27 2013-05-29 詹森药业有限公司 作为parp和微管蛋白聚合抑制剂的四氢菲啶酮和四氢环戊二烯并喹啉酮
ES2367760T3 (es) 2008-03-27 2011-11-08 Janssen Pharmaceutica, N.V. Derivados de quinazolinona como inhibidores de la polimerización de la tubulina.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3819630A (en) * 1972-08-21 1974-06-25 R Parcell 3-(1-piperazinylalkyl)-2,4-quinazolinedione compounds and methods for their production
DE3069468D1 (en) * 1979-12-19 1984-11-22 Nat Res Dev Quinazoline derivatives, processes for their preparation, compositions containing them and their use as anti-cancer agents
JPS58159480A (ja) * 1982-03-17 1983-09-21 Chugai Pharmaceut Co Ltd 新規なフエニルピペラジン誘導体
JPS608274A (ja) * 1983-06-27 1985-01-17 Fujisawa Pharmaceut Co Ltd 新規キナゾリノン誘導体およびその製造法・並びに抗アレルギ−剤
GB8707053D0 (en) * 1987-03-25 1987-04-29 Ici Plc Anti-tumour agents

Also Published As

Publication number Publication date
IE910476A1 (en) 1991-08-14
WO1991012006A2 (en) 1991-08-22
EP0524931B1 (de) 1995-04-26
DE69109283T2 (de) 1995-08-24
JPH05509290A (ja) 1993-12-22
KR927003058A (ko) 1992-12-17
US5160727A (en) 1992-11-03
AU646837B2 (en) 1994-03-10
EP0524931A1 (de) 1993-02-03
CA2076032A1 (en) 1991-08-14
DE69109283D1 (de) 1995-06-01
AU7154491A (en) 1991-09-03
IL97055A0 (en) 1992-03-29

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Legal Events

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