ATE121782T1 - Rekombinante vakzine von flagellin. - Google Patents

Rekombinante vakzine von flagellin.

Info

Publication number
ATE121782T1
ATE121782T1 AT89906507T AT89906507T ATE121782T1 AT E121782 T1 ATE121782 T1 AT E121782T1 AT 89906507 T AT89906507 T AT 89906507T AT 89906507 T AT89906507 T AT 89906507T AT E121782 T1 ATE121782 T1 AT E121782T1
Authority
AT
Austria
Prior art keywords
recombinant
flagellin
epitope
proteins
fusion proteins
Prior art date
Application number
AT89906507T
Other languages
English (en)
Inventor
William Robert Marjarian
Bruce Arnold Dunbar Stocker
Salete Maria Cardozo Newton
Original Assignee
Praxis Biolog Inc
Univ Leland Stanford Junior
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Praxis Biolog Inc, Univ Leland Stanford Junior filed Critical Praxis Biolog Inc
Application granted granted Critical
Publication of ATE121782T1 publication Critical patent/ATE121782T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
    • C07K14/445—Plasmodium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/735—Fusion polypeptide containing domain for protein-protein interaction containing a domain for self-assembly, e.g. a viral coat protein (includes phage display)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT89906507T 1988-05-05 1989-05-05 Rekombinante vakzine von flagellin. ATE121782T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US19057088A 1988-05-05 1988-05-05

Publications (1)

Publication Number Publication Date
ATE121782T1 true ATE121782T1 (de) 1995-05-15

Family

ID=22701885

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89906507T ATE121782T1 (de) 1988-05-05 1989-05-05 Rekombinante vakzine von flagellin.

Country Status (10)

Country Link
EP (1) EP0419513B1 (de)
JP (1) JP2793673B2 (de)
AT (1) ATE121782T1 (de)
AU (1) AU637049B2 (de)
CA (1) CA1340817C (de)
DE (1) DE68922394T2 (de)
DK (1) DK263390A (de)
FI (1) FI104638B (de)
NO (1) NO302031B1 (de)
WO (1) WO1989010967A1 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5712088A (en) * 1987-11-18 1998-01-27 Chiron Corporation Methods for detecting Hepatitis C virus using polynucleotides specific for same
US5698390A (en) * 1987-11-18 1997-12-16 Chiron Corporation Hepatitis C immunoassays
US6861212B1 (en) 1987-11-18 2005-03-01 Chiron Corporation NANBV diagnostics and vaccines
US6171782B1 (en) 1987-11-18 2001-01-09 Chiron Corporation Antibody compositions to HCV and uses thereof
US5714596A (en) * 1987-11-18 1998-02-03 Chiron Corporation NANBV diagnostics: polynucleotides useful for screening for hepatitis C virus
AU640118B2 (en) * 1988-12-19 1993-08-19 De Staat Der Nederlanden Vertegenwoordigd Door De Minister Van Welzijn, Volksgezonheid En Cultuur Meningococcal class 1 outer-membrane protein vaccine
US7118757B1 (en) 1988-12-19 2006-10-10 Wyeth Holdings Corporation Meningococcal class 1 outer-membrane protein vaccine
US6027729A (en) * 1989-04-20 2000-02-22 Chiron Corporation NANBV Diagnostics and vaccines
IE913455A1 (en) * 1990-10-01 1992-04-08 Mini Agriculture & Fisheries Method of testing for salmonella
IE913456A1 (en) * 1990-10-01 1992-04-08 Mini Agriculture & Fisheries Salmonella polynucleotide sequence
GB9101550D0 (en) * 1991-01-24 1991-03-06 Mastico Robert A Antigen-presenting chimaeric protein
IL101639A0 (en) * 1992-04-17 1992-12-30 Yeda Res & Dev Recombinant influenza vaccines
DK1112747T3 (da) * 1999-12-28 2004-10-25 Akzo Nobel Nv Salmonellavaccine, som ikke inducerer antistoffer mod flagellin eller flageller
JPWO2004055045A1 (ja) * 2002-12-16 2006-04-20 株式会社シーエーエフラボラトリーズ サルモネラ抗原処方物、それを使用した抗体検査キット及びサブユニットワクチン
WO2005107381A2 (en) 2004-05-07 2005-11-17 Hans-Gustaf Ljunggren Use of flagellin as an adjuvant for vaccine
JP2008521431A (ja) 2004-12-02 2008-06-26 シーエスアイアール 破壊されたフラゲリン遺伝子を含むグラム陽性細菌細胞、フラゲリンベースの融合タンパク質及び金属イオンの液体からの除去における使用
WO2006081007A2 (en) 2004-12-16 2006-08-03 Wake Forest University Health Sciences Use of flagellin in tumor immunotherapy
AR052195A1 (es) 2005-01-19 2007-03-07 Vaxinnate Corp Composiciones de patrones moleculares asociados a patogenos en metodos de uso
ES2555544T3 (es) 2006-03-07 2016-01-04 Vaxinnate Corporation Composiciones que incluyen hemaglutinina, métodos de preparación y métodos de uso de las mismas
SG190562A1 (en) 2008-04-18 2013-06-28 Vaxinnate Corp Deletion mutants of flagellin and methods of use
US8932598B2 (en) 2012-08-28 2015-01-13 Vaxinnate Corporation Fusion proteins and methods of use
CN102816246B (zh) * 2012-09-04 2014-07-23 成都蓉生药业有限责任公司 一种人巨细胞病毒免疫原融合蛋白及其制备方法和用途
CA2960087C (en) 2014-09-26 2024-02-27 Bavarian Nordic A/S Methods and compositions for intra-nasal immunization with recombinant mva encoding flagellin
EP3221464B1 (de) * 2014-11-18 2022-02-23 The Trustees of Columbia University in the City of New York Detektion von analyten unter verwendung von lebenden zellen
CN104402974B (zh) * 2014-12-10 2017-11-14 重庆医科大学 一种具有粘膜免疫佐剂活性的多肽及其在制备粘膜免疫佐剂中的用途
US10849938B2 (en) 2017-09-13 2020-12-01 ZBiotics Company Gene expression system for probiotic microorganisms
US10806778B2 (en) * 2019-01-30 2020-10-20 Prokarium Limited Modified strain of Salmonella enterica Typhi
JP2023546022A (ja) 2020-10-08 2023-11-01 ジーバイオティクス カンパニー 腸内での繊維合成酵素の発現のための操作されたプロバイオティクス

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4735801A (en) * 1982-09-07 1988-04-05 Board Of Trustees Of Leland Stanford Jr. University Novel non-reverting salmonella live vaccines
WO1987002385A1 (en) * 1985-10-11 1987-04-23 Genetics Institute, Inc. Method for producing heterologous proteins
ES2060580T3 (es) * 1986-03-11 1994-12-01 Shionogi & Co Adn que tiene una secuencia adn codificante de la proteina flagelina y vector que la contiene.
CA1331355C (en) * 1986-04-21 1994-08-09 Bioenterprises Pty. Ltd Immunopotentation

Also Published As

Publication number Publication date
NO904806D0 (no) 1990-11-05
EP0419513B1 (de) 1995-04-26
FI905441A0 (fi) 1990-11-02
DE68922394D1 (de) 1995-06-01
DK263390D0 (da) 1990-11-02
AU3697989A (en) 1989-11-29
NO302031B1 (no) 1998-01-12
FI104638B (fi) 2000-03-15
EP0419513A1 (de) 1991-04-03
AU637049B2 (en) 1993-05-20
NO904806L (no) 1991-01-03
DE68922394T2 (de) 1995-10-05
JP2793673B2 (ja) 1998-09-03
WO1989010967A1 (en) 1989-11-16
CA1340817C (en) 1999-11-09
DK263390A (da) 1991-01-04
JPH04502402A (ja) 1992-05-07

Similar Documents

Publication Publication Date Title
DE68922394D1 (de) Rekombinante vakzine von flagellin.
Birkett et al. A modified hepatitis B virus core particle containing multiple epitopes of the Plasmodium falciparum circumsporozoite protein provides a highly immunogenic malaria vaccine in preclinical analyses in rodent and primate hosts
EP2949340A1 (de) Impfstoffzusammensetzung gegen Streptococcus Suis-Infektion
PT584348E (pt) Vacina genetica para virus da imunodeficiencia
PT101052A (pt) Proteinas hibridas uteis na preparacao de vacinas
NZ510544A (en) Novel adjuvant for subunit or component vaccines
HUT68554A (en) Immunogenic carrier system eliciting an immuneresponse against gnrh, recombinant dna sequence coding for it and its use
WO2003065973A3 (en) Multivalent streptococcal vaccine compositions and methods for use
WO2000000216A3 (en) Use of poxviruses as enhancer of specific immunity
CA2158024A1 (en) A mycoplasma gallisepticum antigen, dna encoding the antigen, recombinant vector bearing the dna and recombinant virus utilizing the recombinant vector as well as use thereof
KR920006503A (ko) 살모넬라 백신 균주의 표면에 면역원성 말라리아 항원을 발현할수 있는 재조합 발현 벡터
NZ213303A (en) Plasmodium protein, dna sequence and vaccine
Camacho et al. TLR5-dependent immunogenicity of a recombinant fusion protein containing an immunodominant epitope of malarial circumsporozoite protein and the FliC flagellin of Salmonella Typhimurium
Frenchick et al. Biochemical and immunological characterization of a novel peptide carrier system using rotavirus VP6 particles
WO2002020048A1 (en) A classical swine fever virus epitope vaccine and its producing method
DK0912195T3 (da) Vaccine indeholdende antigener bundet til bærestoffer gennem labile bindinger
JIANG et al. Effects of the configuration of a multi-epitope chimeric malaria DNA vaccine on its antigenicity to mice
KR101991577B1 (ko) 다수의 에피토프로 구성된 재조합 항원 단백질 및 이의 제조방법
Grosfeld et al. Delineation of protective epitopes on the E2-envelope glycoprotein of Semliki Forest virus
KR890000106A (ko) 원생성 기생충 예방용 백신
WO2002032453A1 (en) Synthetic peptide hog cholera vaccine and method producing it
WO2000063242A8 (en) Chimeric lyssavirus nucleic acids and polypeptides
WO2025191546A2 (en) Chimeric virus-like particle vaccine against rotavirus
ATE62134T1 (de) Biologische zubereitungen.
Chengua et al. Gene fusion of cholera toxin B subunit with HBV PreS epitope and overexpression in E. coli

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EEIH Change in the person of patent owner
REN Ceased due to non-payment of the annual fee