ATE121947T1 - Verbessertes meningokokkale polysaccharidkonjugatvakzin. - Google Patents

Verbessertes meningokokkale polysaccharidkonjugatvakzin.

Info

Publication number
ATE121947T1
ATE121947T1 AT91900142T AT91900142T ATE121947T1 AT E121947 T1 ATE121947 T1 AT E121947T1 AT 91900142 T AT91900142 T AT 91900142T AT 91900142 T AT91900142 T AT 91900142T AT E121947 T1 ATE121947 T1 AT E121947T1
Authority
AT
Austria
Prior art keywords
conjugate vaccine
polysaccharide conjugate
meningococcal polysaccharide
improved
improved meningococcal
Prior art date
Application number
AT91900142T
Other languages
English (en)
Inventor
Harold J Jennings
Francis Michon
Original Assignee
Ca Nat Research Council
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ca Nat Research Council filed Critical Ca Nat Research Council
Application granted granted Critical
Publication of ATE121947T1 publication Critical patent/ATE121947T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Gram-negative bacteria
    • C07K16/1228—Enterobacterales (O), e.g. Citrobacter (G), Serratia (G), Proteus (G), Providencia (G), Morganella (G) or Yersinia (G)
    • C07K16/1232—Escherichia (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0258—Escherichia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Gram-negative bacteria
    • C07K16/1217—Neisseriaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
AT91900142T 1989-12-14 1990-12-13 Verbessertes meningokokkale polysaccharidkonjugatvakzin. ATE121947T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US44819589A 1989-12-14 1989-12-14

Publications (1)

Publication Number Publication Date
ATE121947T1 true ATE121947T1 (de) 1995-05-15

Family

ID=23779371

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91900142T ATE121947T1 (de) 1989-12-14 1990-12-13 Verbessertes meningokokkale polysaccharidkonjugatvakzin.

Country Status (30)

Country Link
US (3) US5576002A (de)
EP (1) EP0504202B1 (de)
JP (1) JP2637845B2 (de)
KR (1) KR0158436B1 (de)
CN (4) CN1049223C (de)
AR (1) AR243934A1 (de)
AT (1) ATE121947T1 (de)
AU (1) AU641715B2 (de)
BR (1) BR9007917A (de)
CA (1) CA2071811C (de)
CZ (1) CZ283530B6 (de)
DE (1) DE69019164T2 (de)
DK (1) DK0504202T3 (de)
ES (1) ES2071288T3 (de)
FI (2) FI104539B (de)
HR (1) HRP920872A2 (de)
HU (2) HU9201966D0 (de)
IE (1) IE68414B1 (de)
IL (1) IL96676A (de)
IN (1) IN171747B (de)
NO (2) NO305275B1 (de)
NZ (1) NZ236471A (de)
PH (1) PH30305A (de)
PL (2) PL166659B1 (de)
RO (1) RO111416B1 (de)
RU (1) RU2105568C1 (de)
SI (1) SI20008B (de)
WO (1) WO1991008772A1 (de)
YU (1) YU24391A (de)
ZA (1) ZA9010065B (de)

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DE69330464T2 (de) * 1992-09-24 2001-11-08 Brigham And Women's Hospital, Boston Gruppe b streptococcus typ ii und typ v polysaccharid-protein konjugate als impfstoffe
US6153406A (en) * 1993-07-23 2000-11-28 North American Vaccine, Inc. Method for the high level expression, purification and refolding of the outer membrane protein P2 from Haemophilus influenzae type B
US5439808A (en) * 1993-07-23 1995-08-08 North American Vaccine, Inc. Method for the high level expression, purification and refolding of the outer membrane group B porin proteins from Neisseria meningitidis
US5679654A (en) * 1994-09-02 1997-10-21 Brigham & Women's Hospital, Inc. Capsular polysaccharide immunomodulator
US5700787A (en) * 1994-09-02 1997-12-23 Brigham & Women's Hospital, Inc. Capsular polysaccharide immunomodulator
US5747287A (en) * 1995-04-28 1998-05-05 North American Vaccine, Inc. Method for the high level expression, purification and refolding of the outer membrane group B porin proteins from Neisseria meningitidis
US5811102A (en) 1995-06-07 1998-09-22 National Research Council Of Canada Modified meningococcal polysaccharide conjugate vaccines
US6284884B1 (en) 1995-06-07 2001-09-04 North American Vaccine, Inc. Antigenic group B streptococcus type II and type III polysaccharide fragments having a 2,5-anhydro-D-mannose terminal structure and conjugate vaccine thereof
NZ311000A (en) * 1995-06-07 1999-04-29 Smithkline Beecham Biolog Vaccine comprising a polysaccharide antigen-carrier protein conjugate and a free carrier protein
ZA97248B (en) * 1996-01-18 1997-07-18 Rohm & Haas Method for identifying and quantifying polymers utilizing immunoassay techniques
US6048527A (en) * 1996-08-27 2000-04-11 Chiron Corporation Antibodies that define unique Meningococcal B epitopes and vaccine compositions
DE69708318T3 (de) † 1996-08-27 2006-11-16 Novartis Vaccines and Diagnostics, Inc., Emeryville Neisseria meningitidis serogruppe b glykokonjugate und verfahren zu deren verwendung
US6426074B1 (en) 1997-03-19 2002-07-30 The Brigham And Women's Hospital Inc. Group B Streptococcus vaccine
EP0994723A1 (de) 1997-06-24 2000-04-26 Chiron Corporation Verfahren um erwachsenen mit anti-meningokokken impfstoffzusammensetzungen zu immunizieren
DE69840508D1 (de) * 1997-08-27 2009-03-12 Childrens Hosp Medical Center Molekular-mimetika von meningokokkus b epitopen
JP4435413B2 (ja) 1997-12-23 2010-03-17 バクスター・ヘルスケヤー・ソシエテ・アノニム ワクチンとしてまたは結合体ワクチンとしてタンパク質に連結して使用するための細菌莢膜多糖の抽出および単離法
CN1263510C (zh) * 1998-08-19 2006-07-12 巴克斯特健康护理股份有限公司 多糖－蛋白质缀合物或寡糖－蛋白质缀合物、其制备方法及其应用
RU2249463C2 (ru) * 1998-08-19 2005-04-10 Бакстер Хелфкэа С.А. Иммуногенный конъюгат бета-пропионамид-связанного полисахарида с белком, использующийся в качестве вакцины
US6436653B1 (en) 1998-12-15 2002-08-20 Exiqon A/S Method for introduction of reporter groups into bacterial lipopolysaccharide-derived carbohydrates and the subsequent coupling of such derivatives onto solid surfaces
US7083777B1 (en) * 1999-04-02 2006-08-01 The Brigham And Women's Hospital, Inc. Immunomodulating polymers
US6518037B2 (en) * 1999-11-12 2003-02-11 University Of Iowa Research Foundation Two-component system that controls bacterial membrane synthesis
GB9928196D0 (en) * 1999-11-29 2000-01-26 Chiron Spa Combinations of B, C and other antigens
GB0011108D0 (en) * 2000-05-08 2000-06-28 Microscience Ltd Virulence gene and protein and their use
SV2003000753A (es) 2000-12-05 2003-06-16 Brigham & Womens Hospital Uso de polisacaridos zwitterionicos para la especifica modulacion del progreso inmunologico
JP2004529643A (ja) * 2001-04-17 2004-09-30 カイロン コーポレイション 機能活性抗体を誘発する髄膜炎菌性ｂエピトープの分子模倣物
GB0115176D0 (en) * 2001-06-20 2001-08-15 Chiron Spa Capular polysaccharide solubilisation and combination vaccines
GB0121591D0 (en) * 2001-09-06 2001-10-24 Chiron Spa Hybrid and tandem expression of neisserial proteins
AR045702A1 (es) 2001-10-03 2005-11-09 Chiron Corp Composiciones de adyuvantes.
ES2616180T3 (es) * 2002-03-26 2017-06-09 Glaxosmithkline Biologicals Sa Sacáridos modificados con estabilidad mejorada en agua para su uso como medicamento
NZ536859A (en) * 2002-05-14 2007-11-30 Chiron Srl Mucosal combination vaccines for bacterial meningitis
RU2364418C2 (ru) * 2002-08-02 2009-08-20 ГлаксоСмитКлайн Байолоджикалз с.а. ВАКЦИННЫЕ КОМПОЗИЦИИ, СОДЕРЖАЩИЕ ЛИПОПОЛИСАХАРИДЫ ИММУНОТИПА L2 И/ИЛИ L3, ПРОИСХОДЯЩИЕ ИЗ ШТАММА NEISSERIA MENINGITIDIS IgtB-
GB0227346D0 (en) * 2002-11-22 2002-12-31 Chiron Spa 741
AU2004227852B2 (en) 2003-03-31 2010-01-14 The Brigham And Women's Hospital, Inc. Zwitterionic immunomodulators for the treatment of asthma and allergy
US7731967B2 (en) 2003-04-30 2010-06-08 Novartis Vaccines And Diagnostics, Inc. Compositions for inducing immune responses
EP1654290B1 (de) 2003-08-12 2019-03-13 Lipoxen Technologies Limited Sialinsäurederivate für die derivatisierung und konjugation von proteinen
US8148335B2 (en) 2004-06-23 2012-04-03 Children's Hospital & Research Center Oakland De-N-acetyl sialic acid antigens, antibodies thereto, and methods of use in cancer therapy
EP1784428A2 (de) * 2004-06-23 2007-05-16 Children's Hospital & Research Center at Oakland Polysaccharidderivate und verwendung bei der induktion einer immunantwort
GB0428394D0 (en) * 2004-12-24 2005-02-02 Chiron Srl Saccharide conjugate vaccines
HUE045482T2 (hu) 2005-06-27 2019-12-30 Glaxosmithkline Biologicals Sa Immunogén készítmény
WO2007092451A2 (en) 2006-02-06 2007-08-16 The Brigham And Women's Hospital, Inc. Zwitterionic polysaccharides for promotion of immune system maturation and health
GB0611914D0 (en) 2006-06-15 2006-07-26 Teti Giuseppe Peptides that mimic non-human cross-reactive protective epitopes of the group Bmeningococcal capsulsar polysaccharide
EP1872791A1 (de) * 2006-06-30 2008-01-02 Institut Pasteur Verwendung von Polysacchariden bakteriellen Ursprungs zur Hemmung der Bildung von Biofilmen
CA2692069C (en) * 2007-06-20 2016-10-18 Baxter Healthcare S.A. Modified polysaccharides for conjugate vaccines
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US9050283B2 (en) 2009-01-16 2015-06-09 University Of Maryland, Baltimore Broad spectrum vaccine against non-typhoidal Salmonella
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Also Published As

Publication number Publication date
EP0504202B1 (de) 1995-05-03
US5902586A (en) 1999-05-11
KR0158436B1 (ko) 1998-12-01
AU6898791A (en) 1991-07-18
FI104539B (fi) 2000-02-29
NO305275B1 (no) 1999-05-03
BR9007917A (pt) 1992-10-20
PH30305A (en) 1997-02-20
NZ236471A (en) 1992-10-28
NO973311D0 (no) 1997-07-17
SI20008B (en) 2001-02-28
CN1100656A (zh) 1995-03-29
PL166035B1 (pl) 1995-03-31
JP2637845B2 (ja) 1997-08-06
CN1055541A (zh) 1991-10-23
CN1072506C (zh) 2001-10-10
FI19991917L (fi) 1999-09-09
DE69019164T2 (de) 1995-09-07
CN1100428A (zh) 1995-03-22
RU2105568C1 (ru) 1998-02-27
CZ628490A3 (en) 1997-12-17
RO111416B1 (ro) 1996-10-31
FI19991917A7 (fi) 1999-09-09
IN171747B (de) 1992-12-26
HU218146B (hu) 2000-06-28
CN1036504C (zh) 1997-11-26
HUT64480A (en) 1994-01-28
CA2071811A1 (en) 1991-06-15
CN1036522C (zh) 1997-11-26
PL288271A1 (en) 1991-12-16
AU641715B2 (en) 1993-09-30
SI20008A (sl) 2000-02-29
US5683699A (en) 1997-11-04
CA2071811C (en) 2003-11-04
NO307835B1 (no) 2000-06-05
HRP920872A2 (en) 1997-06-30
ES2071288T3 (es) 1995-06-16
WO1991008772A1 (en) 1991-06-27
NO973311L (no) 1992-08-14
IE904513A1 (en) 1991-06-19
CZ283530B6 (cs) 1998-04-15
YU24391A (sh) 1995-12-04
DE69019164D1 (de) 1995-06-08
IL96676A (en) 1996-09-12
AR243934A1 (es) 1993-09-30
CN1049223C (zh) 2000-02-09
US5576002A (en) 1996-11-19
FI922737A0 (fi) 1992-06-12
NO922316L (no) 1992-08-14
ZA9010065B (en) 1992-02-26
CN1096516A (zh) 1994-12-21
PL166659B1 (pl) 1995-06-30
HU9201966D0 (en) 1992-10-28
JPH05505392A (ja) 1993-08-12
NO922316D0 (no) 1992-06-12
IL96676A0 (en) 1991-09-16
IE68414B1 (en) 1996-06-12
EP0504202A1 (de) 1992-09-23
DK0504202T3 (da) 1995-10-02

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