ATE122050T1 - Verfahren zur herstellung von radioiodiertem pyrimidin. - Google Patents

Verfahren zur herstellung von radioiodiertem pyrimidin.

Info

Publication number: ATE122050T1
Authority: AT; Austria
Prior art keywords: nucleotide; pyrimidine; pyrimidine nucleoside; water; nucleoside
Prior art date: 1988-01-29

Application number

AT89903657T

Other languages

English (en)

Inventor

Amin I Kassis

Janina Baranowska-Kortylewicz

Original Assignee

Harvard College

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-01-29

Filing date

1989-01-27

Publication date

1995-05-15

1989-01-27 Application filed by Harvard College filed Critical Harvard College

1995-05-15 Application granted granted Critical

1995-05-15 Publication of ATE122050T1 publication Critical patent/ATE122050T1/de

Links

238000004519 manufacturing process Methods 0.000 title abstract 2
CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title 1
125000003729 nucleotide group Chemical group 0.000 abstract 5
239000002718 pyrimidine nucleoside Substances 0.000 abstract 4
239000002719 pyrimidine nucleotide Substances 0.000 abstract 4
239000007800 oxidant agent Substances 0.000 abstract 2
150000003230 pyrimidines Chemical class 0.000 abstract 2
230000002285 radioactive effect Effects 0.000 abstract 2
239000012736 aqueous medium Substances 0.000 abstract 1
XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 abstract 1
XMBWDFGMSWQBCA-UHFFFAOYSA-M iodide Chemical compound [I-] XMBWDFGMSWQBCA-UHFFFAOYSA-M 0.000 abstract 1
229940006461 iodide ion Drugs 0.000 abstract 1
239000002777 nucleoside Substances 0.000 abstract 1
150000003833 nucleoside derivatives Chemical class 0.000 abstract 1
239000002773 nucleotide Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Life Sciences & Earth Sciences (AREA)
Saccharide Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Compounds Of Unknown Constitution (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT89903657T 1988-01-29 1989-01-27 Verfahren zur herstellung von radioiodiertem pyrimidin. ATE122050T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/150,133 US4851520A (en)	1988-01-29	1988-01-29	Method of making radioiodinated pyrimidine nucleoside or nucleotide

Publications (1)

Publication Number	Publication Date
ATE122050T1 true ATE122050T1 (de)	1995-05-15

Family

ID=22533247

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT89903657T ATE122050T1 (de)	1988-01-29	1989-01-27	Verfahren zur herstellung von radioiodiertem pyrimidin.

Country Status (6)

Country	Link
US (1)	US4851520A (de)
EP (1)	EP0403544B1 (de)
JP (1)	JPH0637509B2 (de)
AT (1)	ATE122050T1 (de)
DE (1)	DE68922489T2 (de)
WO (1)	WO1989007106A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0428623A4 (en) *	1988-08-10	1993-12-08	Stephen Leslie Sacks	Production of radioiodinated 1--g(b)-d-arabinofuranosyl)-5(e)-(2-iodovinyl)uracil, and uses thereof, and related analogues incorporating alternative halogen radionuclides, the general radiohalogenation precursors, 1-(2,3,5-tri-o-acetyl--g(b)-d-arabinofuranosyl)-5(z and e)-(2-trimethylsilylvinyl)urac
US5077034A (en) *	1990-03-30	1991-12-31	The President And Fellows Of Harvard College	Treatment of tumors with 5-radioiodo-2'-deoxyuridine
US5468853A (en) *	1993-12-30	1995-11-21	Board Of Regents University Of Nebraska	Synthesis of 5-radiohalo-2'-deoxyuridine
US5574148A (en) *	1995-02-02	1996-11-12	President U Fellows Of Harvard College	Rapid synthesis of radiolabeled pyrimidine nucleosides or nucleotides
US5720935A (en) *	1995-06-09	1998-02-24	President & Fellows Of Harvard College	Rapid synthesis of radiolabeled pyrimidine nucleosides or nucleotides from stannyl precursors
US5811073A (en) *	1995-06-19	1998-09-22	President And Fellows Of Harvard College	Method for radioisotopic detection and localization of inflammation in a host
US7238338B1 (en)	2001-06-22	2007-07-03	Triumf	System and method for the large scale labeling of compounds with radiohalogens
US8597613B2 (en) *	2004-07-02	2013-12-03	Iso-Tex Diagnostics, Inc	Radiolabeled lymphatic staining agents and methods for making

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2949451A (en) *	1959-04-21	1960-08-16	Hoffmann La Roche	Preparation of thymidine and deoxyfluorouridine, and intermediates therefor
US3135787A (en) *	1960-10-22	1964-06-02	Chemische Werke Witten	Process for producing pure sodium salts of 5-sulfo-isophthalic acid and 2-sulfoterephthalic acid
US4649039A (en) *	1984-07-03	1987-03-10	E. I. Du Pont De Nemours And Company	Radiolabeling of methionine-containing proteins and peptides

1988
- 1988-01-29 US US07/150,133 patent/US4851520A/en not_active Expired - Lifetime
1989
- 1989-01-27 EP EP89903657A patent/EP0403544B1/de not_active Expired - Lifetime
- 1989-01-27 DE DE68922489T patent/DE68922489T2/de not_active Expired - Fee Related
- 1989-01-27 JP JP50328589A patent/JPH0637509B2/ja not_active Expired - Lifetime
- 1989-01-27 WO PCT/US1989/000358 patent/WO1989007106A1/en not_active Ceased
- 1989-01-27 AT AT89903657T patent/ATE122050T1/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE68922489D1 (de)	1995-06-08
US4851520A (en)	1989-07-25
JPH03500540A (ja)	1991-02-07
EP0403544A1 (de)	1990-12-27
EP0403544A4 (en)	1991-04-10
JPH0637509B2 (ja)	1994-05-18
DE68922489T2 (de)	1996-02-01
WO1989007106A1 (en)	1989-08-10
EP0403544B1 (de)	1995-05-03

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Legal Events

Date	Code	Title	Description
1995-11-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties