ATE122095T1 - Verfahren zur herstellung von chimären antikörpern. - Google Patents

Verfahren zur herstellung von chimären antikörpern.

Info

Publication number
ATE122095T1
ATE122095T1 AT91117772T AT91117772T ATE122095T1 AT E122095 T1 ATE122095 T1 AT E122095T1 AT 91117772 T AT91117772 T AT 91117772T AT 91117772 T AT91117772 T AT 91117772T AT E122095 T1 ATE122095 T1 AT E122095T1
Authority
AT
Austria
Prior art keywords
region
dna
primers
nucleotides
primer
Prior art date
Application number
AT91117772T
Other languages
English (en)
Inventor
Ulrich Heinz Dr Rer Nat Weidle
Brigitte Dr Rer Nat Kaluza
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Application granted granted Critical
Publication of ATE122095T1 publication Critical patent/ATE122095T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/462—Igs containing a variable region (Fv) from one specie and a constant region (Fc) from another
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2812—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT91117772T 1990-10-18 1991-10-17 Verfahren zur herstellung von chimären antikörpern. ATE122095T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4033120A DE4033120A1 (de) 1990-10-18 1990-10-18 Verfahren zur herstellung von chimaeren antikoerpern

Publications (1)

Publication Number Publication Date
ATE122095T1 true ATE122095T1 (de) 1995-05-15

Family

ID=6416577

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91117772T ATE122095T1 (de) 1990-10-18 1991-10-17 Verfahren zur herstellung von chimären antikörpern.

Country Status (6)

Country Link
EP (1) EP0481502B1 (de)
JP (1) JPH0584082A (de)
AT (1) ATE122095T1 (de)
DE (2) DE4033120A1 (de)
DK (1) DK0481502T3 (de)
ES (1) ES2073089T3 (de)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6147500A (ja) * 1984-08-15 1986-03-07 Res Dev Corp Of Japan キメラモノクロ−ナル抗体及びその製造法
GB8608068D0 (en) * 1986-04-02 1986-05-08 Cobbold S P Monoclonal antibodies
EP0368684B2 (de) * 1988-11-11 2004-09-29 Medical Research Council Klonierung von Immunglobulin sequenzen aus den variabelen Domänen.
DE3900534A1 (de) * 1989-01-10 1990-07-12 Boehringer Mannheim Gmbh Diagnostischer nachweis unter verwendung von chimaeren antikoerpern
DE3909799A1 (de) * 1989-03-24 1990-09-27 Behringwerke Ag Monoklonale antikoerper (mak) gegen tumorassoziierte antigene, ihre herstellung und verwendung

Also Published As

Publication number Publication date
ES2073089T3 (es) 1995-08-01
EP0481502B1 (de) 1995-05-03
JPH0584082A (ja) 1993-04-06
DE59105378D1 (de) 1995-06-08
EP0481502A3 (en) 1992-11-19
DK0481502T3 (da) 1995-10-02
DE4033120A1 (de) 1992-04-23
EP0481502A2 (de) 1992-04-22

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