ATE122232T1 - Melatoninderivate und kombinationen mit antiestrogenen zur behandlung von brustkarzinoma. - Google Patents

Melatoninderivate und kombinationen mit antiestrogenen zur behandlung von brustkarzinoma.

Info

Publication number: ATE122232T1
Authority: AT; Austria
Prior art keywords: derivatives; breast carcinoma; antestrogens; melatonine; combinations
Prior art date: 1991-11-21

Application number

AT92310615T

Other languages

English (en)

Inventor

James Allen Clemens

Michael Edward Flaugh

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-11-21

Filing date

1992-11-20

Publication date

1995-05-15

1992-11-20 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1995-05-15 Application granted granted Critical

1995-05-15 Publication of ATE122232T1 publication Critical patent/ATE122232T1/de

Links

DRLFMBDRBRZALE-UHFFFAOYSA-N melatonin Chemical class COC1=CC=C2NC=C(CCNC(C)=O)C2=C1 DRLFMBDRBRZALE-UHFFFAOYSA-N 0.000 title abstract 3
206010006187 Breast cancer Diseases 0.000 title abstract 2
208000026310 Breast neoplasm Diseases 0.000 title abstract 2
201000008275 breast carcinoma Diseases 0.000 title abstract 2
229940046836 anti-estrogen Drugs 0.000 abstract 1
230000001833 anti-estrogenic effect Effects 0.000 abstract 1
238000011284 combination treatment Methods 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000001419 dependent effect Effects 0.000 abstract 1
239000000328 estrogen antagonist Substances 0.000 abstract 1
239000002974 melatonin derivative Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Indole Compounds (AREA)

AT92310615T 1991-11-21 1992-11-20 Melatoninderivate und kombinationen mit antiestrogenen zur behandlung von brustkarzinoma. ATE122232T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/796,108 US5196435A (en)	1991-11-21	1991-11-21	Melatonin derivatives and combinations with antiestrogen compounds for treating mammalian breast carcinoma

Publications (1)

Publication Number	Publication Date
ATE122232T1 true ATE122232T1 (de)	1995-05-15

Family

ID=25167321

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92310615T ATE122232T1 (de)	1991-11-21	1992-11-20	Melatoninderivate und kombinationen mit antiestrogenen zur behandlung von brustkarzinoma.

Country Status (8)

Country	Link
US (1)	US5196435A (de)
EP (1)	EP0543659B1 (de)
JP (1)	JPH05221861A (de)
AT (1)	ATE122232T1 (de)
CA (1)	CA2083359A1 (de)
DE (1)	DE69202441T2 (de)
DK (1)	DK0543659T3 (de)
ES (1)	ES2072102T3 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK0565296T3 (da) *	1992-04-07	1996-12-09	Neurim Pharma 1991	Anvendelse af melatonin til fremstilling af et lægemiddel til behandling af godartet prostatahyperplasi
US5441563A (en) *	1993-07-06	1995-08-15	Armstrong World Industries, Inc.	Highly insoluble azole embossing inhibitor and the use thereof
US6180657B1 (en)	1993-11-18	2001-01-30	Eli Lilly And Company	Melatonin derivatives for use in treating desynchronization disorders
US5654325A (en) *	1993-11-18	1997-08-05	Eli Lilly And Company	Melatonin derivatives for use in treating sleep disorders
JPH09511514A (ja) *	1994-04-07	1997-11-18	セ・エ・エム・ア・エフ	新規メラトニン作用性アゴニストのスピロ［インドールピロリジン］誘導体とその製造方法および医薬品としての用途
US5589482A (en) *	1994-12-14	1996-12-31	Pfizer Inc.	Benzo-thiophene estrogen agonists to treat prostatic hyperplasia
EP0748627A3 (de) *	1995-06-14	1997-05-21	Lilly Co Eli	Melatoninagonisten zur Behandlung von gutartigen Hyperplasieformen der Prostata
US6403631B1 (en)	1995-11-24	2002-06-11	Equitech Laboratories, Inc.	Method and compositions for enhancing pregnancy success in an animal
US5792785A (en) *	1995-11-24	1998-08-11	Equitech Laboratories, Inc.	Method for enhancing pregnancy success in an animal
FR2787447B1 (fr) *	1998-12-18	2001-03-23	Centre Nat Rech Scient	Nouveaux derives de melatonine et medicament comprenant de tels derives
CN1250563C (zh)	1999-05-04	2006-04-12	斯特拉坎有限公司	雄激素糖苷及其产生雄性征的活性
TW593256B (en)	1999-11-16	2004-06-21	Hormos Medical Oy Ltd	Triphenylalkene derivatives and their use as selective estrogen receptor modulators
US6552064B2 (en) *	2000-09-19	2003-04-22	University Of Iowa Research Foundation	Use of melatonin for induction of general anesthesia
US6638966B2 (en) *	2000-09-19	2003-10-28	University Of Iowa Research Foundation	Use of melatonin analogues for induction of general anesthesia
US7062312B2 (en) *	2001-01-17	2006-06-13	Pediamed Pharmaceuticals, Inc.	Combination and method including a visual marker for determining compliance with a medication regimen
US20040248989A1 (en)	2003-06-05	2004-12-09	Risto Santti	Method for the treatment or prevention of lower urinary tract symptoms
EP1701718A4 (de) *	2003-12-23	2009-06-24	Abraxis Bioscience Llc	Substitutierte melatonin-derivate, verfahren zu ihrer herstellung und anwendungsverfahren
MX2008014825A (es) *	2006-05-22	2008-12-01	Hormos Medical Ltd	Moduladores selectivos del receptor de estrogeno o inhibidores de aromatasa para tratar prostatitis cronica no bacteriana.
PL2121553T3 (pl) *	2007-02-14	2012-11-30	Hormos Medical Ltd	Sposób wytwarzania cennych terapeutycznie pochodnych trifenylobutenu
WO2008099060A2 (en) *	2007-02-14	2008-08-21	Hormos Medical Ltd	Methods for the preparation of fispemifene from ospemifene
US9321712B2 (en)	2012-10-19	2016-04-26	Fermion Oy	Process for the preparation of ospemifene
KR101861081B1 (ko)	2015-08-05	2018-05-28	인제대학교 산학협력단	멜라토닌 유도체를 포함하는 염증성 질환, 알러지 질환 또는 암 질환 예방 또는 치료용 조성물
CN114680114B (zh) *	2022-04-27	2022-11-15	华中农业大学	褪黑素衍生物在防治植物真菌病害中的用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4230862A (en) *	1975-10-28	1980-10-28	Eli Lilly And Company	Antifertility compounds
US4133814A (en) *	1975-10-28	1979-01-09	Eli Lilly And Company	2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
US4087444A (en) *	1976-09-08	1978-05-02	Eli Lilly And Company	Amides as ovulation inhibitors
DE2860900D1 (en) *	1977-08-22	1981-11-05	Ici Plc	Triphenylalkene derivatives, process for their preparation and pharmaceutical compositions containing them
US4418068A (en) *	1981-04-03	1983-11-29	Eli Lilly And Company	Antiestrogenic and antiandrugenic benzothiophenes
US4543360A (en) *	1981-09-10	1985-09-24	Degussa Aktiengesellschaft	2-(Hydroxy-phenyl)-indoles and process for their production
US4614807A (en) *	1984-10-04	1986-09-30	Eli Lilly And Company	6,7-dihalomelatonins
US4997845A (en) *	1987-02-02	1991-03-05	Eli Lilly And Company	β-alkylmelatonins as ovulation inhibitors
CA1299174C (en) *	1987-02-02	1992-04-21	Michael Edward Flaugh	Alkylmelatonins
US4855305A (en) *	1987-03-23	1989-08-08	Applied Medical Research	Compositions and methods of effecting contraception utilizing melatonin
DE3821148A1 (de) *	1988-06-23	1989-12-28	Erwin Von Dr Angerer	Aminoalkylindole, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate

1991
- 1991-11-21 US US07/796,108 patent/US5196435A/en not_active Expired - Fee Related
1992
- 1992-11-19 CA CA002083359A patent/CA2083359A1/en not_active Abandoned
- 1992-11-20 JP JP4311815A patent/JPH05221861A/ja active Pending
- 1992-11-20 DE DE69202441T patent/DE69202441T2/de not_active Expired - Fee Related
- 1992-11-20 AT AT92310615T patent/ATE122232T1/de not_active IP Right Cessation
- 1992-11-20 DK DK92310615.7T patent/DK0543659T3/da active
- 1992-11-20 EP EP92310615A patent/EP0543659B1/de not_active Expired - Lifetime
- 1992-11-20 ES ES92310615T patent/ES2072102T3/es not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP0543659B1 (de)	1995-05-10
US5196435A (en)	1993-03-23
EP0543659A1 (de)	1993-05-26
DK0543659T3 (da)	1995-07-17
DE69202441D1 (de)	1995-06-14
CA2083359A1 (en)	1993-05-22
JPH05221861A (ja)	1993-08-31
DE69202441T2 (de)	1995-10-26
ES2072102T3 (es)	1995-07-01

Legal Events

Date	Code	Title	Description
1995-10-15	UEP	Publication of translation of european patent specification
2004-08-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE122232T1 (de)	1995-05-15	Melatoninderivate und kombinationen mit antiestrogenen zur behandlung von brustkarzinoma.
KR890701107A (ko)	1989-12-19	알쯔하이머 병 치료용 화합물들
ATE142877T1 (de)	1996-10-15	Melatoninderivate zur behandlung von schlafstörungen und zur pre-anästhesie
ATE152111T1 (de)	1997-05-15	K-252a derivate
CY1806A (en)	1995-09-08	Improvements in the treatment of tumors in mammals
ATE116312T1 (de)	1995-01-15	Antimigräne alkoxypyrimidinderivate.
DE69623899D1 (de)	2002-10-31	Behandlung von Tinnitus mit neuroprotektiven Wirkstoffen
ATE91625T1 (de)	1993-08-15	Verwendung von porphyrinderivaten bei der entdeckung und behandlung von tumoren.
DE3854121D1 (de)	1995-08-10	Arzneimittelzusammensetzungen zur behandlung von psoriasis.
ATE222491T1 (de)	2002-09-15	Melatonin-derivate zur verwendung in der behandlung von schlafstörungen
ATE187442T1 (de)	1999-12-15	Tryptamine zur behandlung von störungen der circadianen rhythmik
DE69032000D1 (de)	1998-03-05	Behandlung kardialer Dysfunktion mit 15-Ketoprostaglandinderivaten
DE58902451D1 (de)	1992-11-19	(s)-emopamil zur anwendung bei der behandlung von migraene.
DE3777665D1 (de)	1992-04-30	Heptanoyl-glu-asp-ala-amino-saeure-immunstimulanten.
DE69419954D1 (de)	1999-09-16	Arzneimittel zur Behandlung von Hauterkrankungen
DE69023459D1 (de)	1995-12-14	Behandlung von pulmonarer Disfunktion mit 15-Keto-prostaglandin-Derivaten.
ATE70181T1 (de)	1991-12-15	Verwendung von oxochinazolinderivaten bei der behandlung von hyperurikaemie.
ATA67688A (de)	1993-06-15	Neue 3-(2-haloalkyl)-1,4-oxathiine und 2-(2-halo- alkyl)-1,4-dithiine sowie pharmazeutische zusammensetzungen mit diesen verbindungen zur behandlung von leukaemie und tumoren
NO990436D0 (no)	1999-01-29	FremgangsmÕte for behandling av bipolar forstyrrelse
IL89901A0 (en)	1989-12-15	Strobilurine derivatives
ATE178336T1 (de)	1999-04-15	Verwendung einer therapeutischen zusammensetzung zur behandlung von bronchitis
DE59410340D1 (de)	2004-01-15	Verwendung von Bradykinin-Antagonisten zur Behandlung von Viruserkrankungen
ATE230608T1 (de)	2003-01-15	Verwendung von bradykinin-antagonisten zur herstellung von arzneimitteln zur behandlung und prävention der alzheimer'schen krankheit
ATE68474T1 (de)	1991-11-15	Aktive substanz in der kardiovaskulaeren therapie.
DE69001988D1 (de)	1993-07-22	Behandlung des schocks mit cyclodextrin und dessen derivaten.