ATE122559T1 - Proliposomales pulver für polyenliposomen sowie verfahren zu dessen herstellung. - Google Patents

Proliposomales pulver für polyenliposomen sowie verfahren zu dessen herstellung.

Info

Publication number: ATE122559T1
Authority: AT; Austria
Prior art keywords: polyene; solution; combining; liposomes; production
Prior art date: 1991-01-14

Application number

AT92905027T

Other languages

English (en)

Inventor

Robert P Lenk

Reeta Mehta

Gabriel Lopez-Berestein

Original Assignee

Univ Texas

Argus Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-01-14

Filing date

1992-01-10

Publication date

1995-06-15

1992-01-10 Application filed by Univ Texas, Argus Pharm Inc filed Critical Univ Texas

1995-06-15 Application granted granted Critical

1995-06-15 Publication of ATE122559T1 publication Critical patent/ATE122559T1/de

Links

150000004291 polyenes Chemical class 0.000 title abstract 3
239000002502 liposome Substances 0.000 title abstract 2
239000003960 organic solvent Substances 0.000 abstract 3
239000000843 powder Substances 0.000 abstract 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
229960000988 nystatin Drugs 0.000 abstract 1
VQOXZBDYSJBXMA-NQTDYLQESA-N nystatin A1 Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/CC/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 VQOXZBDYSJBXMA-NQTDYLQESA-N 0.000 abstract 1
150000003904 phospholipids Chemical class 0.000 abstract 1
239000000725 suspension Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1277—Preparation processes; Proliposomes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2984—Microcapsule with fluid core [includes liposome]
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2984—Microcapsule with fluid core [includes liposome]
- Y10T428/2985—Solid-walled microcapsule from synthetic polymer

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Dispersion Chemistry (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Communicable Diseases (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Manufacturing Of Micro-Capsules (AREA)
Saccharide Compounds (AREA)

AT92905027T 1991-01-14 1992-01-10 Proliposomales pulver für polyenliposomen sowie verfahren zu dessen herstellung. ATE122559T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/640,707 US5178875A (en)	1991-01-14	1991-01-14	Liposomal-polyene preliposomal powder and method for its preparation

Publications (1)

Publication Number	Publication Date
ATE122559T1 true ATE122559T1 (de)	1995-06-15

Family

ID=24569381

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92905027T ATE122559T1 (de)	1991-01-14	1992-01-10	Proliposomales pulver für polyenliposomen sowie verfahren zu dessen herstellung.

Country Status (11)

Country	Link
US (2)	US5178875A (de)
EP (1)	EP0567582B1 (de)
JP (1)	JP3267611B2 (de)
AT (1)	ATE122559T1 (de)
AU (1)	AU663074B2 (de)
CA (1)	CA2099771C (de)
DE (1)	DE69202559T2 (de)
DK (1)	DK0567582T3 (de)
ES (1)	ES2074878T3 (de)
GR (1)	GR3017118T3 (de)
WO (1)	WO1992011842A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5178875A (en) *	1991-01-14	1993-01-12	The Board Of Regents, The University Of Texas System	Liposomal-polyene preliposomal powder and method for its preparation
US5830498A (en) *	1987-10-16	1998-11-03	Board Of Regents, The University Of Texas System	Liposomal-polyene preliposomal powder and method for its preparation
US5417978A (en) *	1993-07-29	1995-05-23	Board Of Regents, The University Of Texas System	Liposomal antisense methyl phosphonate oligonucleotides and methods for their preparation and use
US5902604A (en) *	1995-06-06	1999-05-11	Board Of Regents, The University Of Texas System	Submicron liposome suspensions obtained from preliposome lyophilizates
US5855911A (en) *	1995-08-29	1999-01-05	Board Of Regents, The University Of Texas System	Liposomal phosphodiester, phosphorothioate, and P-ethoxy oligonucleotides
US6977244B2 (en) *	1996-10-04	2005-12-20	Board Of Regents, The University Of Texas Systems	Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides
GB2326337A (en) *	1997-06-20	1998-12-23	Phares Pharma Holland	Homogeneous lipid compositions for drug delivery
US6287590B1 (en) *	1997-10-02	2001-09-11	Esperion Therapeutics, Inc.	Peptide/lipid complex formation by co-lyophilization
US7704962B1 (en)	1997-10-03	2010-04-27	Board Of Regents, The University Of Texas System	Small oligonucleotides with anti-tumor activity
US7285288B1 (en)	1997-10-03	2007-10-23	Board Of Regents, The University Of Texas System	Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides
US20010003580A1 (en)	1998-01-14	2001-06-14	Poh K. Hui	Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
CA2318556A1 (en) *	1998-01-16	1999-07-22	Biomira, Inc.	Lipomatrix preparation
DE69917609T2 (de) *	1998-03-05	2005-06-09	Phares Pharmaceutical Research N.V., Curaçao	Arzneimittel und deren verwendung
US6106701A (en) *	1998-08-25	2000-08-22	Betzdearborn Inc.	Deasphalting process
US6613352B2 (en)	1999-04-13	2003-09-02	Universite De Montreal	Low-rigidity liposomal formulation
US6413537B1 (en)	2000-03-10	2002-07-02	Wisconsin Alumni Research Foundation	Nystatin formulation having reduced toxicity
US20040082521A1 (en) *	2002-03-29	2004-04-29	Azaya Therapeutics Inc.	Novel formulations of digitalis glycosides for treating cell-proliferative and other diseases
EP1585504A4 (de) *	2002-11-06	2009-07-15	Azaya Therapeutics Inc	Proteinstabilisierte liposomale formulierungen pharmazeutischer wirkstoffe
WO2006113679A2 (en)	2005-04-15	2006-10-26	Board Of Regents, The University Of Texas System	Delivery of sirna by neutral lipid compositions
CA2631243A1 (en) *	2005-12-08	2007-06-14	Wyeth	Liposomal compositions
WO2010074172A1 (ja)	2008-12-24	2010-07-01	株式会社バイオメッドコア	リポソームの製造方法ならびにコレステロール溶解方法
JP5771366B2 (ja)	2009-09-02	2015-08-26	株式会社バイオメッドコア	リポソーム製造装置及び方法
US9744191B2 (en)	2012-03-19	2017-08-29	Yale University	Antimicrobial compositions and methods
JP2016079351A (ja) *	2014-10-22	2016-05-16	株式会社デンソー	複合蓄熱材
EP3222273B1 (de) *	2014-11-18	2019-09-25	National Institute for Materials Science	Verfahren zur herstellung eines porösen artikels

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1575343A (en) *	1977-05-10	1980-09-17	Ici Ltd	Method for preparing liposome compositions containing biologically active compounds
CH621479A5 (de) *	1977-08-05	1981-02-13	Battelle Memorial Institute
FR2416008A1 (fr) *	1978-02-02	1979-08-31	Oreal	Lyophilisats de liposomes
US4744989A (en) *	1984-02-08	1988-05-17	E. R. Squibb & Sons, Inc.	Method of preparing liposomes and products produced thereby
EP0152379A3 (de) *	1984-02-15	1986-10-29	Ciba-Geigy Ag	Verfahren zur Herstellung von pharmazeutischen Zusammensetzungen enthaltend unilamellare Liposomen
JPH0753661B2 (ja) *	1984-03-08	1995-06-07	フアレスフアーマスーチカルリサーチエヌブイ	プロ―リポソーム組成物及びリポソームの水性分散物を作る方法
JPS60208910A (ja) *	1984-03-31	1985-10-21	Green Cross Corp:The	水難溶性薬物・リン脂質複合体の製造方法
US4880635B1 (en) *	1984-08-08	1996-07-02	Liposome Company	Dehydrated liposomes
JPS6150912A (ja) *	1984-08-16	1986-03-13	Shionogi & Co Ltd	リポソ−ム製剤の製造法
JPS6176414A (ja) *	1984-09-21	1986-04-18	Shionogi & Co Ltd	リポソーム製剤の製法
CA1260393A (en) *	1984-10-16	1989-09-26	Lajos Tarcsay	Liposomes of synthetic lipids
US4897355A (en) *	1985-01-07	1990-01-30	Syntex (U.S.A.) Inc.	N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
US4830858A (en) *	1985-02-11	1989-05-16	E. R. Squibb & Sons, Inc.	Spray-drying method for preparing liposomes and products produced thereby
CA1256372A (en) *	1985-04-11	1989-06-27	Koichiro Miyazima	Process for producing liposome composition
US4766046A (en) *	1985-09-27	1988-08-23	Liposome Technology, Inc.	Stabilized liposome/amphotericin composition and method
US4812312A (en) *	1987-03-03	1989-03-14	Board Of Regents Of The University Of Texas System	Liposome-incorporated nystatin
NZ223660A (en) *	1987-03-05	1990-11-27	Liposome Co Inc	Low toxicity drug-lipid complexes; methods of making them; and method of determining their toxicity
US4963362A (en) *	1987-08-07	1990-10-16	Regents Of The University Of Minnesota	Freeze-dried liposome mixture containing cyclosporin
US4950432A (en) *	1987-10-16	1990-08-21	Board Of Regents, The University Of Texas System	Polyene microlide pre-liposomal powders
US5178875A (en) *	1991-01-14	1993-01-12	The Board Of Regents, The University Of Texas System	Liposomal-polyene preliposomal powder and method for its preparation
US4994213A (en) *	1988-05-17	1991-02-19	Liposome Technology, Inc.	Method of preparing lipid structures
IL90561A (en) *	1988-06-08	1993-08-18	Fountain Pharm Inc	Method for making solvent dilution microcarriers
US4999199A (en) *	1988-11-10	1991-03-12	Board Of Regents, The University Of Texas System	Pharmaceutical formulations: liposomes incorporating aromatic polyene antibiotics
US4935171A (en) *	1989-01-27	1990-06-19	Vestar, Inc.	Method for vesicle formation
DE69026820T2 (de) *	1989-03-31	1996-11-28	Univ California	Zubereitung von liposomen- und lipid-komplexzusammensetzungen

1991
- 1991-01-14 US US07/640,707 patent/US5178875A/en not_active Expired - Fee Related
1992
- 1992-01-10 WO PCT/US1992/000160 patent/WO1992011842A1/en not_active Ceased
- 1992-01-10 CA CA002099771A patent/CA2099771C/en not_active Expired - Fee Related
- 1992-01-10 AT AT92905027T patent/ATE122559T1/de not_active IP Right Cessation
- 1992-01-10 ES ES92905027T patent/ES2074878T3/es not_active Expired - Lifetime
- 1992-01-10 EP EP92905027A patent/EP0567582B1/de not_active Expired - Lifetime
- 1992-01-10 AU AU12527/92A patent/AU663074B2/en not_active Ceased
- 1992-01-10 DK DK92905027.6T patent/DK0567582T3/da active
- 1992-01-10 DE DE69202559T patent/DE69202559T2/de not_active Expired - Fee Related
- 1992-01-10 JP JP50531092A patent/JP3267611B2/ja not_active Expired - Fee Related
1995
- 1995-08-16 GR GR950402237T patent/GR3017118T3/el unknown
1997
- 1997-11-26 US US08/979,578 patent/US5965158A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ES2074878T3 (es)	1995-09-16
DK0567582T3 (da)	1995-10-02
WO1992011842A1 (en)	1992-07-23
DE69202559D1 (de)	1995-06-22
JP3267611B2 (ja)	2002-03-18
EP0567582A1 (de)	1993-11-03
US5178875A (en)	1993-01-12
EP0567582B1 (de)	1995-05-17
GR3017118T3 (en)	1995-11-30
DE69202559T2 (de)	1996-01-11
AU1252792A (en)	1992-08-17
JPH06509547A (ja)	1994-10-27
CA2099771C (en)	2002-04-23
US5965158A (en)	1999-10-12
CA2099771A1 (en)	1992-07-15
AU663074B2 (en)	1995-09-28

Legal Events

Date	Code	Title	Description
1995-12-15	UEP	Publication of translation of european patent specification
2003-10-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE122559T1 (de)	1995-06-15	Proliposomales pulver für polyenliposomen sowie verfahren zu dessen herstellung.
ATE41307T1 (de)	1989-04-15	Waessrige, eine fettloesliche wirksubstanz enthaltende loesung sowie verfahren zu deren herstellung.
ATE53038T1 (de)	1990-06-15	Inositoltriphosphat, verfahren zu seiner herstellung und dieses enthaltende zubereitung.
DE3752362D1 (de)	2003-02-20	Optisch aktive Verbindungen
ES2188750T3 (es)	2003-07-01	Procedimiento para la preparacion de particulas respirables.
ATE126223T1 (de)	1995-08-15	Verfahren zur herstellung von ascorbinsäure.
DK629388D0 (da)	1988-11-11	Fremgangsmaade til fremstilling af amphotericin b liposome
DE69806236D1 (de)	2002-08-01	Verfahren zur herstellung fester pharmazeutischer dosisformen
DE69920945D1 (de)	2004-11-11	Verfahren zur herstellung von arzneistoffpartikeln
HUT59818A (en)	1992-07-28	Process for producing lipide complex containing different components
DE59009603D1 (de)	1995-10-12	Verfahren zur Herstellung von Ascorbinsäure-2-phosphat bzw. dessen Salzen sowie Kaliummagnesium-L-ascorbat-2-phosphat als vorteilhaftes Salz von L-Ascorbinsäure-2-phosphat.
DE3382299D1 (de)	1991-07-04	Pyrazolo(3,4-b)pyridinderivate und verfahren zu ihrer herstellung.
DE69927602D1 (de)	2005-11-10	Verfahren zur herstellung von vitaminpulvern
EP0200068A3 (de)	1987-08-26	Arzneizubereitung enthaltend Dihydropyridine und Verfahren zu ihrer Herstellung
ATE181325T1 (de)	1999-07-15	Verfahren zur herstellung von ascorbinsäure
DE59105400D1 (de)	1995-06-08	Cyclopentanderivate, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung.
ATE111302T1 (de)	1994-09-15	Konzentrierte wässrige emulsionen, verfahren zu ihrer herstellung und ihre verwendung auf dem pestizidgebiet.
ATE17727T1 (de)	1986-02-15	Alkylenverbrueckte guanidinothiazolderivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel.
JPS55127448A (en)	1980-10-02	Gelatin coating
IL58064A (en)	1984-10-31	Phenyl-,thienyl and furyl-fluorononatetraene derivatives,their preparation and pharmaceutical compositions containing them
EP0382779A4 (en)	1991-01-09	Tocopherol-based pharmaceutical systems
ATE203397T1 (de)	2001-08-15	Verfahren zur herstellung einer festen arzneimitteldosierungsform
ATE287879T1 (de)	2005-02-15	Verfahren zur herstellung von isoflavonen
ATE181826T1 (de)	1999-07-15	Wässriges liposomensystem sowie verfahren zur herstellung eines derartigen liposomensystems
ATE72628T1 (de)	1992-03-15	Verfahren zur herstellung von liposomen.