ATE122680T1 - Stabil fest 2-octynyladenozin und verfahren zu ihrer herstellung. - Google Patents

Stabil fest 2-octynyladenozin und verfahren zu ihrer herstellung.

Info

Publication number
ATE122680T1
ATE122680T1 AT92102210T AT92102210T ATE122680T1 AT E122680 T1 ATE122680 T1 AT E122680T1 AT 92102210 T AT92102210 T AT 92102210T AT 92102210 T AT92102210 T AT 92102210T AT E122680 T1 ATE122680 T1 AT E122680T1
Authority
AT
Austria
Prior art keywords
solid
octynyladenozin
production
alcoholic solution
octynyl adenosine
Prior art date
Application number
AT92102210T
Other languages
English (en)
Inventor
Manami Morozumi
Masao Kumagai
Toyofumi Yamaguchi
Original Assignee
Yamasa Shoyu Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamasa Shoyu Kk filed Critical Yamasa Shoyu Kk
Application granted granted Critical
Publication of ATE122680T1 publication Critical patent/ATE122680T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
AT92102210T 1991-02-12 1992-02-10 Stabil fest 2-octynyladenozin und verfahren zu ihrer herstellung. ATE122680T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3040894A JP2740362B2 (ja) 1991-02-12 1991-02-12 安定な固体状２‐オクチニルアデノシンおよびその製造法

Publications (1)

Publication Number Publication Date
ATE122680T1 true ATE122680T1 (de) 1995-06-15

Family

ID=12593220

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92102210T ATE122680T1 (de) 1991-02-12 1992-02-10 Stabil fest 2-octynyladenozin und verfahren zu ihrer herstellung.

Country Status (7)

Country Link
US (1) US5939543A (de)
EP (1) EP0499185B1 (de)
JP (1) JP2740362B2 (de)
AT (1) ATE122680T1 (de)
CA (1) CA2060865C (de)
DE (1) DE69202483T2 (de)
ES (1) ES2073793T3 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6403567B1 (en) 1999-06-22 2002-06-11 Cv Therapeutics, Inc. N-pyrazole A2A adenosine receptor agonists
USRE47351E1 (en) 1999-06-22 2019-04-16 Gilead Sciences, Inc. 2-(N-pyrazolo)adenosines with application as adenosine A2A receptor agonists
US6214807B1 (en) * 1999-06-22 2001-04-10 Cv Therapeutics, Inc. C-pyrazole 2A A receptor agonists
US6180615B1 (en) * 1999-06-22 2001-01-30 Cv Therapeutics, Inc. Propargyl phenyl ether A2A receptor agonists
CA2671940A1 (en) * 2000-02-23 2001-08-30 Cv Therapeutics, Inc. Identification of partial agonists of the a2a adenosine receptor
US8470801B2 (en) 2002-07-29 2013-06-25 Gilead Sciences, Inc. Myocardial perfusion imaging methods and compositions
NZ537975A (en) * 2002-07-29 2007-08-31 Cv Therapeutics Inc Method of producing coronary vasodilation without peripheral vasodilation comprising administering at least 10 mcg of at least one A2A receptor agonist
US20050020915A1 (en) * 2002-07-29 2005-01-27 Cv Therapeutics, Inc. Myocardial perfusion imaging methods and compositions
KR20070083714A (ko) 2004-10-20 2007-08-24 씨브이 쎄러퓨틱스, 인코포레이티드 Ａ2ａ 아데노신 수용체 작용제의 용도
US7732595B2 (en) 2006-02-03 2010-06-08 Gilead Palo Alto, Inc. Process for preparing an A2A-adenosine receptor agonist and its polymorphs
CA2655310A1 (en) * 2006-06-22 2008-05-29 Cv Therapeutics, Inc. Use of a2a adenosine receptor agonists in the treatment of ischemia
US20090081120A1 (en) * 2006-09-01 2009-03-26 Cv Therapeutics, Inc. Methods and Compositions for Increasing Patient Tolerability During Myocardial Imaging Methods
RU2459626C2 (ru) * 2006-09-01 2012-08-27 Гайлид Сайэнсиз, Инк. Способы и композиции, повышающие переносимость пациентом методов визуализации миокарда
US20080170990A1 (en) * 2006-09-29 2008-07-17 Cv Therapeutics, Inc. Methods for Myocardial Imaging in Patients Having a History of Pulmonary Disease
JP2010515081A (ja) * 2007-01-03 2010-05-06 ギリアード・パロ・アルト・インコーポレイテッド 心筋灌流画像化
AU2009296235A1 (en) * 2008-09-29 2010-04-01 Gilead Sciences, Inc. Combinations of a rate control agent and an A-2-alpha receptor antagonist for use in multidetector computed tomography methods

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5134443B2 (de) * 1972-10-09 1976-09-27
JPS5140134B2 (de) * 1972-12-27 1976-11-01
JPS50142595A (de) * 1974-05-14 1975-11-17
JPS6299395A (ja) * 1985-10-25 1987-05-08 Yamasa Shoyu Co Ltd ２−アルキニルアデノシンおよび抗高血圧剤
EP0444196B1 (de) * 1988-11-15 1994-06-08 Yamasa Shoyu Kabushiki Kaisha Mittel zur behandlung und prophylaxe koronarer und zerebraler ischämischer erkrankungen
ES2077070T3 (es) * 1989-06-20 1995-11-16 Yamasa Shoyu Kk Intermedio de sintesis de 2-alquiniladenosina, produccion de dicho intermedio, produccion de 2-alquiniladenosina a partir de dicho intermedio, y derivado de 2-alquiniladenosina estable.
JPH095526A (ja) * 1995-06-14 1997-01-10 Asahi Glass Co Ltd 重畳型ホログラム

Also Published As

Publication number Publication date
DE69202483D1 (de) 1995-06-22
DE69202483T2 (de) 1995-09-28
JP2740362B2 (ja) 1998-04-15
ES2073793T3 (es) 1995-08-16
US5939543A (en) 1999-08-17
EP0499185A1 (de) 1992-08-19
CA2060865C (en) 2000-05-16
JPH05194579A (ja) 1993-08-03
CA2060865A1 (en) 1992-08-13
EP0499185B1 (de) 1995-05-17

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