ATE122680T1 - Stabil fest 2-octynyladenozin und verfahren zu ihrer herstellung. - Google Patents

Stabil fest 2-octynyladenozin und verfahren zu ihrer herstellung.

Info

Publication number
ATE122680T1
ATE122680T1 AT92102210T AT92102210T ATE122680T1 AT E122680 T1 ATE122680 T1 AT E122680T1 AT 92102210 T AT92102210 T AT 92102210T AT 92102210 T AT92102210 T AT 92102210T AT E122680 T1 ATE122680 T1 AT E122680T1
Authority
AT
Austria
Prior art keywords
solid
octynyladenozin
production
alcoholic solution
octynyl adenosine
Prior art date
Application number
AT92102210T
Other languages
English (en)
Inventor
Manami Morozumi
Masao Kumagai
Toyofumi Yamaguchi
Original Assignee
Yamasa Shoyu Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamasa Shoyu Kk filed Critical Yamasa Shoyu Kk
Application granted granted Critical
Publication of ATE122680T1 publication Critical patent/ATE122680T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
AT92102210T 1991-02-12 1992-02-10 Stabil fest 2-octynyladenozin und verfahren zu ihrer herstellung. ATE122680T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3040894A JP2740362B2 (ja) 1991-02-12 1991-02-12 安定な固体状２‐オクチニルアデノシンおよびその製造法

Publications (1)

Publication Number Publication Date
ATE122680T1 true ATE122680T1 (de) 1995-06-15

Family

ID=12593220

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92102210T ATE122680T1 (de) 1991-02-12 1992-02-10 Stabil fest 2-octynyladenozin und verfahren zu ihrer herstellung.

Country Status (7)

Country Link
US (1) US5939543A (de)
EP (1) EP0499185B1 (de)
JP (1) JP2740362B2 (de)
AT (1) ATE122680T1 (de)
CA (1) CA2060865C (de)
DE (1) DE69202483T2 (de)
ES (1) ES2073793T3 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6214807B1 (en) * 1999-06-22 2001-04-10 Cv Therapeutics, Inc. C-pyrazole 2A A receptor agonists
US6180615B1 (en) * 1999-06-22 2001-01-30 Cv Therapeutics, Inc. Propargyl phenyl ether A2A receptor agonists
USRE47351E1 (en) 1999-06-22 2019-04-16 Gilead Sciences, Inc. 2-(N-pyrazolo)adenosines with application as adenosine A2A receptor agonists
US6403567B1 (en) * 1999-06-22 2002-06-11 Cv Therapeutics, Inc. N-pyrazole A2A adenosine receptor agonists
CA2439222C (en) * 2000-02-23 2009-07-14 Cv Therapeutics, Inc. Identification of partial agonists of the a2a adenosine receptor
WO2004011010A1 (en) * 2002-07-29 2004-02-05 Cv Therapeutics, Inc. Myocardial perfusion imaging using a2a receptor agonists
US20050020915A1 (en) * 2002-07-29 2005-01-27 Cv Therapeutics, Inc. Myocardial perfusion imaging methods and compositions
US8470801B2 (en) 2002-07-29 2013-06-25 Gilead Sciences, Inc. Myocardial perfusion imaging methods and compositions
CA2583185A1 (en) 2004-10-20 2006-04-27 Cv Therapeutics, Inc. Use of a2a adenosine receptor agonists
PL1989214T3 (pl) 2006-02-03 2017-07-31 Gilead Sciences, Inc. Proces otrzymywania agonisty receptora adenozynowego a2a i jego polimorfów
CA2655310A1 (en) * 2006-06-22 2008-05-29 Cv Therapeutics, Inc. Use of a2a adenosine receptor agonists in the treatment of ischemia
US20090081120A1 (en) * 2006-09-01 2009-03-26 Cv Therapeutics, Inc. Methods and Compositions for Increasing Patient Tolerability During Myocardial Imaging Methods
JP2010502649A (ja) * 2006-09-01 2010-01-28 シーブイ・セラピューティクス・インコーポレイテッド 心筋層画像化法中の患者の耐性を増加させるための方法および組成物
JP2011502101A (ja) * 2006-09-29 2011-01-20 ギリアード・パロ・アルト・インコーポレイテッド 肺疾患の病歴を有する患者における心筋画像化法
EP2099360A2 (de) * 2007-01-03 2009-09-16 CV Therapeutics Inc. Abbildung myokardialer perfusionen
EP2344145A1 (de) * 2008-09-29 2011-07-20 Gilead Sciences, Inc. Kombinationen eines ratenkontrollierenden mittels und eines a-2-alpha-rezeptor-antagonisten zur verwendung in multidetektor-computertomographie-verfahren

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5134443B2 (de) * 1972-10-09 1976-09-27
JPS5140134B2 (de) * 1972-12-27 1976-11-01
JPS50142595A (de) * 1974-05-14 1975-11-17
JPS6299395A (ja) * 1985-10-25 1987-05-08 Yamasa Shoyu Co Ltd ２−アルキニルアデノシンおよび抗高血圧剤
DE68916036T2 (de) * 1988-11-15 1994-09-29 Toa Eiyo Ltd Mittel zur behandlung und prophylaxe koronarer und zerebraler ischämischer erkrankungen.
KR920700218A (ko) * 1989-06-20 1992-02-19 원본미기재 2-알키닐 아데노신의 합성중간체, 그 합성 중간체의 제조법, 그 합성중간체를 이용한 2-알키닐 아데노신의 제조법 및 안정한 2-알키닐 아데노신 유도체
JPH095526A (ja) * 1995-06-14 1997-01-10 Asahi Glass Co Ltd 重畳型ホログラム

Also Published As

Publication number Publication date
EP0499185B1 (de) 1995-05-17
DE69202483T2 (de) 1995-09-28
DE69202483D1 (de) 1995-06-22
ES2073793T3 (es) 1995-08-16
CA2060865C (en) 2000-05-16
EP0499185A1 (de) 1992-08-19
US5939543A (en) 1999-08-17
JPH05194579A (ja) 1993-08-03
JP2740362B2 (ja) 1998-04-15
CA2060865A1 (en) 1992-08-13

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