ES2073793T3 - 2-octiniladenosina estable solida y procedimiento para su preparacion. - Google Patents

2-octiniladenosina estable solida y procedimiento para su preparacion.

Info

Publication number
ES2073793T3
ES2073793T3 ES92102210T ES92102210T ES2073793T3 ES 2073793 T3 ES2073793 T3 ES 2073793T3 ES 92102210 T ES92102210 T ES 92102210T ES 92102210 T ES92102210 T ES 92102210T ES 2073793 T3 ES2073793 T3 ES 2073793T3
Authority
ES
Spain
Prior art keywords
solid
octinyladenosine
procedure
preparation
alcoholic solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92102210T
Other languages
English (en)
Inventor
Manami Morozumi
Masao Kumagai
Toyofumi Yamaguchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamasa Shoyu KK
Original Assignee
Yamasa Shoyu KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamasa Shoyu KK filed Critical Yamasa Shoyu KK
Application granted granted Critical
Publication of ES2073793T3 publication Critical patent/ES2073793T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

ESTA INVENCION SUMINISTRA DOS CLASES DE PRODUCTOS DE ENDENOSINA 2-OCTINIL SOLIDAS CON PROPIEDADES NOVELES QUE SON ESTABILIZADOS CON RELACION A LA TEMPERATURA O A LA TEMPERATURA Y HUMEDAD, UNA SIENDO ENDENOSINA 2-OCTINIL SOLIDA CON UN CONTENIDO EN HUMEDAD DE NO MAS DE UN 3%, Y LA OTRA SIENDO ENDENOSINA 2-OCTINIL SOLIDA DEPOSITADA DE UNA SOLUCION ALCOHOLICA ANHIDRA O UNA SOLUCION ALCOHOLICA HIDRATADA DE LA ENDENOSINA 2-OCTINIL, TENIENDO DICHA SOLUCION ALCOHOLICA HIDRATADA UN CONTENIDO EN AGUA MENOR QUE 1%.
ES92102210T 1991-02-12 1992-02-10 2-octiniladenosina estable solida y procedimiento para su preparacion. Expired - Lifetime ES2073793T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3040894A JP2740362B2 (ja) 1991-02-12 1991-02-12 安定な固体状２‐オクチニルアデノシンおよびその製造法

Publications (1)

Publication Number Publication Date
ES2073793T3 true ES2073793T3 (es) 1995-08-16

Family

ID=12593220

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92102210T Expired - Lifetime ES2073793T3 (es) 1991-02-12 1992-02-10 2-octiniladenosina estable solida y procedimiento para su preparacion.

Country Status (7)

Country Link
US (1) US5939543A (es)
EP (1) EP0499185B1 (es)
JP (1) JP2740362B2 (es)
AT (1) ATE122680T1 (es)
CA (1) CA2060865C (es)
DE (1) DE69202483T2 (es)
ES (1) ES2073793T3 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6214807B1 (en) * 1999-06-22 2001-04-10 Cv Therapeutics, Inc. C-pyrazole 2A A receptor agonists
US6180615B1 (en) * 1999-06-22 2001-01-30 Cv Therapeutics, Inc. Propargyl phenyl ether A2A receptor agonists
US6403567B1 (en) * 1999-06-22 2002-06-11 Cv Therapeutics, Inc. N-pyrazole A2A adenosine receptor agonists
USRE47351E1 (en) 1999-06-22 2019-04-16 Gilead Sciences, Inc. 2-(N-pyrazolo)adenosines with application as adenosine A2A receptor agonists
AU2001238665A1 (en) * 2000-02-23 2001-09-03 Cv Therapeutics, Inc. Method of identifying partial agonists of the a2a receptor
US20050020915A1 (en) * 2002-07-29 2005-01-27 Cv Therapeutics, Inc. Myocardial perfusion imaging methods and compositions
US8470801B2 (en) 2002-07-29 2013-06-25 Gilead Sciences, Inc. Myocardial perfusion imaging methods and compositions
JP2005538190A (ja) * 2002-07-29 2005-12-15 シーブイ・セラピューティクス・インコーポレイテッド 心筋潅流イメージング
CN101076343A (zh) * 2004-10-20 2007-11-21 Cv医药有限公司 A2a腺苷受体激动剂的应用
WO2007092372A1 (en) 2006-02-03 2007-08-16 Cv Therapeutics, Inc. Process for preparing an a2a-adenosine receptor agonist and its polymorphs
JP2009541354A (ja) * 2006-06-22 2009-11-26 シーブイ・セラピューティクス・インコーポレイテッド 虚血の治療におけるａ２ａアデノシン受容体アゴニストの使用
US20090081120A1 (en) * 2006-09-01 2009-03-26 Cv Therapeutics, Inc. Methods and Compositions for Increasing Patient Tolerability During Myocardial Imaging Methods
WO2008028140A1 (en) * 2006-09-01 2008-03-06 Cv Therapeutics, Inc. Methods and compositions for increasing patient tolerability during myocardial imaging methods
US20080170990A1 (en) * 2006-09-29 2008-07-17 Cv Therapeutics, Inc. Methods for Myocardial Imaging in Patients Having a History of Pulmonary Disease
WO2008086096A2 (en) * 2007-01-03 2008-07-17 Cv Therapeutics, Inc. Myocardial perfusion imaging
MX2011003168A (es) * 2008-09-29 2011-05-19 Gilead Sciences Inc Combinaciones de un agente de control de cantidad y un antagonista del receptor a-2-alfa para utilizarse en metodos de tomografia computarizada de detectores multiples.

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5134443B2 (es) * 1972-10-09 1976-09-27
JPS5140134B2 (es) * 1972-12-27 1976-11-01
JPS50142595A (es) * 1974-05-14 1975-11-17
JPS6299395A (ja) * 1985-10-25 1987-05-08 Yamasa Shoyu Co Ltd ２−アルキニルアデノシンおよび抗高血圧剤
US5270304A (en) * 1988-11-15 1993-12-14 Yamasa Shoyu Kabushiki Kaisha Therapeutic 2-alkynyl adenosine agent for ischemic diseases of the heart or brain
KR920700218A (ko) * 1989-06-20 1992-02-19 원본미기재 2-알키닐 아데노신의 합성중간체, 그 합성 중간체의 제조법, 그 합성중간체를 이용한 2-알키닐 아데노신의 제조법 및 안정한 2-알키닐 아데노신 유도체
JPH095526A (ja) * 1995-06-14 1997-01-10 Asahi Glass Co Ltd 重畳型ホログラム

Also Published As

Publication number Publication date
CA2060865C (en) 2000-05-16
JP2740362B2 (ja) 1998-04-15
DE69202483T2 (de) 1995-09-28
US5939543A (en) 1999-08-17
JPH05194579A (ja) 1993-08-03
DE69202483D1 (de) 1995-06-22
EP0499185B1 (en) 1995-05-17
ATE122680T1 (de) 1995-06-15
EP0499185A1 (en) 1992-08-19
CA2060865A1 (en) 1992-08-13

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