ATE123282T1 - Renininhibitoren. - Google Patents

Renininhibitoren.

Info

Publication number: ATE123282T1
Authority: AT; Austria
Prior art keywords: thiazolyl; piperazinyl; methyl; naphthylmethyl; pyrazolyl
Prior art date: 1990-05-11

Application number

AT91107400T

Other languages

English (en)

Inventor

Saul H Rosenberg

Jon F Denissen

Original Assignee

Abbott Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-05-11

Filing date

1991-05-07

Publication date

1995-06-15

1991-05-07 Application filed by Abbott Lab filed Critical Abbott Lab

1995-06-15 Application granted granted Critical

1995-06-15 Publication of ATE123282T1 publication Critical patent/ATE123282T1/de

Links

239000002461 renin inhibitor Substances 0.000 title 1
229940086526 renin-inhibitors Drugs 0.000 title 1
-1 4-piperazinyl Chemical group 0.000 abstract 13
125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 2
125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 abstract 1
KDDQRKBRJSGMQE-UHFFFAOYSA-N 4-thiazolyl Chemical group [C]1=CSC=N1 KDDQRKBRJSGMQE-UHFFFAOYSA-N 0.000 abstract 1
CWDWFSXUQODZGW-UHFFFAOYSA-N 5-thiazolyl Chemical group [C]1=CN=CS1 CWDWFSXUQODZGW-UHFFFAOYSA-N 0.000 abstract 1
102100028255 Renin Human genes 0.000 abstract 1
108090000783 Renin Proteins 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 abstract 1
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
229940002612 prodrug Drugs 0.000 abstract 1
239000000651 prodrug Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/26—Sulfur atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/28—Radicals substituted by nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Biochemistry (AREA)
Endocrinology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Diabetes (AREA)
Heart & Thoracic Surgery (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Virology (AREA)
Urology & Nephrology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Emergency Medicine (AREA)
Obesity (AREA)
Hematology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Thiazole And Isothizaole Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

AT91107400T 1990-05-11 1991-05-07 Renininhibitoren. ATE123282T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date
US52234990A	1990-05-11	1990-05-11
US56492590A	1990-08-09	1990-08-09
US68366391A	1991-04-15	1991-04-15

Publications (1)

Publication Number	Publication Date
ATE123282T1 true ATE123282T1 (de)	1995-06-15

Family

ID=27414825

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91107400T ATE123282T1 (de)	1990-05-11	1991-05-07	Renininhibitoren.

Country Status (14)

Country	Link
US (2)	US5310740A (de)
EP (1)	EP0456185B1 (de)
JP (2)	JPH07607B2 (de)
AT (1)	ATE123282T1 (de)
AU (1)	AU646859B2 (de)
CA (1)	CA2041825A1 (de)
DE (1)	DE69110086T2 (de)
DK (1)	DK0456185T3 (de)
ES (1)	ES2075261T3 (de)
GR (1)	GR3017168T3 (de)
IE (1)	IE68045B1 (de)
IL (1)	IL97994A (de)
MX (1)	MX9202877A (de)
PT (1)	PT97631B (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5442044A (en) *	1991-01-04	1995-08-15	Pfizer Inc.	Orally active renin inhibitors
US5523289A (en) *	1991-04-15	1996-06-04	Abbott Laboratories	Pharmaceutical composition
DE4215874A1 (de) *	1992-05-14	1993-11-18	Bayer Ag	Dithiolanylglycinhaltige HIV-Proteaseinhibitoren vom Hydroxyethylenisostertyp
GB9211707D0 (en) *	1992-06-03	1992-07-15	Celltech Ltd	Peptidyl derivatives
US5559256A (en) *	1992-07-20	1996-09-24	E. R. Squibb & Sons, Inc.	Aminediol protease inhibitors
US5298505A (en) *	1992-08-14	1994-03-29	G. D. Searle & Co.	Ethynyl alanine amino diol compounds having a piperazinyl-terminated group or a piperazinyl-alkylamino-terminated group for treatment of hypertension
US5252591A (en) *	1992-08-14	1993-10-12	G. D. Searle & Company	Pyridinyl-terminated alkylamino ethynyl alanine amino diol compounds for treatment of hypertension
US5373017A (en) *	1992-08-14	1994-12-13	G. D. Searle & Co.	Imidazolyl/benzimidazolyl-terminated alkylamino ethynyl alanine amino diol compounds for treatment of hypertension
US5422349A (en) *	1992-08-14	1995-06-06	G. D. Seale & Co.	Morpholino-oxazinyl-terminated alkylamino ethynyl alanine amino diol compounds for treatment of hypertension
US5212185A (en) *	1992-08-14	1993-05-18	G. D. Searle & Co.	Piperidinyl-terminated alkylamino ethynyl alanine amino diol compounds for treatment of hypertension
JP2787539B2 (ja) *	1993-02-26	1998-08-20	松森　　昭	ウイルス性疾患の予防または治療剤
IL108924A0 (en) *	1993-03-19	1994-06-24	Ciba Vision Ag	Compositions for the treatment of eye diseases
US5601801A (en) *	1994-08-02	1997-02-11	Merck Frosst Canada, Inc.	Radiolabelled angiotensin converting enzyme inhibitors
US5705524A (en) *	1994-11-04	1998-01-06	Gilead Sciences, Inc.	Thiepane compounds
US6034118A (en) *	1994-11-04	2000-03-07	Gilead Sciences, Inc.	Thiepane compounds
US6376506B1 (en)	1997-01-23	2002-04-23	Syntex (U.S.A.) Llc	Sulfamide-metalloprotease inhibitors
PT958287E (pt) *	1997-01-23	2002-12-31	Hoffmann La Roche	Inibidores de sulfamida-metaloprotease
ZA98376B (en) *	1997-01-23	1998-07-23	Hoffmann La Roche	Sulfamide-metalloprotease inhibitors
US6130220A (en) *	1997-10-16	2000-10-10	Syntex (Usa) Inc.	Sulfamide-metalloprotease inhibitors
US8168616B1 (en)	2000-11-17	2012-05-01	Novartis Ag	Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension
US20050147629A1 (en) *	2002-06-28	2005-07-07	Jutta Riedl	Pharmaceutical formulation comprising non-peptide renin inhibitor and surfactant
US7819192B2 (en) *	2006-02-10	2010-10-26	Halliburton Energy Services, Inc.	Consolidating agent emulsions and associated methods
EP2163245A1 (de) *	2008-09-10	2010-03-17	Novartis Ag	Renin-Inhibitoren zur Behandlung von Psoriasis
UA108742C2 (uk)	2009-09-23	2015-06-10		Фармацевтична композиція для лікування запальних захворювань, опосередкованих mcp-1

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4812442A (en) *	1984-05-29	1989-03-14	Merck & Co., Inc.	Tripeptide renin inhibitors
US4845079A (en) *	1985-01-23	1989-07-04	Luly Jay R	Peptidylaminodiols
DE3538749A1 (de) *	1985-10-31	1987-05-07	Merck Patent Gmbh	Peptide
US4906613A (en) *	1985-11-05	1990-03-06	Schering Corporation	Antiglaucoma compositions and methods
EP0309766B1 (de) *	1987-09-29	1998-04-15	Banyu Pharmaceutical Co., Ltd.	N-Acylaminosäurederivate und deren Verwendung
US4927807A (en) *	1987-10-06	1990-05-22	Abbott Laboratories	Glaucoma treatment
CA1328333C (en) *	1988-03-04	1994-04-05	Quirico Branca	Amino acid derivatives
US5036053A (en) *	1988-05-27	1991-07-30	Warner-Lambert Company	Diol-containing renin inhibitors
WO1990005531A1 (en) *	1988-11-21	1990-05-31	Abbott Laboratories	Method for treating vascular diseases
DE3839559A1 (de) *	1988-11-24	1990-05-31	Hoechst Ag	Renin-hemmende aminodiol-derivate
US5238923A (en) *	1989-05-26	1993-08-24	Warner-Lambert Company	Amino-substituted heterocycles as renin inhibitors
DE59004292D1 (de) *	1989-07-25	1994-03-03	Hoechst Ag	Renin-hemmende Aminooligohydroxy-Derivate.
IE902446A1 (en) *	1989-07-26	1991-02-13	Abbott Lab	Peptidyl aminodiol renin inhibitors
CA2023099A1 (en) *	1989-09-04	1991-03-05	Quirico Branca	Amino acid derivatives
US5374731A (en) *	1989-09-12	1994-12-20	Hoechst Aktiengesellschaft	Amino acid derivatives with renin-inhibiting properties, a process for the preparation thereof, agents containing these, and the use thereof
US5122514A (en) *	1990-04-23	1992-06-16	Abbott Laboratories	Psoriasis treatment
US5089616A (en) *	1991-04-23	1992-02-18	Warner-Lambert Company	Process for the preparation of [1S-(1R,2S,3R*)]-N-(4-morpholinylsulfonyl)-L-phenylalanyl-3-(2-amino-4-thiazolyl-N-[(1-cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl]-L-alaninamide

1991
- 1991-04-25 IE IE140491A patent/IE68045B1/en not_active IP Right Cessation
- 1991-04-29 AU AU76077/91A patent/AU646859B2/en not_active Ceased
- 1991-04-29 IL IL9799491A patent/IL97994A/en not_active IP Right Cessation
- 1991-05-03 CA CA002041825A patent/CA2041825A1/en not_active Abandoned
- 1991-05-07 EP EP91107400A patent/EP0456185B1/de not_active Expired - Lifetime
- 1991-05-07 AT AT91107400T patent/ATE123282T1/de active
- 1991-05-07 ES ES91107400T patent/ES2075261T3/es not_active Expired - Lifetime
- 1991-05-07 DE DE69110086T patent/DE69110086T2/de not_active Expired - Fee Related
- 1991-05-07 DK DK91107400.3T patent/DK0456185T3/da active
- 1991-05-09 PT PT97631A patent/PT97631B/pt not_active IP Right Cessation
- 1991-05-13 JP JP3202614A patent/JPH07607B2/ja not_active Expired - Lifetime
1992
- 1992-06-15 MX MX9202877A patent/MX9202877A/es unknown
- 1992-06-19 US US07/901,368 patent/US5310740A/en not_active Expired - Fee Related
- 1992-08-14 US US07/928,190 patent/US5284849A/en not_active Expired - Fee Related
- 1992-12-01 JP JP4321852A patent/JPH05271194A/ja active Pending
1995
- 1995-08-23 GR GR950402278T patent/GR3017168T3/el unknown

Also Published As

Publication number	Publication date
EP0456185B1 (de)	1995-05-31
AU7607791A (en)	1991-11-14
DE69110086T2 (de)	1995-12-14
US5284849A (en)	1994-02-08
DE69110086D1 (de)	1995-07-06
IL97994A (en)	1996-10-16
JPH07607B2 (ja)	1995-01-11
JPH05271194A (ja)	1993-10-19
AU646859B2 (en)	1994-03-10
MX9202877A (es)	1992-06-30
US5310740A (en)	1994-05-10
IL97994A0 (en)	1992-06-21
PT97631A (pt)	1992-03-31
GR3017168T3 (en)	1995-11-30
IE68045B1 (en)	1996-05-15
IE911404A1 (en)	1991-11-20
ES2075261T3 (es)	1995-10-01
DK0456185T3 (da)	1995-10-30
JPH04279572A (ja)	1992-10-05
EP0456185A3 (en)	1992-10-14
EP0456185A2 (de)	1991-11-13
PT97631B (pt)	1998-08-31
CA2041825A1 (en)	1991-11-12

Publication	Publication Date	Title
DE69110086D1 (de)	1995-07-06	Renininhibitoren.
CA2039056A1 (en)	1991-09-28	3,5-di-tertiarybutyl-4-hydroxyphenylmethylene derivatives of 2-substituted thiazolidinones, oxazolidinones, and imidazolidinones as antiinflammatory agents
MXPA06001274A (es)	2006-04-11	Compuestos novedosos que poseen actividad inhibitoria contra transporador dependiente de sodio.
DK0590919T3 (da)	2000-04-17	Terapeutiske midler mod Parkinsons sygdom
DK0412404T3 (da)	1996-02-26	Thiazolderivater, fremgangsmåder til fremstilling deraf og farmaceutiske præparater omfattende derivaterne
NZ507144A (en)	2002-10-25	Benzamide derivatives useful for the treatment of diseases mediated by cytokines
HUP9903111A2 (hu)	2000-01-28	Helyettesített 3,5-difenil-1,2,4-triazolok és fémkelátképzőként való gyógyászati alkalmazásuk
GR3001395T3 (en)	1992-09-11	Arylcyclobutylalkylamine-derivative for the treatment of parkinson's disease
WO2002083111A3 (en)	2004-04-15	Imidazole, thiazole and oxazole derivatives and their use for the manufacture of a medicament for the treatment and/or prevention of pollakiuria or urinary incontinence
NO175256C (no)	1994-09-21	Analogifremgangsmåte til fremstilling av terapeutisk aktive 4-oksokinolin-3-karboksylsyrederivater
MY157949A (en)	2016-08-30	Thioxanthine derivatives as myeloperoxidase inhibitors
GEP20074045B (en)	2007-02-26	(4-phenyl) piperidin-3-yl-phenylcarboxylate derivatives and related compounds as beta-secretase inhibitors for the treatment of alzheimer's disease
IL106307A (en)	1997-06-10	Isoxazole derivatives for the treatment of irritable bowel syndrome
JP2002519408A5 (de)	2006-08-17
KR920701240A (ko)	1992-08-11	글루타티온 유도체
MY144338A (en)	2011-08-29	Morpholine derivatives for use as dopamine agonists in the treatment of i.a. sexual dysfunction
AU686934B2 (en)	1998-02-12	2-heterocyclicethylamine derivatives and their use as pharmaceuticals
EP1034783A4 (de)	2001-03-28	Amidederivaten
ATE187729T1 (de)	2000-01-15	Cephalosporinverbindungen und ihre pharmazeutische präparate
PL308180A1 (en)	1995-07-24	Renin inhibiting derivatives of n-(2-amino-2-oxoethyl)butane diamide
DK0534655T3 (da)	1995-08-28	Thiazolidin-2,4-dioner til behandling af hypertension