ATE123767T1 - 24-cyclopropan-vitamin-d-derivate. - Google Patents

24-cyclopropan-vitamin-d-derivate.

Info

Publication number: ATE123767T1
Authority: AT; Austria
Prior art keywords: vitamin; alpha; activity; derivatives; compounds
Prior art date: 1992-07-08

Application number

AT93305347T

Other languages

English (en)

Inventor

Hector F Deluca

Naoshi Nakagawa

Original Assignee

Wisconsin Alumni Res Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-07-08

Filing date

1993-07-08

Publication date

1995-06-15

1993-07-08 Application filed by Wisconsin Alumni Res Found filed Critical Wisconsin Alumni Res Found

1995-06-15 Application granted granted Critical

1995-06-15 Publication of ATE123767T1 publication Critical patent/ATE123767T1/de

Links

OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 2
229910052791 calcium Inorganic materials 0.000 abstract 2
239000011575 calcium Substances 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
230000000694 effects Effects 0.000 abstract 2
GMRQFYUYWCNGIN-UHFFFAOYSA-N 1,25-Dihydroxy-vitamin D3' Natural products C1CCC2(C)C(C(CCCC(C)(C)O)C)CCC2C1=CC=C1CC(O)CC(O)C1=C GMRQFYUYWCNGIN-UHFFFAOYSA-N 0.000 abstract 1
ZGLHBRQAEXKACO-XJRQOBMKSA-N 1alpha,25-dihydroxyvitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](\C=C\[C@H](C)C(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C ZGLHBRQAEXKACO-XJRQOBMKSA-N 0.000 abstract 1
208000001132 Osteoporosis Diseases 0.000 abstract 1
210000000988 bone and bone Anatomy 0.000 abstract 1
230000000125 calcaemic effect Effects 0.000 abstract 1
239000011612 calcitriol Substances 0.000 abstract 1
235000020964 calcitriol Nutrition 0.000 abstract 1
GMRQFYUYWCNGIN-NKMMMXOESA-N calcitriol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-NKMMMXOESA-N 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
HKXBNHCUPKIYDM-CGMHZMFXSA-N doxercalciferol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C HKXBNHCUPKIYDM-CGMHZMFXSA-N 0.000 abstract 1
230000001747 exhibiting effect Effects 0.000 abstract 1
230000000968 intestinal effect Effects 0.000 abstract 1
230000011164 ossification Effects 0.000 abstract 1
150000003703 vitamin D2 derivatives Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Hematology (AREA)
Diabetes (AREA)
Orthopedic Medicine & Surgery (AREA)
Obesity (AREA)
Nutrition Science (AREA)
Endocrinology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT93305347T 1992-07-08 1993-07-08 24-cyclopropan-vitamin-d-derivate. ATE123767T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/910,423 US5194431A (en)	1992-07-08	1992-07-08	24-cyclopropane vitamin D derivatives

Publications (1)

Publication Number	Publication Date
ATE123767T1 true ATE123767T1 (de)	1995-06-15

Family

ID=25428763

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93305347T ATE123767T1 (de)	1992-07-08	1993-07-08	24-cyclopropan-vitamin-d-derivate.

Country Status (8)

Country	Link
US (1)	US5194431A (de)
EP (1)	EP0578494B1 (de)
JP (1)	JP3253425B2 (de)
KR (1)	KR100273182B1 (de)
AT (1)	ATE123767T1 (de)
AU (1)	AU659745B2 (de)
DE (1)	DE69300196T2 (de)
IL (1)	IL106167A (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9017890D0 (en) *	1990-08-15	1990-09-26	Leo Pharm Prod Ltd	Chemical compounds i
US20040009958A1 (en) *	1991-01-08	2004-01-15	Bone Care International, Inc.	Methods for preparation and use of 1alpha,24(S)-dihydroxyvitamin D2
IL99368A (en) *	1991-09-02	1996-01-19	Teva Pharma	Preparations for the treatment of psoriasis and atopic dermatitis, which contain the result of xanthine
DE4220757A1 (de) *	1992-06-24	1994-01-05	Schering Ag	Derivate in der Vitamin D-Reihe mit Modifikationen in der 20-Position, Verfahren zu ihrer Herstellung, Zwischenprodukte für dieses Verfahren, diese Derivate enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln
DE4221961A1 (de) *	1992-06-30	1994-01-05	Schering Ag	22-En-25-oxa-Derivate in der Vitamin D-Reihe, Verfahren zu ihrer Herstellung, diese Derivate enthaltenen pharmazeutische Präparate sowie deren Verwendung als Arzneimittel
GB9223061D0 (en) *	1992-11-04	1992-12-16	Leo Pharm Prod Ltd	Chemical compounds
US5401733A (en) *	1993-10-01	1995-03-28	Hoffmann-La Roche Inc.	Stable and active metabolites of 1,25-dihydroxy-16-ene-cholecalciferol
US5373004A (en) *	1993-11-24	1994-12-13	Wisconsin Alumni Research Foundation	26,28-methylene-1α, 25-dihydroxyvitamin D2 compounds
ZA95906B (en) *	1994-02-07	1996-08-06	Res Developments Foundation	Non-viral vector
IT1311923B1 (it)	1999-04-13	2002-03-20	Nicox Sa	Composti farmaceutici.
IT1311922B1 (it)	1999-04-13	2002-03-20	Nicox Sa	Composti farmaceutici.
IT1319201B1 (it)	2000-10-12	2003-09-26	Nicox Sa	Farmaci per il diabete.
TWI329105B (en) *	2002-02-01	2010-08-21	Rigel Pharmaceuticals Inc	2,4-pyrimidinediamine compounds and their uses
CA2481909C (en) *	2002-04-11	2013-07-02	Instytut Farmaceutyczny	Preparation of 24-alkyl analogs of cholecalciferol
WO2005012294A1 (en) *	2003-07-30	2005-02-10	Rigel Pharmaceuticals, Inc.	2,4-pyrimidinediamine compounds for use in the treatment or prevention of autoimmune diseases
JP2008543855A (ja)	2005-06-13	2008-12-04	ライジェルファーマシューティカルズ，インコーポレイテッド	変形性骨疾患を処置するための方法および組成物
ATE352714T1 (de) *	2005-06-17	2007-02-15	Magneti Marelli Powertrain Spa	Brennstoffeinspritzventil
CA2981549A1 (en) *	2009-01-27	2010-08-05	Berg Llc	Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy
CN106265695B (zh)	2009-08-14	2021-05-07	博格有限责任公司	用于治疗脱发的维生素d3及其类似物
JP5732471B2 (ja) *	2009-12-22	2015-06-10	レオファーマアクティーゼルスカブ	溶媒混合物およびビタミンｄ誘導体から成る医薬品組成物または類似体
JP6055314B2 (ja)	2013-01-10	2016-12-27	理想科学工業株式会社	給紙装置
CN112156097A (zh)	2013-05-29	2021-01-01	博格有限责任公司	使用维生素d预防或减轻化疗诱发的脱发

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3833622A (en) *	1969-03-17	1974-09-03	Upjohn Co	Crystalline 25-hydroxycholecalciferol hydrate and structurally related compounds
US3901928A (en) *	1973-01-10	1975-08-26	Robert Henry Hesse	1' ,3' -dihydroxy steroid-5-enes method of preparing same and their use for preparing 1' -hydroxy-25-hydrogen vitamin d compounds
US4225596A (en) *	1978-10-13	1980-09-30	Wisconsin Alumni Research Foundation	Method for treating calcium imbalance and improving calcium absorption in mammals
US4255596A (en)	1980-02-25	1981-03-10	Gulf Research & Development Company	Preparation of ethylene glycol from ethylene
US4769181A (en) *	1983-11-07	1988-09-06	Wisconsin Alumni Research Foundation	1,25-dihydroxyvitamin D2 compounds
US4588716A (en) *	1984-05-04	1986-05-13	Wisconsin Alumni Research Foundation	Method for treating metabolic bone disease in mammals
EP0321572B1 (de)	1987-03-30	1993-06-09	Kuraray Co., Ltd.	Pregnanabkömmlinge und verfahren zur herstellung
JP2608322B2 (ja) *	1988-04-11	1997-05-07	日清製粉株式会社	１α，２５‐ジヒドロキシビタミンＤ▲下２▼類の製造法
KR0144358B1 (ko) *	1988-04-21	1998-07-15	피. 라이달 크리스텐슨	비타민 d 동족체
US4851401A (en) *	1988-07-14	1989-07-25	Wisconsin Alumni Research Foundation	Novel cyclopentano-vitamin D analogs
US4973584A (en) *	1989-03-09	1990-11-27	Deluca Hector F	Novel 1α-hydroxyvitamin D2 epimer and derivatives
JP2645130B2 (ja) *	1989-03-31	1997-08-25	日清製粉株式会社	ステロイド誘導体
US4928065A (en) *	1989-03-31	1990-05-22	E. I. Du Pont De Nemours And Company	Voltammetry in low-permitivity suspensions

1992
- 1992-07-08 US US07/910,423 patent/US5194431A/en not_active Expired - Lifetime
1993
- 1993-06-29 IL IL10616793A patent/IL106167A/en not_active IP Right Cessation
- 1993-07-07 JP JP19180793A patent/JP3253425B2/ja not_active Expired - Fee Related
- 1993-07-07 KR KR1019930012709A patent/KR100273182B1/ko not_active Expired - Fee Related
- 1993-07-07 AU AU41817/93A patent/AU659745B2/en not_active Ceased
- 1993-07-08 AT AT93305347T patent/ATE123767T1/de not_active IP Right Cessation
- 1993-07-08 EP EP93305347A patent/EP0578494B1/de not_active Expired - Lifetime
- 1993-07-08 DE DE69300196T patent/DE69300196T2/de not_active Expired - Fee Related

Also Published As

Publication number	Publication date
KR100273182B1 (ko)	2000-12-01
JP3253425B2 (ja)	2002-02-04
IL106167A0 (en)	1993-10-20
JPH0672995A (ja)	1994-03-15
EP0578494B1 (de)	1995-06-14
US5194431A (en)	1993-03-16
EP0578494A1 (de)	1994-01-12
AU4181793A (en)	1994-01-13
AU659745B2 (en)	1995-05-25
IL106167A (en)	1998-08-16
DE69300196D1 (de)	1995-07-20
DE69300196T2 (de)	1995-10-19
KR940002210A (ko)	1994-02-16

Legal Events

Date	Code	Title	Description
1995-12-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69300196D1 (de)	1995-07-20	24-Cyclopropan-Vitamin-D-Derivate.
ATE165819T1 (de)	1998-05-15	26,28-methylen-1alpha,25-dihydroxy-vitamin-d2- verbindungen
EP0549318A3 (en)	1993-10-06	26,27-dimethylene-1 alpha, 25-dihydroxyvitamin d2 and 26,27-dihydroxyvitamin d2 and methods for preparing same
EP0550702A4 (en)	1994-06-08	Methods for preparation and use of 1-g(a),24-dihydroxy vitamin d 2?
BR9509739A (pt)	1997-10-21	Compostos 18,19-dinor-vitamina d
GB2026494B (en)	1982-12-15	Fluorinated compounds of the vitamin d structure
GB9217780D0 (en)	1992-10-07	Fatty acid treatment
CY1109341T1 (el)	2014-07-02	Διαμορφωτες υποδοχεα βιταμινης d τυπου φαινυλο-θειοφαινιου
HU902288D0 (en)	1991-07-29	Process for producing new epimers of 1-alpha-hydroxy-d vitamin and their derivatives as well as pharmaceutical preparatives containing these compounds
DE3873855D1 (de)	1992-09-24	Mischung von cholecalciferol-derivaten fuer die behandlung von nierenbezogenen knochenkrankheiten.
DK8685A (da)	1985-01-08	Fremgangsmaade til fremstilling af 1alfa,25-hydroxylerede vitamin d2-og beslaegtede forbindelser
DE3560902D1 (en)	1987-12-10	Vitamin d3 derivatives
AU4444793A (en)	1994-02-10	Preparation of 19-nor-vitamin D compounds
GR3029334T3 (en)	1999-05-28	Novel use of 1alpha-hydroxylated-19-nor-vitamin D compounds to treat psoriasis
NZ230179A (en)	1991-10-25	Synthetic derivatives of paraherquamide and pesticidal compositions for treating man, animals and plants
HU9203689D0 (en)	1993-03-29	Method for fish breeding
DK0575974T3 (de)	1997-02-24
JPS5524105A (en)	1980-02-21	Method and agent for control of calcium metabolism of warm-blooded animal
MX9703720A (es)	1997-09-30	Compuestos de 18-nor-vitamina d.
MX9305151A (es)	1994-05-31	Metodo para el tratamiento de enfermedades de la piel.
PT891979E (pt)	2005-02-28	Uma forma cristalina do mono-hidrato do sal monossodico do acido n,n-dimetil-3-amino-1-hidroxipropan-1,1-difosfonico e o procedimento para a sua preparacao
IT1260502B (it)	1996-04-09	Rivestimenti in gomma per ambienti e procedimento per la loro produzione
ATE79541T1 (de)	1992-09-15	Mischung von cholecalciferol-derivaten fuer die behandlung von nierenbezogenen knochenkrankheiten.