ATE165819T1 - 26,28-methylen-1alpha,25-dihydroxy-vitamin-d2- verbindungen - Google Patents

26,28-methylen-1alpha,25-dihydroxy-vitamin-d2- verbindungen

Info

Publication number: ATE165819T1
Authority: AT; Austria
Prior art keywords: compounds; 1alpha; methylene; dihydroxy vitamin; activity
Prior art date: 1993-11-24

Application number

AT94931967T

Other languages

English (en)

Inventor

Hector F Deluca

Naoshi Nakagawa

Original Assignee

Wisconsin Alumni Res Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-11-24

Filing date

1994-10-19

Publication date

1998-05-15

1994-10-19 Application filed by Wisconsin Alumni Res Found filed Critical Wisconsin Alumni Res Found

1998-05-15 Application granted granted Critical

1998-05-15 Publication of ATE165819T1 publication Critical patent/ATE165819T1/de

Links

OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 2
229910052791 calcium Inorganic materials 0.000 abstract 2
239000011575 calcium Substances 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
230000000694 effects Effects 0.000 abstract 2
GMRQFYUYWCNGIN-UHFFFAOYSA-N 1,25-Dihydroxy-vitamin D3' Natural products C1CCC2(C)C(C(CCCC(C)(C)O)C)CCC2C1=CC=C1CC(O)CC(O)C1=C GMRQFYUYWCNGIN-UHFFFAOYSA-N 0.000 abstract 1
ZGLHBRQAEXKACO-XJRQOBMKSA-N 1alpha,25-dihydroxyvitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](\C=C\[C@H](C)C(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C ZGLHBRQAEXKACO-XJRQOBMKSA-N 0.000 abstract 1
208000001132 Osteoporosis Diseases 0.000 abstract 1
210000000988 bone and bone Anatomy 0.000 abstract 1
230000000125 calcaemic effect Effects 0.000 abstract 1
235000020964 calcitriol Nutrition 0.000 abstract 1
239000011612 calcitriol Substances 0.000 abstract 1
GMRQFYUYWCNGIN-NKMMMXOESA-N calcitriol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-NKMMMXOESA-N 0.000 abstract 1
125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
230000001747 exhibiting effect Effects 0.000 abstract 1
230000000968 intestinal effect Effects 0.000 abstract 1
230000011164 ossification Effects 0.000 abstract 1
150000003703 vitamin D2 derivatives Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Physical Education & Sports Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Rheumatology (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Orthopedic Medicine & Surgery (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Obesity (AREA)
Diabetes (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Steroid Compounds (AREA)

AT94931967T 1993-11-24 1994-10-19 26,28-methylen-1alpha,25-dihydroxy-vitamin-d2- verbindungen ATE165819T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/157,970 US5373004A (en)	1993-11-24	1993-11-24	26,28-methylene-1α, 25-dihydroxyvitamin D2 compounds

Publications (1)

Publication Number	Publication Date
ATE165819T1 true ATE165819T1 (de)	1998-05-15

Family

ID=22566140

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94931967T ATE165819T1 (de)	1993-11-24	1994-10-19	26,28-methylen-1alpha,25-dihydroxy-vitamin-d2- verbindungen

Country Status (9)

Country	Link
US (2)	US5373004A (de)
EP (1)	EP0730577B1 (de)
JP (1)	JP3681390B2 (de)
AT (1)	ATE165819T1 (de)
AU (1)	AU8086494A (de)
DE (1)	DE69410112T2 (de)
DK (1)	DK0730577T3 (de)
ES (1)	ES2115267T3 (de)
WO (1)	WO1995014662A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6407082B1 (en)	1996-09-13	2002-06-18	New Life Pharmaceuticals Inc.	Prevention of ovarian cancer by administration of a vitamin D compound
US20040167106A1 (en) *	1993-06-04	2004-08-26	Rodriguez Gustavo C.	Prevention of ovarian cancer by administration of a Vitamin D compound
US5716946A (en) *	1996-02-13	1998-02-10	Wisconsin Alumni Research Foundation	Multiple sclerosis treatment
US6028064A (en)	1996-09-13	2000-02-22	New Life Pharmaceuticals Inc.	Prevention of ovarian cancer by administration of progestin products
US6511970B1 (en)	1996-09-13	2003-01-28	New Life Pharmaceuticals Inc.	Prevention of ovarian cancer by administration of products that induce transforming growth factor-beta and/or apoptosis in the ovarian epithelium
US6765002B2 (en)	2000-03-21	2004-07-20	Gustavo Rodriguez	Prevention of ovarian cancer by administration of products that induce transforming growth factor-β and/or apoptosis in the ovarian epithelium
US6034074A (en)	1996-09-13	2000-03-07	New Life Pharmaceuticals Inc.	Prevention of ovarian cancer by administration of a Vitamin D compound
CN1090180C (zh) *	1997-06-25	2002-09-04	帝人株式会社	维生素d3衍生物及其用于炎性呼吸道疾病的治疗剂
WO2000038692A1 (fr) *	1998-12-24	2000-07-06	Teijin Limited	Remedes contre la mucoviscidose contenant des derives de la vitamine d¿3?
US6479474B2 (en)	1999-07-08	2002-11-12	Wisconsin Alumni Research Foundation	Dietary calcium as a supplement to vitamin D compound treatment of multiple sclerosis
RU2261244C2 (ru) *	2000-01-10	2005-09-27	Лео Фарма А/С	Новые аналоги витамина d
US20010044431A1 (en) *	2000-03-21	2001-11-22	Rodriguez Gustavo C.	Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium
US20040235809A1 (en) *	2000-07-27	2004-11-25	Alexander John C	Epoxy steroidal aldosterone antagonist and beta-adremergic antagonist combination therepy for treatment of congestive heart failure
SG173119A1 (en)	2009-01-27	2011-08-29	Berg Biosystems Llc	Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy
MX366076B (es)	2009-08-14	2019-06-27	Berg Llc	Vitamina d3 y analogos de la misma para tratar alopecia.
SG10201709894RA (en)	2013-05-29	2018-01-30	Berg Llc	Preventing or mitigating chemotherapy induced alopecia using vitamin d

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3247836A1 (de) *	1981-12-29	1983-07-07	Teijin Ltd., Osaka	Arzneimittel und verwendung derselben zur steuerung der serumcalciumkonzentration bei warmbluetern
US4512925A (en) *	1983-09-14	1985-04-23	Wisconsin Alumini Research Foundation	1,23-Dihydroxyvitamin D compounds
US4769181A (en) *	1983-11-07	1988-09-06	Wisconsin Alumni Research Foundation	1,25-dihydroxyvitamin D2 compounds
US4588716A (en) *	1984-05-04	1986-05-13	Wisconsin Alumni Research Foundation	Method for treating metabolic bone disease in mammals
WO1987000834A1 (en) *	1985-08-02	1987-02-12	Leo Pharmaceutical Products Ltd. A/S	Novel vitamin d analogues
US5206229A (en) *	1988-04-21	1993-04-27	Leo Pharmaceutical Products Ltd	Vitamin d analogues
US5250523A (en) *	1988-04-29	1993-10-05	Wisconsin Alumni Research Foundation	Side chain unsaturated 1α-hydroxyvitanim D homologs
US4851401A (en) *	1988-07-14	1989-07-25	Wisconsin Alumni Research Foundation	Novel cyclopentano-vitamin D analogs
US4973584A (en) *	1989-03-09	1990-11-27	Deluca Hector F	Novel 1α-hydroxyvitamin D2 epimer and derivatives
GB8915770D0 (en) *	1989-07-10	1989-08-31	Leo Pharm Prod Ltd	Chemical compounds
AU656829B2 (en) *	1991-12-26	1995-02-16	Wisconsin Alumni Research Foundation	26, 27-dimethylene-1 alpha, 25-dihydroxyvitamin D2 and 26,27-dihydroxyvitamin D2 and methods for preparing same
US5194431A (en) *	1992-07-08	1993-03-16	Wisconsin Alumni Research Foundation	24-cyclopropane vitamin D derivatives

1993
- 1993-11-24 US US08/157,970 patent/US5373004A/en not_active Expired - Lifetime
1994
- 1994-10-19 WO PCT/US1994/012092 patent/WO1995014662A1/en not_active Ceased
- 1994-10-19 JP JP51506595A patent/JP3681390B2/ja not_active Expired - Fee Related
- 1994-10-19 DE DE69410112T patent/DE69410112T2/de not_active Expired - Fee Related
- 1994-10-19 AU AU80864/94A patent/AU8086494A/en not_active Abandoned
- 1994-10-19 EP EP94931967A patent/EP0730577B1/de not_active Expired - Lifetime
- 1994-10-19 DK DK94931967T patent/DK0730577T3/da active
- 1994-10-19 ES ES94931967T patent/ES2115267T3/es not_active Expired - Lifetime
- 1994-10-19 AT AT94931967T patent/ATE165819T1/de not_active IP Right Cessation
- 1994-12-09 US US08/353,457 patent/US5457217A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0730577B1 (de)	1998-05-06
US5373004A (en)	1994-12-13
WO1995014662A1 (en)	1995-06-01
JP3681390B2 (ja)	2005-08-10
JPH09506343A (ja)	1997-06-24
AU8086494A (en)	1995-06-13
EP0730577A1 (de)	1996-09-11
DE69410112T2 (de)	1999-01-14
DK0730577T3 (da)	1999-01-18
US5457217A (en)	1995-10-10
DE69410112D1 (de)	1998-06-10
ES2115267T3 (es)	1998-06-16

Legal Events

Date	Code	Title	Description
1999-01-15	UEP	Publication of translation of european patent specification
2003-07-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69300196D1 (de)	1995-07-20	24-Cyclopropan-Vitamin-D-Derivate.
DE69410112D1 (de)	1998-06-10	26,28-methylen-1alpha,25-dihydroxy-vitamin-d2-verbindungen
BR9509739A (pt)	1997-10-21	Compostos 18,19-dinor-vitamina d
EP0549318A3 (en)	1993-10-06	26,27-dimethylene-1 alpha, 25-dihydroxyvitamin d2 and 26,27-dihydroxyvitamin d2 and methods for preparing same
ES2126157T3 (es)	1999-03-16	Compuesto de (e)-20(22)-deshidrovitamina d.
NZ190939A (en)	1982-09-07	Fluoro-derivatives of vitamin d
GB9004544D0 (en)	1990-04-25	Novel treatment ii
AR007241A1 (es)	1999-10-27	Analogos de 20-epi-16-eno de vitamina d3, composiciones farmaceuticas que los contienen, procedimiento para la preparacion de dichos compuestos yempleo de dichos compuestos para la preparacion de composiciones farmaceuticas
ES2058306T3 (es)	1994-11-01	Tetralinas substituidas, cromanos y compuestos relacionados en el tratamiento del asma, artritis y enfermedades relacionadas.
DK8685A (da)	1985-01-08	Fremgangsmaade til fremstilling af 1alfa,25-hydroxylerede vitamin d2-og beslaegtede forbindelser
ATE537834T1 (de)	2012-01-15	2-methylen-19-nor-vitamin d2-verbindungen
ES2056048T3 (es)	1994-10-01	Proceso mejorado para agentes antibacterianos de acido quinolein-3-carboxilico.
DE60326082D1 (de)	2009-03-19	Modulatoren von vitamin d rezeptoren
DE3560902D1 (en)	1987-12-10	Vitamin d3 derivatives
IL145122A0 (en)	2002-06-30	C16 unsaturated fp-selective prostaglandin analogs
ATE238986T1 (de)	2003-05-15	1,3-dihydroxy-20,20-dialkyl-vitamin d3 analoga
BE901603A (fr)	1985-05-17	Isomeres de l'hydroxyvitamine d2.
UY23678A1 (es)	1994-05-20	Procedimiento para la preparacion de analogos de la vitamina d3
PE26691A1 (es)	1991-10-21	Procedimiento de preparacion de azabencimidazoles, utiles en el tratamiento de asma, artritis y enfermedades relacionadas
MX9305506A (es)	1994-05-31	PROCEDIMIENTO PARA LA OBTENCIóN DE 2,4/2,6-DIAMINO-TOLUENO MIXTO EXENTO DE RESIDUOS.
WO2000010548A3 (en)	2001-11-29	19-nor-vitamin d3 compounds with calcemic activity
ES2061293T3 (es)	1994-12-01	Procedimiento para el acondicionamiento y/o purificacion de isocianatos organicos.
DE69907681D1 (de)	2003-06-12	24,24-difluorierte analogen von 1-alpha,25-dihydroxy vitamin d3
MX9703720A (es)	1997-09-30	Compuestos de 18-nor-vitamina d.
ES486799A1 (es)	1980-10-01	Un procedimiento de preparacion de 10-bromo-vincamina