ATE165819T1 - 26,28-methylen-1alpha,25-dihydroxy-vitamin-d2- verbindungen - Google Patents

26,28-methylen-1alpha,25-dihydroxy-vitamin-d2- verbindungen

Info

Publication number: ATE165819T1
Authority: AT; Austria
Prior art keywords: compounds; 1alpha; methylene; dihydroxy vitamin; activity
Prior art date: 1993-11-24

Application number

AT94931967T

Other languages

English (en)

Inventor

Hector F Deluca

Naoshi Nakagawa

Original Assignee

Wisconsin Alumni Res Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-11-24

Filing date

1994-10-19

Publication date

1998-05-15

1994-10-19 Application filed by Wisconsin Alumni Res Found filed Critical Wisconsin Alumni Res Found

1998-05-15 Application granted granted Critical

1998-05-15 Publication of ATE165819T1 publication Critical patent/ATE165819T1/de

Links

OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 2
229910052791 calcium Inorganic materials 0.000 abstract 2
239000011575 calcium Substances 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
230000000694 effects Effects 0.000 abstract 2
GMRQFYUYWCNGIN-UHFFFAOYSA-N 1,25-Dihydroxy-vitamin D3' Natural products C1CCC2(C)C(C(CCCC(C)(C)O)C)CCC2C1=CC=C1CC(O)CC(O)C1=C GMRQFYUYWCNGIN-UHFFFAOYSA-N 0.000 abstract 1
ZGLHBRQAEXKACO-XJRQOBMKSA-N 1alpha,25-dihydroxyvitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](\C=C\[C@H](C)C(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C ZGLHBRQAEXKACO-XJRQOBMKSA-N 0.000 abstract 1
208000001132 Osteoporosis Diseases 0.000 abstract 1
210000000988 bone and bone Anatomy 0.000 abstract 1
230000000125 calcaemic effect Effects 0.000 abstract 1
235000020964 calcitriol Nutrition 0.000 abstract 1
239000011612 calcitriol Substances 0.000 abstract 1
GMRQFYUYWCNGIN-NKMMMXOESA-N calcitriol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-NKMMMXOESA-N 0.000 abstract 1
125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
230000001747 exhibiting effect Effects 0.000 abstract 1
230000000968 intestinal effect Effects 0.000 abstract 1
230000011164 ossification Effects 0.000 abstract 1
150000003703 vitamin D2 derivatives Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Physical Education & Sports Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Rheumatology (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Orthopedic Medicine & Surgery (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Obesity (AREA)
Diabetes (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Steroid Compounds (AREA)

AT94931967T 1993-11-24 1994-10-19 26,28-methylen-1alpha,25-dihydroxy-vitamin-d2- verbindungen ATE165819T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/157,970 US5373004A (en)	1993-11-24	1993-11-24	26,28-methylene-1α, 25-dihydroxyvitamin D2 compounds

Publications (1)

Publication Number	Publication Date
ATE165819T1 true ATE165819T1 (de)	1998-05-15

Family

ID=22566140

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94931967T ATE165819T1 (de)	1993-11-24	1994-10-19	26,28-methylen-1alpha,25-dihydroxy-vitamin-d2- verbindungen

Country Status (9)

Country	Link
US (2)	US5373004A (de)
EP (1)	EP0730577B1 (de)
JP (1)	JP3681390B2 (de)
AT (1)	ATE165819T1 (de)
AU (1)	AU8086494A (de)
DE (1)	DE69410112T2 (de)
DK (1)	DK0730577T3 (de)
ES (1)	ES2115267T3 (de)
WO (1)	WO1995014662A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20040167106A1 (en) *	1993-06-04	2004-08-26	Rodriguez Gustavo C.	Prevention of ovarian cancer by administration of a Vitamin D compound
US6407082B1 (en)	1996-09-13	2002-06-18	New Life Pharmaceuticals Inc.	Prevention of ovarian cancer by administration of a vitamin D compound
US5716946A (en) *	1996-02-13	1998-02-10	Wisconsin Alumni Research Foundation	Multiple sclerosis treatment
US6034074A (en) *	1996-09-13	2000-03-07	New Life Pharmaceuticals Inc.	Prevention of ovarian cancer by administration of a Vitamin D compound
US6028064A (en)	1996-09-13	2000-02-22	New Life Pharmaceuticals Inc.	Prevention of ovarian cancer by administration of progestin products
US6765002B2 (en)	2000-03-21	2004-07-20	Gustavo Rodriguez	Prevention of ovarian cancer by administration of products that induce transforming growth factor-β and/or apoptosis in the ovarian epithelium
US6511970B1 (en)	1996-09-13	2003-01-28	New Life Pharmaceuticals Inc.	Prevention of ovarian cancer by administration of products that induce transforming growth factor-beta and/or apoptosis in the ovarian epithelium
CN1090180C (zh) *	1997-06-25	2002-09-04	帝人株式会社	维生素d3衍生物及其用于炎性呼吸道疾病的治疗剂
AU1798600A (en) *	1998-12-24	2000-07-31	Teijin Limited	Cystic fibrosis remedies containing vitamin D3 derivatives
US6479474B2 (en) *	1999-07-08	2002-11-12	Wisconsin Alumni Research Foundation	Dietary calcium as a supplement to vitamin D compound treatment of multiple sclerosis
HUP0204117A3 (en) *	2000-01-10	2004-09-28	Leo Pharma As	Novel vitamin d analogues, pharmaceutical compositions containing them and their use
US20010044431A1 (en) *	2000-03-21	2001-11-22	Rodriguez Gustavo C.	Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium
WO2002009760A2 (en) *	2000-07-27	2002-02-07	Pharmacia Corporation	Epoxy-steroidal aldosterone antagonist and beta-adrenergic antagonist combination therapy for treatment of congestive heart failure
CA2981549A1 (en)	2009-01-27	2010-08-05	Berg Llc	Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy
CN106265695B (zh)	2009-08-14	2021-05-07	博格有限责任公司	用于治疗脱发的维生素d3及其类似物
CN112156097A (zh)	2013-05-29	2021-01-01	博格有限责任公司	使用维生素d预防或减轻化疗诱发的脱发

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3247836A1 (de) *	1981-12-29	1983-07-07	Teijin Ltd., Osaka	Arzneimittel und verwendung derselben zur steuerung der serumcalciumkonzentration bei warmbluetern
US4512925A (en) *	1983-09-14	1985-04-23	Wisconsin Alumini Research Foundation	1,23-Dihydroxyvitamin D compounds
US4769181A (en) *	1983-11-07	1988-09-06	Wisconsin Alumni Research Foundation	1,25-dihydroxyvitamin D2 compounds
US4588716A (en) *	1984-05-04	1986-05-13	Wisconsin Alumni Research Foundation	Method for treating metabolic bone disease in mammals
JPH07100685B2 (ja) *	1985-08-02	1995-11-01	レオ・ファ−マシュ−ティカル・プロダクツ・リミテッド・エイ／エス（レ−ベンス・ケミスケ・ファブリック・プロデュクチオンスアクチ−セルスカブ）	新規ビタミンｄ類似体
KR0144358B1 (ko) *	1988-04-21	1998-07-15	피. 라이달 크리스텐슨	비타민 d 동족체
US5250523A (en) *	1988-04-29	1993-10-05	Wisconsin Alumni Research Foundation	Side chain unsaturated 1α-hydroxyvitanim D homologs
US4851401A (en) *	1988-07-14	1989-07-25	Wisconsin Alumni Research Foundation	Novel cyclopentano-vitamin D analogs
US4973584A (en) *	1989-03-09	1990-11-27	Deluca Hector F	Novel 1α-hydroxyvitamin D2 epimer and derivatives
GB8915770D0 (en) *	1989-07-10	1989-08-31	Leo Pharm Prod Ltd	Chemical compounds
ATE144250T1 (de) *	1991-12-26	1996-11-15	Wisconsin Alumni Res Found	26,27-dimethylen-1-alpha, 25-dihydroxyvitamin-d2 und 26,27-dihydroxyvitamin-d2 und verfahren zu ihrer herstellung
US5194431A (en) *	1992-07-08	1993-03-16	Wisconsin Alumni Research Foundation	24-cyclopropane vitamin D derivatives

1993
- 1993-11-24 US US08/157,970 patent/US5373004A/en not_active Expired - Lifetime
1994
- 1994-10-19 WO PCT/US1994/012092 patent/WO1995014662A1/en not_active Ceased
- 1994-10-19 ES ES94931967T patent/ES2115267T3/es not_active Expired - Lifetime
- 1994-10-19 AT AT94931967T patent/ATE165819T1/de not_active IP Right Cessation
- 1994-10-19 JP JP51506595A patent/JP3681390B2/ja not_active Expired - Fee Related
- 1994-10-19 AU AU80864/94A patent/AU8086494A/en not_active Abandoned
- 1994-10-19 DE DE69410112T patent/DE69410112T2/de not_active Expired - Fee Related
- 1994-10-19 DK DK94931967T patent/DK0730577T3/da active
- 1994-10-19 EP EP94931967A patent/EP0730577B1/de not_active Expired - Lifetime
- 1994-12-09 US US08/353,457 patent/US5457217A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ES2115267T3 (es)	1998-06-16
US5373004A (en)	1994-12-13
JPH09506343A (ja)	1997-06-24
AU8086494A (en)	1995-06-13
WO1995014662A1 (en)	1995-06-01
EP0730577A1 (de)	1996-09-11
DK0730577T3 (da)	1999-01-18
EP0730577B1 (de)	1998-05-06
DE69410112D1 (de)	1998-06-10
JP3681390B2 (ja)	2005-08-10
US5457217A (en)	1995-10-10
DE69410112T2 (de)	1999-01-14

Legal Events

Date	Code	Title	Description
1999-01-15	UEP	Publication of translation of european patent specification
2003-07-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE123767T1 (de)	1995-06-15	24-cyclopropan-vitamin-d-derivate.
ATE165819T1 (de)	1998-05-15	26,28-methylen-1alpha,25-dihydroxy-vitamin-d2- verbindungen
NO972258D0 (no)	1997-05-16	18, 19-dinor-vitamin D-forbindelser
EP0549318A3 (en)	1993-10-06	26,27-dimethylene-1 alpha, 25-dihydroxyvitamin d2 and 26,27-dihydroxyvitamin d2 and methods for preparing same
GB2026494B (en)	1982-12-15	Fluorinated compounds of the vitamin d structure
ES2169023T3 (es)	2002-07-01	Nueva 1alfa-hidroxi vitaminada d4 y nuevos intermedios y analogos.
GB9004544D0 (en)	1990-04-25	Novel treatment ii
UY24895A1 (es)	2001-08-27	Arilsulfonamidas y análogos útiles para el tratamiento de enfermedades neurodegenerativas
AR007241A1 (es)	1999-10-27	Analogos de 20-epi-16-eno de vitamina d3, composiciones farmaceuticas que los contienen, procedimiento para la preparacion de dichos compuestos yempleo de dichos compuestos para la preparacion de composiciones farmaceuticas
ES2058306T3 (es)	1994-11-01	Tetralinas substituidas, cromanos y compuestos relacionados en el tratamiento del asma, artritis y enfermedades relacionadas.
EP0550702A4 (en)	1994-06-08	Methods for preparation and use of 1-g(a),24-dihydroxy vitamin d 2?
DK8685A (da)	1985-01-08	Fremgangsmaade til fremstilling af 1alfa,25-hydroxylerede vitamin d2-og beslaegtede forbindelser
ATE537834T1 (de)	2012-01-15	2-methylen-19-nor-vitamin d2-verbindungen
ES2056048T3 (es)	1994-10-01	Proceso mejorado para agentes antibacterianos de acido quinolein-3-carboxilico.
IL145122A0 (en)	2002-06-30	C16 unsaturated fp-selective prostaglandin analogs
PE26691A1 (es)	1991-10-21	Procedimiento de preparacion de azabencimidazoles, utiles en el tratamiento de asma, artritis y enfermedades relacionadas
MX9305506A (es)	1994-05-31	PROCEDIMIENTO PARA LA OBTENCIóN DE 2,4/2,6-DIAMINO-TOLUENO MIXTO EXENTO DE RESIDUOS.
WO2000010548A3 (en)	2001-11-29	19-nor-vitamin d3 compounds with calcemic activity
ES2061293T3 (es)	1994-12-01	Procedimiento para el acondicionamiento y/o purificacion de isocianatos organicos.
MX9703720A (es)	1997-09-30	Compuestos de 18-nor-vitamina d.
JPS5524105A (en)	1980-02-21	Method and agent for control of calcium metabolism of warm-blooded animal
ES486799A1 (es)	1980-10-01	Un procedimiento de preparacion de 10-bromo-vincamina
MX9305151A (es)	1994-05-31	Metodo para el tratamiento de enfermedades de la piel.
ATE79541T1 (de)	1992-09-15	Mischung von cholecalciferol-derivaten fuer die behandlung von nierenbezogenen knochenkrankheiten.