ATE123805T1 - Mikroorganismus zur selektiven herstellung einer spezifischen komponente von avermectin und verfahren zu deren selektiven herstellung. - Google Patents

Mikroorganismus zur selektiven herstellung einer spezifischen komponente von avermectin und verfahren zu deren selektiven herstellung.

Info

Publication number
ATE123805T1
ATE123805T1 AT90308842T AT90308842T ATE123805T1 AT E123805 T1 ATE123805 T1 AT E123805T1 AT 90308842 T AT90308842 T AT 90308842T AT 90308842 T AT90308842 T AT 90308842T AT E123805 T1 ATE123805 T1 AT E123805T1
Authority
AT
Austria
Prior art keywords
avermectin
selective production
microorganism
specific component
acid
Prior art date
Application number
AT90308842T
Other languages
English (en)
Inventor
Satoshi Omura
Haruo Ikeda
Original Assignee
Kitasato Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kitasato Inst filed Critical Kitasato Inst
Application granted granted Critical
Publication of ATE123805T1 publication Critical patent/ATE123805T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/02—Preparation of hybrid cells by fusion of two or more cells, e.g. protoplast fusion
    • C12N15/03—Bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C12P19/623—Avermectin; Milbemycin; Ivermectin; C-076
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/886—Streptomyces

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AT90308842T 1990-03-05 1990-08-10 Mikroorganismus zur selektiven herstellung einer spezifischen komponente von avermectin und verfahren zu deren selektiven herstellung. ATE123805T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2053411A JP2888586B2 (ja) 1990-03-05 1990-03-05 エバーメクチンの特定成分を選択生産するための微生物およびその選択的製造法

Publications (1)

Publication Number Publication Date
ATE123805T1 true ATE123805T1 (de) 1995-06-15

Family

ID=12942087

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90308842T ATE123805T1 (de) 1990-03-05 1990-08-10 Mikroorganismus zur selektiven herstellung einer spezifischen komponente von avermectin und verfahren zu deren selektiven herstellung.

Country Status (10)

Country Link
US (2) US5206155A (de)
EP (1) EP0445460B1 (de)
JP (1) JP2888586B2 (de)
AT (1) ATE123805T1 (de)
AU (1) AU629966B2 (de)
CA (1) CA2023114C (de)
DE (1) DE69020138T2 (de)
DK (1) DK0445460T3 (de)
ES (1) ES2075881T3 (de)
NZ (1) NZ234741A (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6103504A (en) * 1992-03-25 2000-08-15 Pfizer Inc. Process for production of avermectins and cultures therefor
IT1255135B (it) * 1992-05-05 1995-10-20 Principio attivo a base di avermectine, ceppo e procedimento per la sua preparazione e composizione veterinaria che lo contiene.
US5292647A (en) * 1992-11-30 1994-03-08 Eli Lilly And Company Strain of streptomyces for producing avermectins and processes therewith
BR9407141A (pt) * 1993-07-23 1996-09-17 Pfizer Método para a precipatação de avermectinas naturais
PL194270B1 (pl) * 1998-02-13 2007-05-31 Pfizer Prod Inc Wyizolowana cząsteczka polinukleotydowa, cząsteczka oligonukleotydowa, zrekombinowany wektor, komórka gospodarza, wyizolowany produkt genu AveC S. avermitilis, wyizolowany produkt homologu genu AveC S. hygroscopicus, sposób wytwarzania zrekombinowanego produktu genu AveC, sposób wytwarzania zrekombinowanego produktu homologu genu AveC, cząsteczka polinukleotydowa, wektor do zastępowania genu, sposób identyfikowania mutacji otwartej ramki odczytuAveC, sposób wytwarzania nowych szczepów S. avermitilis, szczep S. avermitilis i sposób wytwarzaniaawermektyn
CA2362253C (en) 1999-02-09 2008-09-23 The Kitasato Institute Avermectin derivatives
JP2000245457A (ja) 1999-02-24 2000-09-12 Kitasato Inst:The エバーメクチンアグリコン合成酵素遺伝子
AU2001277712A1 (en) 2000-08-09 2002-02-18 The Kitasato Institute Avermectin derivatives
US20040087519A1 (en) * 2000-08-09 2004-05-06 Satoshi Omura Avermectin derivatives
CN101429536B (zh) * 2008-12-15 2011-09-14 浙江升华拜克生物股份有限公司 一种采用全孢子接种工艺生产阿维菌素的方法
US10334850B2 (en) * 2014-03-10 2019-07-02 Zhejiang Hisun Pharmaceutical Co., Ltd. Recombinant microorganism expressing avermectin analogue and use thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE434277B (sv) * 1976-04-19 1984-07-16 Merck & Co Inc Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis
US4429042A (en) * 1978-09-08 1984-01-31 Merck & Co., Inc. Strain of Streptomyces for producing antiparasitic compounds
IN167980B (de) * 1987-01-23 1991-01-19 Pfizer
ATE89604T1 (de) * 1987-10-23 1993-06-15 Pfizer Verfahren zur herstellung von aglykonen von avermectin und sie enthaltende kulturen.

Also Published As

Publication number Publication date
US5206155A (en) 1993-04-27
JPH03254678A (ja) 1991-11-13
NZ234741A (en) 1992-03-26
JP2888586B2 (ja) 1999-05-10
DK0445460T3 (da) 1995-08-14
CA2023114C (en) 1996-12-17
EP0445460B1 (de) 1995-06-14
US5369021A (en) 1994-11-29
DE69020138T2 (de) 1995-12-14
CA2023114A1 (en) 1991-09-06
EP0445460A1 (de) 1991-09-11
DE69020138D1 (de) 1995-07-20
ES2075881T3 (es) 1995-10-16
AU629966B2 (en) 1992-10-15
AU6020190A (en) 1991-09-05

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee