ATE124046T1 - (+)-isomere von endoetheno/endoethano- epoxymorphinan-derivaten als mittel gegen husten. - Google Patents

(+)-isomere von endoetheno/endoethano- epoxymorphinan-derivaten als mittel gegen husten.

Info

Publication number: ATE124046T1
Authority: AT; Austria
Prior art keywords: alkyl; hydrido; phenyl; derivatives; epoxymorphinane
Prior art date: 1989-08-24

Application number

AT90116248T

Other languages

English (en)

Inventor

Kenner C Rice

John M Farah Jr

Neile A Grayson

Original Assignee

Searle & Co

Nat Inst Health

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-08-24

Filing date

1990-08-24

Publication date

1995-07-15

1990-08-24 Application filed by Searle & Co, Nat Inst Health filed Critical Searle & Co

1995-07-15 Application granted granted Critical

1995-07-15 Publication of ATE124046T1 publication Critical patent/ATE124046T1/de

Links

239000003434 antitussive agent Substances 0.000 title abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 4
125000001145 hydrido group Chemical group *[H] 0.000 abstract 3
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
229940124584 antitussives Drugs 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000000753 cycloalkyl group Chemical group 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 abstract 1
125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000005157 alkyl carboxy group Chemical group 0.000 abstract 1
230000000954 anitussive effect Effects 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
125000006254 cycloalkyl carbonyl group Chemical group 0.000 abstract 1
PCHPORCSPXIHLZ-UHFFFAOYSA-N diphenhydramine hydrochloride Chemical compound [Cl-].C=1C=CC=CC=1C(OCC[NH+](C)C)C1=CC=CC=C1 PCHPORCSPXIHLZ-UHFFFAOYSA-N 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
230000003533 narcotic effect Effects 0.000 abstract 1
125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/08—Bridged systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
- C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
- C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Pulmonology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Epoxy Compounds (AREA)
Epoxy Resins (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Hydrogenated Pyridines (AREA)

AT90116248T 1989-08-24 1990-08-24 (+)-isomere von endoetheno/endoethano- epoxymorphinan-derivaten als mittel gegen husten. ATE124046T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US39821389A	1989-08-24	1989-08-24
US56873290A	1990-08-20	1990-08-20

Publications (1)

Publication Number	Publication Date
ATE124046T1 true ATE124046T1 (de)	1995-07-15

Family

ID=27016167

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90116248T ATE124046T1 (de)	1989-08-24	1990-08-24	(+)-isomere von endoetheno/endoethano- epoxymorphinan-derivaten als mittel gegen husten.

Country Status (11)

Country	Link
EP (1)	EP0418591B1 (de)
JP (1)	JP3313361B2 (de)
KR (1)	KR0172596B1 (de)
AT (1)	ATE124046T1 (de)
CA (1)	CA2023858C (de)
DE (1)	DE69020277T2 (de)
DK (1)	DK0418591T3 (de)
ES (1)	ES2072946T3 (de)
GR (1)	GR3017445T3 (de)
IE (1)	IE67526B1 (de)
PT (1)	PT95069B (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2130457A1 (en) *	1992-12-22	1994-07-07	Hiroshi Nagase	Antitussive
KR100204659B1 (ko) *	1996-05-28	1999-06-15	강재헌	신규한 부프레노핀계 진통제용 화합물
KR20000016052A (ko)	1997-03-27	2000-03-25	히라이 가쯔히꼬	몰피난 유도체 및 의약용도_
US8993764B2 (en) *	2006-01-05	2015-03-31	Mallinckrodt Llc	Use of oripavine as a starting material for buprenorphine
AU2007313103C1 (en)	2006-10-17	2014-01-30	Penick Corporation	Process for preparing oxymorphone
CA2674915C (en)	2006-10-17	2015-06-30	Penick Corporation	Process for preparing oxymorphone
US20080125592A1 (en)	2006-10-17	2008-05-29	Penick Corporation	Process for preparing oxymorphone, naltrexone, and buprenorphine
UA104004C2 (uk)	2008-07-30	2013-12-25	Пердью Фарма Л.П.	Аналоги бупренорфіну
US8227608B2 (en)	2008-09-30	2012-07-24	Mallinckrodt Llc	Processes for increasing the yield of opiate alkaloid derivatives
TWI541246B (zh)	2008-12-08	2016-07-11	歐陸斯迪公司	二氫羥戊甲嗎啡
WO2010096790A1 (en)	2009-02-23	2010-08-26	Mallinckrodt Inc.	(+)-morphinananium n-oxides and processes for their production
US8946419B2 (en)	2009-02-23	2015-02-03	Mallinckrodt Llc	(+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
JP2012518652A (ja) *	2009-02-23	2012-08-16	マリンクロッドインコーポレイテッド	（＋）−６−ヒドロキシ−モルフィナンまたは（＋）−６−アミノ−モルフィナン誘導体
US8436174B2 (en)	2009-02-23	2013-05-07	Mallinckrodt Llc	(+)-morphinanium quaternary salts and processes for their production
US10363251B2 (en)	2009-07-16	2019-07-30	Mallinckrodt Llc	(+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof
WO2011009020A2 (en)	2009-07-16	2011-01-20	Mallinckrodt Inc.	Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
TR201809739T4 (tr) *	2009-07-16	2018-07-23	Mallinckrodt Llc	Toll benzeri reseptör 9 antagonistleri olarak (+)-morfinanlar ve bunların terapötik amaçlı kullanımları.
ES2728701T3 (es)	2010-07-16	2019-10-28	Mallinckrodt Llc	(+)-Morfinanos como antagonistas del receptor 9 de tipo Toll y aplicaciones terapéuticas de los mismos
CN103917543A (zh)	2011-09-08	2014-07-09	马林克罗特有限公司	在不分离中间体的情况下制备生物碱
US8969358B2 (en)	2013-03-15	2015-03-03	Purdue Pharma L.P.	Buprenorphine analogs
GB201309654D0 (en)	2013-05-30	2013-07-17	Euro Celtique Sa	Method
BR112020010901A2 (pt)	2017-12-12	2020-11-17	Xalud Therapeutics, Inc.	derivados halogenados de morfinanos e usos dos mesmos
EP4125990A4 (de) *	2020-03-24	2024-07-03	University of Padova	Morphinanisomere und ihre strukturmodifikationen als nmdar-antagonisten und neuroplastigene

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3474101A (en)	1960-09-05	1969-10-21	Reckitt & Sons Ltd	Thebaine and oripavine derivatives
GB1178537A (en) *	1966-10-20	1970-01-21	Reckitt & Sons Ltd	Antitussive and Analgesic Compositions
GB1300419A (en) *	1969-05-16	1972-12-20	Organon Labor Ltd	New morphinone derivatives and their preparation
US4521601A (en) *	1981-05-20	1985-06-04	The United States Of America As Represented By The Department Of Health & Human Services	Practical total synthesis unnatural enantiomers of opium-derived morphinans
US4806543A (en) *	1986-11-25	1989-02-21	Board Of Trustees Of The Leland Stanford Junior University	Method and compositions for reducing neurotoxic injury

1990
- 1990-08-22 PT PT95069A patent/PT95069B/pt not_active IP Right Cessation
- 1990-08-23 CA CA002023858A patent/CA2023858C/en not_active Expired - Fee Related
- 1990-08-24 IE IE309990A patent/IE67526B1/en not_active IP Right Cessation
- 1990-08-24 EP EP90116248A patent/EP0418591B1/de not_active Expired - Lifetime
- 1990-08-24 DK DK90116248.7T patent/DK0418591T3/da active
- 1990-08-24 DE DE69020277T patent/DE69020277T2/de not_active Expired - Fee Related
- 1990-08-24 AT AT90116248T patent/ATE124046T1/de not_active IP Right Cessation
- 1990-08-24 KR KR1019900013140A patent/KR0172596B1/ko not_active Expired - Fee Related
- 1990-08-24 JP JP22414290A patent/JP3313361B2/ja not_active Expired - Fee Related
- 1990-08-24 ES ES90116248T patent/ES2072946T3/es not_active Expired - Lifetime
1995
- 1995-09-20 GR GR950402571T patent/GR3017445T3/el unknown

Also Published As

Publication number	Publication date
CA2023858A1 (en)	1991-02-25
EP0418591A3 (en)	1991-08-07
EP0418591A2 (de)	1991-03-27
DE69020277D1 (de)	1995-07-27
IE67526B1 (en)	1996-04-03
JPH03163083A (ja)	1991-07-15
KR0172596B1 (ko)	1999-02-01
IE903099A1 (en)	1991-02-27
JP3313361B2 (ja)	2002-08-12
PT95069A (pt)	1991-04-18
PT95069B (pt)	1997-10-31
ES2072946T3 (es)	1995-08-01
EP0418591B1 (de)	1995-06-21
DK0418591T3 (da)	1995-08-14
GR3017445T3 (en)	1995-12-31
DE69020277T2 (de)	1995-12-21
CA2023858C (en)	2002-01-01
KR910004625A (ko)	1991-03-29

Legal Events

Date	Code	Title	Description
1995-12-15	UEP	Publication of translation of european patent specification
2007-05-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69020277D1 (de)	1995-07-27	(+)-Isomere von Endoetheno/Endoethano-epoxymorphinan-Derivaten als Mittel gegen Husten.
DK550588A (da)	1988-09-30	Fungicide kompositioner
NO893628D0 (no)	1989-09-11	Biocid preparat.
DE69124446D1 (de)	1997-03-13	Organosiliciumzusammensetzungen
IT1229528B (it)	1991-09-04	Sali cefalosporinici e relative composizioni iniettabili, nonche' procedimento di preparazione
IT1192677B (it)	1988-05-04	Composizione antistatica in qualita' di additivo per composizioni e tergenti
FI892175A7 (fi)	1989-11-07	Säilytysainekompositiot
IT8848606A0 (it)	1988-11-30	Composizioni fungicide
DE69430905D1 (de)	2002-08-08	4-(R)-1'-Formylethyl Azetidin-2-on-Derivate
BR9104279A (pt)	1992-06-02	Composicao e composto
FR2618293B1 (fr)	1992-05-22	Plaque de protection d'arbre
DE69120992D1 (de)	1996-08-29	Alkyldiamide und kosmetische Behandlungszusammensetzungen
FI931934A7 (fi)	1993-05-31	Dekstrometorfaania sisältäviä yskänlääkekoostumuksia
FI934360A7 (fi)	1993-10-04	Benflumetolia sisältävät synergistiset malarialääkekoostumukset
ITMI910503A1 (it)	1992-08-27	Cuscinetto per alta velocita'
IT8635662V0 (it)	1986-03-18	Porta di legno
GR880100452A (el)	1989-04-12	Μυκητοκτονες συνθεσεις με βαση νικοτινικα παραγωγα,νεα νικοτινικα παραγωγα και η παρασκευη τους
DE69123975D1 (de)	1997-02-13	Peroxidische zusammensetzungen
IT8922535A0 (it)	1989-11-29	Composizioni fungicide
IT8922508A0 (it)	1989-11-24	Composizioni fungicide
IT8903790A0 (it)	1989-12-28	Gioco di societa'
IT8603380A1 (it)	1987-10-04	Ventilatore perfezionato per l'areazione di ambienti chiusi
IT8604837V0 (it)	1986-04-04	Ventilatore perfezionato per l' areazione di ambienti chiusi
KR930001411U (ko)	1993-01-21	씨디롬 드라이브의 캐디오삽입 방지 장치
IT8922530A0 (it)	1989-11-28	Composizioni fungicide