ES2072946T3 - Isomeros (+) de derivados de endoeteno/endoetano-epoximorfinano como agentes antitusivos. - Google Patents

Isomeros (+) de derivados de endoeteno/endoetano-epoximorfinano como agentes antitusivos.

Info

Publication number
ES2072946T3
ES2072946T3 ES90116248T ES90116248T ES2072946T3 ES 2072946 T3 ES2072946 T3 ES 2072946T3 ES 90116248 T ES90116248 T ES 90116248T ES 90116248 T ES90116248 T ES 90116248T ES 2072946 T3 ES2072946 T3 ES 2072946T3
Authority
ES
Spain
Prior art keywords
rent
hybrid
square
epoxymorfinan
endoethene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90116248T
Other languages
English (en)
Inventor
Kenner C Rice
John M Farah Jr
Neile A Grayson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
National Institutes of Health NIH
Original Assignee
GD Searle LLC
National Institutes of Health NIH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC, National Institutes of Health NIH filed Critical GD Searle LLC
Application granted granted Critical
Publication of ES2072946T3 publication Critical patent/ES2072946T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
    • C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
    • C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Epoxy Compounds (AREA)
  • Epoxy Resins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

UNA CLASE DERIVADA DE EPOXIMORFINA TIENE AGENTES ANTITUXIVOS EN USO. LOS COMPONENTES DE ESTA CLASE SE CARACTERIZAN PORQUE TIENEN POTENCIA ATITUXIVA, PERO CARECEN DE EFECTOS NARCOTICOS LATERALES. LOS COMPONENTES SON INTERESADOS EN ESTA FORMULA. EN DONDE R (RAIZ CUADRADA) SE PRODUCE A PARTIR DE HIDROXI, ALQUILCARBOXILO, ALCOXY Y FENOXY; EN DONDE R (AL CUADRADO) SE PRODUCE A PARTIR DE UN HIBRIDO, ALQUIL, ACIL Y FENIL; EN DONDE R (ELEVADO A N) SE PRODUCE A PARTIR DE (FIG) Y DONDE CADA R5, R6, R7 Y R8 SON SELECCIONADOS INDEPENDIENTEMENTE DESDE UN HIBRIDO, ALQUIL, FENIL Y FENALQUIL, EN DONDE R4 ES SELECCIONADO DESDE UN HIBRIDO, ALQUIL CIANATO,CICLOALQUIL, CICLOALQUILALQUIL, CILCOALQUILCARBONIL, ALIL, FENIL, BENCIL, FENETIL, Y FEPROPIL; Y EN DONDE ALGUNO DE LOS SUSTITUYENTES ANTERIORMENTE MENCIONADOS R (RAIZ CUADRADA) , R (AL CUADRADO) , R (ELEVADO A N) , R4, R5, R6, R7, R8, TIENEN UNA POSICION DE SUSTITUCION, EN LA QUE PUEDEN SER SUSTITUIDOS POR UNO O MAS GRUPOS SELECCIONADOS A PARTIR DE UN HIDROXI, HALO, ALQUIL, CICLOALQUIL; O SALES DE LOS MISMOS ACEPTABLES FARMACEUTICAMENTE.
ES90116248T 1989-08-24 1990-08-24 Isomeros (+) de derivados de endoeteno/endoetano-epoximorfinano como agentes antitusivos. Expired - Lifetime ES2072946T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39821389A 1989-08-24 1989-08-24
US56873290A 1990-08-20 1990-08-20

Publications (1)

Publication Number Publication Date
ES2072946T3 true ES2072946T3 (es) 1995-08-01

Family

ID=27016167

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90116248T Expired - Lifetime ES2072946T3 (es) 1989-08-24 1990-08-24 Isomeros (+) de derivados de endoeteno/endoetano-epoximorfinano como agentes antitusivos.

Country Status (11)

Country Link
EP (1) EP0418591B1 (es)
JP (1) JP3313361B2 (es)
KR (1) KR0172596B1 (es)
AT (1) ATE124046T1 (es)
CA (1) CA2023858C (es)
DE (1) DE69020277T2 (es)
DK (1) DK0418591T3 (es)
ES (1) ES2072946T3 (es)
GR (1) GR3017445T3 (es)
IE (1) IE67526B1 (es)
PT (1) PT95069B (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2130457A1 (en) * 1992-12-22 1994-07-07 Hiroshi Nagase Antitussive
KR100204659B1 (ko) * 1996-05-28 1999-06-15 강재헌 신규한 부프레노핀계 진통제용 화합물
KR20000016052A (ko) 1997-03-27 2000-03-25 히라이 가쯔히꼬 몰피난 유도체 및 의약용도_
US8993764B2 (en) * 2006-01-05 2015-03-31 Mallinckrodt Llc Use of oripavine as a starting material for buprenorphine
AU2007313103C1 (en) 2006-10-17 2014-01-30 Penick Corporation Process for preparing oxymorphone
CA2674915C (en) 2006-10-17 2015-06-30 Penick Corporation Process for preparing oxymorphone
US20080125592A1 (en) 2006-10-17 2008-05-29 Penick Corporation Process for preparing oxymorphone, naltrexone, and buprenorphine
UA104004C2 (uk) 2008-07-30 2013-12-25 Пердью Фарма Л.П. Аналоги бупренорфіну
US8227608B2 (en) 2008-09-30 2012-07-24 Mallinckrodt Llc Processes for increasing the yield of opiate alkaloid derivatives
TWI541246B (zh) 2008-12-08 2016-07-11 歐陸斯迪公司 二氫羥戊甲嗎啡
WO2010096790A1 (en) 2009-02-23 2010-08-26 Mallinckrodt Inc. (+)-morphinananium n-oxides and processes for their production
US8946419B2 (en) 2009-02-23 2015-02-03 Mallinckrodt Llc (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
JP2012518652A (ja) * 2009-02-23 2012-08-16 マリンクロッド インコーポレイテッド （＋）−６−ヒドロキシ−モルフィナンまたは（＋）−６−アミノ−モルフィナン誘導体
US8436174B2 (en) 2009-02-23 2013-05-07 Mallinckrodt Llc (+)-morphinanium quaternary salts and processes for their production
US10363251B2 (en) 2009-07-16 2019-07-30 Mallinckrodt Llc (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof
WO2011009020A2 (en) 2009-07-16 2011-01-20 Mallinckrodt Inc. Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
TR201809739T4 (tr) * 2009-07-16 2018-07-23 Mallinckrodt Llc Toll benzeri reseptör 9 antagonistleri olarak (+)-morfinanlar ve bunların terapötik amaçlı kullanımları.
ES2728701T3 (es) 2010-07-16 2019-10-28 Mallinckrodt Llc (+)-Morfinanos como antagonistas del receptor 9 de tipo Toll y aplicaciones terapéuticas de los mismos
CN103917543A (zh) 2011-09-08 2014-07-09 马林克罗特有限公司 在不分离中间体的情况下制备生物碱
US8969358B2 (en) 2013-03-15 2015-03-03 Purdue Pharma L.P. Buprenorphine analogs
GB201309654D0 (en) 2013-05-30 2013-07-17 Euro Celtique Sa Method
BR112020010901A2 (pt) 2017-12-12 2020-11-17 Xalud Therapeutics, Inc. derivados halogenados de morfinanos e usos dos mesmos
EP4125990A4 (en) * 2020-03-24 2024-07-03 University of Padova MORPHINE ISOMERS AND THEIR STRUCTURAL MODIFICATIONS AS NMDAR ANTAGONISTS AND NEUROPLASTIGENS

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3474101A (en) 1960-09-05 1969-10-21 Reckitt & Sons Ltd Thebaine and oripavine derivatives
GB1178537A (en) * 1966-10-20 1970-01-21 Reckitt & Sons Ltd Antitussive and Analgesic Compositions
GB1300419A (en) * 1969-05-16 1972-12-20 Organon Labor Ltd New morphinone derivatives and their preparation
US4521601A (en) * 1981-05-20 1985-06-04 The United States Of America As Represented By The Department Of Health & Human Services Practical total synthesis unnatural enantiomers of opium-derived morphinans
US4806543A (en) * 1986-11-25 1989-02-21 Board Of Trustees Of The Leland Stanford Junior University Method and compositions for reducing neurotoxic injury

Also Published As

Publication number Publication date
CA2023858A1 (en) 1991-02-25
EP0418591A3 (en) 1991-08-07
EP0418591A2 (en) 1991-03-27
DE69020277D1 (de) 1995-07-27
IE67526B1 (en) 1996-04-03
JPH03163083A (ja) 1991-07-15
KR0172596B1 (ko) 1999-02-01
IE903099A1 (en) 1991-02-27
JP3313361B2 (ja) 2002-08-12
PT95069A (pt) 1991-04-18
ATE124046T1 (de) 1995-07-15
PT95069B (pt) 1997-10-31
EP0418591B1 (en) 1995-06-21
DK0418591T3 (da) 1995-08-14
GR3017445T3 (en) 1995-12-31
DE69020277T2 (de) 1995-12-21
CA2023858C (en) 2002-01-01
KR910004625A (ko) 1991-03-29

Similar Documents

Publication Publication Date Title
ES2103786T3 (es) Derivados de 4-benzoil-isoxazol.
MX9306986A (es) Composiciones farmaceuticas a base de taxoides.
ES2131116T3 (es) Analogos de nucleotidos enantiomericos antirretrovirales.
ES2053451T3 (es) Un procedimiento para la preparacion de un compuesto que tiene propiedades farmacologicas utiles.
ES2084702T3 (es) Imidazoles sustituidos utiles como inhibidores de la angiotensina ii.
ES2112377T3 (es) Procedimiento para la preparacion de derivados del taxano y productos intermedios.
ES2110003T3 (es) Nuevas composiciones a base de derivados de la clase de los taxanos.
ES2160596T3 (es) Derivados de quinuclidina como antagonistas de la sustancia p.
ES8507534A1 (es) Procedimiento para la preparacion de derivados benzopiranicos
ES2063036T3 (es) Compuestos (aralquil-sustituido) heterociclicos.
MX9207494A (es) 4(5)-amino-1,8-naftiridinas substituidas, procedimiento para su preparacion y composiciones farmaceuticas que las contienen.
IT8767157A0 (it) Composizioni di tintura per fibre cheratiniche a base di derivati del l indolo nuovi derivati dell indolo e loro impiego
ES2104570T3 (es) Analogos de nucleotidos.
GR900100380A (el) Μέ?οδος παρασκευής αντι-φλεγμονωδών παραγώγων αμινοφενόλης.
ES2038660T3 (es) Un procedimiento para la preparacion de nuevos benzopiranos con actividad farmacologica.
BG33153A3 (bg) Метод за получаване на 1-арилокси-2-хидрокси-3-алкиленаминопропани
ES2123873T3 (es) Pirrolocarbazol.
AR241082A1 (es) Nuevos derivados de pirazol utiles como agentes herbicidas, las composiciones herbicidas que los contienen y los procedimientos para producir estos derivados de pirazol".
ES2052603T3 (es) Derivados de bencimidazol, procedimiento para su produccion y composicion farmaceutica que los contienen.
ES2118203T3 (es) Nuevos derivados benzopiranicos, su procedimiento de preparacion y composiciones farmaceuticas que los contienen.
ES2136888T3 (es) Inhibidores de la proliferacion de las celulas de la musculatura lisa.
ES2145234T3 (es) Derivados de la diosmetina, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
ES2010513B3 (es) Nuevos derivados de 6- o 7-metilenoandrosta-1,4-dieno3,17-diona y procedimiento para su preparacion.
ES2070002T3 (es) Composiciones terapeuticas a base de derivados de 1,2-ditiol-3-tiona.
ES2160308T3 (es) Nuevos derivados amino-metil-heterociclicos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 418591

Country of ref document: ES