ATE124997T1 - Enzymatische entfernung einer aminoterminalen proteinsequenz. - Google Patents

Enzymatische entfernung einer aminoterminalen proteinsequenz.

Info

Publication number
ATE124997T1
ATE124997T1 AT90304890T AT90304890T ATE124997T1 AT E124997 T1 ATE124997 T1 AT E124997T1 AT 90304890 T AT90304890 T AT 90304890T AT 90304890 T AT90304890 T AT 90304890T AT E124997 T1 ATE124997 T1 AT E124997T1
Authority
AT
Austria
Prior art keywords
protein sequence
compounds
enzymatic removal
protein
human insulin
Prior art date
Application number
AT90304890T
Other languages
English (en)
Inventor
Gerald Wayne Becker
Thomas Charles Furman
Warren C Mackellar
James Patrick Mcdonough
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of ATE124997T1 publication Critical patent/ATE124997T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
AT90304890T 1989-05-09 1990-05-04 Enzymatische entfernung einer aminoterminalen proteinsequenz. ATE124997T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/349,472 US5126249A (en) 1989-05-09 1989-05-09 Enzymatic removal of a protein amino-terminal sequence

Publications (1)

Publication Number Publication Date
ATE124997T1 true ATE124997T1 (de) 1995-07-15

Family

ID=23372543

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90304890T ATE124997T1 (de) 1989-05-09 1990-05-04 Enzymatische entfernung einer aminoterminalen proteinsequenz.

Country Status (12)

Country Link
US (2) US5126249A (de)
EP (1) EP0397420B1 (de)
JP (1) JP2592981B2 (de)
AT (1) ATE124997T1 (de)
AU (1) AU630951B2 (de)
CA (1) CA2016049A1 (de)
DE (1) DE69020794T2 (de)
DK (1) DK0397420T3 (de)
ES (1) ES2075155T3 (de)
HU (1) HU215582B (de)
IE (1) IE67531B1 (de)
IL (1) IL94305A (de)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5514646A (en) * 1989-02-09 1996-05-07 Chance; Ronald E. Insulin analogs modified at position 29 of the B chain
IL93282A (en) * 1989-02-09 1995-08-31 Lilly Co Eli Insulin analogues
IL104086A (en) * 1991-12-18 1998-03-10 Lilly Co Eli Translational activating oligonucleotide sequence useful for the high level expression of polypeptides and a method for producing such polypeptides
IL104727A (en) * 1992-02-18 1997-01-10 Lilly Co Eli Selective removal of n-terminal extensions from folded insulin precursors using dipeptidyl-aminopeptidase-1
TW257792B (de) * 1992-10-01 1995-09-21 Lilly Co Eli
JP2887060B2 (ja) * 1993-06-30 1999-04-26 日清製粉株式会社 グリセンチンの生産方法
US5573923A (en) * 1993-12-22 1996-11-12 Eli Lilly And Company Method for removing N-terminal dipeptides from precursor polypeptides with immobilized dipeptidylaminopeptidase from dictyostelium discoideum
JP2887063B2 (ja) * 1993-12-28 1999-04-26 日清製粉株式会社 グリセンチンの製造方法
WO1995030685A1 (en) * 1994-05-09 1995-11-16 Unizyme Laboratories A/S An enzymatic process for producing a desired protein from an amino terminal extended protein
BR9408638A (pt) * 1994-12-29 2004-09-21 Bio Technology General Corp Geração de insulina humana
US5840517A (en) * 1995-04-26 1998-11-24 Eli Lilly And Company Process for preparing obesity protein analogs
US5614379A (en) * 1995-04-26 1997-03-25 Eli Lilly And Company Process for preparing anti-obesity protein
WO1997042306A1 (en) * 1996-05-08 1997-11-13 Eli Lilly And Company Bovine dipeptidylaminopeptidase 1
CA2257474A1 (en) * 1996-06-07 1997-12-11 Eli Lilly And Company Ob protein binding protein
DE19943177C2 (de) * 1999-09-09 2002-10-24 Dieter Jenne Verfahren zur Herstellung von aktiven Serienproteasen und inaktiven Varianten
IL141647A0 (en) * 2001-02-26 2002-03-10 Yeda Res & Dev Synthetic human peptides and pharmaceutical compositions comprising them for the treatment of systemic lupus erythematosus
DK1404829T3 (da) * 2001-07-06 2008-03-25 Lg Life Sciences Ltd Hidtil ukendt aminopeptidase afledt af bacillus licheniformis, gen der koder for aminopeptidasen, ekspressionsvektor indeholdende genet, transformant og fremgangsmåde til fremstilling deraf
WO2004060403A2 (en) * 2003-01-06 2004-07-22 Angiochem Inc. Aprotinin and anglos as carriers across the blood-brain barrier
KR20050100617A (ko) * 2003-01-14 2005-10-19 테바 파마슈티컬 인더스트리즈 리미티드 전신 홍반 루푸스 치료용 펩티드의 비 경구 제형
JP2006516034A (ja) * 2003-01-14 2006-06-15 テバ ファーマシューティカル インダストリーズ リミティド 全身性エリテマトーデスを治療するためのペプチドの非経口製剤
US8618054B2 (en) * 2004-05-05 2013-12-31 Valorisation-Rechereche Société en Commandite Interleukin-1 receptor antagonists, compositions, and methods of treatment
EP1751175B1 (de) 2004-05-05 2012-07-25 VALORISATION-RECHERCHE, Société en Commandite Antagonisten des interleukin-1-rezeptors, zusammensetzungen und behandlungsverfahren
WO2007004060A2 (en) 2005-05-05 2007-01-11 Valorisation Hsj, Societe En Commandite Cytokine receptor modulators and uses thereof
US9365634B2 (en) * 2007-05-29 2016-06-14 Angiochem Inc. Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
AU2008255556B2 (en) 2007-05-29 2014-08-07 Angiochem, Inc. Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
MX355683B (es) 2008-04-18 2018-04-26 Angiochem Inc Composiciones farmacéuticas de paclitaxel, análogos de paclitaxel o conjugados de paclitaxel, y métodos relacionados de preparación y uso.
WO2010043049A1 (en) 2008-10-15 2010-04-22 Angiochem Inc. Etoposide and doxorubicin conjugates for drug delivery
CA2740316A1 (en) 2008-10-15 2010-04-22 Angiochem Inc. Conjugates of glp-1 agonists and uses thereof
CA2745524C (en) 2008-12-05 2020-06-09 Angiochem Inc. Conjugates of neurotensin or neurotensin analogs and uses thereof
US8853353B2 (en) 2008-12-17 2014-10-07 Angiochem, Inc. Membrane type-1 matrix metalloprotein inhibitors and uses thereof
MX2011011023A (es) 2009-04-20 2012-01-20 Angiochem Inc Tratamiento de cancer de ovarios usando un agente anti-cancer conjugado con un analogo de angiopep-2.
RU2012103240A (ru) 2009-07-02 2013-08-10 Ангиокем Инк. Мультимерные пептидные конъюгаты и их применение
JP2013530993A (ja) 2010-07-02 2013-08-01 アンジオケム インコーポレーテッド 治療用コンジュゲートのための短く且つｄ−アミノ酸を含有するポリペプチドおよびその使用
WO2014096985A2 (en) * 2012-12-19 2014-06-26 Wockhardt Limited A stable aqueous composition comprising human insulin or an analogue or derivative thereof
US11326255B2 (en) 2013-02-07 2022-05-10 Uchicago Argonne, Llc ALD reactor for coating porous substrates
EP3307326B9 (de) 2015-06-15 2021-02-24 Angiochem Inc. Verfahren zur behandlung von leptomeningealer karzinomatose
US11111578B1 (en) 2020-02-13 2021-09-07 Uchicago Argonne, Llc Atomic layer deposition of fluoride thin films
US12065738B2 (en) 2021-10-22 2024-08-20 Uchicago Argonne, Llc Method of making thin films of sodium fluorides and their derivatives by ALD
US11901169B2 (en) 2022-02-14 2024-02-13 Uchicago Argonne, Llc Barrier coatings

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ199391A (en) * 1981-01-02 1985-12-13 Genentech Inc Chimeric polypeptides comprising a proinsulin sequence,and preparation by recombinant dna technique;production of human insulin
DK55685A (da) * 1985-02-07 1986-08-08 Nordisk Gentofte Enzym eller enzymkompleks med proteolytisk aktivitet
WO1986001229A1 (en) * 1984-08-16 1986-02-27 Bio-Technology General Corp. Method of removing n-terminal amino acid residues from eucaryotic polypetide analogs and polypeptides produced thereby
US4946828A (en) * 1985-03-12 1990-08-07 Novo Nordisk A/S Novel insulin peptides
US4865974A (en) * 1985-09-20 1989-09-12 Cetus Corporation Bacterial methionine N-terminal peptidase
PT83613B (en) * 1985-10-28 1988-11-21 Lilly Co Eli Process for the selective chemical removal of a protein amino-terminal residue
IL91771A0 (en) * 1988-09-30 1990-06-10 Lilly Co Eli Increased expression of small molecular weight recombinant proteins
HUT56857A (en) * 1988-12-23 1991-10-28 Novo Nordisk As Human insulin analogues
IL93282A (en) * 1989-02-09 1995-08-31 Lilly Co Eli Insulin analogues

Also Published As

Publication number Publication date
IE67531B1 (en) 1996-04-03
AU630951B2 (en) 1992-11-12
DK0397420T3 (da) 1995-08-21
IE901673L (en) 1990-11-09
IL94305A0 (en) 1991-03-10
HU215582B (hu) 1999-01-28
DE69020794T2 (de) 1995-12-14
US5352769A (en) 1994-10-04
CA2016049A1 (en) 1990-11-09
AU5483390A (en) 1990-11-15
ES2075155T3 (es) 1995-10-01
DE69020794D1 (de) 1995-08-17
EP0397420B1 (de) 1995-07-12
HUT54213A (en) 1991-01-28
IL94305A (en) 1995-12-08
JP2592981B2 (ja) 1997-03-19
EP0397420A1 (de) 1990-11-14
US5126249A (en) 1992-06-30
JPH0334995A (ja) 1991-02-14
HU902697D0 (en) 1990-09-28

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee