DK0397420T3 - Enzymatisk fjernelse af en aminoterminal proteinsekvens - Google Patents

Enzymatisk fjernelse af en aminoterminal proteinsekvens

Info

Publication number: DK0397420T3
Authority: DK; Denmark
Prior art keywords: amino; protein sequence; terminal protein; compounds; enzymatic removal
Prior art date: 1989-05-09

Application number

DK90304890.8T

Other languages

Danish (da)

English (en)

Inventor

Gerald Wayne Becker

Thomas Charles Furman

Warren C Mackellar

James Patrick Mcdonough

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-05-09

Filing date

1990-05-04

Publication date

1995-08-21

1990-05-04 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1995-08-21 Application granted granted Critical

1995-08-21 Publication of DK0397420T3 publication Critical patent/DK0397420T3/da

Links

102000004169 proteins and genes Human genes 0.000 title abstract 2
108090000623 proteins and genes Proteins 0.000 title abstract 2
230000002255 enzymatic effect Effects 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 abstract 2
102000003902 Cathepsin C Human genes 0.000 abstract 1
108090000267 Cathepsin C Proteins 0.000 abstract 1
108010016626 Dipeptides Proteins 0.000 abstract 1
101000976075 Homo sapiens Insulin Proteins 0.000 abstract 1
150000001413 amino acids Chemical group 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000002243 precursor Substances 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Gastroenterology & Hepatology (AREA)
Endocrinology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Toxicology (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Diabetes (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Enzymes And Modification Thereof (AREA)

DK90304890.8T 1989-05-09 1990-05-04 Enzymatisk fjernelse af en aminoterminal proteinsekvens DK0397420T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/349,472 US5126249A (en)	1989-05-09	1989-05-09	Enzymatic removal of a protein amino-terminal sequence

Publications (1)

Publication Number	Publication Date
DK0397420T3 true DK0397420T3 (da)	1995-08-21

Family

ID=23372543

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK90304890.8T DK0397420T3 (da)	1989-05-09	1990-05-04	Enzymatisk fjernelse af en aminoterminal proteinsekvens

Country Status (12)

Country	Link
US (2)	US5126249A (de)
EP (1)	EP0397420B1 (de)
JP (1)	JP2592981B2 (de)
AT (1)	ATE124997T1 (de)
AU (1)	AU630951B2 (de)
CA (1)	CA2016049A1 (de)
DE (1)	DE69020794T2 (de)
DK (1)	DK0397420T3 (de)
ES (1)	ES2075155T3 (de)
HU (1)	HU215582B (de)
IE (1)	IE67531B1 (de)
IL (1)	IL94305A (de)

Families Citing this family (39)

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PT93057B (pt) *	1989-02-09	1995-12-29	Lilly Co Eli	Processo para a preparacao de analogos da insulina
US5514646A (en) *	1989-02-09	1996-05-07	Chance; Ronald E.	Insulin analogs modified at position 29 of the B chain
IL104086A (en) *	1991-12-18	1998-03-10	Lilly Co Eli	Translational activating oligonucleotide sequence useful for the high level expression of polypeptides and a method for producing such polypeptides
IL104727A (en) *	1992-02-18	1997-01-10	Lilly Co Eli	Selective removal of n-terminal extensions from folded insulin precursors using dipeptidyl-aminopeptidase-1
TW257792B (de) *	1992-10-01	1995-09-21	Lilly Co Eli
JP2887060B2 (ja) *	1993-06-30	1999-04-26	日清製粉株式会社	グリセンチンの生産方法
US5573923A (en) *	1993-12-22	1996-11-12	Eli Lilly And Company	Method for removing N-terminal dipeptides from precursor polypeptides with immobilized dipeptidylaminopeptidase from dictyostelium discoideum
JP2887063B2 (ja) *	1993-12-28	1999-04-26	日清製粉株式会社	グリセンチンの製造方法
AU2445495A (en) *	1994-05-09	1995-11-29	Unizyme Laboratories A/S	An enzymatic process for producing a desired protein from an amino terminal extended protein
ATE350053T1 (de) *	1994-12-29	2007-01-15	Ferring Int Ct Sa	Herstellung von humaninsulin
US5614379A (en) *	1995-04-26	1997-03-25	Eli Lilly And Company	Process for preparing anti-obesity protein
US5840517A (en) *	1995-04-26	1998-11-24	Eli Lilly And Company	Process for preparing obesity protein analogs
US6008041A (en) *	1996-05-08	1999-12-28	Eli Lilly And Company	Bovine dipeptidylaminopeptidase 1
AU3640397A (en) *	1996-06-07	1998-01-05	Eli Lilly And Company	Ob protein binding protein
DE19943177C2 (de) *	1999-09-09	2002-10-24	Dieter Jenne	Verfahren zur Herstellung von aktiven Serienproteasen und inaktiven Varianten
IL141647A0 (en) *	2001-02-26	2002-03-10	Yeda Res & Dev	Synthetic human peptides and pharmaceutical compositions comprising them for the treatment of systemic lupus erythematosus
ATE380863T1 (de) *	2001-07-06	2007-12-15	Lg Life Sciences Ltd	Neue, aus bacillus licheniformis stammende aminopeptidase, die aminopeptidase codierendes gen, das gen enthaltender expressionsvektor, transformant sowie verfahren zur herstellung davon
CN1747747B (zh) *	2003-01-06	2012-09-05	安吉奥开米公司	作为穿过血脑屏障的载体的抑酶肽及类似物
KR20050100616A (ko)	2003-01-14	2005-10-19	테바 파마슈티컬 인더스트리즈 리미티드	전신성 홍반성 낭창의 치료를 위한 펩티드의 비경구 제제
EP1594434B1 (de) *	2003-01-14	2016-09-07	Yeda Research and Development Co.	Parenterale peptidformulierungen zur behandlung von systemischem lupus erythematodes
ES2395087T3 (es)	2004-05-05	2013-02-08	Valorisation-Recherche, Société en Commandite	Antagonistas del receptor de interleuquina-1, composiciones y métodos de tratamiento
US8618054B2 (en) *	2004-05-05	2013-12-31	Valorisation-Rechereche Société en Commandite	Interleukin-1 receptor antagonists, compositions, and methods of treatment
WO2007004060A2 (en)	2005-05-05	2007-01-11	Valorisation Hsj, Societe En Commandite	Cytokine receptor modulators and uses thereof
US9365634B2 (en) *	2007-05-29	2016-06-14	Angiochem Inc.	Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
EP2789628A3 (de)	2007-05-29	2015-03-04	Angiochem Inc.	Aprotininähnliche Polypeptide zur Abgabe von an Geweben konjugierten Mitteln
RU2518240C2 (ru)	2008-04-18	2014-06-10	Ангиочем Инк.	Композиция, на основе гидрофобных агентов и способ ее получения(варианты)
US8921314B2 (en)	2008-10-15	2014-12-30	Angiochem, Inc.	Conjugates of GLP-1 agonists and uses thereof
RU2531591C2 (ru)	2008-10-15	2014-10-20	Ангиокем Инк.	Конъюгаты этопозида и доксорубицина для доставки лекарственных средств
MX2011005963A (es)	2008-12-05	2011-09-01	Angiochem Inc	Conjugados de neurotensina o analogos de neurotensina y sus usos.
CN102300987A (zh)	2008-12-17	2011-12-28	安吉奥开米公司	膜型-1基质金属蛋白抑制剂及其用途
AU2010239069B2 (en)	2009-04-20	2015-05-14	Angiochem Inc	Treatment of ovarian cancer using an anticancer agent conjugated to an Angiopep-2 analog
MX2012000016A (es)	2009-07-02	2012-03-26	Angiochem Inc	Conjugados de peptidos multimericos y sus usos.
RU2013103763A (ru)	2010-07-02	2014-08-10	Ангиохем Инк.	Короткие и содержащие d-аминокислоты полипептиды для терапевтических конъюгатов и их применения
MX360420B (es) *	2012-12-19	2018-10-31	Wockhardt Ltd	Una composicion acuosa estable que comprende insulina humana o un analogo o derivado de la misma.
US11326255B2 (en)	2013-02-07	2022-05-10	Uchicago Argonne, Llc	ALD reactor for coating porous substrates
US10980892B2 (en)	2015-06-15	2021-04-20	Angiochem Inc.	Methods for the treatment of leptomeningeal carcinomatosis
US11111578B1 (en)	2020-02-13	2021-09-07	Uchicago Argonne, Llc	Atomic layer deposition of fluoride thin films
US12065738B2 (en)	2021-10-22	2024-08-20	Uchicago Argonne, Llc	Method of making thin films of sodium fluorides and their derivatives by ALD
US11901169B2 (en)	2022-02-14	2024-02-13	Uchicago Argonne, Llc	Barrier coatings

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ199391A (en) *	1981-01-02	1985-12-13	Genentech Inc	Chimeric polypeptides comprising a proinsulin sequence,and preparation by recombinant dna technique;production of human insulin
DK55685A (da) *	1985-02-07	1986-08-08	Nordisk Gentofte	Enzym eller enzymkompleks med proteolytisk aktivitet
EP0489711B1 (de) *	1984-08-16	2003-10-01	Savient Pharmaceuticals, Inc.	Methode zur Herstellung von menschlichen Wachstumshormonen
US4946828A (en) *	1985-03-12	1990-08-07	Novo Nordisk A/S	Novel insulin peptides
US4865974A (en) *	1985-09-20	1989-09-12	Cetus Corporation	Bacterial methionine N-terminal peptidase
PT83613B (en) *	1985-10-28	1988-11-21	Lilly Co Eli	Process for the selective chemical removal of a protein amino-terminal residue
DK470689A (da) *	1988-09-30	1990-03-31	Lilly Co Eli	Hidtil ukendte dna-sekvenser, der koder for protein-derivater, som tillader hoej udtrykkelse af rekombinante proteiner med ringe molekylevaegt
AU641631B2 (en) *	1988-12-23	1993-09-30	Novo Nordisk A/S	Human insulin analogues
PT93057B (pt) *	1989-02-09	1995-12-29	Lilly Co Eli	Processo para a preparacao de analogos da insulina

1989
- 1989-05-09 US US07/349,472 patent/US5126249A/en not_active Expired - Lifetime
1990
- 1990-05-04 CA CA002016049A patent/CA2016049A1/en not_active Abandoned
- 1990-05-04 DK DK90304890.8T patent/DK0397420T3/da active
- 1990-05-04 EP EP90304890A patent/EP0397420B1/de not_active Expired - Lifetime
- 1990-05-04 DE DE69020794T patent/DE69020794T2/de not_active Expired - Fee Related
- 1990-05-04 AT AT90304890T patent/ATE124997T1/de not_active IP Right Cessation
- 1990-05-04 ES ES90304890T patent/ES2075155T3/es not_active Expired - Lifetime
- 1990-05-06 IL IL9430590A patent/IL94305A/en not_active IP Right Cessation
- 1990-05-07 HU HU902697A patent/HU215582B/hu not_active IP Right Cessation
- 1990-05-08 IE IE167390A patent/IE67531B1/en not_active IP Right Cessation
- 1990-05-08 JP JP2118497A patent/JP2592981B2/ja not_active Expired - Lifetime
- 1990-05-08 AU AU54833/90A patent/AU630951B2/en not_active Ceased
1992
- 1992-04-06 US US07/864,098 patent/US5352769A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
HUT54213A (en)	1991-01-28
JP2592981B2 (ja)	1997-03-19
IE901673L (en)	1990-11-09
IE67531B1 (en)	1996-04-03
EP0397420A1 (de)	1990-11-14
HU215582B (hu)	1999-01-28
DE69020794T2 (de)	1995-12-14
HU902697D0 (en)	1990-09-28
DE69020794D1 (de)	1995-08-17
AU5483390A (en)	1990-11-15
CA2016049A1 (en)	1990-11-09
AU630951B2 (en)	1992-11-12
JPH0334995A (ja)	1991-02-14
IL94305A (en)	1995-12-08
US5126249A (en)	1992-06-30
IL94305A0 (en)	1991-03-10
ES2075155T3 (es)	1995-10-01
ATE124997T1 (de)	1995-07-15
US5352769A (en)	1994-10-04
EP0397420B1 (de)	1995-07-12

Publication	Publication Date	Title
ATE124997T1 (de)	1995-07-15	Enzymatische entfernung einer aminoterminalen proteinsequenz.
KR100261030B1 (en)	2000-06-15	N-terminally chemically modified protein compositions and methods
DE3785864D1 (de)	1993-06-24	Verfahren zur herstellung von menschlichem epidermalwachstumsfaktor und dessen analogen.
EP0552240A4 (en)	1993-09-01	New method of treating depression
DE68918246D1 (de)	1994-10-20	Verbindungen zur Verhinderung von Thrombose.
DE60237791D1 (de)	2010-11-04	Zytokinproteinfamilie
ES2081817T3 (es)	1996-03-16	Polipeptido con secuencias principales repetidas que se fijan en la celula.
ATE70067T1 (de)	1991-12-15	Peptidaminoalkoholderivate, welche ein tetrasubstituiertes kohlenstoffatom besitzen, hemmungsstoffe von renin und proteasesaeuren, verfahren zur herstellung und pharmazeutische zusammensetzungen.
EP0330700A4 (de)	1990-01-08	Menschlicher Prourokinase ähnliches Polypeptid.
EP0587571A4 (de)	1995-03-15	Humanes galanin, cdna-klone die für humanes galanin kodieren und eine methode humanes galamin herzustellen.
ES520493A0 (es)	1983-12-16	Procedimiento para la preparacion de insulinas a partir de compuestos analogos a preproinsulina.
DE58908857D1 (de)	1995-02-16	Verfahren zur Herstellung von 2,6-Dichlordiphenylaminessigsäurederivaten.
ATE84074T1 (de)	1993-01-15	Verfahren zur fermentativen herstellung von 2-(4- hydroxiphenoxi-)propionsaeure.
FR2569111B1 (fr)	1987-04-17	Nouveaux medicaments contenant des tripeptides
BG90414A (bg)	1993-12-24	2-азабицикло (2,2,1)-хепт-5- ен-2-оцетна киселина и нейни производни, метод за получаване и приложението им
DE69834929D1 (de)	2006-07-27	Verwendung eines organspezifischen ernährungmittels
AU542310B2 (en)	1985-02-14	Glicentin related purified peptide having 30 amino acids
SE9000793L (sv)	1990-09-12	Sdk-peptider,foerfarande foer framstaellning daerav och terapeutiska kompositioner innehaallande dem
DE69427148D1 (de)	2001-05-31	Verfahren zur Herstellung von 2,4,5-Tribrompyrrol-3-carbonitril
ATE147268T1 (de)	1997-01-15	Hypoglycemische peptide
ATE110775T1 (de)	1994-09-15	Verfahren zur herstellung von hirudin.
FI915933A0 (fi)	1991-12-17	Korta peptider som har insulininverkan.
FI956247A0 (fi)	1995-12-22	Uusia menetelmiä (S)-4-amino-hepta-5,6-dieenihappo ja sen välituotteiden valmistamiseksi
DE3887854D1 (de)	1994-03-24	Verfahren zur Herstellung von Dipeptiden.
ATE110385T1 (de)	1994-09-15	Derivate von aminocarboxylsäure.