ATE125544T1 - Verfahren zur herstellung von amikacin. - Google Patents

Verfahren zur herstellung von amikacin.

Info

Publication number: ATE125544T1
Authority: AT; Austria
Prior art keywords: amikacin; producing; synthesis; derivative; economicity
Prior art date: 1987-11-27

Application number

AT88119460T

Other languages

English (en)

Inventor

Alberto Mangia

Original Assignee

Gist Brocades Italy

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-11-27

Filing date

1988-11-23

Publication date

1995-08-15

1988-11-23 Application filed by Gist Brocades Italy filed Critical Gist Brocades Italy

1995-08-15 Application granted granted Critical

1995-08-15 Publication of ATE125544T1 publication Critical patent/ATE125544T1/de

Links

229960004821 amikacin Drugs 0.000 title abstract 2
LKCWBDHBTVXHDL-RMDFUYIESA-N amikacin Chemical compound O([C@@H]1[C@@H](N)C[C@H]([C@@H]([C@H]1O)O[C@@H]1[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O1)O)NC(=O)[C@@H](O)CCN)[C@H]1O[C@H](CN)[C@@H](O)[C@H](O)[C@H]1O LKCWBDHBTVXHDL-RMDFUYIESA-N 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
230000015572 biosynthetic process Effects 0.000 abstract 2
238000003786 synthesis reaction Methods 0.000 abstract 2
IVUOMFWNDGNLBJ-VKHMYHEASA-N (2s)-4-amino-2-hydroxybutanoic acid Chemical class NCC[C@H](O)C(O)=O IVUOMFWNDGNLBJ-VKHMYHEASA-N 0.000 abstract 1
230000010933 acylation Effects 0.000 abstract 1
238000005917 acylation reaction Methods 0.000 abstract 1
239000007810 chemical reaction solvent Substances 0.000 abstract 1
SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical class O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
- C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/12—Acyclic radicals, not substituted by cyclic structures attached to a nitrogen atom of the saccharide radical
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Crystallography & Structural Chemistry (AREA)
Saccharide Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Organic Insulating Materials (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Polymerisation Methods In General (AREA)
Quinoline Compounds (AREA)
Silicates, Zeolites, And Molecular Sieves (AREA)
Financial Or Insurance-Related Operations Such As Payment And Settlement (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Steroid Compounds (AREA)
Peptides Or Proteins (AREA)

AT88119460T 1987-11-27 1988-11-23 Verfahren zur herstellung von amikacin. ATE125544T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT8722783A IT1225484B (it)	1987-11-27	1987-11-27	Procedimento di sintesi dell'amikacina

Publications (1)

Publication Number	Publication Date
ATE125544T1 true ATE125544T1 (de)	1995-08-15

Family

ID=11200418

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT88119460T ATE125544T1 (de)	1987-11-27	1988-11-23	Verfahren zur herstellung von amikacin.

Country Status (23)

Country	Link
US (1)	US5763587A (de)
EP (1)	EP0317970B1 (de)
JP (1)	JPH0637512B2 (de)
AT (1)	ATE125544T1 (de)
AU (1)	AU608665B2 (de)
BG (1)	BG49048A3 (de)
CA (1)	CA1324375C (de)
CS (1)	CS277017B6 (de)
DD (1)	DD283564A5 (de)
DE (1)	DE3854225T2 (de)
DK (1)	DK170050B1 (de)
ES (1)	ES2074431T3 (de)
FI (1)	FI90243C (de)
HU (1)	HU201771B (de)
IT (1)	IT1225484B (de)
NO (1)	NO171505C (de)
NZ (1)	NZ227113A (de)
PH (1)	PH25818A (de)
PL (1)	PL161416B1 (de)
RO (1)	RO102339B1 (de)
RU (1)	RU1776262C (de)
YU (1)	YU47063B (de)
ZA (1)	ZA888855B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW465235B (en)	1998-09-17	2001-11-21	United Video Properties Inc	Electronic program guide with digital storage
US7794713B2 (en)	2004-04-07	2010-09-14	Lpath, Inc.	Compositions and methods for the treatment and prevention of hyperproliferative diseases
WO2007041156A2 (en)	2005-09-29	2007-04-12	Nektar Therapeutics	Antibiotic formulations, unit doses, kits, and methods
CA2632968A1 (en)	2005-12-02	2007-06-07	Isis Pharmaceuticals, Inc.	Antibacterial 4,5-substituted aminoglycoside analogs having multiple substituents
US7862812B2 (en)	2006-05-31	2011-01-04	Lpath, Inc.	Methods for decreasing immune response and treating immune conditions
JP2010527913A (ja) *	2007-04-10	2010-08-19	アカオジェンインコーポレイテッド	抗菌性１，４，５置換アミノグリコシド類似体
WO2010030704A2 (en)	2008-09-10	2010-03-18	Achaogen, Inc.	Antibacterial aminoglycoside analogs
WO2010030690A1 (en) *	2008-09-10	2010-03-18	Isis Pharmaceuticals, Inc.	Antibacterial 4,6-substituted 6', 6" and 1 modified aminoglycoside analogs
AU2009299118B2 (en)	2008-10-03	2015-12-17	Glycan Biosciences Llc	Anionic conjugates of glycosylated bacterial metabolite
WO2010042850A1 (en)	2008-10-09	2010-04-15	Achaogen, Inc.	Antibacterial aminoglycoside analogs
WO2010042851A1 (en)	2008-10-09	2010-04-15	Achaogen, Inc.	Antibacterial aminoglycoside analogs
MX2012004036A (es)	2009-10-09	2012-06-27	Achaogen Inc	Analogos de aminoglicosidos antibacterianos.
AR083879A1 (es)	2010-11-17	2013-03-27	Achaogen Inc	Analogos de aminoglicosidos antibacterianos, metodos de preparacion y uso como agentes terapeuticos
CN103113429B (zh) *	2013-03-05	2015-02-18	齐鲁天和惠世制药有限公司	一种由阿米卡星制备硫酸阿米卡星的方法
CN105440090B (zh) *	2014-08-27	2018-03-09	北大医药重庆大新药业股份有限公司	一种阿米卡星的合成方法
CN111233952A (zh) *	2020-04-02	2020-06-05	管炫棣	一种阿卡米星的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1485450A (en) *	1973-11-14	1977-09-14	Bristol Myers Co	Process for the preparation of a kanamycin derivative
JPS51127045A (en) *	1975-04-24	1976-11-05	Microbial Chem Res Found	A process for preparing 3'- deoxykanamycin a derivatives.
GB1530201A (en) *	1976-04-14	1978-10-25	Pfizer Ltd	Process for the preparation of aminoglycoside antibiotics and intermediates therefor
US4136254A (en) *	1976-06-17	1979-01-23	Schering Corporation	Process of selectively blocking amino functions in aminoglycosides using transition metal salts and intermediates used thereby
IE54288B1 (en) *	1982-03-05	1989-08-16	Fujisawa Pharmaceutical Co	New 1,4-diaminocyclitol derivatives, processes for their preparation and pharmaceutical compositions containing them
JPS6041692A (ja) *	1983-08-15	1985-03-05	Microbial Chem Res Found	２′，３′−ジデオキシカナマイシンａ誘導体
IT1200774B (it) *	1985-10-10	1989-01-27	Pierrel Spa	Procedimento di sentisi dell'amikacina

1987
- 1987-11-27 IT IT8722783A patent/IT1225484B/it active
1988
- 1988-11-23 DE DE3854225T patent/DE3854225T2/de not_active Expired - Fee Related
- 1988-11-23 EP EP88119460A patent/EP0317970B1/de not_active Expired - Lifetime
- 1988-11-23 ES ES88119460T patent/ES2074431T3/es not_active Expired - Lifetime
- 1988-11-23 AT AT88119460T patent/ATE125544T1/de not_active IP Right Cessation
- 1988-11-25 DD DD88322213A patent/DD283564A5/de not_active IP Right Cessation
- 1988-11-25 CS CS887779A patent/CS277017B6/cs unknown
- 1988-11-25 BG BG086218A patent/BG49048A3/xx unknown
- 1988-11-25 HU HU886072A patent/HU201771B/hu not_active IP Right Cessation
- 1988-11-25 PH PH37859A patent/PH25818A/en unknown
- 1988-11-25 CA CA000584227A patent/CA1324375C/en not_active Expired - Fee Related
- 1988-11-25 NO NO885270A patent/NO171505C/no unknown
- 1988-11-25 RU SU884356995A patent/RU1776262C/ru active
- 1988-11-25 DK DK661588A patent/DK170050B1/da not_active IP Right Cessation
- 1988-11-25 FI FI885489A patent/FI90243C/fi not_active IP Right Cessation
- 1988-11-25 ZA ZA888855A patent/ZA888855B/xx unknown
- 1988-11-26 JP JP63299382A patent/JPH0637512B2/ja not_active Expired - Lifetime
- 1988-11-28 RO RO88136098A patent/RO102339B1/ro unknown
- 1988-11-28 AU AU25963/88A patent/AU608665B2/en not_active Ceased
- 1988-11-28 PL PL1988276047A patent/PL161416B1/pl unknown
- 1988-11-28 YU YU218888A patent/YU47063B/sh unknown
- 1988-11-28 NZ NZ227113A patent/NZ227113A/en unknown
1992
- 1992-02-14 US US07/834,991 patent/US5763587A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
BG49048A3 (en)	1991-07-15
JPH0637512B2 (ja)	1994-05-18
DK661588D0 (da)	1988-11-25
DK170050B1 (da)	1995-05-08
FI90243C (fi)	1994-01-10
NO171505C (no)	1993-03-24
DK661588A (da)	1989-05-28
DE3854225D1 (de)	1995-08-31
YU218888A (en)	1989-12-31
AU2596388A (en)	1989-06-01
RO102339B1 (ro)	1992-08-01
CS277017B6 (en)	1992-11-18
ZA888855B (en)	1990-02-28
EP0317970B1 (de)	1995-07-26
IT8722783A0 (it)	1987-11-27
NZ227113A (en)	1991-01-29
HU201771B (en)	1990-12-28
IT1225484B (it)	1990-11-14
JPH01186900A (ja)	1989-07-26
FI885489A0 (fi)	1988-11-25
AU608665B2 (en)	1991-04-11
US5763587A (en)	1998-06-09
HUT49144A (en)	1989-08-28
NO885270D0 (no)	1988-11-25
PL276047A1 (en)	1989-07-10
FI885489L (fi)	1989-05-28
ES2074431T3 (es)	1995-09-16
NO171505B (no)	1992-12-14
NO885270L (no)	1989-05-29
DD283564A5 (de)	1990-10-17
EP0317970A2 (de)	1989-05-31
CS777988A3 (en)	1992-06-17
PL161416B1 (pl)	1993-06-30
EP0317970A3 (de)	1991-08-28
FI90243B (fi)	1993-09-30
PH25818A (en)	1991-11-05
YU47063B (sh)	1994-12-28
RU1776262C (ru)	1992-11-15
CA1324375C (en)	1993-11-16
DE3854225T2 (de)	1996-01-04

Legal Events

Date	Code	Title	Description
1996-02-15	UEP	Publication of translation of european patent specification
2000-08-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE125544T1 (de)	1995-08-15	Verfahren zur herstellung von amikacin.
DE69031534D1 (de)	1997-11-06	Verfahren zur Herstellung von optisch aktiven Zyklobutannukleosiden
ATE82569T1 (de)	1992-12-15	Herstellung von chinolincarbonsaeuren.
DE3865604D1 (de)	1991-11-21	Verfahren zur herstellung von 1,6-di(n3-cyano-n1-guanidino)hexan.
ATE172734T1 (de)	1998-11-15	Verfahren zur herstellung von ceftriaxon
ATE96796T1 (de)	1993-11-15	Verfahren zur herstellung von natriumpurinen.
ATE61329T1 (de)	1991-03-15	Verfahren zur herstellung von rooperol, hypoxosid und deren derivaten.
ATE25680T1 (de)	1987-03-15	Verfahren zur herstellung von 4-amino-5-dialkoxy- methylpyrimidinderivaten.
DE3768350D1 (de)	1991-04-11	Verfahren zur herstellung von anthracyclin-derivat r2ox2.
ATE177737T1 (de)	1999-04-15	Verfahren zur herstellung von 5-arylhydantoin
DE69024114D1 (de)	1996-01-25	Verfahren zur Herstellung von Penemen
DE69407938D1 (de)	1998-02-19	Verfahren zur herstellung von alpha-hydroximinophenylacetonitril
IT1136579B (it)	1986-09-03	Processo per la produzione di acido l-aspartico usando microorganismi immobilizzati
FI915109A0 (fi)	1991-10-30	Foerfarande foer framstaellning av alifatisk amid och salter daerav.
ATE24507T1 (de)	1987-01-15	Verfahren zur herstellung von lysergsaeure-estern.