ATE125568T1 - Analoge der untereinheit des von rekombinanter dns abgeleiteten bordetella-toxins. - Google Patents

Analoge der untereinheit des von rekombinanter dns abgeleiteten bordetella-toxins.

Info

Publication number: ATE125568T1
Authority: AT; Austria
Prior art keywords: recombinant dna; derived; toxin subunit; bordetella; subunits
Prior art date: 1987-09-04

Application number

AT88308124T

Other languages

English (en)

Inventor

Iii Walter Neal Burnette

Original Assignee

Amgen Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-09-04

Filing date

1988-09-01

Publication date

1995-08-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26788722&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE125568(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1988-09-01 Application filed by Amgen Inc filed Critical Amgen Inc

1995-08-15 Application granted granted Critical

1995-08-15 Publication of ATE125568T1 publication Critical patent/ATE125568T1/de

Links

241000588807 Bordetella Species 0.000 title abstract 2
239000003053 toxin Substances 0.000 title abstract 2
231100000765 toxin Toxicity 0.000 title abstract 2
OTLLEIBWKHEHGU-UHFFFAOYSA-N 2-[5-[[5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy]-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,5-dihydroxy-4-phosphonooxyhexanedioic acid Chemical compound C1=NC=2C(N)=NC=NC=2N1C(C(C1O)O)OC1COC1C(CO)OC(OC(C(O)C(OP(O)(O)=O)C(O)C(O)=O)C(O)=O)C(O)C1O OTLLEIBWKHEHGU-UHFFFAOYSA-N 0.000 abstract 1
108020004511 Recombinant DNA Proteins 0.000 abstract 1
230000004071 biological effect Effects 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
230000002255 enzymatic effect Effects 0.000 abstract 1
231100000776 exotoxin Toxicity 0.000 abstract 1
239000002095 exotoxin Substances 0.000 abstract 1
230000002163 immunogen Effects 0.000 abstract 1
230000005847 immunogenicity Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
238000012986 modification Methods 0.000 abstract 1
230000004048 modification Effects 0.000 abstract 1
229960005486 vaccine Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/235—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bordetella (G)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K2039/10—Brucella; Bordetella, e.g. Bordetella pertussis; Not used, see subgroups
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Communicable Diseases (AREA)
Genetics & Genomics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Immunology (AREA)
Oncology (AREA)
Molecular Biology (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Virology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Saccharide Compounds (AREA)

AT88308124T 1987-09-04 1988-09-01 Analoge der untereinheit des von rekombinanter dns abgeleiteten bordetella-toxins. ATE125568T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US9430787A	1987-09-04	1987-09-04
US23248288A	1988-08-17	1988-08-17

Publications (1)

Publication Number	Publication Date
ATE125568T1 true ATE125568T1 (de)	1995-08-15

Family

ID=26788722

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT88308124T ATE125568T1 (de)	1987-09-04	1988-09-01	Analoge der untereinheit des von rekombinanter dns abgeleiteten bordetella-toxins.

Country Status (16)

Country	Link
US (1)	US5773600A (de)
EP (2)	EP0629696A1 (de)
JP (1)	JP2918895B2 (de)
KR (1)	KR0168039B1 (de)
CN (1)	CN1033866C (de)
AT (1)	ATE125568T1 (de)
CA (1)	CA1341560C (de)
DE (1)	DE3854213T3 (de)
DK (1)	DK175821B1 (de)
ES (1)	ES2076160T5 (de)
FI (1)	FI101632B1 (de)
GR (1)	GR3017497T3 (de)
IE (1)	IE69753B1 (de)
IL (3)	IL103121A (de)
NO (2)	NO301844B1 (de)
WO (1)	WO1989001976A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1223334B (it) *	1987-11-02	1990-09-19	Sclavo Spa	Polipeptidi immunologicamente attivi con una tossicita' alterata utili per la preparazione di un vaccino antipertosse
US5925546A (en) *	1987-11-02	1999-07-20	Chiron S.P.A.	Immunologically active polypeptides with altered toxicity useful for the preparation of an antipertussis vaccine
US6713072B1 (en) *	1987-11-02	2004-03-30	Chiron S.R.L.	Immunologically active polypeptides with altered toxicity useful for the preparation of an antipertussis vaccine
US5332583A (en) *	1987-11-24	1994-07-26	Connaught Laboratories Limited	Vaccine containing genetically-detoxified pertussis holotoxin
GB8727489D0 (en) *	1987-11-24	1987-12-23	Connaught Lab	Detoxification of pertussis toxin
US5358868A (en) *	1987-11-24	1994-10-25	Connaught Laboratories Limited	Genetic detoxification of pertussis toxin
CA2009991A1 (en) *	1989-02-15	1990-08-15	Witold Cieplak	Pertussis toxin gene: cloning and expression of protective antigen
US7232671B2 (en) *	1989-02-15	2007-06-19	The United States Of America As Represented By The Secretary, Department Of Health And Human Services	Pertussis toxin gene: cloning and expression of protective antigen
ATE127347T1 (de) *	1989-04-28	1995-09-15	Sclavo Spa	Pertussistoxin-mutanten, dieselbe produzierende bordetella-stämme und ihre verwendung als vakzin gegen pertussis.
US5786189A (en) *	1989-11-29	1998-07-28	Smithkline Beecham Biologicals (S.A.)	Vaccine
GB9326174D0 (en) *	1993-12-22	1994-02-23	Biocine Sclavo	Mucosal adjuvant
US20030072774A1 (en) *	1994-06-10	2003-04-17	Diane M. Gajewczyk	Proteinaceous adjuvants
ATE496634T1 (de) *	1995-05-04	2011-02-15	Sanofi Pasteur Ltd	Azelluläre pertussis-impfstoffe und verfahren zu deren herstellung
CA2253937A1 (en) *	1996-05-10	1997-11-20	Phylomed Corporation	Methods for oxidizing disulfide bonds using ozone
FR2754543B1 (fr)	1996-10-11	1998-12-31	Pasteur Institut	Souche de bordetella deficiente dans la production de toxine et exprimant une proteine hydride, liposomes comprenant de la fha et leurs utilisations comme vaccins, et utilisation de la fha pour stimuler les reponses immunitaires
US6818222B1 (en)	1997-03-21	2004-11-16	Chiron Corporation	Detoxified mutants of bacterial ADP-ribosylating toxins as parenteral adjuvants
US9453251B2 (en)	2002-10-08	2016-09-27	Pfenex Inc.	Expression of mammalian proteins in Pseudomonas fluorescens
GB0313916D0 (en)	2003-06-16	2003-07-23	Glaxosmithkline Biolog Sa	Vaccine composition
BRPI0513826A2 (pt)	2004-07-26	2010-06-22	Dow Global Technologies Inc	processo para expressão de proteìna melhorada através de engenharia de cepa
BRPI0519923A8 (pt) *	2004-12-17	2018-01-23	De Staat Der Nederlanden Vertegenwoordigd Door De Mini Van Vws	polipeptídeo, seqüência de dna, vetor de dna, anticorpo, bactéria, método para produzir lps parcialmente 3-0-desacilado, composição, usos da bactéria, e de lps de bordetella isolado compreendendo lps pelo menos parcialmente 3-0-desacilado, vacina, e, método in vitro para a desacilação de lps gram-negativo ou de composições compreendendo lps gram-negativo, e, para induzir uma resposta imune contra bordetella.
US9394571B2 (en)	2007-04-27	2016-07-19	Pfenex Inc.	Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins
US9580719B2 (en)	2007-04-27	2017-02-28	Pfenex, Inc.	Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins
ITMI20090946A1 (it)	2009-05-28	2010-11-29	Novartis Ag	Espressione di proteine ricombinanti
KR20130072201A (ko)	2010-03-30	2013-07-01	피페넥스 인크.	재조합 독소 단백질의 고수준 발현
US9169304B2 (en)	2012-05-01	2015-10-27	Pfenex Inc.	Process for purifying recombinant Plasmodium falciparum circumsporozoite protein
US20140037680A1 (en)	2012-08-06	2014-02-06	Glaxosmithkline Biologicals, S.A.	Novel method
AU2013301312A1 (en)	2012-08-06	2015-03-19	Glaxosmithkline Biologicals S.A.	Method for eliciting in infants an immune response against RSV and B. pertussis
WO2014135651A1 (en)	2013-03-08	2014-09-12	Crucell Holland B.V.	Acellular pertussis vaccine
MX2016001695A (es)	2013-08-05	2016-05-02	Glaxosmithkline Biolog Sa	Composiciones inmunogenas de combinacion.
CN109172818B (zh) *	2018-08-02	2021-10-22	浙江康佰裕生物科技有限公司	一种蛋白牛痘疫苗及其效力检测方法
CN113226361A (zh) *	2018-10-15	2021-08-06	代表亚利桑那大学的亚利桑那校董会	疫苗多肽组合物及方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4704362A (en) *	1977-11-08	1987-11-03	Genentech, Inc.	Recombinant cloning vehicle microbial polypeptide expression
FR2590483B1 (fr) *	1985-11-22	1988-12-09	Pasteur Institut	Antigenes purifies ayant des proprietes vaccinantes contre b. pertussis, moyens notamment adns recombinants pour les produire et compositions de vaccins les contenant
CA1340373C (en) *	1986-01-28	1999-02-02	Rino Rappuoli	Cloning and sequencing of the dna fragment which codes for the five subunits of the pertussis toxin, a hybrid plasmid containing the dna fragment and micro-organisms transformed by the hybrid plasmid and capable of expressing all or some of the subunits of the pertussis toxin
ES2044959T3 (es) *	1986-12-23	1994-01-16	Univ Leland Stanford Junior	Exotoxina de tos ferina modificada.
IT1223334B (it) *	1987-11-02	1990-09-19	Sclavo Spa	Polipeptidi immunologicamente attivi con una tossicita' alterata utili per la preparazione di un vaccino antipertosse
GB8727489D0 (en) *	1987-11-24	1987-12-23	Connaught Lab	Detoxification of pertussis toxin
IT1223529B (it) *	1987-12-18	1990-09-19	Sclavo Spa	Epitopo immunodominante protettivo contenuto nella subunita' s1 della tossina della pertosse

1988
- 1988-08-26 KR KR1019890700803A patent/KR0168039B1/ko not_active Expired - Fee Related
- 1988-08-26 JP JP63507460A patent/JP2918895B2/ja not_active Expired - Lifetime
- 1988-08-26 WO PCT/US1988/002983 patent/WO1989001976A1/en not_active Ceased
- 1988-08-30 IL IL10312188A patent/IL103121A/en not_active IP Right Cessation
- 1988-08-30 IL IL87608A patent/IL87608A0/xx not_active IP Right Cessation
- 1988-09-01 DE DE3854213T patent/DE3854213T3/de not_active Expired - Lifetime
- 1988-09-01 ES ES88308124T patent/ES2076160T5/es not_active Expired - Lifetime
- 1988-09-01 EP EP94109317A patent/EP0629696A1/de not_active Withdrawn
- 1988-09-01 AT AT88308124T patent/ATE125568T1/de not_active IP Right Cessation
- 1988-09-01 EP EP88308124A patent/EP0306318B2/de not_active Expired - Lifetime
- 1988-09-02 CA CA 576469 patent/CA1341560C/en not_active Expired - Fee Related
- 1988-09-02 IE IE266888A patent/IE69753B1/en not_active IP Right Cessation
- 1988-09-05 CN CN88107056A patent/CN1033866C/zh not_active Expired - Lifetime
1989
- 1989-05-03 FI FI892131A patent/FI101632B1/fi not_active IP Right Cessation
- 1989-05-03 NO NO891842A patent/NO301844B1/no not_active IP Right Cessation
- 1989-05-03 DK DK198902162A patent/DK175821B1/da active
1992
- 1992-09-09 IL IL103121A patent/IL103121A0/xx unknown
1995
- 1995-06-06 US US08/468,679 patent/US5773600A/en not_active Expired - Lifetime
- 1995-09-21 GR GR950402614T patent/GR3017497T3/el unknown
1997
- 1997-06-09 NO NO19972642A patent/NO325016B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
JP2918895B2 (ja)	1999-07-12
NO972642D0 (no)	1997-06-09
EP0306318A1 (de)	1989-03-08
EP0306318B1 (de)	1995-07-26
DE3854213T3 (de)	2004-10-21
KR890701758A (ko)	1989-12-21
IE69753B1 (en)	1996-10-02
AU2386488A (en)	1989-03-31
CN1033866C (zh)	1997-01-22
FI101632B (fi)	1998-07-31
DK216289D0 (da)	1989-05-03
CA1341560C (en)	2007-10-30
FI892131L (fi)	1989-05-03
EP0306318B2 (de)	2004-04-28
IL103121A (en)	1995-08-31
DK216289A (da)	1989-06-30
FI101632B1 (fi)	1998-07-31
IL87608A0 (en)	1989-01-31
DE3854213T2 (de)	1995-12-07
WO1989001976A1 (en)	1989-03-09
ES2076160T3 (es)	1995-11-01
JPH04501051A (ja)	1992-02-27
IL103121A0 (en)	1993-02-21
EP0629696A1 (de)	1994-12-21
FI892131A0 (fi)	1989-05-03
NO301844B1 (no)	1997-12-15
CN1033072A (zh)	1989-05-24
IE882668L (en)	1989-03-04
DK175821B1 (da)	2005-03-14
DE3854213D1 (de)	1995-08-31
NO891842L (no)	1989-06-21
NO972642L (no)	1997-07-28
NO325016B1 (no)	2008-01-14
ES2076160T5 (es)	2004-12-01
NO891842D0 (no)	1989-05-03
KR0168039B1 (ko)	1999-01-15
US5773600A (en)	1998-06-30
GR3017497T3 (en)	1995-12-31
AU623867B2 (en)	1992-05-28

Legal Events

Date

Code

Title

Description

1996-02-15

UEP

Publication of translation of european patent specification

2006-11-15

UEP