ATE125712T1 - 19f-markierte verbindungen zur verwendung als nmr-bilderzeugungs- und spektroskopiermittel. - Google Patents

19f-markierte verbindungen zur verwendung als nmr-bilderzeugungs- und spektroskopiermittel.

Info

Publication number
ATE125712T1
ATE125712T1 AT91905554T AT91905554T ATE125712T1 AT E125712 T1 ATE125712 T1 AT E125712T1 AT 91905554 T AT91905554 T AT 91905554T AT 91905554 T AT91905554 T AT 91905554T AT E125712 T1 ATE125712 T1 AT E125712T1
Authority
AT
Austria
Prior art keywords
perfluorocarbon emulsion
tissue
subject
spin
oxygen tension
Prior art date
Application number
AT91905554T
Other languages
English (en)
Inventor
Peter P Antich
Padmakar V Kulkarni
Original Assignee
Univ Texas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas filed Critical Univ Texas
Application granted granted Critical
Publication of ATE125712T1 publication Critical patent/ATE125712T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds
    • A61K49/126—Linear polymers, e.g. dextran, inulin, PEG
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • A61K49/146—Peptides, e.g. proteins the peptide being a polyamino acid, e.g. poly-lysine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/806—Electrical property or magnetic property
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
AT91905554T 1990-02-21 1991-02-21 19f-markierte verbindungen zur verwendung als nmr-bilderzeugungs- und spektroskopiermittel. ATE125712T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/482,879 US5236694A (en) 1990-02-21 1990-02-21 19f labelled dextrans and antibodies as nmr imaging and spectroscopy agents

Publications (1)

Publication Number Publication Date
ATE125712T1 true ATE125712T1 (de) 1995-08-15

Family

ID=23917811

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91905554T ATE125712T1 (de) 1990-02-21 1991-02-21 19f-markierte verbindungen zur verwendung als nmr-bilderzeugungs- und spektroskopiermittel.

Country Status (9)

Country Link
US (3) US5236694A (de)
EP (1) EP0517788B1 (de)
JP (1) JPH05506432A (de)
AT (1) ATE125712T1 (de)
AU (1) AU641233B2 (de)
CA (1) CA2075953A1 (de)
DE (1) DE69111798T2 (de)
ES (1) ES2075433T3 (de)
WO (1) WO1991012824A2 (de)

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US5368840A (en) * 1990-04-10 1994-11-29 Imarx Pharmaceutical Corp. Natural polymers as contrast media for magnetic resonance imaging
US5370901A (en) * 1991-02-15 1994-12-06 Bracco International B.V. Compositions for increasing the image contrast in diagnostic investigations of the digestive tract of patients
GB9216843D0 (en) * 1992-08-07 1992-09-23 Cancer Res Inst Contrast agents for medical imaging
US5468467A (en) * 1993-04-23 1995-11-21 Bracco International B.V. Methods for the in vivo measurement of the concentration of non-imaging nmr-detectable xenobiotic compounds
DE4318369C1 (de) * 1993-05-28 1995-02-09 Schering Ag Verwendung von makrocyclischen Metallkomplexen als Temperatursonden
GB9325330D0 (en) * 1993-12-10 1994-02-16 Univ Toronto Fluorocyclodextrin drug delivery system
EP0831935A4 (de) * 1995-06-07 2001-08-29 Mallinckrodt Medical Inc Gasförmige ultraschallkontrastmittel und dazugehörige verfahren
US5807978A (en) * 1995-06-07 1998-09-15 Kokolus; William J. Immunogenic peptides of prostate specific antigen
US5678548A (en) * 1995-07-20 1997-10-21 The United States Of America As Represented By The Department Of Health And Human Services System and method for performing in vivo imaging and oxymetry and FT microscopy by pulsed radiofrequency electron paramagnetic resonance
US5753207A (en) * 1995-08-21 1998-05-19 Beth Israel Deaconess Medical Center, Inc. Use of paramagnetic compounds to measure temperature and pH in vivo
US5828216A (en) * 1996-08-19 1998-10-27 The United States Of America As Represented By The Department Of Health And Human Services Gated RF preamplifier for use in pulsed radiofrequency electron paramagnetic resonance and MRI
AT409929B (de) * 1997-03-07 2002-12-27 Tritthart Helmut A Dr Polymere-infusionslösung zur anwendung bei der diagnose von tumoren, gegebenenfalls zu deren behandlung
US6419174B1 (en) * 2000-08-18 2002-07-16 J. M. Huber Corporation Abrasive compositions and methods for making same
US6574497B1 (en) 2000-12-22 2003-06-03 Advanced Cardiovascular Systems, Inc. MRI medical device markers utilizing fluorine-19
NO20015802D0 (no) * 2001-11-28 2001-11-28 Amersham Health As Diagnostisk metode
WO2003086563A2 (en) * 2002-04-11 2003-10-23 Carbomer, Inc. Diabetes imaging probes
WO2003087165A2 (en) * 2002-04-11 2003-10-23 Carbomer, Inc. Biocompatible materials and probes
US7090829B2 (en) * 2002-04-11 2006-08-15 Carbomer, Inc. Imaging probes
WO2004078990A1 (en) * 2003-02-28 2004-09-16 Carbomer, Inc. Halogenated emulsans
AU2005209169B2 (en) 2004-01-16 2010-12-16 Carnegie Mellon University Cellular labeling for nuclear magnetic resonance techniques
AU2005310986A1 (en) * 2004-11-12 2006-06-08 Bellus Health (International) Limited Methods and fluorinated compositions for treating amyloid-related diseases
DE102005005704B4 (de) 2005-02-03 2010-08-12 Leibniz-Institut Für Festkörper- Und Werkstoffforschung Dresden E.V. Verwendung von Partikeln für die Ermittlung der lokalen Temperatur in organischen und nichtorganischen Körpern
WO2007120911A2 (en) * 2006-04-14 2007-10-25 Carnegie Mellon University Cellular labeling and quantification for nuclear magnetic resonance techniques
EP2012832A2 (de) * 2006-04-14 2009-01-14 Celsense, Inc. Verfahren zur beurteilung von zellmarkierungen
GB0711662D0 (en) * 2007-06-15 2007-07-25 Cancercure As Magnetic resonance guided cancer treatment system
CA2693678C (en) * 2007-07-10 2017-02-14 Carnegie Mellon University Compositions and methods for producing cellular labels for nuclear magnetic resonance techniques
US8093060B2 (en) * 2008-02-28 2012-01-10 Canon Kabushiki Kaisha Multisite phosphorylated peptide (protein) recognizing compound and detection method, imaging method, alzheimer's disease diagnosing method and reagent kit using the same
WO2009134435A2 (en) * 2008-05-02 2009-11-05 Celsense Inc. Compositions and methods for producing emulsions for nuclear magnetic resonance techniques and other applications
CN102497888B (zh) 2009-07-31 2014-10-29 皇家飞利浦电子股份有限公司 用于成像的全氟化合物
WO2012076191A1 (en) * 2010-12-10 2012-06-14 Merck Patent Gmbh Aptamer labeled with f-19 nucleus for targeted molecular imaging by mri
WO2012142670A1 (en) * 2011-04-20 2012-10-26 The University Of Queensland Nuclear magnetic resonance agent
JP6234064B2 (ja) * 2012-05-23 2017-11-22 キヤノン株式会社 重合体、前記重合体を用いた核磁気共鳴分析用または磁気共鳴イメージング用の造影剤、化合物、前記重合体を用いた核磁気共鳴分析方法および磁気共鳴イメージング方法

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US5236694A (en) * 1990-02-21 1993-08-17 The Board Of Regents, The University Of Texas System 19f labelled dextrans and antibodies as nmr imaging and spectroscopy agents
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Also Published As

Publication number Publication date
ES2075433T3 (es) 1995-10-01
EP0517788B1 (de) 1995-08-02
EP0517788A1 (de) 1992-12-16
DE69111798D1 (de) 1995-09-07
WO1991012824A2 (en) 1991-09-05
US5397562A (en) 1995-03-14
US5422094A (en) 1995-06-06
CA2075953A1 (en) 1991-08-22
US5236694A (en) 1993-08-17
WO1991012824A3 (en) 1992-02-20
AU7453991A (en) 1991-09-18
JPH05506432A (ja) 1993-09-22
DE69111798T2 (de) 1995-11-30
AU641233B2 (en) 1993-09-16

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Legal Events

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