ATE449615T1 - Bilderzeugung mittels magnetischer kernresonanz unter einwirkung hyperpolarisierter edelgase - Google Patents

Bilderzeugung mittels magnetischer kernresonanz unter einwirkung hyperpolarisierter edelgase

Info

Publication number
ATE449615T1
ATE449615T1 AT95916198T AT95916198T ATE449615T1 AT E449615 T1 ATE449615 T1 AT E449615T1 AT 95916198 T AT95916198 T AT 95916198T AT 95916198 T AT95916198 T AT 95916198T AT E449615 T1 ATE449615 T1 AT E449615T1
Authority
AT
Austria
Prior art keywords
noble gas
spatial distribution
imaging
hyperpolarized
xenon
Prior art date
Application number
AT95916198T
Other languages
English (en)
Inventor
Dilip Balamore
Gordon Cates
Bastiaan Driehuys
William Happer
Brian Saam
Arnold Wishnia
Mitchell Albert
Original Assignee
Univ New York State Res Found
Univ Princeton
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ New York State Res Found, Univ Princeton filed Critical Univ New York State Res Found
Application granted granted Critical
Publication of ATE449615T1 publication Critical patent/ATE449615T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions
    • A61K49/1815—Suspensions, emulsions, colloids, dispersions compo-inhalant, e.g. breath tests
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/282—Means specially adapted for hyperpolarisation or for hyperpolarised contrast agents, e.g. for the generation of hyperpolarised gases using optical pumping cells, for storing hyperpolarised contrast agents or for the determination of the polarisation of a hyperpolarised contrast agent
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Signal Processing (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Magnetic Variables (AREA)
AT95916198T 1994-04-08 1995-04-04 Bilderzeugung mittels magnetischer kernresonanz unter einwirkung hyperpolarisierter edelgase ATE449615T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/225,243 US5545396A (en) 1994-04-08 1994-04-08 Magnetic resonance imaging using hyperpolarized noble gases
PCT/US1995/004175 WO1995027438A1 (en) 1994-04-08 1995-04-04 Magnetic resonance imaging using hyperpolarized noble gases

Publications (1)

Publication Number Publication Date
ATE449615T1 true ATE449615T1 (de) 2009-12-15

Family

ID=22844121

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95916198T ATE449615T1 (de) 1994-04-08 1995-04-04 Bilderzeugung mittels magnetischer kernresonanz unter einwirkung hyperpolarisierter edelgase

Country Status (8)

Country Link
US (5) US5545396A (de)
EP (2) EP0754009B1 (de)
JP (1) JP3645569B2 (de)
AT (1) ATE449615T1 (de)
AU (1) AU709515B2 (de)
CA (1) CA2183740C (de)
DE (1) DE69536022D1 (de)
WO (1) WO1995027438A1 (de)

Families Citing this family (167)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6088613A (en) 1989-12-22 2000-07-11 Imarx Pharmaceutical Corp. Method of magnetic resonance focused surgical and therapeutic ultrasound
US6551576B1 (en) 1989-12-22 2003-04-22 Bristol-Myers Squibb Medical Imaging, Inc. Container with multi-phase composition for use in diagnostic and therapeutic applications
US5542935A (en) 1989-12-22 1996-08-06 Imarx Pharmaceutical Corp. Therapeutic delivery systems related applications
US6001335A (en) 1989-12-22 1999-12-14 Imarx Pharmaceutical Corp. Contrasting agents for ultrasonic imaging and methods for preparing the same
US5469854A (en) 1989-12-22 1995-11-28 Imarx Pharmaceutical Corp. Methods of preparing gas-filled liposomes
US20020150539A1 (en) 1989-12-22 2002-10-17 Unger Evan C. Ultrasound imaging and treatment
US5585112A (en) 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US5776429A (en) 1989-12-22 1998-07-07 Imarx Pharmaceutical Corp. Method of preparing gas-filled microspheres using a lyophilized lipids
US5922304A (en) 1989-12-22 1999-07-13 Imarx Pharmaceutical Corp. Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents
US6146657A (en) 1989-12-22 2000-11-14 Imarx Pharmaceutical Corp. Gas-filled lipid spheres for use in diagnostic and therapeutic applications
US5874062A (en) 1991-04-05 1999-02-23 Imarx Pharmaceutical Corp. Methods of computed tomography using perfluorocarbon gaseous filled microspheres as contrast agents
US5205290A (en) 1991-04-05 1993-04-27 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
US6280383B1 (en) 1993-03-01 2001-08-28 Fonar Corporation Magnetic resonance imaging
US7083572B2 (en) 1993-11-30 2006-08-01 Bristol-Myers Squibb Medical Imaging, Inc. Therapeutic delivery systems
US5545396A (en) * 1994-04-08 1996-08-13 The Research Foundation Of State University Of New York Magnetic resonance imaging using hyperpolarized noble gases
US6743779B1 (en) 1994-11-29 2004-06-01 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell
US5830430A (en) 1995-02-21 1998-11-03 Imarx Pharmaceutical Corp. Cationic lipids and the use thereof
US5997898A (en) 1995-06-06 1999-12-07 Imarx Pharmaceutical Corp. Stabilized compositions of fluorinated amphiphiles for methods of therapeutic delivery
US6033645A (en) 1996-06-19 2000-03-07 Unger; Evan C. Methods for diagnostic imaging by regulating the administration rate of a contrast agent
US6231834B1 (en) 1995-06-07 2001-05-15 Imarx Pharmaceutical Corp. Methods for ultrasound imaging involving the use of a contrast agent and multiple images and processing of same
US6139819A (en) 1995-06-07 2000-10-31 Imarx Pharmaceutical Corp. Targeted contrast agents for diagnostic and therapeutic use
US5617860A (en) * 1995-06-07 1997-04-08 Smithsonian Astrophysical Observatory Method and system for producing polarized 129 Xe gas
US6521211B1 (en) 1995-06-07 2003-02-18 Bristol-Myers Squibb Medical Imaging, Inc. Methods of imaging and treatment with targeted compositions
US5626137A (en) * 1995-10-02 1997-05-06 General Electric Company Apparatus and methods for magnetic resonance (MR) angiography using fluids polarized at low temperatures
FR2744932B1 (fr) * 1996-02-16 1998-04-30 Centre Nat Rech Scient Installation et procede pour la production d'helium-3 polarise en phase vapeur, en particulier pour l'imagerie par rmn
US5809801A (en) * 1996-03-29 1998-09-22 The Trustees Of Princeton University Cryogenic accumulator for spin-polarized xenon-129
FI982069A7 (fi) * 1996-03-29 1998-11-10 Lawrence Berkeley Nat Laboratory NMR:n ja MRI:n tehostaminen hyperpolaroitujen jalokaasujen läsnä olles sa
US5642625A (en) * 1996-03-29 1997-07-01 The Trustees Of Princeton University High volume hyperpolarizer for spin-polarized noble gas
US8765099B2 (en) * 1996-04-08 2014-07-01 Koninklijke Philips N.V. Magnetic resonance imaging hyperpolarization of liquids or solids by light with orbital angular momentum
WO1997040679A1 (en) 1996-05-01 1997-11-06 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell
DE19619471C1 (de) * 1996-05-14 1997-10-16 Siemens Ag Kernspintomographiegerät mit Vorpolarisation
US6414139B1 (en) 1996-09-03 2002-07-02 Imarx Therapeutics, Inc. Silicon amphiphilic compounds and the use thereof
ES2289188T3 (es) 1996-09-11 2008-02-01 Bristol-Myers Squibb Medical Imaging, Inc. Procedimiento para la obtencion de imagenes para el diagnostico usando un agente de contraste y un vasodilatador.
US5846517A (en) 1996-09-11 1998-12-08 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a renal contrast agent and a vasodilator
EP0951650B1 (de) 1997-01-08 2003-12-10 Amersham Health AS Verfahren zur bilderzeugung mit magnetischer resonanz
NZ337535A (en) * 1997-03-10 2000-06-23 Michael Georgieff A device for controlled anaesthesia, analgesia and/or sedation using an emulsion containing inert gas
DE19709704C2 (de) * 1997-03-10 1999-11-04 Michael Georgieff Verwendung einer flüssigen Präparation von Xenon zur intravenösen Verabreichung bei Einleitung und/oder Aufrechterhaltung der Anaesthesie
US6537246B1 (en) 1997-06-18 2003-03-25 Imarx Therapeutics, Inc. Oxygen delivery agents and uses for the same
US6090800A (en) 1997-05-06 2000-07-18 Imarx Pharmaceutical Corp. Lipid soluble steroid prodrugs
US6143276A (en) 1997-03-21 2000-11-07 Imarx Pharmaceutical Corp. Methods for delivering bioactive agents to regions of elevated temperatures
US7452551B1 (en) 2000-10-30 2008-11-18 Imarx Therapeutics, Inc. Targeted compositions for diagnostic and therapeutic use
US6416740B1 (en) 1997-05-13 2002-07-09 Bristol-Myers Squibb Medical Imaging, Inc. Acoustically active drug delivery systems
ATE252916T1 (de) * 1997-08-12 2003-11-15 Bracco Research Sa Verabreichbare formulierugen und ihre anwendung in mri
ATE366134T1 (de) 1997-08-18 2007-07-15 Univ Princeton Spin-polarisation eines edelgases über spinaustausch mit optisch gepumpten alkalimetallen
US6112108A (en) * 1997-09-12 2000-08-29 Ramot University For Applied Research & Industrial Development Ltd. Method for diagnosing malignancy in pelvic tumors
US6548047B1 (en) 1997-09-15 2003-04-15 Bristol-Myers Squibb Medical Imaging, Inc. Thermal preactivation of gaseous precursor filled compositions
FR2768568B1 (fr) 1997-09-17 2000-02-25 Centre Nat Rech Scient Procede et equipement pour la preparation d'un gaz d'helium hyperpolarise a forte pression, application dudit procede
EP1030594A1 (de) 1997-11-14 2000-08-30 Norbert Weiler Vorrichtung zur verabreichung eines flüssigen mediums
HU222711B1 (hu) * 1997-12-12 2003-09-29 Medi-Physics, Inc, Polarizált gáz akkumulátor és fżtżköpeny, eljárás polarizált gáz összegyżjtésére és felengedésére, valamint polarizált gáztermék
AU2003203796B2 (en) * 1997-12-12 2006-10-12 Medi-Physics, Inc. Polarized gas accumulators and heating jackets and associated gas collection and thaw methods and polarized gas products
EP1279912B1 (de) * 1997-12-12 2005-03-02 Medi-Physics, Inc. Verfahren zum Sammeln und Auftauen polarisierter Gase, dessen Sammler und Heizmanschette
US6079213A (en) * 1997-12-12 2000-06-27 Magnetic Imaging Technologies Incorporated Methods of collecting, thawing, and extending the useful life of polarized gases and associated accumulators and heating jackets
EP1051602B1 (de) 1997-12-12 2003-04-23 Medi-Physics, Inc. Verfahren zum sägen und auftauen eines xenon enthaltenden polarisierten gases
US6123923A (en) 1997-12-18 2000-09-26 Imarx Pharmaceutical Corp. Optoacoustic contrast agents and methods for their use
US6278893B1 (en) 1998-01-05 2001-08-21 Nycomed Imaging As Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
US6185444B1 (en) * 1998-03-13 2001-02-06 Skelscan, Inc. Solid-state magnetic resonance imaging
EP1286171A3 (de) * 1998-03-18 2003-05-28 Medi-Physics, Inc. Ermittlung der Gefässdurchblutung mittels magnetischer Resonanz mit hyperpolarisiertem 129Xe
JP2002507438A (ja) 1998-03-18 2002-03-12 メディ−フィジックス・インコーポレイテッド 溶解化した極性化１２９Ｘｅを用いる肺および心臓脈管構造の映像化および血流を上昇するＭＲ方法
WO1999053332A1 (en) * 1998-04-09 1999-10-21 Medi-Physics, Inc. Use of a hyperpolarized gas for mri detection of regional variations in oxygen uptake from the lungs
GB9807879D0 (en) * 1998-04-09 1998-06-10 Weiler Norbert Magnetic resonance imaging method
US6370415B1 (en) 1998-04-10 2002-04-09 Medi-Physics Inc. Magnetic resonance imaging method
AU3386799A (en) * 1998-04-13 1999-11-01 Duke University (in vivo) magnetic resonance vascular imaging using laser-polarized gas microbubbles
ATE523776T1 (de) 1998-06-17 2011-09-15 Medi Physics Inc Elastische behälter für hyperpolarisierte gase
US6128918A (en) * 1998-07-30 2000-10-10 Medi-Physics, Inc. Containers for hyperpolarized gases and associated methods
BR9911346A (pt) * 1998-06-17 2001-03-13 Medi Physics Inc Dispositivo de transporte de gás hiperpolarizado e método de transporte associado
US6423387B1 (en) 1998-06-17 2002-07-23 Medi-Physics, Inc. Resilient containers for hyperpolarized gases and associated methods
DE19833014A1 (de) * 1998-07-23 2000-01-27 Messer Griesheim Gmbh Edelgashaltige Injektionsanästhesiemittel
US6023162A (en) * 1998-07-23 2000-02-08 Duke University Three-dimensional morphology by magnetic resonance imaging
US6159444A (en) * 1998-09-11 2000-12-12 The Regents Of The University Of California NMR/MRI with hyperpolarized gas and high Tc SQUID
US6286319B1 (en) 1998-09-30 2001-09-11 Medi-Physics, Inc. Meted hyperpolarized noble gas dispensing methods and associated devices
US6237363B1 (en) 1998-09-30 2001-05-29 Medi-Physics, Inc. Hyperpolarized noble gas extraction methods masking methods and associated transport containers
US6523356B2 (en) 1998-09-30 2003-02-25 Medi-Physics, Inc. Meted hyperpolarized noble gas dispensing methods and associated devices
US6125654A (en) * 1998-10-16 2000-10-03 Syracuse University Bulk production and usage of hyperpolarized 129 Xenon
US6284222B1 (en) 1998-11-03 2001-09-04 Medi--Physics, Inc. Hyperpolarized helium-3 microbubble gas entrapment methods
FR2787835B1 (fr) 1998-12-23 2004-09-24 Centre Nat Rech Scient Compresseurs peristaltiques adaptes a la compression non relaxante de gaz polarise
GB9828853D0 (en) * 1998-12-30 1999-02-17 Nycomed Amersham Plc Nmr spectroscopy method
US7501236B1 (en) 1998-12-30 2009-03-10 Ge Healthcare Limited NMR spectroscopic in vitro assay using hyperpolarization
EP1155339A1 (de) 1999-02-23 2001-11-21 Medi-Physics, Inc. Tragbares system zur überwachung des polarisationsgrades eines hyperpolarisierten gases während des transports
US6408849B1 (en) * 1999-06-18 2002-06-25 Aeronex, Inc. Recovery and purification of gases used in medical processes
US6295834B1 (en) 1999-06-30 2001-10-02 Medi-Physics, Inc. NMR polarization monitoring coils, hyperpolarizers with same, and methods for determining the polarization level of accumulated hyperpolarized noble gases during production
WO2001005409A1 (de) * 1999-07-19 2001-01-25 Michael Georgieff Neues spinal- und epiduralanästhetikum
US6611540B1 (en) 1999-07-29 2003-08-26 Otward Maria Mueller Diode-laser system for hyperpolarized He-3 and Xe-129 gas generation and other applications
US6338836B1 (en) 1999-09-28 2002-01-15 Siemens Aktiengesellschaft Asthma analysis method employing hyperpolarized gas and magnetic resonance imaging
DE10000675C2 (de) 2000-01-11 2001-11-15 Otten Ernst Wilhelm Lineardurchführung, Vorrichtung und Verfahren zur hochproduktiven Erzeugung von hoch kernspinpolarisiertem Helium-3 Gas
US6630126B2 (en) * 2000-03-13 2003-10-07 Medi-Physics, Inc. Diagnostic procedures using direct injection of gaseous hyperpolarized 129Xe and associated systems and products
US6845262B2 (en) 2000-03-29 2005-01-18 The Brigham And Women's Hospital, Inc. Low-field MRI
WO2001074247A2 (en) * 2000-04-03 2001-10-11 Iep Pharmaceutical Devices Inc. Method for measuring changes in the airways of humans and other mammals
US6775568B2 (en) * 2000-04-12 2004-08-10 University Of Virginia Patent Foundation Exchange-based NMR imaging and spectroscopy of hyperpolarized xenon-129
GB0014463D0 (en) * 2000-06-14 2000-08-09 Nycomed Amersham Plc NMR Method
EP1303646B1 (de) * 2000-07-12 2008-04-16 The University of New Hampshire Verfahren zur polarisierung nuklearer spezies
US20030165431A1 (en) * 2000-07-13 2003-09-04 The Regents Of The University Of California Method for detecting macromolecular conformational change and binding information
US6652833B2 (en) * 2000-07-13 2003-11-25 The Regents Of The University Of California Functionalized active-nucleus complex sensor
CA2414610A1 (en) * 2000-07-13 2002-01-24 Medi-Physics, Inc. Diagnostic procedures using 129xe spectroscopy characteristic chemical shift to detect pathology in vivo
US7061237B2 (en) * 2000-07-13 2006-06-13 The Regents Of The University Of California Remote NMR/MRI detection of laser polarized gases
US6714808B2 (en) 2000-10-03 2004-03-30 University Of Arkansas Method for detecting and excising nonpalpable lesions
US7174200B2 (en) * 2001-04-13 2007-02-06 University Of Virginia Patent Foundation Optimized high-speed magnetic resonance imaging method and system using hyperpolarized noble gases
US7850152B2 (en) 2001-04-24 2010-12-14 Medi Physics, Inc. Methods and devices for moisturizing hyperpolarized noble gases and associated moisturized pharmaceutical grade inhalable hyperpolarized gas products
US6626027B1 (en) 2001-06-12 2003-09-30 Intertech Development Company Method and apparatus for detecting a gas leak using nuclear magnetic resonance
EP1436637A1 (de) * 2001-09-20 2004-07-14 Medi-Physics, Inc. Verfahren zur in-vivo-bewertung physiologischer zustände und/oder der organ- oder systemfunktion, einschliesslich verfahren zur bewertung von herz-lungen-krankheiten, wie z.b. chronischem herzversagen unter verwendung von polarisiertem 129 xe
US7179450B2 (en) * 2001-09-20 2007-02-20 Medi-Physics, Inc. Methods for in vivo evaluation of pulmonary physiology and/or function using NMR signals of polarized Xe
US20030212320A1 (en) * 2001-10-01 2003-11-13 Michael Wilk Coordinate registration system for dual modality imaging systems
CA2463739C (en) * 2001-10-22 2013-10-08 Medi-Physics Inc. Automated modular hyperpolarizers
AU2002348040A1 (en) * 2001-10-22 2003-05-06 Medi-Physics, Inc. Optical pumping modules, polarized gas blending and dispensing systems, and automated polarized gas distribution systems
AU2003237848A1 (en) * 2002-05-15 2003-12-02 University Of Virginia Patent Foundation Method and system for rapid magnetic resonance imaging of gases with reduced diffusion-induced signal loss
AU2003269207A1 (en) * 2002-05-16 2003-12-02 Medi-Physics, Inc Methods and systems for determining polarization of a gas based on electron paramagnetic resonance
AU2003248529A1 (en) * 2002-05-17 2003-12-02 Medi-Physics, Inc Methods, systems, circuits, and computer program products for determining polarization of a gas
EP1534990B1 (de) * 2002-07-23 2006-10-25 Medi-Physics, Inc. Automatisierte dynamische druckempfindliche systeme zur abgabe von hyperpolarisiertem gas und zugehörige verfahren und rechnerprogrammprodukte
AU2003259846A1 (en) * 2002-08-16 2004-03-03 The General Hospital Corporation Non-invasive functional imaging of peripheral nervous system activation in humans and animals
US20040082851A1 (en) * 2002-10-29 2004-04-29 Mehmet Bilgen Tunable electromagnetic device and method of use
US6867591B2 (en) * 2002-12-20 2005-03-15 Medi-Physics, Inc. NMR transfer standard
JP3998243B2 (ja) * 2003-01-10 2007-10-24 東横化学株式会社 核スピン偏極キセノンガスの製造方法及び製造装置
US20040184963A1 (en) 2003-01-17 2004-09-23 Cella Patrick A. Recirculating hyperpolarized gas cells and associated methods of producing optically pumped hyperpolarized gas
US7275540B2 (en) * 2003-04-22 2007-10-02 Medi-Physics, Inc. MRI/NMR-compatible, tidal volume control and measurement systems, methods, and devices for respiratory and hyperpolarized gas delivery
US7805176B2 (en) * 2004-03-10 2010-09-28 University Of Virginia Patent Foundation Exchange-weighted xenon-129 nuclear magnetic resonance system and related method
US20070197903A1 (en) * 2004-03-10 2007-08-23 Mugler John P Iii System and method for improved detection and assessment of changes in lung-tissue structure
US7281393B2 (en) * 2004-04-21 2007-10-16 University Of New Hampshire Method and apparatus for accumulating hyperpolarized xenon
FI20045381A0 (fi) * 2004-10-12 2004-10-12 Oulun Yliopisto Huokosominaisuuden määritysmenetelmä, näyteyksikön valmistusmenetelmä ja näyteyksikkö
US7991449B2 (en) * 2005-04-26 2011-08-02 Mayo Foundation For Medical Education And Research Imaging elastic properties of the lung with magnetic resonance elastography
JP4696262B2 (ja) * 2005-05-18 2011-06-08 独立行政法人産業技術総合研究所 超偏極希ガス製造装置及び超偏極希ガスを用いた核磁気共鳴分光装置並びに磁気共鳴イメージング装置
DE102005026604A1 (de) * 2005-06-09 2006-12-14 Membrana Gmbh Verfahren zum Lösen von Gasen mit kurzlebigen physikalischen Eigenschaften in einer Flüssigkeit
US20070190663A1 (en) * 2005-08-12 2007-08-16 Lee Ray F System and method for using polarized or hyperpolarized contrast agent to perform parallel magnetic resonance imaging of a sample
EP1926425B1 (de) 2005-09-13 2015-08-19 Philips Intellectual Property & Standards GmbH Mehrfache kontrastmittelinjektion für bildgebung
WO2007038626A2 (en) * 2005-09-28 2007-04-05 President And Fellows Of Harvard College Hyperpolarized solid materials with long spin relaxation times for use as imaging agents in magnetic resonance imaging
WO2007070466A2 (en) * 2005-12-10 2007-06-21 The President And Fellows Of Harvard College In situ hyperpolarization of imaging agents
EP1984757A4 (de) * 2006-01-11 2009-11-04 Harvard College Ex-vivo-hyperpolarisation von abbildungsmitteln
WO2007087313A2 (en) * 2006-01-25 2007-08-02 The Trustees Of Columbia University In The City Of New York Systems and methods for determining metabolic rate using temperature sensitive magnetic resonance imaging
US20090227859A1 (en) * 2006-01-25 2009-09-10 John Pile-Spellman Systems and methods for determining a cardiovascular parameter using temperature sensitive magnetic resonance imaging
US20140218029A1 (en) * 2006-02-21 2014-08-07 Millikelvin Technologies Llc Techniques, systems and machine readable programs for magnetic resonance
US9207298B2 (en) 2011-03-23 2015-12-08 Millikelvin Technologies Llc Techniques, systems and machine readable programs for magnetic resonance
EP1986702A4 (de) * 2006-02-21 2012-12-12 Avrum Belzer Hyperpolarisationsverfahren, systeme und zusammensetzungen
US8703102B2 (en) * 2008-04-04 2014-04-22 Millikelvin Technologies Llc Systems and methods for producing hyperpolarized materials and mixtures thereof
US7576538B2 (en) * 2006-03-14 2009-08-18 Thomas Meersmann Nuclear electric quadrupolar properties of hyperpolarized gases to probe surfaces and interfaces
WO2007123799A2 (en) * 2006-04-03 2007-11-01 The Trustees Of The University Of Pennsylvania Assessing subject's reactivity to psychological stress using fmri
US7282910B1 (en) * 2006-04-19 2007-10-16 Northrop Grumman Corporation Nuclear magnetic resonance gyroscope
US7714581B2 (en) 2006-04-19 2010-05-11 Wisconsin Alumni Research Foundation RF coil assembly for magnetic resonance imaging and spectroscopy systems
US7885702B2 (en) * 2006-04-19 2011-02-08 Wisconsin Alumni Research Foundation Segmentation of the airway tree using hyperpolarized noble gases and diffusion weighted magnetic resonance imaging
EP2067052B1 (de) * 2006-09-20 2016-05-11 University Of New Hampshire Thermisches management zur polarisierung von xenon
US8405022B2 (en) 2006-09-20 2013-03-26 University Of New Hampshire Thermal management technology for polarizing xenon
CA3065182C (en) * 2006-10-03 2022-05-17 Duke University Systems and methods for assessing pulmonary gas transfer using hyperpolarized 129xe mri
US7508212B2 (en) 2007-03-22 2009-03-24 Wisconsin Alumni Research Foundation RF coil assembly and method for practicing magnetization transfer on magnetic resonance imaging and spectroscopy systems
WO2009143368A2 (en) * 2008-05-23 2009-11-26 University Of Utah Non-cryogenic storage cell for hyperpolarized 129xe
US20100092390A1 (en) * 2008-10-09 2010-04-15 President And Fellows Of Harvard College Methods for Making Particles Having Long Spin-Lattice Relaxation Times
CN102460136A (zh) * 2009-06-19 2012-05-16 皇家飞利浦电子股份有限公司 与利用具有轨道角动量的光子的超极化装置组合的mri温度测定
RU2526895C2 (ru) * 2009-06-19 2014-08-27 Конинклейке Филипс Электроникс Н.В. Мрт с гиперполяризационным устройством, использующим фотоны с орбитальным угловым моментом
JP3180510U (ja) * 2009-08-26 2012-12-27 アスペクト マグネット テクノロジーズ リミテッド 不分極ガスを過分極化するシステム及び過分極化ガス・イメージングシステム
CA2772190A1 (en) * 2009-08-31 2011-03-03 Millikelvin Technologies Llc Systems and methods for producing hyperpolarized materials and mixtures thereof
BR112012020235A2 (pt) * 2010-02-16 2017-11-07 Koninl Philips Electronics Nv "dispensador para a produção de um agente de contraste hiperpolarizado e sistema de exame de ressonância magnética"
US8598881B2 (en) 2011-01-11 2013-12-03 General Electric Company Magnetic resonance imaging system with thermal reservoir and method for cooling
US9714995B2 (en) 2011-03-23 2017-07-25 Millikelvin Technologies Llc Techniques, systems and machine readable programs for magnetic resonance
US8660634B2 (en) * 2012-04-23 2014-02-25 The Brigham and Woman's Hospital System and method for improved lung fourier decomposition magnetic resonance imaging
CN110464709A (zh) 2012-08-10 2019-11-19 德克萨斯州大学系统董事会 用于治疗中风的神经保护性脂质体组合物和方法
US9329246B2 (en) * 2012-10-03 2016-05-03 Bruker Biospin Ag Method for hyperpolarization transfer in the liquid state
US9170215B2 (en) 2012-10-25 2015-10-27 Hexagon Metrology, Inc. Apparatus and method of imaging a heterogeneous object
US20140200437A1 (en) * 2013-01-16 2014-07-17 Empire Technology Development Llc Detection of internal gas leakage
AU2013200526B1 (en) * 2013-02-01 2014-05-08 Empire Technology Development Llc Detection of internal gas leakage
JP6625966B2 (ja) 2013-03-15 2019-12-25 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム 希ガスが豊富な液体ならびにその調製及び使用の方法
DE102013209832A1 (de) * 2013-05-27 2014-11-27 Siemens Aktiengesellschaft Vorrichtung und Verfahren zur Kontrastmittelgabe bei einer Magnetresonanztomographie
EP3107583B1 (de) 2014-02-21 2019-05-29 Duke University Systeme zur herstellung von hyperpolarisiertem edelgas mit nanoclusterunterdrückung, -detektion und/oder -filtrierung und zugehörige verfahren und vorrichtungen
US10126438B2 (en) 2014-09-19 2018-11-13 University Of Virginia Patent Foundation Systems and methods for polarized nuclear imaging and spectroscopy
EP3258850B1 (de) 2015-02-20 2020-06-24 Bayer HealthCare LLC Kontrastmittel mit aufgelöster gaserzeugender flüssigkeit
US10692692B2 (en) * 2015-05-27 2020-06-23 Kla-Tencor Corporation System and method for providing a clean environment in an electron-optical system
WO2018053256A1 (en) 2016-09-15 2018-03-22 Yuan Zheng Systems and methods for polarized nuclear imaging and spectroscopy
US11944424B2 (en) 2018-05-18 2024-04-02 Duke University Dynamic 129Xe gas exchange spectroscopy
CN114487959B (zh) * 2022-01-26 2024-05-31 中国科学院精密测量科学与技术创新研究院 一种超低场核磁共振测量装置与方法
CN115792758B (zh) * 2022-11-30 2024-10-15 中国科学院精密测量科学与技术创新研究院 一种用于活体超极化氙分子探针的磁共振定量成像方法
WO2025151298A1 (en) 2024-01-10 2025-07-17 Polarean, Inc. Hyperpolarizers with a load-lock chamber for alkali metal

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4006736A (en) * 1974-11-27 1977-02-08 Medrad, Inc. Angiographic injector
US4157495A (en) 1976-08-14 1979-06-05 Litton Systems, Inc. Nuclear magnetic resonance gyro
DE2758855A1 (de) * 1977-12-30 1979-07-12 Litton Systems Inc Vorrichtung zum bestimmen der magnetischen kernresonanz
US4450407A (en) * 1981-10-02 1984-05-22 Litton Systems, Inc. Magnetic resonance cell and method for its fabrication
DE3141641A1 (de) * 1981-10-16 1983-04-28 Schering Ag, 1000 Berlin Und 4619 Bergkamen Ultraschall-kontrastmittel und dessen herstellung
US4775522A (en) * 1983-03-04 1988-10-04 Children's Hospital Research Foundation, A Division Of Children's Hospital Medical Center NMR compositions for indirectly detecting a dissolved gas in an animal
US4586511A (en) * 1983-03-04 1986-05-06 Children's Hospital Medical Center Methods and compositions for detecting and imaging a gas in an animal by nuclear magnetic resonance
US4586111A (en) * 1984-08-01 1986-04-29 Sfe Technologies Capacitor with dielectric comprising a polymer of polyacrylate polyether pre-polymer
US4862359A (en) * 1984-08-31 1989-08-29 Bio-Logic Systems Corporation Topographical mapping of brain functionality from neuropsychological test results
US4793357A (en) * 1986-11-24 1988-12-27 Picker International, Inc. CT blood flow mapping with xenon gas enhancement
US4996041A (en) * 1988-08-19 1991-02-26 Toshiyuki Arai Method for introducing oxygen-17 into tissue for imaging in a magnetic resonance imaging system
DE3828905A1 (de) * 1988-08-23 1990-03-15 Schering Ag Mittel bestehend aus cavitate oder clathrate bildenden wirt/gast-komplexen als kontrastmittel
US4971258A (en) 1988-08-26 1990-11-20 Ihi Master Metal Ltd. Method of making high-purity fine particles of reactive metals and manufacturing vessel therefor
US5039500A (en) 1988-11-18 1991-08-13 Kyodo Oxygen Co., Ltd. Process for producing xenon
US5773024A (en) 1989-12-22 1998-06-30 Imarx Pharmaceutical Corp. Container with multi-phase composition for use in diagnostic and therapeutic applications
US6088613A (en) * 1989-12-22 2000-07-11 Imarx Pharmaceutical Corp. Method of magnetic resonance focused surgical and therapeutic ultrasound
US5046498A (en) * 1991-01-16 1991-09-10 Union Carbide Industrial Gases Technology Corporation Magnetic resonance human medical and veterinary imaging method
US5186924A (en) * 1991-01-16 1993-02-16 Praxair Technology Inc. Magnetic resonance human medical and veterinary imaging method
US5647361A (en) * 1992-09-28 1997-07-15 Fonar Corporation Magnetic resonance imaging method and apparatus for guiding invasive therapy
US6280383B1 (en) * 1993-03-01 2001-08-28 Fonar Corporation Magnetic resonance imaging
US5357959A (en) * 1993-04-16 1994-10-25 Praxair Technology, Inc. Altered dipole moment magnetic resonance imaging method
US5433196A (en) * 1993-06-02 1995-07-18 The Board Of Trustees Of The University Of Illinois Oxygen-17 NMR spectroscopy and imaging in the human
US5545396A (en) * 1994-04-08 1996-08-13 The Research Foundation Of State University Of New York Magnetic resonance imaging using hyperpolarized noble gases
FR2744932B1 (fr) * 1996-02-16 1998-04-30 Centre Nat Rech Scient Installation et procede pour la production d'helium-3 polarise en phase vapeur, en particulier pour l'imagerie par rmn
US5809801A (en) * 1996-03-29 1998-09-22 The Trustees Of Princeton University Cryogenic accumulator for spin-polarized xenon-129
FI982069A7 (fi) * 1996-03-29 1998-11-10 Lawrence Berkeley Nat Laboratory NMR:n ja MRI:n tehostaminen hyperpolaroitujen jalokaasujen läsnä olles sa
DE19619471C1 (de) * 1996-05-14 1997-10-16 Siemens Ag Kernspintomographiegerät mit Vorpolarisation
EP0951650B1 (de) * 1997-01-08 2003-12-10 Amersham Health AS Verfahren zur bilderzeugung mit magnetischer resonanz

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US5785953A (en) 1998-07-28
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US5545396A (en) 1996-08-13
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