ATE125819T1 - Enzymatischer prozess zur herstellung immunomodulatorischer pentapeptide und intermediate zu deren herstellung. - Google Patents

Enzymatischer prozess zur herstellung immunomodulatorischer pentapeptide und intermediate zu deren herstellung.

Info

Publication number: ATE125819T1
Authority: AT; Austria
Prior art keywords: amino acid; acid residue; amino; omega; derivative
Prior art date: 1988-01-14

Application number

AT89300369T

Other languages

English (en)

Inventor

Stig Aasmul-Olsen

Anders J Andersen

Original Assignee

Carlbiotech Ltd As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-01-14

Filing date

1989-01-16

Publication date

1995-08-15

1989-01-16 Application filed by Carlbiotech Ltd As filed Critical Carlbiotech Ltd As

1995-08-15 Application granted granted Critical

1995-08-15 Publication of ATE125819T1 publication Critical patent/ATE125819T1/de

Links

238000000034 method Methods 0.000 title abstract 3
230000002255 enzymatic effect Effects 0.000 title abstract 2
230000002519 immonomodulatory effect Effects 0.000 title abstract 2
238000005859 coupling reaction Methods 0.000 abstract 4
150000008574 D-amino acids Chemical group 0.000 abstract 3
230000008878 coupling Effects 0.000 abstract 3
238000010168 coupling process Methods 0.000 abstract 3
108090000765 processed proteins & peptides Proteins 0.000 abstract 3
150000008575 L-amino acids Chemical group 0.000 abstract 2
108091005804 Peptidases Proteins 0.000 abstract 2
102000035195 Peptidases Human genes 0.000 abstract 2
125000001931 aliphatic group Chemical group 0.000 abstract 2
150000001413 amino acids Chemical class 0.000 abstract 2
125000003710 aryl alkyl group Chemical group 0.000 abstract 2
230000015572 biosynthetic process Effects 0.000 abstract 2
230000002209 hydrophobic effect Effects 0.000 abstract 2
108010004032 Bromelains Proteins 0.000 abstract 1
102000005572 Cathepsin A Human genes 0.000 abstract 1
108010059081 Cathepsin A Proteins 0.000 abstract 1
108090000790 Enzymes Proteins 0.000 abstract 1
102000004190 Enzymes Human genes 0.000 abstract 1
ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 abstract 1
102000015636 Oligopeptides Human genes 0.000 abstract 1
108010038807 Oligopeptides Proteins 0.000 abstract 1
102000016387 Pancreatic elastase Human genes 0.000 abstract 1
108010067372 Pancreatic elastase Proteins 0.000 abstract 1
239000004365 Protease Substances 0.000 abstract 1
108090000787 Subtilisin Proteins 0.000 abstract 1
108090001109 Thermolysin Proteins 0.000 abstract 1
102400000160 Thymopentin Human genes 0.000 abstract 1
101800001703 Thymopentin Proteins 0.000 abstract 1
102000004142 Trypsin Human genes 0.000 abstract 1
108090000631 Trypsin Proteins 0.000 abstract 1
230000002378 acidificating effect Effects 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
150000003862 amino acid derivatives Chemical class 0.000 abstract 1
125000000539 amino acid group Chemical group 0.000 abstract 1
239000012736 aqueous medium Substances 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
235000019835 bromelain Nutrition 0.000 abstract 1
238000012412 chemical coupling Methods 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
239000012634 fragment Substances 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1
230000002194 synthesizing effect Effects 0.000 abstract 1
PSWFFKRAVBDQEG-YGQNSOCVSA-N thymopentin Chemical compound NC(N)=NCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](C(O)=O)CC1=CC=C(O)C=C1 PSWFFKRAVBDQEG-YGQNSOCVSA-N 0.000 abstract 1
229960004517 thymopentin Drugs 0.000 abstract 1
239000012588 trypsin Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/66—Thymopoietins
- C07K14/662—Thymopoietins at least 1 amino acid in D-form

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Biophysics (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Biochemistry (AREA)
Toxicology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Endocrinology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)

AT89300369T 1988-01-14 1989-01-16 Enzymatischer prozess zur herstellung immunomodulatorischer pentapeptide und intermediate zu deren herstellung. ATE125819T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DK015888A DK15888D0 (da)	1988-01-14	1988-01-14	Enzymatisk fremgangsmaade til fremstilling af immunmodulerende pentapeptider samt mellemprodukter til brug ved fremgangsmaaden

Publications (1)

Publication Number	Publication Date
ATE125819T1 true ATE125819T1 (de)	1995-08-15

Family

ID=8090415

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT89300369T ATE125819T1 (de)	1988-01-14	1989-01-16	Enzymatischer prozess zur herstellung immunomodulatorischer pentapeptide und intermediate zu deren herstellung.

Country Status (9)

Country	Link
EP (1)	EP0324659B1 (de)
AT (1)	ATE125819T1 (de)
AU (1)	AU2943989A (de)
DE (1)	DE68923625T2 (de)
DK (2)	DK15888D0 (de)
ES (1)	ES2079374T3 (de)
HU (1)	HUT57794A (de)
IT (1)	IT1223774B (de)
WO (1)	WO1989006656A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6461834B1 (en)	1998-11-06	2002-10-08	Bionebraska, Inc.	Clostripain catalyzed amidation of peptides
MXPA04007408A (es) *	2003-05-17	2005-08-15	Microsoft Corp	Sistema y metodo para proporcionar interpretaciones multiples de contenido de documento.
KR20100058559A (ko) *	2007-09-11	2010-06-03	몬도바이오테크 래보래토리즈 아게	스플레노펜틴 및 티모펜틴의 배합물 및 약제에서 이의 용도
US20100204149A1 (en) *	2007-09-11	2010-08-12	Dorian Bevec	Use of octreotide as a therapeutic agent
CA2698980A1 (en) *	2007-09-11	2009-03-19	Mondobiotech Laboratories Ag	Use of a peptide as a therapeutic agent
HRP20171478T1 (hr)	2011-01-27	2017-11-17	Neuren Pharmaceuticals Limited	Liječenje poremećaja autističnog spektra pomoću glicil-l-2-metilprolil-l-glutaminske kiseline
CN119753067B (zh) *	2024-12-25	2025-12-19	河北保食健健康科技有限公司	一种提高免疫力的小牛胸腺肽及其制备方法和应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1184770C2 (de) *	1961-06-01	1965-09-02	Hoffmann La Roche	Verfahren zur Herstellung von antibacteriell wirksamen Peptiden
FI40902B (de) *	1962-10-12	1969-03-31	Hoffmann La Roche
JPS5443076B2 (de) *	1974-04-24	1979-12-18
FR2294715A1 (fr) *	1974-12-17	1976-07-16	Inst Rech Scient	Nouveau peptide utilisable en therapeutique et son procede d'obtention
FI70597C (fi) *	1979-04-06	1986-09-24	Carlsberg Biotechnology Ltd	Foerfarande foer enzymatisk framstaellning av peptider
US4361673A (en) *	1980-09-19	1982-11-30	American Home Products Corporation	Polypeptide compositions
HU185263B (en) *	1981-06-12	1984-12-28	Richter Gedeon Vegyeszet	Process for producing peptides effective on the immuncontroll analogous with the tp5
JPS5917997A (ja) *	1982-07-23	1984-01-30	Toyo Soda Mfg Co Ltd	ジペプチドエステルとアミノ酸エステルとの付加化合物の製造方法
IT1188645B (it) *	1986-04-09	1988-01-20	Ellem Ind Farmaceutica	Tripeptide ad attivita' immunostimolante
DE3619633A1 (de) *	1986-06-11	1987-12-17	Hoechst Ag	Peptide mit einfluss auf die diurese und natriurese, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung
EP0288965A2 (de) *	1987-04-29	1988-11-02	Hoechst Aktiengesellschaft	Peptide mit Phospholipase A2- hemmender Wirkung

1988
- 1988-01-14 DK DK015888A patent/DK15888D0/da not_active Application Discontinuation
- 1988-08-12 IT IT67761/88A patent/IT1223774B/it active
1989
- 1989-01-16 EP EP89300369A patent/EP0324659B1/de not_active Expired - Lifetime
- 1989-01-16 WO PCT/DK1989/000005 patent/WO1989006656A1/en not_active Ceased
- 1989-01-16 AU AU29439/89A patent/AU2943989A/en not_active Abandoned
- 1989-01-16 ES ES89300369T patent/ES2079374T3/es not_active Expired - Lifetime
- 1989-01-16 AT AT89300369T patent/ATE125819T1/de not_active IP Right Cessation
- 1989-01-16 DE DE68923625T patent/DE68923625T2/de not_active Expired - Lifetime
- 1989-01-16 HU HU89937A patent/HUT57794A/hu unknown
1990
- 1990-07-13 DK DK169090A patent/DK169090A/da not_active Application Discontinuation

Also Published As

Publication number	Publication date
WO1989006656A1 (en)	1989-07-27
DE68923625D1 (de)	1995-09-07
HU890937D0 (en)	1991-11-28
AU2943989A (en)	1989-08-11
HUT57794A (en)	1991-12-30
DK15888D0 (da)	1988-01-14
DK169090D0 (da)	1990-07-13
DK169090A (da)	1990-09-14
ES2079374T3 (es)	1996-01-16
EP0324659A3 (de)	1991-04-03
EP0324659B1 (de)	1995-08-02
DE68923625T2 (de)	1996-03-28
IT1223774B (it)	1990-09-29
EP0324659A2 (de)	1989-07-19
IT8867761A0 (it)	1988-08-12

Legal Events

Date	Code	Title	Description
1996-04-15	UEP	Publication of translation of european patent specification
2009-04-15	EELA	Cancelled due to lapse of time

Publication	Publication Date	Title
EP0017485B1 (de)	1984-09-26	Verfahren zur enzymatischen Herstellung von Peptiden
WO1995020039B1 (en)	1996-05-30	Customized proteases with altered transacylation activity
HUT54213A (en)	1991-01-28	Process for the enzymatic removal of n-terminal sequence of proteins
WO2005027953A3 (en)	2005-06-16	Use of proline specific endoproteases to hydrolyse peptides and proteins
US4086136A (en)	1978-04-25	Process for producing a peptide using a serine or thiol proteinase
WO1995020039A3 (en)	1996-03-21	Customized proteases with altered transacylation activity
EP1005526A4 (de)	2005-02-09	Direkte expression von peptiden ins kulturmedium.
TW242165B (de)	1995-03-01
ATE125819T1 (de)	1995-08-15	Enzymatischer prozess zur herstellung immunomodulatorischer pentapeptide und intermediate zu deren herstellung.
DE69739013D1 (de)	2008-11-13	Verfahren zur Herstellung sekretorischer KEX2-Derivate
Shui-Tein et al.	1991	Stable industrial protease catalyzed peptide bond formation in organic solvent.
WO1999002708A8 (en)	1999-04-01	Fusion proteins comprising sequences derived from bovine if1 atpase inhibitor protein
AU589289B2 (en)	1989-10-05	Novel inhibitor peptides
CA1059938A (en)	1979-08-07	Process for producing a peptide
ATE101616T1 (de)	1994-03-15	Verfahren zur herstellung von dipeptiden.
EP0945512A3 (de)	2002-01-16	Serinproteasen
Shibata et al.	1984	A novel type of substrate specificity of rice BAPAase (benzoyl-L-arginine p-nitroanilide hydrolase) with mixed endopeptidase and carboxypeptidase
NO157706B (no)	1988-01-25	Fremgangsmÿte for enzymatisk fremstilling av peptider.
IT1214410B (it)	1990-01-18	Metodo di ottenimento di n-formil-l-peptidi