DK169090A - Enzymatisk fremgangsmaade til fremstilling af immunmodulerende pentapeptider samt mellemprodukter til brug ved fremgangsmaaden - Google Patents

Enzymatisk fremgangsmaade til fremstilling af immunmodulerende pentapeptider samt mellemprodukter til brug ved fremgangsmaaden Download PDF

Info

Publication number: DK169090A
Authority: DK; Denmark
Prior art keywords: amino acid; acid residue; amino; omega; derivative
Prior art date: 1988-01-14

Application number

DK169090A

Other languages

English (en)

Other versions

DK169090D0 (da

Inventor

Stig Aasmul-Olsen

Anders J Andersen

Original Assignee

Carlsberg Biotechnology Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-01-14

Filing date

1990-07-13

Publication date

1990-09-14

1990-07-13 Application filed by Carlsberg Biotechnology Ltd filed Critical Carlsberg Biotechnology Ltd

1990-07-13 Publication of DK169090D0 publication Critical patent/DK169090D0/da

1990-09-14 Publication of DK169090A publication Critical patent/DK169090A/da

Links

238000000034 method Methods 0.000 title abstract 4
230000002255 enzymatic effect Effects 0.000 title abstract 2
230000002519 immonomodulatory effect Effects 0.000 title abstract 2
239000000543 intermediate Substances 0.000 title abstract 2
238000005859 coupling reaction Methods 0.000 abstract 4
150000008574 D-amino acids Chemical group 0.000 abstract 3
230000008878 coupling Effects 0.000 abstract 3
238000010168 coupling process Methods 0.000 abstract 3
108090000765 processed proteins & peptides Proteins 0.000 abstract 3
150000008575 L-amino acids Chemical group 0.000 abstract 2
108091005804 Peptidases Proteins 0.000 abstract 2
102000035195 Peptidases Human genes 0.000 abstract 2
125000001931 aliphatic group Chemical group 0.000 abstract 2
150000001413 amino acids Chemical class 0.000 abstract 2
125000003710 aryl alkyl group Chemical group 0.000 abstract 2
230000015572 biosynthetic process Effects 0.000 abstract 2
230000002209 hydrophobic effect Effects 0.000 abstract 2
108010004032 Bromelains Proteins 0.000 abstract 1
102000005572 Cathepsin A Human genes 0.000 abstract 1
108010059081 Cathepsin A Proteins 0.000 abstract 1
108090000790 Enzymes Proteins 0.000 abstract 1
102000004190 Enzymes Human genes 0.000 abstract 1
ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 abstract 1
102000015636 Oligopeptides Human genes 0.000 abstract 1
108010038807 Oligopeptides Proteins 0.000 abstract 1
102000016387 Pancreatic elastase Human genes 0.000 abstract 1
108010067372 Pancreatic elastase Proteins 0.000 abstract 1
239000004365 Protease Substances 0.000 abstract 1
108090000787 Subtilisin Proteins 0.000 abstract 1
108090001109 Thermolysin Proteins 0.000 abstract 1
102400000160 Thymopentin Human genes 0.000 abstract 1
101800001703 Thymopentin Proteins 0.000 abstract 1
102000004142 Trypsin Human genes 0.000 abstract 1
108090000631 Trypsin Proteins 0.000 abstract 1
230000002378 acidificating effect Effects 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
150000003862 amino acid derivatives Chemical class 0.000 abstract 1
125000000539 amino acid group Chemical group 0.000 abstract 1
239000012736 aqueous medium Substances 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
235000019835 bromelain Nutrition 0.000 abstract 1
238000012412 chemical coupling Methods 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
239000012634 fragment Substances 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1
230000002194 synthesizing effect Effects 0.000 abstract 1
PSWFFKRAVBDQEG-YGQNSOCVSA-N thymopentin Chemical compound NC(N)=NCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](C(O)=O)CC1=CC=C(O)C=C1 PSWFFKRAVBDQEG-YGQNSOCVSA-N 0.000 abstract 1
229960004517 thymopentin Drugs 0.000 abstract 1
239000012588 trypsin Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/66—Thymopoietins
- C07K14/662—Thymopoietins at least 1 amino acid in D-form

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Biophysics (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Biochemistry (AREA)
Toxicology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Endocrinology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)

DK169090A 1988-01-14 1990-07-13 Enzymatisk fremgangsmaade til fremstilling af immunmodulerende pentapeptider samt mellemprodukter til brug ved fremgangsmaaden DK169090A (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DK015888A DK15888D0 (da)	1988-01-14	1988-01-14	Enzymatisk fremgangsmaade til fremstilling af immunmodulerende pentapeptider samt mellemprodukter til brug ved fremgangsmaaden
PCT/DK1989/000005 WO1989006656A1 (en)	1988-01-14	1989-01-16	Enzymatic process for producing immunomodulating pentapeptides and intermediates for use in the process

Publications (2)

Publication Number	Publication Date
DK169090D0 DK169090D0 (da)	1990-07-13
DK169090A true DK169090A (da)	1990-09-14

Family

ID=8090415

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK015888A DK15888D0 (da)	1988-01-14	1988-01-14	Enzymatisk fremgangsmaade til fremstilling af immunmodulerende pentapeptider samt mellemprodukter til brug ved fremgangsmaaden
DK169090A DK169090A (da)	1988-01-14	1990-07-13	Enzymatisk fremgangsmaade til fremstilling af immunmodulerende pentapeptider samt mellemprodukter til brug ved fremgangsmaaden

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK015888A DK15888D0 (da)	1988-01-14	1988-01-14	Enzymatisk fremgangsmaade til fremstilling af immunmodulerende pentapeptider samt mellemprodukter til brug ved fremgangsmaaden

Country Status (9)

Country	Link
EP (1)	EP0324659B1 (da)
AT (1)	ATE125819T1 (da)
AU (1)	AU2943989A (da)
DE (1)	DE68923625T2 (da)
DK (2)	DK15888D0 (da)
ES (1)	ES2079374T3 (da)
HU (1)	HUT57794A (da)
IT (1)	IT1223774B (da)
WO (1)	WO1989006656A1 (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6461834B1 (en)	1998-11-06	2002-10-08	Bionebraska, Inc.	Clostripain catalyzed amidation of peptides
WO2004107214A1 (en) *	2003-05-17	2004-12-09	Microsoft Corporation	System and method for providing multiple renditions of document content
WO2009033660A2 (en) *	2007-09-11	2009-03-19	Mondobiotech Laboratories Ag	Use of octreotide as a therapeutic agent
EP2185181A2 (en) *	2007-09-11	2010-05-19	Mondobiotech Laboratories AG	Therapeutic uses of gastrin-1 and g-pen-grgdspca
EP2187918A2 (en) *	2007-09-11	2010-05-26	Mondobiotech Laboratories AG	Combination of splenopentin and thymopentin and the use thereof in medicine
US9708366B2 (en)	2011-01-27	2017-07-18	Neuren Pharmaceuticals Ltd.	Treatment of fragile X syndrome using glycyl-L-2-methylprolyl-L-glutamate
CN119753067B (zh) *	2024-12-25	2025-12-19	河北保食健健康科技有限公司	一种提高免疫力的小牛胸腺肽及其制备方法和应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1184770C2 (de) *	1961-06-01	1965-09-02	Hoffmann La Roche	Verfahren zur Herstellung von antibacteriell wirksamen Peptiden
FI40902B (da) *	1962-10-12	1969-03-31	Hoffmann La Roche
JPS5443076B2 (da) *	1974-04-24	1979-12-18
FR2294715A1 (fr) *	1974-12-17	1976-07-16	Inst Rech Scient	Nouveau peptide utilisable en therapeutique et son procede d'obtention
FI70597C (fi) *	1979-04-06	1986-09-24	Carlsberg Biotechnology Ltd	Foerfarande foer enzymatisk framstaellning av peptider
US4361673A (en) *	1980-09-19	1982-11-30	American Home Products Corporation	Polypeptide compositions
HU185263B (en) *	1981-06-12	1984-12-28	Richter Gedeon Vegyeszet	Process for producing peptides effective on the immuncontroll analogous with the tp5
JPS5917997A (ja) *	1982-07-23	1984-01-30	Toyo Soda Mfg Co Ltd	ジペプチドエステルとアミノ酸エステルとの付加化合物の製造方法
IT1188645B (it) *	1986-04-09	1988-01-20	Ellem Ind Farmaceutica	Tripeptide ad attivita' immunostimolante
DE3619633A1 (de) *	1986-06-11	1987-12-17	Hoechst Ag	Peptide mit einfluss auf die diurese und natriurese, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung
EP0288965A2 (de) *	1987-04-29	1988-11-02	Hoechst Aktiengesellschaft	Peptide mit Phospholipase A2- hemmender Wirkung

1988
- 1988-01-14 DK DK015888A patent/DK15888D0/da not_active Application Discontinuation
- 1988-08-12 IT IT67761/88A patent/IT1223774B/it active
1989
- 1989-01-16 WO PCT/DK1989/000005 patent/WO1989006656A1/en not_active Ceased
- 1989-01-16 HU HU89937A patent/HUT57794A/hu unknown
- 1989-01-16 AT AT89300369T patent/ATE125819T1/de not_active IP Right Cessation
- 1989-01-16 DE DE68923625T patent/DE68923625T2/de not_active Expired - Lifetime
- 1989-01-16 ES ES89300369T patent/ES2079374T3/es not_active Expired - Lifetime
- 1989-01-16 AU AU29439/89A patent/AU2943989A/en not_active Abandoned
- 1989-01-16 EP EP89300369A patent/EP0324659B1/en not_active Expired - Lifetime
1990
- 1990-07-13 DK DK169090A patent/DK169090A/da not_active Application Discontinuation

Also Published As

Publication number	Publication date
DE68923625T2 (de)	1996-03-28
EP0324659A3 (en)	1991-04-03
EP0324659B1 (en)	1995-08-02
DE68923625D1 (de)	1995-09-07
ATE125819T1 (de)	1995-08-15
HU890937D0 (en)	1991-11-28
HUT57794A (en)	1991-12-30
IT8867761A0 (it)	1988-08-12
EP0324659A2 (en)	1989-07-19
IT1223774B (it)	1990-09-29
WO1989006656A1 (en)	1989-07-27
AU2943989A (en)	1989-08-11
ES2079374T3 (es)	1996-01-16
DK15888D0 (da)	1988-01-14
DK169090D0 (da)	1990-07-13

Legal Events

Date	Code	Title
1994-08-08	B1	Patent granted (law 1993)
2000-04-10	PBP	Patent lapsed
2003-02-24	AHS	Application shelved for other reasons than non-payment

Publication	Publication Date	Title
EP0017485B1 (en)	1984-09-26	A process for enzymatic production of peptides
WO1995020039B1 (en)	1996-05-30	Customized proteases with altered transacylation activity
HUT54213A (en)	1991-01-28	Process for the enzymatic removal of n-terminal sequence of proteins
Polgar et al.	1987	Dissociation of ionizing groups in the binding cleft inversely controls the endo-and exopeptidase activities of cathepsin B.
ATE484572T1 (de)	2010-10-15	Direkte expression von peptiden ins kulturmedium
DK0518999T3 (da)	1995-12-18	Proteinhydrolysater
US4086136A (en)	1978-04-25	Process for producing a peptide using a serine or thiol proteinase
EP0308067A3 (en)	1989-07-26	Alpha-amidating enzyme compositions and processes for their production and use
EP0387231A3 (en)	1991-05-02	Novel inhibitors of retroviral protease
AU1003888A (en)	1988-09-01	Pancreatic secretory trypsin inhibitor and variants thereof produced by a recombinant host, process, expression vector and recombinant host therefore and pharmaceutical use thereof
CA2281956A1 (en)	1992-04-25	A novel protease
DK169090D0 (da)	1990-07-13	Enzymatisk fremgangsmaade til fremstilling af immunmodulerende pentapeptider samt mellemprodukter til brug ved fremgangsmaaden
WO1999002708A8 (en)	1999-04-01	Fusion proteins comprising sequences derived from bovine if1 atpase inhibitor protein
AU589289B2 (en)	1989-10-05	Novel inhibitor peptides
Shui-Tein et al.	1991	Stable industrial protease catalyzed peptide bond formation in organic solvent.
Tai	2003	Enzymatic peptide synthesis: From the substrate point of view
CA1059938A (en)	1979-08-07	Process for producing a peptide
DK0534992T3 (da)	1996-01-22	Fremgangsmåde til fremstilling af peptider
Shibata et al.	1984	A novel type of substrate specificity of rice BAPAase (benzoyl-L-arginine p-nitroanilide hydrolase) with mixed endopeptidase and carboxypeptidase
NO157706B (no)	1988-01-25	Fremgangsmÿte for enzymatisk fremstilling av peptider.
EP0945512A3 (en)	2002-01-16	Novel serine proteases
Miyazawa et al.	2008	Peptide synthesis using carbamoylmethyl esters as acyl donors mediated by Bacillus amyloliquefaciens protease
IT1214410B (it)	1990-01-18	Metodo di ottenimento di n-formil-l-peptidi
DK155613B (da)	1989-04-24	Fremgangsmaade til enzymatisk fremstilling af peptider