ATE126696T1 - Regulierung der retroviralen replikation, infektion und pathogenese. - Google Patents

Regulierung der retroviralen replikation, infektion und pathogenese.

Info

Publication number: ATE126696T1
Authority: AT; Austria
Prior art keywords: infection; pathogenesis; regulation; glucosidase; infected cells
Prior art date: 1985-12-23

Application number

AT87900752T

Other languages

English (en)

Inventor

Larry R Rohrschneider

Original Assignee

Hutchinson Fred Cancer Res

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-12-23

Filing date

1986-11-26

Publication date

1995-09-15

1986-11-26 Application filed by Hutchinson Fred Cancer Res filed Critical Hutchinson Fred Cancer Res

1995-09-15 Application granted granted Critical

1995-09-15 Publication of ATE126696T1 publication Critical patent/ATE126696T1/de

Links

208000015181 infectious disease Diseases 0.000 title abstract 2
230000010076 replication Effects 0.000 title abstract 2
230000001177 retroviral effect Effects 0.000 title abstract 2
230000008506 pathogenesis Effects 0.000 title 1
102100025315 Mannosyl-oligosaccharide glucosidase Human genes 0.000 abstract 2
108010050669 glucosidase I Proteins 0.000 abstract 2
239000003112 inhibitor Substances 0.000 abstract 2
208000030507 AIDS Diseases 0.000 abstract 1
JDVVGAQPNNXQDW-WCMLQCRESA-N Castanospermine Natural products O[C@H]1[C@@H](O)[C@H]2[C@@H](O)CCN2C[C@H]1O JDVVGAQPNNXQDW-WCMLQCRESA-N 0.000 abstract 1
JDVVGAQPNNXQDW-TVNFTVLESA-N Castinospermine Chemical compound C1[C@H](O)[C@@H](O)[C@H](O)[C@H]2[C@@H](O)CCN21 JDVVGAQPNNXQDW-TVNFTVLESA-N 0.000 abstract 1
208000004729 Feline Leukemia Diseases 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
108010078428 env Gene Products Proteins 0.000 abstract 1
244000052769 pathogen Species 0.000 abstract 1
230000001717 pathogenic effect Effects 0.000 abstract 1
231100000255 pathogenic effect Toxicity 0.000 abstract 1
229940124597 therapeutic agent Drugs 0.000 abstract 1
241001430294 unidentified retrovirus Species 0.000 abstract 1
210000002845 virion Anatomy 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine

Landscapes

Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Saccharide Compounds (AREA)

AT87900752T 1985-12-23 1986-11-26 Regulierung der retroviralen replikation, infektion und pathogenese. ATE126696T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US81293785A	1985-12-23	1985-12-23
PCT/US1986/002586 WO1987003903A1 (en)	1985-12-23	1986-11-26	Regulating retroviral replication, infection, and pathogenesis

Publications (1)

Publication Number	Publication Date
ATE126696T1 true ATE126696T1 (de)	1995-09-15

Family

ID=37103004

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT87900752T ATE126696T1 (de)	1985-12-23	1986-11-26	Regulierung der retroviralen replikation, infektion und pathogenese.

Country Status (8)

Country	Link
US (2)	US5264356A (de)
EP (1)	EP0252962B1 (de)
JP (1)	JPS63501925A (de)
AT (1)	ATE126696T1 (de)
AU (1)	AU599381B2 (de)
CA (1)	CA1306951C (de)
DE (1)	DE3650377T2 (de)
WO (1)	WO1987003903A1 (de)

Families Citing this family (77)

* Cited by examiner, † Cited by third party
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EP0282618A1 (de) *	1987-03-18	1988-09-21	Vereniging Het Nederlands Kanker Instituut	1-Deoxynojirimycin als Anti-HIV-Therapeutikum
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US4994572A (en) *	1989-10-12	1991-02-19	Monsanto Company	Synthesis of nojirimycin derivatives
US5030638A (en) *	1990-02-26	1991-07-09	G. D. Searle & Co.	Method of antiviral enhancement
US5536732A (en) *	1990-04-27	1996-07-16	Merrell Pharmaceuticals Inc.	N-derivatives of 1-deoxy nojirimycin
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US5248779A (en) *	1991-06-17	1993-09-28	Monsanto Company	Synthesis of nojirimycin derivatives
US5216168A (en) *	1992-04-01	1993-06-01	G. D. Searle & Co.	2- and 3- amino and azido derivatives of 1,5-iminosugars
US5268482A (en) *	1992-04-01	1993-12-07	G. D. Searle & Co.	2- and 3-sulfur derivatives of 1,5-iminosugars
US5331096A (en) *	1992-04-01	1994-07-19	G. D. Searle & Co.	2- and 3-sulfur derivatives of 1,5-iminosugars
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US6465488B1 (en)	1997-12-11	2002-10-15	Chancellor, Masters & Scholars Of The University Of Oxford	Inhibition of glycolipid biosynthesis
KR20010033028A (ko)	1997-12-11	2001-04-25	더 챈슬러 마스터즈 앤드 스칼라스 오브 더 유니버시티 오브 옥스포드	막-관련 바이러스 복제의 억제
DE69932154T2 (de)	1998-02-12	2007-05-31	G.D. Searle Llc, Chicago	Verwendung von n-substituirten-1,5-dideoxy-1,5-imino-d-glucitolen zur behandlung von hepatitis infektionen
US6689759B1 (en)	1998-02-12	2004-02-10	G. D. Searle & Co.	Methods of Treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy
US6274597B1 (en)	1998-06-01	2001-08-14	Mount Sinai School Of Medicine Of New York University	Method of enhancing lysosomal α-Galactosidase A
JP2003505501A (ja)	1999-02-12	2003-02-12	ジー・ディー・サール・アンド・カンパニー	肝炎ウィルス感染の処置のためのグルカミン化合物
ATE402701T1 (de) *	1999-02-12	2008-08-15	United Therapeutics Corp	N-(8,8,8-trifluorooctyl)-1,5-dideoxy-1,5-imino- - glucitol zur behandlung von hepatitis-virus- infektionen
ES2302697T3 (es)	1999-08-10	2008-08-01	The Chancellor, Masters And Scholars Of The University Of Oxford	Compuestos n-alquilicos de cadena larga y derivados oxa de los mismos y uso como composiciones antivirales.
JP2003522791A (ja) *	2000-02-14	2003-07-29	ファルマシアコーポレイション	肝炎ウイルス感染症治療用ｎ‐置換‐１，５‐ジデオキシ‐１，５‐イミノ‐ｄ‐グルシトール化合物の使用
US6462197B2 (en)	2000-03-31	2002-10-08	Board Of Trustees Of Michigan State University	Process for the preparation of 1,5-dideoxy-1,5-imino hexitols from oximes or imines
WO2003096985A2 (en) *	2002-05-15	2003-11-27	University Of Utah Research Foundation	3d structure of the tsg101 uev domain
US7342010B2 (en) *	2004-11-15	2008-03-11	Board Of Trustees Of Michigan State University	2-thiaquinolizidines and process for the preparation thereof
US20070099823A1 (en) *	2005-10-28	2007-05-03	Board Of Trustees Of The University Of Arkansas	Inhibitors of sporeforming pathogens and applications of the same
JP2009545621A (ja) *	2006-08-02	2009-12-24	ユナイテッドセラピューティクスコーポレーション	ウィルス感染症のリポソーム処置
US8097728B2 (en)	2007-04-30	2012-01-17	Philadelphia Health & Education Corporation	Iminosugar compounds with antiflavirus activity
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US9662347B2 (en)	2010-05-11	2017-05-30	Gachon University Of Industry-Academic Cooperation Foundation	Method for inhibiting the induction of cell death by inhibiting the synthesis or secretion of age-albumin in cells of the mononuclear phagocyte system
HUE037408T2 (hu)	2011-06-10	2018-08-28	Univ Oregon Health & Science	CMV glikoproteinek és rekombináns vektorok
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BE902199A (fr) *	1984-10-29	1985-07-31	Vira Tek Inc	Procede de traitement medical de maladies virales utilisant le 1-beta-d-ribofurannosyl-1, 2,4-triazole-3-carboxamide.
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US4837237A (en) *	1985-07-09	1989-06-06	Fred Hutchinson Cancer Research Center	Therapy using glucosidase processing inhibitors
DE3650377T2 (de) *	1985-12-23	1996-02-22	Hutchinson Fred Cancer Res	Regulierung der retroviralen replikation, infektion und pathogenese.
US4857315A (en) *	1986-09-29	1989-08-15	Mount Sinai Hospital Corporation	Compositions containing golgi alpha-mannosidase II inhibitors
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ATE183100T1 (de) *	1991-01-10	1999-08-15	Merrell Pharma Inc	Neuartige glukohydrolase-inhibitoren nützlich als antidiabetische, antivirale und antimetastatische mittel

1986
- 1986-11-26 DE DE3650377T patent/DE3650377T2/de not_active Expired - Fee Related
- 1986-11-26 WO PCT/US1986/002586 patent/WO1987003903A1/en not_active Ceased
- 1986-11-26 AT AT87900752T patent/ATE126696T1/de active
- 1986-11-26 JP JP62500706A patent/JPS63501925A/ja active Pending
- 1986-11-26 EP EP87900752A patent/EP0252962B1/de not_active Expired - Lifetime
- 1986-12-22 CA CA000525987A patent/CA1306951C/en not_active Expired - Lifetime
1987
- 1987-05-29 AU AU73623/87A patent/AU599381B2/en not_active Ceased
1991
- 1991-10-30 US US07/784,145 patent/US5264356A/en not_active Expired - Fee Related
1994
- 1994-11-03 US US08/334,188 patent/US5643888A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE3650377T2 (de)	1996-02-22
EP0252962A4 (en)	1992-09-09
DE3650377D1 (de)	1995-09-28
JPS63501925A (ja)	1988-08-04
CA1306951C (en)	1992-09-01
EP0252962A1 (de)	1988-01-20
US5264356A (en)	1993-11-23
US5643888A (en)	1997-07-01
WO1987003903A1 (en)	1987-07-02
AU7362387A (en)	1988-06-02
EP0252962B1 (de)	1995-08-23
AU599381B2 (en)	1990-07-19

Publication	Publication Date	Title
DE3650377D1 (de)	1995-09-28	Regulierung der retroviralen replikation, infektion und pathogenese.
ATE61050T1 (de)	1991-03-15	Pyridazinamine wirksam gegen viren.
ES554967A0 (es)	1987-12-16	Un procedimiento para preparar una formulacion farmaceutica que contiene un 2'3'-didesoxi-nucleosido.
ES2041729T3 (es)	1993-12-01	Dispositivo para secar madera aserrada.
TR199800720T2 (xx)	1998-09-21	Farnesil transferaz inhibe eden 2-kinolon t�revleri.
FI872864A0 (fi)	1987-06-29	Menetelmä farmaseuttisesti aktiivisten bentsimidatsolijohdannaisten valmistamiseksi
ES2192201T3 (es)	2003-10-01	Compuestos de piranona utiles para el tratamiento de infecciones retrovirales.
TR199700574T1 (xx)	1999-08-23	Molek�ler �aperon �retiminin haz�rlanmas� i�in yararl� hidroksilamin t�revleri ve bu t�revlerin haz�rlanmas�.
FI903866A0 (fi)	1990-08-03	Terapeutiskt aktiva albuminderivat.
ES2084702T3 (es)	1996-05-16	Imidazoles sustituidos utiles como inhibidores de la angiotensina ii.
ES472659A1 (es)	1979-10-16	Un procedimiento para la preparacion de nuevos derivados aminicos de polioles
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ES2058417T3 (es)	1994-11-01	Combinaciones herbicidas sinergisticas y metodo de aplicacion.
ATE14222T1 (de)	1985-07-15	Sekundaere aethanolamine, ihre herstellung und ihre verwendung in pharmazeutischen zusammensetzungen.
ES2045484T3 (es)	1994-01-16	Nuevos derivados de la vitamina d: aplicaciones terapeuticas y a las dosificaciones de los metabolitos de la vitamina d.
KR900005993A (ko)	1990-05-07	레트로바이러스에 의해 유발되는 질병 치료용 약제
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