ATE126801T1 - Neuroschützende cyclooctanmittel. - Google Patents

Neuroschützende cyclooctanmittel.

Info

Publication number
ATE126801T1
ATE126801T1 AT88202618T AT88202618T ATE126801T1 AT E126801 T1 ATE126801 T1 AT E126801T1 AT 88202618 T AT88202618 T AT 88202618T AT 88202618 T AT88202618 T AT 88202618T AT E126801 T1 ATE126801 T1 AT E126801T1
Authority
AT
Austria
Prior art keywords
hydroxy
alkyl
hydrogen
agents
fluoro
Prior art date
Application number
AT88202618T
Other languages
English (en)
Inventor
Raymond Baker
William R Carling
Kim James
Paul D Leeson
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Application granted granted Critical
Publication of ATE126801T1 publication Critical patent/ATE126801T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cephalosporin Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT88202618T 1987-11-30 1988-11-22 Neuroschützende cyclooctanmittel. ATE126801T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878727989A GB8727989D0 (en) 1987-11-30 1987-11-30 Therapeutic agents

Publications (1)

Publication Number Publication Date
ATE126801T1 true ATE126801T1 (de) 1995-09-15

Family

ID=10627761

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88202618T ATE126801T1 (de) 1987-11-30 1988-11-22 Neuroschützende cyclooctanmittel.

Country Status (8)

Country Link
US (1) US4927819A (de)
EP (1) EP0319073B1 (de)
JP (1) JP2791069B2 (de)
AT (1) ATE126801T1 (de)
CA (1) CA1336514C (de)
DE (1) DE3854343T2 (de)
DK (1) DK664888A (de)
GB (1) GB8727989D0 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU639722B2 (en) * 1989-10-27 1993-08-05 Astra Aktiebolag Use of arylalkylamides in the treatment of neurodegenerative diseases
GB9002834D0 (en) * 1990-02-08 1990-04-04 Ici America Inc Compounds
US8283358B2 (en) * 2008-09-05 2012-10-09 Elan Pharmaceuticals, Inc. N-sulfonamido polycyclic pyrazolyl compounds
CN103339127A (zh) * 2010-08-24 2013-10-02 Sgc制药股份有限公司 盐化合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7007464A (de) * 1969-05-30 1970-12-02
NL7808848A (nl) * 1977-09-19 1979-03-21 Merck & Co Inc Dibenzoa.dcyclo-octeen-5.12-(en 6.12)-iminen.
US4414154A (en) * 1977-09-19 1983-11-08 Merck & Co. Inc. Dibenzo[a,d]cycloocten-5,12-imines
IL59004A0 (en) * 1978-12-30 1980-03-31 Beecham Group Ltd Substituted benzamides their preparation and pharmaceutical compositions containing them
GB8600783D0 (en) * 1986-01-14 1986-02-19 Merck Sharp & Dohme N-methyl-d-aspartate receptor antagonists

Also Published As

Publication number Publication date
CA1336514C (en) 1995-08-01
DE3854343T2 (de) 1996-03-28
GB8727989D0 (en) 1988-01-06
EP0319073B1 (de) 1995-08-23
US4927819A (en) 1990-05-22
DK664888A (da) 1989-07-20
JP2791069B2 (ja) 1998-08-27
JPH01186890A (ja) 1989-07-26
EP0319073A2 (de) 1989-06-07
DK664888D0 (da) 1988-11-29
EP0319073A3 (en) 1990-12-19
DE3854343D1 (de) 1995-09-28

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Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties