ATE126801T1 - Neuroschützende cyclooctanmittel. - Google Patents

Neuroschützende cyclooctanmittel.

Info

Publication number: ATE126801T1
Authority: AT; Austria
Prior art keywords: hydroxy; alkyl; hydrogen; agents; fluoro
Prior art date: 1987-11-30

Application number

AT88202618T

Other languages

English (en)

Inventor

Raymond Baker

William R Carling

Kim James

Paul D Leeson

Original Assignee

Merck Sharp & Dohme

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-11-30

Filing date

1988-11-22

Publication date

1995-09-15

1988-11-22 Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme

1995-09-15 Application granted granted Critical

1995-09-15 Publication of ATE126801T1 publication Critical patent/ATE126801T1/de

Links

WJTCGQSWYFHTAC-UHFFFAOYSA-N cyclooctane Chemical compound C1CCCCCCC1 WJTCGQSWYFHTAC-UHFFFAOYSA-N 0.000 title 1
230000000324 neuroprotective effect Effects 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
125000000217 alkyl group Chemical group 0.000 abstract 3
150000002431 hydrogen Chemical class 0.000 abstract 3
239000004215 Carbon black (E152) Substances 0.000 abstract 2
125000003342 alkenyl group Chemical group 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000001153 fluoro group Chemical group F* 0.000 abstract 2
125000000623 heterocyclic group Chemical group 0.000 abstract 2
229930195733 hydrocarbon Natural products 0.000 abstract 2
150000002430 hydrocarbons Chemical class 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
-1 amino, hydroxy, carboxy Chemical group 0.000 abstract 1
125000004103 aminoalkyl group Chemical group 0.000 abstract 1
229940125681 anticonvulsant agent Drugs 0.000 abstract 1
239000001961 anticonvulsive agent Substances 0.000 abstract 1
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
208000015122 neurodegenerative disease Diseases 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Diabetes (AREA)
Neurology (AREA)
Hematology (AREA)
Endocrinology (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Hospice & Palliative Care (AREA)
Obesity (AREA)
Emergency Medicine (AREA)
Psychiatry (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Cephalosporin Compounds (AREA)
Steroid Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

AT88202618T 1987-11-30 1988-11-22 Neuroschützende cyclooctanmittel. ATE126801T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB878727989A GB8727989D0 (en)	1987-11-30	1987-11-30	Therapeutic agents

Publications (1)

Publication Number	Publication Date
ATE126801T1 true ATE126801T1 (de)	1995-09-15

Family

ID=10627761

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT88202618T ATE126801T1 (de)	1987-11-30	1988-11-22	Neuroschützende cyclooctanmittel.

Country Status (8)

Country	Link
US (1)	US4927819A (de)
EP (1)	EP0319073B1 (de)
JP (1)	JP2791069B2 (de)
AT (1)	ATE126801T1 (de)
CA (1)	CA1336514C (de)
DE (1)	DE3854343T2 (de)
DK (1)	DK664888A (de)
GB (1)	GB8727989D0 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU639722B2 (en) *	1989-10-27	1993-08-05	Astra Aktiebolag	Use of arylalkylamides in the treatment of neurodegenerative diseases
GB9002834D0 (en) *	1990-02-08	1990-04-04	Ici America Inc	Compounds
US8283358B2 (en) *	2008-09-05	2012-10-09	Elan Pharmaceuticals, Inc.	N-sulfonamido polycyclic pyrazolyl compounds
EP2609093B1 (de) *	2010-08-24	2018-10-17	SGC Pharma Inc.	Salzverbindung

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL7007464A (de) *	1969-05-30	1970-12-02
US4414154A (en) *	1977-09-19	1983-11-08	Merck & Co. Inc.	Dibenzo[a,d]cycloocten-5,12-imines
NL7808848A (nl) *	1977-09-19	1979-03-21	Merck & Co Inc	Dibenzoa.dcyclo-octeen-5.12-(en 6.12)-iminen.
IL59004A0 (en) *	1978-12-30	1980-03-31	Beecham Group Ltd	Substituted benzamides their preparation and pharmaceutical compositions containing them
GB8600783D0 (en) *	1986-01-14	1986-02-19	Merck Sharp & Dohme	N-methyl-d-aspartate receptor antagonists

1987
- 1987-11-30 GB GB878727989A patent/GB8727989D0/en active Pending
1988
- 1988-11-22 US US07/274,436 patent/US4927819A/en not_active Expired - Fee Related
- 1988-11-22 EP EP88202618A patent/EP0319073B1/de not_active Expired - Lifetime
- 1988-11-22 DE DE3854343T patent/DE3854343T2/de not_active Expired - Fee Related
- 1988-11-22 AT AT88202618T patent/ATE126801T1/de not_active IP Right Cessation
- 1988-11-25 CA CA000584238A patent/CA1336514C/en not_active Expired - Fee Related
- 1988-11-29 DK DK664888A patent/DK664888A/da not_active Application Discontinuation
- 1988-11-30 JP JP63301105A patent/JP2791069B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
GB8727989D0 (en)	1988-01-06
DK664888A (da)	1989-07-20
US4927819A (en)	1990-05-22
EP0319073A3 (en)	1990-12-19
EP0319073B1 (de)	1995-08-23
JPH01186890A (ja)	1989-07-26
EP0319073A2 (de)	1989-06-07
DK664888D0 (da)	1988-11-29
DE3854343D1 (de)	1995-09-28
DE3854343T2 (de)	1996-03-28
CA1336514C (en)	1995-08-01
JP2791069B2 (ja)	1998-08-27

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Legal Events

Date	Code	Title	Description
1996-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties