ATE127124T1 - 2'-fluorofuranosylderivate und verfahren zur herstellung von 2'-fluoropyrimidin- und 2'- fluoropurin-nucleosiden. - Google Patents

2'-fluorofuranosylderivate und verfahren zur herstellung von 2'-fluoropyrimidin- und 2'- fluoropurin-nucleosiden.

Info

Publication number: ATE127124T1
Authority: AT; Austria
Prior art keywords: formula; image; compound; under conditions; conditions effective
Prior art date: 1990-07-23

Application number

AT91915632T

Other languages

English (en)

Inventor

Victor E Marquez

John S Driscoll

Ronald J Wysocki Jr

Maqbool A Siddiqui

Original Assignee

Us Commerce

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-07-23

Filing date

1991-07-19

Publication date

1995-09-15

1991-07-19 Application filed by Us Commerce filed Critical Us Commerce

1995-09-15 Application granted granted Critical

1995-09-15 Publication of ATE127124T1 publication Critical patent/ATE127124T1/de

Links

238000004519 manufacturing process Methods 0.000 title 1
239000002777 nucleoside Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 5
QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
150000004820 halides Chemical class 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 1
229910015844 BCl3 Inorganic materials 0.000 abstract 1
241000725303 Human immunodeficiency virus Species 0.000 abstract 1
BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical compound [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
229910021529 ammonia Inorganic materials 0.000 abstract 1
230000036436 anti-hiv Effects 0.000 abstract 1
239000003153 chemical reaction reagent Substances 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
150000003212 purines Chemical class 0.000 abstract 1
150000003230 pyrimidines Chemical class 0.000 abstract 1
229910000077 silane Inorganic materials 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1
FAQYAMRNWDIXMY-UHFFFAOYSA-N trichloroborane Chemical compound ClB(Cl)Cl FAQYAMRNWDIXMY-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Virology (AREA)
Oncology (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Communicable Diseases (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT91915632T 1990-07-23 1991-07-19 2'-fluorofuranosylderivate und verfahren zur herstellung von 2'-fluoropyrimidin- und 2'- fluoropurin-nucleosiden. ATE127124T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/556,713 US5817799A (en)	1990-07-23	1990-07-23	2'-Fluorofuranosyl derivatives and methods for preparing 2'-fluoropyrimidine and 2'-fluoropurine nucleosides

Publications (1)

Publication Number	Publication Date
ATE127124T1 true ATE127124T1 (de)	1995-09-15

Family

ID=24222534

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91915632T ATE127124T1 (de)	1990-07-23	1991-07-19	2'-fluorofuranosylderivate und verfahren zur herstellung von 2'-fluoropyrimidin- und 2'- fluoropurin-nucleosiden.

Country Status (10)

Country	Link
US (2)	US5817799A (de)
EP (1)	EP0540686B1 (de)
JP (2)	JPH0714956B2 (de)
AT (1)	ATE127124T1 (de)
CA (1)	CA2087425C (de)
DE (1)	DE69112628T2 (de)
DK (1)	DK0540686T3 (de)
ES (1)	ES2080332T3 (de)
GR (1)	GR3017571T3 (de)
WO (1)	WO1992001700A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SG94686A1 (en) *	1992-06-22	2003-03-18	Lilly Co Eli	Stereoselective gylcosylation process
BR9302431A (pt) *	1992-06-22	1994-01-11	Lilly Co Eli	Processo de glicosilacao de anion estereosseletivo
UA41261C2 (uk) *	1992-06-22	2001-09-17	Елі Ліллі Енд Компані	Спосіб одержання збагачених бета-аномером нуклеозидів
AT400953B (de) *	1994-08-25	1996-05-28	Joern Saischek	Pentofuranosid-derivate, deren herstellung und verwendung
EA200700564A1 (ru) *	1998-02-25	2007-08-31	Эмори Юниверсити	2`-фторнуклеозиды
US6462191B1 (en) *	2000-07-13	2002-10-08	Air Products And Chemicals, Inc.	Synthesis of 2-deoxy-2-fluoro-arabinose derivatives
WO2003000200A2 (en)	2001-06-22	2003-01-03	Pharmasset Ltd.	β-2'-OR 3'-HALONUCLEOSIDES
EA200800932A1 (ru) *	2005-09-26	2008-10-30	Фармассет, Инк.	Модифицированные 4`-нуклеозиды в качестве противовирусных агентов
US8895531B2 (en) *	2006-03-23	2014-11-25	Rfs Pharma Llc	2′-fluoronucleoside phosphonates as antiviral agents
US20090274686A1 (en) *	2008-05-02	2009-11-05	Yat Sun Or	Nucleoside phosphonate derivatives

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4211773A (en) *	1978-10-02	1980-07-08	Sloan Kettering Institute For Cancer Research	5-Substituted 1-(2'-Deoxy-2'-substituted-β-D-arabinofuranosyl)pyrimidine nucleosides
US4625020A (en) *	1983-11-18	1986-11-25	Bristol-Myers Company	Nucleoside process
US4751221A (en) *	1985-10-18	1988-06-14	Sloan-Kettering Institute For Cancer Research	2-fluoro-arabinofuranosyl purine nucleosides
US4908440A (en) *	1987-11-12	1990-03-13	Bristol Myers Company	2',3'-dideoxy-2'-fluoroarabinopyrimidine nucleosides
GB8816345D0 (en) *	1988-07-08	1988-08-10	Hoffmann La Roche	Purine derivatives
FI105556B (fi) *	1991-09-30	2000-09-15	Sankyo Co	Menetelmä lääkeaineina käyttökelpoisten pyrimidiiniukleosidijohdannaisten valmistamiseksi, joilla on kasvaimen vastaista vaikutusta
US5594124A (en) *	1992-06-22	1997-01-14	Eli Lilly And Company	Stereoselective glycosylation process for preparing 2'-Deoxy-2',2'-difluoropyrimidine nucleosides and 2'-deoxy-2'-fluoropyrimidine nucleosides and intermediates thereof

1990
- 1990-07-23 US US07/556,713 patent/US5817799A/en not_active Expired - Fee Related
1991
- 1991-07-19 JP JP3514075A patent/JPH0714956B2/ja not_active Expired - Fee Related
- 1991-07-19 AT AT91915632T patent/ATE127124T1/de not_active IP Right Cessation
- 1991-07-19 WO PCT/US1991/005001 patent/WO1992001700A1/en not_active Ceased
- 1991-07-19 EP EP91915632A patent/EP0540686B1/de not_active Expired - Lifetime
- 1991-07-19 DK DK91915632.3T patent/DK0540686T3/da active
- 1991-07-19 CA CA002087425A patent/CA2087425C/en not_active Expired - Fee Related
- 1991-07-19 DE DE69112628T patent/DE69112628T2/de not_active Expired - Fee Related
- 1991-07-19 ES ES91915632T patent/ES2080332T3/es not_active Expired - Lifetime
1992
- 1992-10-29 US US07/968,567 patent/US5336764A/en not_active Expired - Lifetime
1995
- 1995-09-28 GR GR950402685T patent/GR3017571T3/el unknown
1996
- 1996-03-08 JP JP8080564A patent/JP2770162B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CA2087425A1 (en)	1992-01-24
WO1992001700A1 (en)	1992-02-06
EP0540686A1 (de)	1993-05-12
EP0540686A4 (en)	1993-05-26
AU8403991A (en)	1992-02-18
DE69112628D1 (de)	1995-10-05
US5817799A (en)	1998-10-06
EP0540686B1 (de)	1995-08-30
US5336764A (en)	1994-08-09
JP2770162B2 (ja)	1998-06-25
AU641545B2 (en)	1993-09-23
JPH06501927A (ja)	1994-03-03
DE69112628T2 (de)	1996-04-04
CA2087425C (en)	1998-08-04
ES2080332T3 (es)	1996-02-01
DK0540686T3 (da)	1995-12-27
JPH08333382A (ja)	1996-12-17
GR3017571T3 (en)	1995-12-31
JPH0714956B2 (ja)	1995-02-22

Legal Events

Date	Code	Title	Description
1996-03-15	UEP	Publication of translation of european patent specification
2008-04-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69330853D1 (de)	2001-11-08	Verfahren zur Herstellung von Aryl-piperazinyl-heterocyclischen Derivaten
ES8506324A1 (es)	1985-07-01	Procedimiento para la fabricacion de 4'-demetil-epipodofilotoxin-b-d-etiliden-glucosido y derivado acilico del mismo
ATE158568T1 (de)	1997-10-15	Verfahren zur herstellung von quaternären diestern
DE69224184D1 (de)	1998-02-26	Verfahren zur Herstellung von verbrückten, chiralen Metallocenkatalysatoren des Types Bisindenyl
ATE282020T1 (de)	2004-11-15	Verfahren zur herstellung von 2-aminomalonsäure- derivaten
ATE26263T1 (de)	1987-04-15	1-aryloxy-2,3,4,5-tetrahydro-3-benzazepine, verfahren zur herstellung derselben und ihre verwendung als heilmittel.
DE69112628D1 (de)	1995-10-05	2'-fluorofuranosylderivate und verfahren zur herstellung von 2'-fluoropyrimidin- und 2'-fluoropurin-nucleosiden.
ES2005746A6 (es)	1989-03-16	Un procedimiento para la preparacion de un haluro de piridinio.
ATE93521T1 (de)	1993-09-15	Verfahren zur herstellung von substituierten indolinonderivaten.
KR850000442A (ko)	1985-02-27	7-피페리디노-1,2,3,5-테트라하이드로 이미다조[2,1-b] 퀴나졸린-2-온의 제조방법
DE69632919D1 (de)	2004-08-19	Verfahren zur herstellung von 2-chlor-5-chloromethyl-thiazol
KR850001213A (ko)	1985-03-16	이미다조[1,5-a] 피리미딘 유도체의 제조방법
DE59009430D1 (de)	1995-08-31	Verfahren zur Herstellung von Organosiloxanen.
KR930010008A (ko)	1993-06-21	2-치환된 4,6-디알콕시피리미딘의 제조 방법
DE69531219D1 (de)	2003-08-07	Verfahren zur umwandlung von 2,4-dichlorpyridinen in 2-aryloxy-4-chlorpyridine
ATE8257T1 (de)	1984-07-15	Verfahren zur herstellung von 4-chinolinonen.
DE50004382D1 (de)	2003-12-18	Verfahren zur Herstellung von Guanidinderivaten
DE69605873D1 (de)	2000-02-03	Verfahren zur Herstellung von Isothiocyanat-Derivaten
JPS6440467A (en)	1989-02-10	Novel substituted diphenylimidazole derivative
DE3767618D1 (de)	1991-02-28	Verfahren zur herstellung von tetrafluorphthalsaeure.
DE59309077D1 (de)	1998-11-26	Verfahren zur Herstellung von 2-Halogen-4,6-dialkoxypyrimidinen
DE50107832D1 (de)	2005-12-01	Verfahren zur herstellung von chlorcarbonsäurechloriden
DE69130995D1 (de)	1999-04-22	Verfahren zur Herstellung von 5-Arylhydantoin
ATE25680T1 (de)	1987-03-15	Verfahren zur herstellung von 4-amino-5-dialkoxy- methylpyrimidinderivaten.
JPS5626895A (en)	1981-03-16	Preparation of silicon isocyanate compound