ATE127124T1 - 2'-fluorofuranosylderivate und verfahren zur herstellung von 2'-fluoropyrimidin- und 2'- fluoropurin-nucleosiden. - Google Patents

2'-fluorofuranosylderivate und verfahren zur herstellung von 2'-fluoropyrimidin- und 2'- fluoropurin-nucleosiden.

Info

Publication number: ATE127124T1
Authority: AT; Austria
Prior art keywords: formula; image; compound; under conditions; conditions effective
Prior art date: 1990-07-23

Application number

AT91915632T

Other languages

English (en)

Inventor

Victor E Marquez

John S Driscoll

Ronald J Wysocki Jr

Maqbool A Siddiqui

Original Assignee

Us Commerce

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-07-23

Filing date

1991-07-19

Publication date

1995-09-15

1991-07-19 Application filed by Us Commerce filed Critical Us Commerce

1995-09-15 Application granted granted Critical

1995-09-15 Publication of ATE127124T1 publication Critical patent/ATE127124T1/de

Links

238000004519 manufacturing process Methods 0.000 title 1
239000002777 nucleoside Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 5
QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
150000004820 halides Chemical class 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 1
229910015844 BCl3 Inorganic materials 0.000 abstract 1
241000725303 Human immunodeficiency virus Species 0.000 abstract 1
BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical compound [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
229910021529 ammonia Inorganic materials 0.000 abstract 1
230000036436 anti-hiv Effects 0.000 abstract 1
239000003153 chemical reaction reagent Substances 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
150000003212 purines Chemical class 0.000 abstract 1
150000003230 pyrimidines Chemical class 0.000 abstract 1
229910000077 silane Inorganic materials 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1
FAQYAMRNWDIXMY-UHFFFAOYSA-N trichloroborane Chemical compound ClB(Cl)Cl FAQYAMRNWDIXMY-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Virology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Tropical Medicine & Parasitology (AREA)
AIDS & HIV (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT91915632T 1990-07-23 1991-07-19 2'-fluorofuranosylderivate und verfahren zur herstellung von 2'-fluoropyrimidin- und 2'- fluoropurin-nucleosiden. ATE127124T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/556,713 US5817799A (en)	1990-07-23	1990-07-23	2'-Fluorofuranosyl derivatives and methods for preparing 2'-fluoropyrimidine and 2'-fluoropurine nucleosides

Publications (1)

Publication Number	Publication Date
ATE127124T1 true ATE127124T1 (de)	1995-09-15

Family

ID=24222534

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91915632T ATE127124T1 (de)	1990-07-23	1991-07-19	2'-fluorofuranosylderivate und verfahren zur herstellung von 2'-fluoropyrimidin- und 2'- fluoropurin-nucleosiden.

Country Status (10)

Country	Link
US (2)	US5817799A (de)
EP (1)	EP0540686B1 (de)
JP (2)	JPH0714956B2 (de)
AT (1)	ATE127124T1 (de)
CA (1)	CA2087425C (de)
DE (1)	DE69112628T2 (de)
DK (1)	DK0540686T3 (de)
ES (1)	ES2080332T3 (de)
GR (1)	GR3017571T3 (de)
WO (1)	WO1992001700A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
UA41261C2 (uk) *	1992-06-22	2001-09-17	Елі Ліллі Енд Компані	Спосіб одержання збагачених бета-аномером нуклеозидів
SG94686A1 (en) *	1992-06-22	2003-03-18	Lilly Co Eli	Stereoselective gylcosylation process
CZ123493A3 (en) *	1992-06-22	1994-02-16	Lilly Co Eli	Stereoselective anionic glycosylation process
AT400953B (de) *	1994-08-25	1996-05-28	Joern Saischek	Pentofuranosid-derivate, deren herstellung und verwendung
WO1999043691A1 (en) *	1998-02-25	1999-09-02	Emory University	2'-fluoronucleosides
US6462191B1 (en) *	2000-07-13	2002-10-08	Air Products And Chemicals, Inc.	Synthesis of 2-deoxy-2-fluoro-arabinose derivatives
EP1478322A4 (de)	2001-06-22	2007-08-08	Pharmasset Ltd	Beta-2'-OR 3'-HALONUCLEOSIDE
EA200800932A1 (ru) *	2005-09-26	2008-10-30	Фармассет, Инк.	Модифицированные 4`-нуклеозиды в качестве противовирусных агентов
US8895531B2 (en) *	2006-03-23	2014-11-25	Rfs Pharma Llc	2′-fluoronucleoside phosphonates as antiviral agents
US20090274686A1 (en) *	2008-05-02	2009-11-05	Yat Sun Or	Nucleoside phosphonate derivatives

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4211773A (en) *	1978-10-02	1980-07-08	Sloan Kettering Institute For Cancer Research	5-Substituted 1-(2'-Deoxy-2'-substituted-β-D-arabinofuranosyl)pyrimidine nucleosides
US4625020A (en) *	1983-11-18	1986-11-25	Bristol-Myers Company	Nucleoside process
US4751221A (en) *	1985-10-18	1988-06-14	Sloan-Kettering Institute For Cancer Research	2-fluoro-arabinofuranosyl purine nucleosides
US4908440A (en) *	1987-11-12	1990-03-13	Bristol Myers Company	2',3'-dideoxy-2'-fluoroarabinopyrimidine nucleosides
GB8816345D0 (en) *	1988-07-08	1988-08-10	Hoffmann La Roche	Purine derivatives
FI105556B (fi) *	1991-09-30	2000-09-15	Sankyo Co	Menetelmä lääkeaineina käyttökelpoisten pyrimidiiniukleosidijohdannaisten valmistamiseksi, joilla on kasvaimen vastaista vaikutusta
US5594124A (en) *	1992-06-22	1997-01-14	Eli Lilly And Company	Stereoselective glycosylation process for preparing 2'-Deoxy-2',2'-difluoropyrimidine nucleosides and 2'-deoxy-2'-fluoropyrimidine nucleosides and intermediates thereof

1990
- 1990-07-23 US US07/556,713 patent/US5817799A/en not_active Expired - Fee Related
1991
- 1991-07-19 JP JP3514075A patent/JPH0714956B2/ja not_active Expired - Fee Related
- 1991-07-19 EP EP91915632A patent/EP0540686B1/de not_active Expired - Lifetime
- 1991-07-19 AT AT91915632T patent/ATE127124T1/de not_active IP Right Cessation
- 1991-07-19 ES ES91915632T patent/ES2080332T3/es not_active Expired - Lifetime
- 1991-07-19 DK DK91915632.3T patent/DK0540686T3/da active
- 1991-07-19 DE DE69112628T patent/DE69112628T2/de not_active Expired - Fee Related
- 1991-07-19 CA CA002087425A patent/CA2087425C/en not_active Expired - Fee Related
- 1991-07-19 WO PCT/US1991/005001 patent/WO1992001700A1/en not_active Ceased
1992
- 1992-10-29 US US07/968,567 patent/US5336764A/en not_active Expired - Lifetime
1995
- 1995-09-28 GR GR950402685T patent/GR3017571T3/el unknown
1996
- 1996-03-08 JP JP8080564A patent/JP2770162B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JP2770162B2 (ja)	1998-06-25
DK0540686T3 (da)	1995-12-27
CA2087425A1 (en)	1992-01-24
JPH06501927A (ja)	1994-03-03
DE69112628T2 (de)	1996-04-04
JPH08333382A (ja)	1996-12-17
AU8403991A (en)	1992-02-18
WO1992001700A1 (en)	1992-02-06
CA2087425C (en)	1998-08-04
EP0540686B1 (de)	1995-08-30
GR3017571T3 (en)	1995-12-31
DE69112628D1 (de)	1995-10-05
EP0540686A1 (de)	1993-05-12
US5817799A (en)	1998-10-06
EP0540686A4 (en)	1993-05-26
JPH0714956B2 (ja)	1995-02-22
ES2080332T3 (es)	1996-02-01
US5336764A (en)	1994-08-09
AU641545B2 (en)	1993-09-23

Legal Events

Date	Code	Title	Description
1996-03-15	UEP	Publication of translation of european patent specification
2008-04-15	REN	Ceased due to non-payment of the annual fee

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