ES2080332T3 - Derivados de 2'-fluorofuranosil y nuevo procedimiento de preparacion de nucleosidos de 2'-fluoropirimidina y 2'-fluoropurina. - Google Patents

Derivados de 2'-fluorofuranosil y nuevo procedimiento de preparacion de nucleosidos de 2'-fluoropirimidina y 2'-fluoropurina.

Info

Publication number
ES2080332T3
ES2080332T3 ES91915632T ES91915632T ES2080332T3 ES 2080332 T3 ES2080332 T3 ES 2080332T3 ES 91915632 T ES91915632 T ES 91915632T ES 91915632 T ES91915632 T ES 91915632T ES 2080332 T3 ES2080332 T3 ES 2080332T3
Authority
ES
Spain
Prior art keywords
fluorofuranosil
nucleosids
fluoropurine
fluoropyrimidine
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91915632T
Other languages
English (en)
Inventor
Victor E Marquez
John S Driscoll
Ronald J Wysocki Jr
Maqbool A Siddiqui
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
United States Department of Commerce
Original Assignee
United States Department of Commerce
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by United States Department of Commerce filed Critical United States Department of Commerce
Application granted granted Critical
Publication of ES2080332T3 publication Critical patent/ES2080332T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LA INVENCION INSTANTANEA SE DIRIGE A COMPUESTOS DE 2FLUORARABINOFURANOSILO Y A UN PROCESO PARA PREPARARLO.
ES91915632T 1990-07-23 1991-07-19 Derivados de 2'-fluorofuranosil y nuevo procedimiento de preparacion de nucleosidos de 2'-fluoropirimidina y 2'-fluoropurina. Expired - Lifetime ES2080332T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/556,713 US5817799A (en) 1990-07-23 1990-07-23 2'-Fluorofuranosyl derivatives and methods for preparing 2'-fluoropyrimidine and 2'-fluoropurine nucleosides

Publications (1)

Publication Number Publication Date
ES2080332T3 true ES2080332T3 (es) 1996-02-01

Family

ID=24222534

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91915632T Expired - Lifetime ES2080332T3 (es) 1990-07-23 1991-07-19 Derivados de 2'-fluorofuranosil y nuevo procedimiento de preparacion de nucleosidos de 2'-fluoropirimidina y 2'-fluoropurina.

Country Status (10)

Country Link
US (2) US5817799A (es)
EP (1) EP0540686B1 (es)
JP (2) JPH0714956B2 (es)
AT (1) ATE127124T1 (es)
CA (1) CA2087425C (es)
DE (1) DE69112628T2 (es)
DK (1) DK0540686T3 (es)
ES (1) ES2080332T3 (es)
GR (1) GR3017571T3 (es)
WO (1) WO1992001700A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG94686A1 (en) * 1992-06-22 2003-03-18 Lilly Co Eli Stereoselective gylcosylation process
JPH0673086A (ja) * 1992-06-22 1994-03-15 Eli Lilly & Co 立体選択的な陰イオングリコシル化法
UA41261C2 (uk) * 1992-06-22 2001-09-17 Елі Ліллі Енд Компані Спосіб одержання збагачених бета-аномером нуклеозидів
AT400953B (de) * 1994-08-25 1996-05-28 Joern Saischek Pentofuranosid-derivate, deren herstellung und verwendung
KR100719606B1 (ko) * 1998-02-25 2007-05-17 에모리 유니버시티 2'-플루오로뉴클레오사이드
US6462191B1 (en) * 2000-07-13 2002-10-08 Air Products And Chemicals, Inc. Synthesis of 2-deoxy-2-fluoro-arabinose derivatives
CN100343268C (zh) 2001-06-22 2007-10-17 法玛塞特有限公司 β－2′－或3′－卤代核苷
NZ567272A (en) * 2005-09-26 2012-02-24 Pharmasset Inc Modified 4'-nucleosides as antiviral agents
US8895531B2 (en) * 2006-03-23 2014-11-25 Rfs Pharma Llc 2′-fluoronucleoside phosphonates as antiviral agents
US20090274686A1 (en) * 2008-05-02 2009-11-05 Yat Sun Or Nucleoside phosphonate derivatives

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4211773A (en) * 1978-10-02 1980-07-08 Sloan Kettering Institute For Cancer Research 5-Substituted 1-(2'-Deoxy-2'-substituted-β-D-arabinofuranosyl)pyrimidine nucleosides
US4625020A (en) * 1983-11-18 1986-11-25 Bristol-Myers Company Nucleoside process
US4751221A (en) * 1985-10-18 1988-06-14 Sloan-Kettering Institute For Cancer Research 2-fluoro-arabinofuranosyl purine nucleosides
US4908440A (en) * 1987-11-12 1990-03-13 Bristol Myers Company 2',3'-dideoxy-2'-fluoroarabinopyrimidine nucleosides
GB8816345D0 (en) * 1988-07-08 1988-08-10 Hoffmann La Roche Purine derivatives
RU2085557C1 (ru) * 1991-09-30 1997-07-27 Санкио Компани Лимитед Производные нуклеозидов пиримидина или их фармацевтически приемлемые соли и способ их получения
US5594124A (en) * 1992-06-22 1997-01-14 Eli Lilly And Company Stereoselective glycosylation process for preparing 2'-Deoxy-2',2'-difluoropyrimidine nucleosides and 2'-deoxy-2'-fluoropyrimidine nucleosides and intermediates thereof

Also Published As

Publication number Publication date
CA2087425A1 (en) 1992-01-24
DK0540686T3 (da) 1995-12-27
CA2087425C (en) 1998-08-04
JPH06501927A (ja) 1994-03-03
EP0540686A4 (en) 1993-05-26
AU8403991A (en) 1992-02-18
US5817799A (en) 1998-10-06
JPH08333382A (ja) 1996-12-17
GR3017571T3 (en) 1995-12-31
EP0540686A1 (en) 1993-05-12
EP0540686B1 (en) 1995-08-30
DE69112628D1 (de) 1995-10-05
JP2770162B2 (ja) 1998-06-25
US5336764A (en) 1994-08-09
ATE127124T1 (de) 1995-09-15
JPH0714956B2 (ja) 1995-02-22
DE69112628T2 (de) 1996-04-04
AU641545B2 (en) 1993-09-23
WO1992001700A1 (en) 1992-02-06

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