ATE127459T1 - Benzisoxazole und benzisothiazolederivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen. - Google Patents

Benzisoxazole und benzisothiazolederivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen.

Info

Publication number: ATE127459T1
Authority: AT; Austria
Prior art keywords: zero; derivatives; benzisoxazoles; production; pharmaceutical compositions
Prior art date: 1991-01-08

Application number

AT92400033T

Other languages

English (en)

Inventor

Jean-Louis Peglion

Joel Vian

Original Assignee

Adir

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-01-08

Filing date

1992-01-08

Publication date

1995-09-15

1992-01-08 Application filed by Adir filed Critical Adir

1995-09-15 Application granted granted Critical

1995-09-15 Publication of ATE127459T1 publication Critical patent/ATE127459T1/de

Links

CSNIZNHTOVFARY-UHFFFAOYSA-N 1,2-benzothiazole Chemical class C1=CC=C2C=NSC2=C1 CSNIZNHTOVFARY-UHFFFAOYSA-N 0.000 title abstract 2
150000008316 benzisoxazoles Chemical class 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
239000003814 drug Substances 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
-1 nitro, amino Chemical group 0.000 abstract 2
125000006527 (C1-C5) alkyl group Chemical group 0.000 abstract 1
KTZQTRPPVKQPFO-UHFFFAOYSA-N 1,2-benzoxazole Chemical compound C1=CC=C2C=NOC2=C1 KTZQTRPPVKQPFO-UHFFFAOYSA-N 0.000 abstract 1
125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 abstract 1
125000004423 acyloxy group Chemical group 0.000 abstract 1
239000000730 antalgic agent Substances 0.000 abstract 1
230000002539 anti-aggressive effect Effects 0.000 abstract 1
239000002249 anxiolytic agent Substances 0.000 abstract 1
230000000949 anxiolytic effect Effects 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
201000000980 schizophrenia Diseases 0.000 abstract 1
239000000932 sedative agent Substances 0.000 abstract 1
230000001624 sedative effect Effects 0.000 abstract 1
239000003091 serenic agent Substances 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Life Sciences & Earth Sciences (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Neurology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Thiazole And Isothizaole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

AT92400033T 1991-01-08 1992-01-08 Benzisoxazole und benzisothiazolederivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen. ATE127459T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9100135A FR2671350A1 (fr)	1991-01-08	1991-01-08	Nouveaux derives de benzisoxazole et de benzisothiazole, leur procede de preparation, et les compositions pharmaceutiques les renfermant.

Publications (1)

Publication Number	Publication Date
ATE127459T1 true ATE127459T1 (de)	1995-09-15

Family

ID=9408502

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92400033T ATE127459T1 (de)	1991-01-08	1992-01-08	Benzisoxazole und benzisothiazolederivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen.

Country Status (14)

Country	Link
US (1)	US5173490A (de)
EP (1)	EP0494817B1 (de)
JP (1)	JPH0832689B2 (de)
AT (1)	ATE127459T1 (de)
AU (1)	AU642570B2 (de)
CA (1)	CA2058878A1 (de)
DE (1)	DE69204474T2 (de)
DK (1)	DK0494817T3 (de)
ES (1)	ES2079808T3 (de)
FR (1)	FR2671350A1 (de)
GR (1)	GR3018211T3 (de)
IE (1)	IE70069B1 (de)
NZ (1)	NZ241232A (de)
ZA (1)	ZA92109B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ240863A (en) *	1991-09-11	1995-04-27	Mcneilab Inc	Substituted 4-aryl piperidine and 4-aryl piperazine derivatives, preparation and pharmaceutical compositions thereof
US5532240A (en) *	1991-12-26	1996-07-02	Yoshitomi Pharmaceutical Industries, Ltd.	Condensed thiophene compound and pharmaceutical use thereof
WO1995007893A1 (en) *	1993-09-15	1995-03-23	Merck Sharp & Dohme Limited	Fused tricyclic heteroaromatic derivatives as dopamine receptor subtype ligands
US6074642A (en)	1994-05-02	2000-06-13	Alexion Pharmaceuticals, Inc.	Use of antibodies specific to human complement component C5 for the treatment of glomerulonephritis
ATE184005T1 (de) *	1995-06-02	1999-09-15	Synthelabo	Oxazolidinone derivate, ihre herstellung und ihre therapeutische verwendung
FR2734820B1 (fr) *	1995-06-02	1997-07-11	Synthelabo	Derives de 3-(1,2-benzisoxazol-3-yl)oxazolidin-2-one, leur preparation et leur application en therapeutique
FR2734821B1 (fr) *	1995-06-02	1997-07-11	Synthelabo	Derives de 5-methoxymethyl-3-(1,2-benzisoxazol-3-yl) oxazolidin-2-one, leur preparation et leur application en therapeutique
JP3057763B2 (ja) *	1995-06-06	2000-07-04	ヘキスト・マリオン・ルセル・インコーポレイテツド	抗精神病薬としてのベンゾイソオキサゾール及びインダゾール誘導体
US5724027A (en) *	1995-09-28	1998-03-03	Intel Corporation	Method and apparatus for providing system security to personal computer systems using transparent system interrupt
AU2003272030A1 (en) *	2002-11-08	2004-06-07	Warner-Lambert Company Llc	Phenylalkyl and pyridylalkyl piperazine derivatives
WO2005056540A1 (en) *	2003-12-08	2005-06-23	Warner-Lambert Company Llc	Heterocyclic substituted indane derivatives and related compounds for the treatment of schizophrenia
FR2941695B1 (fr) *	2009-02-04	2011-02-18	Servier Lab	Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE787059A (fr) *	1971-08-03	1973-02-01	Wander Ag Dr A	Nouveaux derives du thiazole, leur preparation et leur application comme medicaments
US4104388A (en) *	1977-05-23	1978-08-01	E. R. Squibb & Sons, Inc.	3-Substituted benzisothiazole, 1,1-dioxides
US4104387A (en) *	1977-05-23	1978-08-01	E. R. Squibb & Sons, Inc.	3-(Arylcycloiminoalkyl)benzisothiazole 1,1-dioxides
OA06083A (fr) *	1977-11-09	1981-06-30	Science Union & Cie Ste Franca	Nouvelles pipérazines disubstituées, leurs procédés de préparation et les compositions pharmaceutiques les renfermant.
US4355037A (en) *	1981-11-12	1982-10-19	Hoechst-Roussel Pharmaceuticals	3-(4-Piperidyl)-1,2-benzisoxales
US4352811A (en) *	1981-11-12	1982-10-05	Hoechst-Roussel Pharmaceuticals Inc.	3-(1-Substituted-4-piperidyl)-1,2-benzisoxazoles
US4411901A (en) *	1981-12-23	1983-10-25	Mead Johnson & Company	Benzisothiazole and benzisoxazole piperazine derivatives
US4452799A (en) *	1981-12-23	1984-06-05	Mead Johnson & Company	Benzisothiazole and benzisoxazole piperazine derivatives
US4544663A (en) *	1984-05-07	1985-10-01	Sandoz, Inc.	Indolamine derivatives as anti-fertility agents
US4590196A (en) *	1984-08-23	1986-05-20	Bristol-Myers Company	Analgesic 1,2-benzisothiazol-3-ylpiperazine derivatives
US4804663A (en) *	1985-03-27	1989-02-14	Janssen Pharmaceutica N.V.	3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
JPH0625181B2 (ja) *	1985-03-27	1994-04-06	住友製薬株式会社	新規なイミド誘導体
AU593194B2 (en) *	1986-09-26	1990-02-01	Sumitomo Pharmaceuticals Company, Limited	Imide derivatives ,and their production and use
MX173362B (es) *	1987-03-02	1994-02-23	Pfizer	Compuestos de piperazinil heterociclicos y procedimiento para su preparacion
CA1335289C (en) *	1987-10-26	1995-04-18	Fujio Antoku	Piperidinyl benzisoxazole derivatives, their production and pharmaceutical use
JPS63132887A (ja) *	1987-10-27	1988-06-04	Sumitomo Pharmaceut Co Ltd	新規なイミド誘導体
US5001130A (en) *	1988-02-18	1991-03-19	Bristol-Myers Company	Psychotropic heterobicycloalkylpiperazine derivatives
NZ230045A (en) *	1988-08-05	1990-11-27	Janssen Pharmaceutica Nv	3-piperazinylbenzazole derivatives and pharmaceutical compositions

1991
- 1991-01-08 FR FR9100135A patent/FR2671350A1/fr active Granted
1992
- 1992-01-07 US US07/817,666 patent/US5173490A/en not_active Expired - Fee Related
- 1992-01-07 CA CA002058878A patent/CA2058878A1/fr not_active Abandoned
- 1992-01-07 NZ NZ241232A patent/NZ241232A/xx unknown
- 1992-01-07 IE IE920036A patent/IE70069B1/en not_active IP Right Cessation
- 1992-01-07 AU AU10065/92A patent/AU642570B2/en not_active Ceased
- 1992-01-08 EP EP92400033A patent/EP0494817B1/de not_active Expired - Lifetime
- 1992-01-08 DK DK92400033.4T patent/DK0494817T3/da active
- 1992-01-08 ES ES92400033T patent/ES2079808T3/es not_active Expired - Lifetime
- 1992-01-08 DE DE69204474T patent/DE69204474T2/de not_active Expired - Fee Related
- 1992-01-08 JP JP4001710A patent/JPH0832689B2/ja not_active Expired - Lifetime
- 1992-01-08 AT AT92400033T patent/ATE127459T1/de not_active IP Right Cessation
- 1992-01-08 ZA ZA92109A patent/ZA92109B/xx unknown
1995
- 1995-11-27 GR GR950403325T patent/GR3018211T3/el unknown

Also Published As

Publication number	Publication date
FR2671350A1 (fr)	1992-07-10
DE69204474D1 (de)	1995-10-12
DE69204474T2 (de)	1996-05-02
JPH0832689B2 (ja)	1996-03-29
ES2079808T3 (es)	1996-01-16
US5173490A (en)	1992-12-22
EP0494817B1 (de)	1995-09-06
AU1006592A (en)	1992-07-16
JPH04308584A (ja)	1992-10-30
CA2058878A1 (fr)	1992-07-09
EP0494817A1 (de)	1992-07-15
IE70069B1 (en)	1996-10-30
FR2671350B1 (de)	1993-02-26
DK0494817T3 (da)	1996-01-29
GR3018211T3 (en)	1996-02-29
IE920036A1 (en)	1992-07-15
ZA92109B (en)	1992-10-28
AU642570B2 (en)	1993-10-21
NZ241232A (en)	1993-04-28

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Legal Events

Date	Code	Title	Description
1996-02-15	UEP	Publication of translation of european patent specification
1998-10-15	REN	Ceased due to non-payment of the annual fee