ES2079808T3 - Nuevos derivados de benzo-isoxazol y de benzo-isotiazol, su procedimiento de preparacion y composiciones farmaceuticas que los contienen. - Google Patents
Nuevos derivados de benzo-isoxazol y de benzo-isotiazol, su procedimiento de preparacion y composiciones farmaceuticas que los contienen.Info
- Publication number
- ES2079808T3 ES2079808T3 ES92400033T ES92400033T ES2079808T3 ES 2079808 T3 ES2079808 T3 ES 2079808T3 ES 92400033 T ES92400033 T ES 92400033T ES 92400033 T ES92400033 T ES 92400033T ES 2079808 T3 ES2079808 T3 ES 2079808T3
- Authority
- ES
- Spain
- Prior art keywords
- benzo
- zero
- isotiazol
- isoxazol
- contain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- KTZQTRPPVKQPFO-UHFFFAOYSA-N 1,2-benzoxazole Chemical class C1=CC=C2C=NOC2=C1 KTZQTRPPVKQPFO-UHFFFAOYSA-N 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000003814 drug Substances 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- -1 nitro, amino Chemical group 0.000 abstract 2
- 125000006527 (C1-C5) alkyl group Chemical group 0.000 abstract 1
- CSNIZNHTOVFARY-UHFFFAOYSA-N 1,2-benzothiazole Chemical class C1=CC=C2C=NSC2=C1 CSNIZNHTOVFARY-UHFFFAOYSA-N 0.000 abstract 1
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 230000002539 anti-aggressive effect Effects 0.000 abstract 1
- 239000002249 anxiolytic agent Substances 0.000 abstract 1
- 230000000949 anxiolytic effect Effects 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 239000000932 sedative agent Substances 0.000 abstract 1
- 230000001624 sedative effect Effects 0.000 abstract 1
- 239000003091 serenic agent Substances 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
NUEVOS DERIVADOS DE BENCISOXAZOL Y DE BENCISOTIAZOL, UTILIZABLES COMO MEDICAMENTO Y QUE RESPONDEN A LA FORMULA: EN LA QUE DIFERENTES, SON CADA UNO: HIDROGENO, HALOGENO, [(C SUB 1-C SUB 5)-ALQUILO, -ALCOXI O -ALQUILTIO], HIDROXI, ACILOXI, TRIFLUORMETILO, NITRO, AMINO O ACETAMIDO, O SICION ADYACENTE, FORMAN JUNTOS UN RADICAL METILENODIOXI, ETILENODIOXI O VINILIDENODIOXI; SUB 5) ALQUILO SIEMPRE QUE M + N SEA (MAYOR O IGUAL) 1; RO ENTERO DE 1 A 6; SUB Z, SIENDO Z CERO, UNO O DOS; EN FORMA RACEMICA Y OPTICAMENTE ACTIVO. ESTOS DERIVADOS Y SUS SALES FISIOLOGICAMENTE TOLERABLES PUEDEN UTILIZARSE EN TERAPIA COMO AGENTE SEDATIVO, ANSIOLITICO, ANTIAGRESIVO Y ANALGESICOS Y PARA EL TRATAMIENTO DE LA ESQUIZOFRENIA Y DE LA DEPRESION.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9100135A FR2671350A1 (fr) | 1991-01-08 | 1991-01-08 | Nouveaux derives de benzisoxazole et de benzisothiazole, leur procede de preparation, et les compositions pharmaceutiques les renfermant. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2079808T3 true ES2079808T3 (es) | 1996-01-16 |
Family
ID=9408502
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES92400033T Expired - Lifetime ES2079808T3 (es) | 1991-01-08 | 1992-01-08 | Nuevos derivados de benzo-isoxazol y de benzo-isotiazol, su procedimiento de preparacion y composiciones farmaceuticas que los contienen. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5173490A (es) |
| EP (1) | EP0494817B1 (es) |
| JP (1) | JPH0832689B2 (es) |
| AT (1) | ATE127459T1 (es) |
| AU (1) | AU642570B2 (es) |
| CA (1) | CA2058878A1 (es) |
| DE (1) | DE69204474T2 (es) |
| DK (1) | DK0494817T3 (es) |
| ES (1) | ES2079808T3 (es) |
| FR (1) | FR2671350A1 (es) |
| GR (1) | GR3018211T3 (es) |
| IE (1) | IE70069B1 (es) |
| NZ (1) | NZ241232A (es) |
| ZA (1) | ZA92109B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE914218A1 (en) * | 1991-09-11 | 1993-03-24 | Mcneilab Inc | Novel 4-arylpiperazines and 4-arylpiperidines |
| US5532240A (en) * | 1991-12-26 | 1996-07-02 | Yoshitomi Pharmaceutical Industries, Ltd. | Condensed thiophene compound and pharmaceutical use thereof |
| US6080745A (en) * | 1993-09-15 | 2000-06-27 | Merck Sharp & Dohme Limited | Fused tricyclic heteroaromatic derivatives as dopamine receptor subtype ligands |
| US6074642A (en) | 1994-05-02 | 2000-06-13 | Alexion Pharmaceuticals, Inc. | Use of antibodies specific to human complement component C5 for the treatment of glomerulonephritis |
| FR2734820B1 (fr) * | 1995-06-02 | 1997-07-11 | Synthelabo | Derives de 3-(1,2-benzisoxazol-3-yl)oxazolidin-2-one, leur preparation et leur application en therapeutique |
| FR2734821B1 (fr) * | 1995-06-02 | 1997-07-11 | Synthelabo | Derives de 5-methoxymethyl-3-(1,2-benzisoxazol-3-yl) oxazolidin-2-one, leur preparation et leur application en therapeutique |
| KR100457502B1 (ko) * | 1995-06-02 | 2005-09-05 | 사노피-신델라보 | 옥사졸리디논유도체,그것의제법및치료학적사용 |
| HUP9802492A3 (en) * | 1995-06-06 | 1999-10-28 | Hoechst Marion Roussel Inc Cin | Benzisoxazole and indazole derivatives as antipsychotic agents, process for their preparation and pharmaceutical compositions containing the same |
| US5724027A (en) * | 1995-09-28 | 1998-03-03 | Intel Corporation | Method and apparatus for providing system security to personal computer systems using transparent system interrupt |
| JP2006508101A (ja) * | 2002-11-08 | 2006-03-09 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | フェニルアルキルおよびピリジルアルキルピペラジン誘導体 |
| WO2005056540A1 (en) * | 2003-12-08 | 2005-06-23 | Warner-Lambert Company Llc | Heterocyclic substituted indane derivatives and related compounds for the treatment of schizophrenia |
| FR2941695B1 (fr) * | 2009-02-04 | 2011-02-18 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE787059A (fr) * | 1971-08-03 | 1973-02-01 | Wander Ag Dr A | Nouveaux derives du thiazole, leur preparation et leur application comme medicaments |
| US4104388A (en) * | 1977-05-23 | 1978-08-01 | E. R. Squibb & Sons, Inc. | 3-Substituted benzisothiazole, 1,1-dioxides |
| US4104387A (en) * | 1977-05-23 | 1978-08-01 | E. R. Squibb & Sons, Inc. | 3-(Arylcycloiminoalkyl)benzisothiazole 1,1-dioxides |
| OA06083A (fr) * | 1977-11-09 | 1981-06-30 | Science Union & Cie Ste Franca | Nouvelles pipérazines disubstituées, leurs procédés de préparation et les compositions pharmaceutiques les renfermant. |
| US4355037A (en) * | 1981-11-12 | 1982-10-19 | Hoechst-Roussel Pharmaceuticals | 3-(4-Piperidyl)-1,2-benzisoxales |
| US4352811A (en) * | 1981-11-12 | 1982-10-05 | Hoechst-Roussel Pharmaceuticals Inc. | 3-(1-Substituted-4-piperidyl)-1,2-benzisoxazoles |
| US4411901A (en) * | 1981-12-23 | 1983-10-25 | Mead Johnson & Company | Benzisothiazole and benzisoxazole piperazine derivatives |
| US4452799A (en) * | 1981-12-23 | 1984-06-05 | Mead Johnson & Company | Benzisothiazole and benzisoxazole piperazine derivatives |
| US4544663A (en) * | 1984-05-07 | 1985-10-01 | Sandoz, Inc. | Indolamine derivatives as anti-fertility agents |
| US4590196A (en) * | 1984-08-23 | 1986-05-20 | Bristol-Myers Company | Analgesic 1,2-benzisothiazol-3-ylpiperazine derivatives |
| JPH0625181B2 (ja) * | 1985-03-27 | 1994-04-06 | 住友製薬株式会社 | 新規なイミド誘導体 |
| US4804663A (en) * | 1985-03-27 | 1989-02-14 | Janssen Pharmaceutica N.V. | 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles |
| JP2660407B2 (ja) * | 1986-09-26 | 1997-10-08 | 住友製薬株式会社 | 新規なイミド誘導体 |
| MX173362B (es) * | 1987-03-02 | 1994-02-23 | Pfizer | Compuestos de piperazinil heterociclicos y procedimiento para su preparacion |
| CA1335289C (en) * | 1987-10-26 | 1995-04-18 | Fujio Antoku | Piperidinyl benzisoxazole derivatives, their production and pharmaceutical use |
| JPS63132887A (ja) * | 1987-10-27 | 1988-06-04 | Sumitomo Pharmaceut Co Ltd | 新規なイミド誘導体 |
| US5001130A (en) * | 1988-02-18 | 1991-03-19 | Bristol-Myers Company | Psychotropic heterobicycloalkylpiperazine derivatives |
| NZ230045A (en) * | 1988-08-05 | 1990-11-27 | Janssen Pharmaceutica Nv | 3-piperazinylbenzazole derivatives and pharmaceutical compositions |
-
1991
- 1991-01-08 FR FR9100135A patent/FR2671350A1/fr active Granted
-
1992
- 1992-01-07 NZ NZ241232A patent/NZ241232A/xx unknown
- 1992-01-07 CA CA002058878A patent/CA2058878A1/fr not_active Abandoned
- 1992-01-07 AU AU10065/92A patent/AU642570B2/en not_active Ceased
- 1992-01-07 US US07/817,666 patent/US5173490A/en not_active Expired - Fee Related
- 1992-01-07 IE IE920036A patent/IE70069B1/en not_active IP Right Cessation
- 1992-01-08 AT AT92400033T patent/ATE127459T1/de not_active IP Right Cessation
- 1992-01-08 DE DE69204474T patent/DE69204474T2/de not_active Expired - Fee Related
- 1992-01-08 DK DK92400033.4T patent/DK0494817T3/da active
- 1992-01-08 EP EP92400033A patent/EP0494817B1/fr not_active Expired - Lifetime
- 1992-01-08 ZA ZA92109A patent/ZA92109B/xx unknown
- 1992-01-08 ES ES92400033T patent/ES2079808T3/es not_active Expired - Lifetime
- 1992-01-08 JP JP4001710A patent/JPH0832689B2/ja not_active Expired - Lifetime
-
1995
- 1995-11-27 GR GR950403325T patent/GR3018211T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IE70069B1 (en) | 1996-10-30 |
| EP0494817B1 (fr) | 1995-09-06 |
| FR2671350A1 (fr) | 1992-07-10 |
| DE69204474T2 (de) | 1996-05-02 |
| ZA92109B (en) | 1992-10-28 |
| US5173490A (en) | 1992-12-22 |
| CA2058878A1 (fr) | 1992-07-09 |
| JPH04308584A (ja) | 1992-10-30 |
| EP0494817A1 (fr) | 1992-07-15 |
| IE920036A1 (en) | 1992-07-15 |
| DK0494817T3 (da) | 1996-01-29 |
| ATE127459T1 (de) | 1995-09-15 |
| FR2671350B1 (es) | 1993-02-26 |
| JPH0832689B2 (ja) | 1996-03-29 |
| GR3018211T3 (en) | 1996-02-29 |
| NZ241232A (en) | 1993-04-28 |
| AU1006592A (en) | 1992-07-16 |
| DE69204474D1 (de) | 1995-10-12 |
| AU642570B2 (en) | 1993-10-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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