ATE127476T1 - Lhrh-analoge. - Google Patents

Lhrh-analoge.

Info

Publication number: ATE127476T1
Authority: AT; Austria
Prior art keywords: moiety; methotrexoyl; trp; arg; group
Prior art date: 1990-04-06

Application number

AT91104730T

Other languages

English (en)

Inventor

Andrew Victor Schally

Tamas Janaky

Atilla Juhasz

Sandor Bajusz

Original Assignee

Univ Tulane

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-04-06

Filing date

1991-03-26

Publication date

1995-09-15

1991-03-26 Application filed by Univ Tulane filed Critical Univ Tulane

1995-09-15 Application granted granted Critical

1995-09-15 Publication of ATE127476T1 publication Critical patent/ATE127476T1/de

Links

XLXSAKCOAKORKW-UHFFFAOYSA-N gonadorelin Chemical class C1CCC(C(=O)NCC(N)=O)N1C(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(NC(=O)C(CO)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C(CC=1NC=NC=1)NC(=O)C1NC(=O)CC1)CC1=CC=C(O)C=C1 XLXSAKCOAKORKW-UHFFFAOYSA-N 0.000 title abstract 2
125000003277 amino group Chemical group 0.000 abstract 2
-1 aziridine-2-carbonyl Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
231100000433 cytotoxic Toxicity 0.000 abstract 2
230000001472 cytotoxic effect Effects 0.000 abstract 2
ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical compound OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 abstract 1
AHLPHDHHMVZTML-SCSAIBSYSA-N D-Ornithine Chemical compound NCCC[C@@H](N)C(O)=O AHLPHDHHMVZTML-SCSAIBSYSA-N 0.000 abstract 1
QNAYBMKLOCPYGJ-UWTATZPHSA-N D-alanine Chemical compound C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 abstract 1
KDXKERNSBIXSRK-RXMQYKEDSA-N D-lysine Chemical compound NCCCC[C@@H](N)C(O)=O KDXKERNSBIXSRK-RXMQYKEDSA-N 0.000 abstract 1
COLNVLDHVKWLRT-MRVPVSSYSA-N D-phenylalanine Chemical compound OC(=O)[C@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-MRVPVSSYSA-N 0.000 abstract 1
QIVBCDIJIAJPQS-SECBINFHSA-N D-tryptophane Chemical compound C1=CC=C2C(C[C@@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-SECBINFHSA-N 0.000 abstract 1
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 1
102000006771 Gonadotropins Human genes 0.000 abstract 1
108010086677 Gonadotropins Proteins 0.000 abstract 1
XMAUFHMAAVTODF-STQMWFEESA-N His-Phe Chemical compound C([C@H](N)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CN=CN1 XMAUFHMAAVTODF-STQMWFEESA-N 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
230000001270 agonistic effect Effects 0.000 abstract 1
230000003042 antagnostic effect Effects 0.000 abstract 1
230000000118 anti-neoplastic effect Effects 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
239000002622 gonadotropin Substances 0.000 abstract 1
229940094892 gonadotropins Drugs 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
230000001817 pituitary effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Immunology (AREA)
Epidemiology (AREA)
Gastroenterology & Hepatology (AREA)
Mycology (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
Endocrinology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Biochemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Microbiology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Peptides Or Proteins (AREA)
Luminescent Compositions (AREA)
Electric Double-Layer Capacitors Or The Like (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Saccharide Compounds (AREA)

AT91104730T 1990-04-06 1991-03-26 Lhrh-analoge. ATE127476T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US50551790A	1990-04-06	1990-04-06

Publications (1)

Publication Number	Publication Date
ATE127476T1 true ATE127476T1 (de)	1995-09-15

Family

ID=24010633

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91104730T ATE127476T1 (de)	1990-04-06	1991-03-26	Lhrh-analoge.

Country Status (17)

Country	Link
EP (1)	EP0450461B1 (de)
JP (1)	JPH04224600A (de)
KR (1)	KR940701270A (de)
AT (1)	ATE127476T1 (de)
AU (1)	AU638319B2 (de)
CA (1)	CA2039908A1 (de)
DE (1)	DE69112684T2 (de)
DK (1)	DK0450461T3 (de)
ES (1)	ES2076393T3 (de)
HR (1)	HRP921273A2 (de)
HU (1)	HU208159B (de)
IE (1)	IE63278B1 (de)
MC (1)	MC2265A1 (de)
NZ (1)	NZ237705A (de)
WO (1)	WO1992022322A1 (de)
YU (1)	YU61991A (de)
ZA (1)	ZA914552B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6326467B1 (en)	1989-02-23	2001-12-04	Colorado State University Research Foundation	Hormone-recombinant toxin compounds and methods for using same
US6419655B1 (en)	1998-07-16	2002-07-16	Gonex, Inc.	Method for controlling animal populations utilizing a sterilant projectile
US5502035A (en) *	1993-08-06	1996-03-26	Tap Holdings Inc.	N-terminus modified analogs of LHRH
US5413990A (en) *	1993-08-06	1995-05-09	Tap Pharmaceuticals Inc.	N-terminus modified analogs of LHRH
DE4338015A1 (de) *	1993-11-08	1995-05-11	Asta Medica Ag	Verwendung von D-glucopyranuronsäuren und deren Derivaten zum Einbau in pharmakologisch wirksame Peptide und deren Salze
US5677184A (en) *	1994-04-19	1997-10-14	Takeda Chemical Industries, Ltd.	CHO cells that express human LH-RH receptor
US5753206A (en)	1995-06-07	1998-05-19	Immunomedics, Inc.	Radiometal-binding analogues of luteinizing hormone releasing hormone
US5843903A (en) *	1995-11-27	1998-12-01	The Administrators Of The Tulane Educational Fund	Targeted cytotoxic anthracycline analogs
CN101791409A (zh)	2003-04-22	2010-08-04	研究及应用科学协会股份有限公司	肽载体
CA2727082C (en)	2008-06-12	2019-02-26	Syntaxin Limited	Fusion proteins for use in suppression of acromegaly
GB0820970D0 (en)	2008-11-17	2008-12-24	Syntaxin Ltd	Suppression of cancer
KR101346262B1 (ko) *	2013-06-19	2014-01-03	엘아이지넥스원 주식회사	다단 분리형 수중 운동체 및 이의 동작 방법
KR101355886B1 (ko) *	2013-11-19	2014-01-27	엘아이지넥스원 주식회사	다단 분리형 수중 운동체 및 이의 동작 방법
CA3072399A1 (en) *	2017-08-09	2019-02-14	Helmholtz-Zentrum Fur Infektionsforschung Gmbh	New targeted cytotoxic ratjadone derivatives and conjugates thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4263279A (en) *	1975-08-19	1981-04-21	Yeda Research & Development Co. Ltd	Pharmaceutically active compositions containing adriamycin and daunomycin
US4894443A (en) *	1984-02-08	1990-01-16	Cetus Corporation	Toxin conjugates
US4677193A (en) *	1985-02-22	1987-06-30	The Salk Institute For Biological Studies	Peptides containing an aliphatic-aromatic ketone side chain
CA1275922C (en) *	1985-11-28	1990-11-06	Harunobu Amagase	Treatment of cancer
US4793986A (en) *	1987-02-25	1988-12-27	Johnson Matthey, Inc.	Macromolecular platinum antitumor compounds
AU5186090A (en) *	1989-02-23	1990-09-26	Colorado State University Research Foundation	Gnrh analogs for destroying gonadotrophs
BR9913040A (pt) *	1998-08-17	2001-05-08	Thermo Black Clawson Inc	Processos de extrair um licor rico em açúcar e um componente de açúcar a partir de cana-de-açúcar

1991
- 1991-03-26 DK DK91104730.6T patent/DK0450461T3/da active
- 1991-03-26 ES ES91104730T patent/ES2076393T3/es not_active Expired - Lifetime
- 1991-03-26 DE DE69112684T patent/DE69112684T2/de not_active Expired - Fee Related
- 1991-03-26 AT AT91104730T patent/ATE127476T1/de active
- 1991-03-26 EP EP91104730A patent/EP0450461B1/de not_active Expired - Lifetime
- 1991-04-04 YU YU61991A patent/YU61991A/sh unknown
- 1991-04-05 CA CA002039908A patent/CA2039908A1/en not_active Abandoned
- 1991-04-05 IE IE113491A patent/IE63278B1/en not_active IP Right Cessation
- 1991-04-05 HU HU911116A patent/HU208159B/hu not_active IP Right Cessation
- 1991-04-05 AU AU74106/91A patent/AU638319B2/en not_active Ceased
- 1991-04-05 JP JP3072936A patent/JPH04224600A/ja active Pending
- 1991-04-05 NZ NZ237705A patent/NZ237705A/en unknown
- 1991-04-08 MC MC912183A patent/MC2265A1/fr unknown
- 1991-06-14 WO PCT/US1991/004264 patent/WO1992022322A1/en not_active Ceased
- 1991-06-14 ZA ZA914552A patent/ZA914552B/xx unknown
- 1991-06-14 KR KR1019930703871A patent/KR940701270A/ko not_active Withdrawn
1992
- 1992-11-16 HR HRP-619/91A patent/HRP921273A2/xx not_active Application Discontinuation

Also Published As

Publication number	Publication date
HU911116D0 (en)	1991-10-28
DE69112684D1 (de)	1995-10-12
MC2265A1 (fr)	1993-04-26
EP0450461A2 (de)	1991-10-09
DE69112684T2 (de)	1996-02-01
AU638319B2 (en)	1993-06-24
HRP921273A2 (en)	1998-06-30
IE63278B1 (en)	1995-04-05
JPH04224600A (ja)	1992-08-13
DK0450461T3 (da)	1995-10-23
KR940701270A (ko)	1994-05-28
YU61991A (sh)	1994-04-05
CA2039908A1 (en)	1991-10-07
HU208159B (en)	1993-08-30
EP0450461B1 (de)	1995-09-06
EP0450461A3 (en)	1992-03-11
NZ237705A (en)	1992-11-25
ZA914552B (en)	1992-06-24
ES2076393T3 (es)	1995-11-01
WO1992022322A1 (en)	1992-12-23
IE911134A1 (en)	1991-10-09
AU7410691A (en)	1991-10-10
HUT57235A (en)	1991-11-28

Publication	Publication Date	Title
ATE127476T1 (de)	1995-09-15	Lhrh-analoge.
JPS6434997A (en)	1989-02-06	Peptide, manufacture, lhrh antagonistic medicine and manufacture
KR970701730A (ko)	1997-04-12	GnRH 길항물질(GNRH ANTAGONISTS)
KR870002161A (ko)	1987-03-30	옥사-및 아자 호모사이클로 스타틴 폴리펩티드의 제조방법
KR920702351A (ko)	1992-09-03	GnRH 유사체
GB2207433B (en)	1990-10-10	Acyclic cyclosporins
KR860009041A (ko)	1986-12-19	GnRH길항제 IX의 제조방법
DE3265349D1 (en)	1985-09-19	Gnrh antagonists
GR3017298T3 (en)	1995-12-31	Somatostatin Analogues.
NO934541L (no)	1994-02-07	LHRH analoger
EP0364819A3 (de)	1991-03-06	LHRH-Analoge
JPH09124692A5 (de)	2004-09-30
KR920701242A (ko)	1992-08-11	환원된 비가역성 봄베신 길항제
EP0346068A3 (de)	1991-01-30	D-Cys6-Vasopressin-Antagonisten