ATE12771T1 - 6-chloro- oder 6-bromo-1,2-dihydro-3h-pyrrolo(1,2-a)pyrrol-1-c rbonsaeuren und derivate davon, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zubereitungen. - Google Patents

6-chloro- oder 6-bromo-1,2-dihydro-3h-pyrrolo(1,2-a)pyrrol-1-c rbonsaeuren und derivate davon, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zubereitungen.

Info

Publication number: ATE12771T1
Authority: AT; Austria
Prior art keywords: bromo; chloro; pyrrolo; dihydro; rbonic
Prior art date: 1980-06-09

Application number

AT81104368T

Other languages

English (en)

Inventor

Joseph M Muchowski

Original Assignee

Syntex Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-06-09

Filing date

1981-06-05

Publication date

1985-05-15

1981-06-05 Application filed by Syntex Inc filed Critical Syntex Inc

1985-05-15 Application granted granted Critical

1985-05-15 Publication of ATE12771T1 publication Critical patent/ATE12771T1/de

Links

239000002253 acid Substances 0.000 title 1
150000007513 acids Chemical class 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
238000000034 method Methods 0.000 title 1
239000000825 pharmaceutical preparation Substances 0.000 title 1
XWQXHYYQCCZBSH-UHFFFAOYSA-N 2-bromo-6,7-dihydro-5h-pyrrolizine-1-carboxylic acid Chemical class C1CCC2=C(C(=O)O)C(Br)=CN21 XWQXHYYQCCZBSH-UHFFFAOYSA-N 0.000 abstract 1
125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
125000000389 2-pyrrolyl group Chemical group [H]N1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
125000003682 3-furyl group Chemical group O1C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
239000000730 antalgic agent Substances 0.000 abstract 1
239000002260 anti-inflammatory agent Substances 0.000 abstract 1
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
239000002221 antipyretic Substances 0.000 abstract 1
229940125716 antipyretic agent Drugs 0.000 abstract 1
125000001246 bromo group Chemical group Br* 0.000 abstract 1
125000001309 chloro group Chemical group Cl* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
231100000252 nontoxic Toxicity 0.000 abstract 1
230000003000 nontoxic effect Effects 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000000050 smooth muscle relaxant Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrrole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

AT81104368T 1980-06-09 1981-06-05 6-chloro- oder 6-bromo-1,2-dihydro-3h-pyrrolo(1,2-a)pyrrol-1-c rbonsaeuren und derivate davon, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zubereitungen. ATE12771T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US06/157,719 US4344943A (en)	1980-06-09	1980-06-09	6-Chloro- or 6-bromo-1,2-dihydro-3H-pyrrolo[1,2-a]-pyrrole-1-carboxylic acids and derivatives thereof
EP81104368A EP0041711B1 (de)	1980-06-09	1981-06-05	6-Chloro- oder 6-Bromo-1,2-dihydro-3H-pyrrolo(1,2-a)pyrrol-1-carbonsäuren und Derivate davon, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zubereitungen

Publications (1)

Publication Number	Publication Date
ATE12771T1 true ATE12771T1 (de)	1985-05-15

Family

ID=22564979

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT81104368T ATE12771T1 (de)	1980-06-09	1981-06-05	6-chloro- oder 6-bromo-1,2-dihydro-3h-pyrrolo(1,2-a)pyrrol-1-c rbonsaeuren und derivate davon, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zubereitungen.

Country Status (19)

Country	Link
US (1)	US4344943A (de)
EP (1)	EP0041711B1 (de)
JP (1)	JPS5714591A (de)
KR (1)	KR850000609B1 (de)
AT (1)	ATE12771T1 (de)
AU (1)	AU546012B2 (de)
CA (1)	CA1178277A (de)
DE (1)	DE3169956D1 (de)
DK (1)	DK249781A (de)
ES (1)	ES8203376A1 (de)
GR (1)	GR74615B (de)
HU (1)	HU185430B (de)
IE (1)	IE51523B1 (de)
IL (1)	IL63047A (de)
NZ (1)	NZ197331A (de)
PT (1)	PT73154B (de)
SU (1)	SU1217260A3 (de)
YU (2)	YU43235B (de)
ZA (1)	ZA813829B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4457941A (en) *	1982-03-22	1984-07-03	Syntex (U.S.A.) Inc.	Use of pyrrolo-pyrrole in treating microvascular diseases associated with diabetes
US4454151A (en) *	1982-03-22	1984-06-12	Syntex (U.S.A.) Inc.	Use of pyrrolo pyrroles in treatment of ophthalmic diseases
US4612325A (en) *	1982-06-08	1986-09-16	Syntex (U.S.A) Inc.	5-Aroyl-6-alkylthio-1,2-dihydro-3H-pyrrolo(1,2-A)pyrrole-1-carboxylic acids and use thereof as analgesics and anti-inflammatories
US4511724A (en) *	1982-06-10	1985-04-16	Merck & Co., Inc.	5-(Pyrrol-2-oyl)-1,2-dihydro-3H-pyrrolo [1,2-a]pyrrole derivatives as anti-inflammatory and analgesic agents
US4849526A (en) *	1987-01-14	1989-07-18	Syntex (U.S.A.) Inc.	Process for preparing (±)-2,3-dihydro-1H-pyrrolo[1,2-A]pyrrole-1,7-dicarboxylates
HU198927B (en) *	1987-01-14	1989-12-28	Richter Gedeon Vegyeszet	Process for producing 1-/substituted aminomethyl/-octa-hydroindolo-(2,3-a)quinolizine derivatives, pharmaceutically applicable acid addition salts thereof, as well as pharmaceutical compositions comprising same
US4874872A (en) *	1987-01-14	1989-10-17	Syntex (U.S.A.) Inc.	Process for preparing (+)-2,3-dihydro-1H-pyrrolo[1,2-A]pyrrole-1,7-dicarboxylates
US4835288A (en) *	1987-01-14	1989-05-30	Syntex Inc.	Process for preparing (+)-2,3-dihydro-1H-pyrrolo[1,2-a]pyrrole-1,7-dicarboxylates
US4874871A (en) *	1987-03-25	1989-10-17	Syntex (U.S.A.) Inc.	Process for preparing (+)-2,3-Dihydro-1H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid and related compounds
JP2649168B2 (ja) *	1988-02-25	1997-09-03	久光製薬株式会社	新規な５，６−ジフェニル−１，２−ジヒドロ−３Ｈ−ピロロ［１，２−ａ］ピロール−１−カルボン酸誘導体
US5082950A (en) *	1990-10-12	1992-01-21	Syntex (U.S.A.) Inc.	Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates (II) and intermediates therefor
WO1995001767A1 (en) *	1993-07-08	1995-01-19	Cygnus Therapeutic Systems	Monolithic matrix transdermal delivery system
US5621115A (en) *	1996-02-21	1997-04-15	Ohmeda Pharmaceutical Products Division Inc.	Methods for preparing 5-aroyl-1,2-dihydro-3H-pyrrolo-[1,2-A]pyrrole-1-carboxylic acids
US6191285B1 (en)	1997-07-03	2001-02-20	Abbott Laboratories	Process for the preparation of ketorolac tromethamine
ES2449194T3 (es) *	2000-01-19	2014-03-18	Cadila Healthcare Limited	Compuestos que tienen actividades hipolipidémica e hipocolesterolémica, procedimiento para su preparación y composiciones farmacéuticas que los contienen
WO2002062341A1 (en) *	2001-02-07	2002-08-15	University Of Florida	Method and composition for the control of hair growth

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4089969A (en) *	1976-07-14	1978-05-16	Syntex (U.S.A.) Inc.	5-Aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof
US4087539A (en) *	1976-07-14	1978-05-02	Syntex (U.S.A.) Inc.	5-(2-Furoyl)-, 5-(2-thenoyl)-, 5-(3-furoyl)- and 5-(3-thenoyl)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof
JPS539788A (en) *	1976-07-14	1978-01-28	Syntex Inc	55aloyll122dihydroo3hh pyroro 122a pyroll11 carboxylic acid derivative
US4097579A (en) *	1977-03-31	1978-06-27	Syntex (U.S.A.) Inc.	5-(2-Pyrroyl)-1,2-dihydro-3H-pyrrolo 1,2-a!pyrrole-1-carboxylic acid derivatives and process for the production thereof
US4140698A (en) *	1977-07-25	1979-02-20	Syntex (Usa) Inc.	1,2-Dihydro-3H-pyrrolo[1,2-a]pyrrole-1-nitriles
US4232038A (en) *	1979-08-31	1980-11-04	Syntex (U.S.A.) Inc.	5-Alkylsulfinylbenzoyl- and 5-alkylsulfonylbenzoyl-1,2-dihydro-3H-pyrrolo[1,]pyrrole-1-carboxylic acids

1980
- 1980-06-09 US US06/157,719 patent/US4344943A/en not_active Expired - Lifetime
1981
- 1981-04-02 JP JP4999181A patent/JPS5714591A/ja active Pending
- 1981-06-03 KR KR1019810001987A patent/KR850000609B1/ko not_active Expired
- 1981-06-04 DK DK249781A patent/DK249781A/da not_active Application Discontinuation
- 1981-06-05 AT AT81104368T patent/ATE12771T1/de not_active IP Right Cessation
- 1981-06-05 EP EP81104368A patent/EP0041711B1/de not_active Expired
- 1981-06-05 YU YU1423/81A patent/YU43235B/xx unknown
- 1981-06-05 DE DE8181104368T patent/DE3169956D1/de not_active Expired
- 1981-06-05 IL IL63047A patent/IL63047A/xx unknown
- 1981-06-08 IE IE1269/81A patent/IE51523B1/en unknown
- 1981-06-08 CA CA000379266A patent/CA1178277A/en not_active Expired
- 1981-06-08 GR GR65174A patent/GR74615B/el unknown
- 1981-06-08 ZA ZA00813829A patent/ZA813829B/xx unknown
- 1981-06-08 SU SU813300100A patent/SU1217260A3/ru active
- 1981-06-08 NZ NZ197331A patent/NZ197331A/en unknown
- 1981-06-08 HU HU811700A patent/HU185430B/hu not_active IP Right Cessation
- 1981-06-08 PT PT73154A patent/PT73154B/pt unknown
- 1981-06-08 ES ES502855A patent/ES8203376A1/es not_active Expired
- 1981-06-09 AU AU71438/81A patent/AU546012B2/en not_active Ceased
1983
- 1983-06-22 YU YU01370/83A patent/YU137083A/xx unknown

Also Published As

Publication number	Publication date
GR74615B (de)	1984-06-29
IL63047A0 (en)	1981-09-13
DK249781A (da)	1981-12-10
NZ197331A (en)	1985-05-31
ES502855A0 (es)	1982-04-01
YU43235B (en)	1989-06-30
PT73154A (en)	1981-07-01
IE811269L (en)	1981-12-09
CA1178277A (en)	1984-11-20
KR830006289A (ko)	1983-09-20
DE3169956D1 (en)	1985-05-23
KR850000609B1 (ko)	1985-05-01
AU546012B2 (en)	1985-08-08
IE51523B1 (en)	1987-01-07
SU1217260A3 (ru)	1986-03-07
ZA813829B (en)	1983-01-26
EP0041711B1 (de)	1985-04-17
HU185430B (en)	1985-02-28
ES8203376A1 (es)	1982-04-01
PT73154B (en)	1982-07-16
IL63047A (en)	1984-07-31
JPS5714591A (en)	1982-01-25
YU142381A (en)	1983-12-31
AU7143881A (en)	1981-12-17
YU137083A (en)	1983-12-31
US4344943A (en)	1982-08-17
EP0041711A1 (de)	1981-12-16

Legal Events

Date	Code	Title	Description
1985-07-15	UEP	Publication of translation of european patent specification
1991-03-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE12771T1 (de)	1985-05-15	6-chloro- oder 6-bromo-1,2-dihydro-3h-pyrrolo(1,2-a)pyrrol-1-c rbonsaeuren und derivate davon, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zubereitungen.
ATE4903T1 (de)	1983-10-15	1-, 6- und 2-substituierte 1-carba-2-penem-3carbons[ure, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen.
DE69030206D1 (de)	1997-04-24	Pyrazolopyridinverbindungen und Verfahren zu ihrer Herstellung
IE780605L (en)	1978-09-30	1, 2-DIHYDRO-3H-PYRROLO [1,2-a] PYRROLES
AR010984A1 (es)	2000-08-02	Nuevos esteres de la pleuromutilina, y el acido 1-azabiciclo-4- carbanilcarbanico; procedimiento para su preparacion y composicionesfarmaceuticas que los contienen.
ATE25679T1 (de)	1987-03-15	Isochinolinderivate, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen und ihre verwendung.
IE45051L (en)	1977-11-07	Quinazolines
IE780403L (en)	1978-08-26	Antiphlogistic compositions
SE7902915L (sv)	1979-10-04	4-oxo-4h-pyrido(1,2-a)pyrimidin-3-n-(1h-tetrazol-5-yl) karboxamidderivat och deras anvendning sasom inhibitorer av allergiska reaktioner
ATE7224T1 (de)	1984-05-15	Propanolamin-derivate, ihre salze, verfahren zu ihrer herstellung und pharmazeutische praeparate.
DE3262732D1 (en)	1985-05-02	Anthranilic acids substituted by basic groups, process for their preparation and their use
EP0049999A3 (de)	1982-06-23	Cyclische Verbindungen, ihre Herstellung und ihre Verwendung
PT70656A (de)	1980-02-01	Neue linksdrehende bicyclische thia-diaza-verbindung verfahren zu ihrer herstellung diese enthaltende pharmazeutische praparate und ihre verwendung
FI911616A0 (fi)	1991-04-04	Substituerade 3-tia- eller 3-oxa-alkyl -flavoner, foerfarande foer deras framstaellning, deras anvaendning, pao dessa foereningar baserade laekemedel samt mellanprodukter.
PT73789B (de)	1983-10-14	Neue cephalosporine verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
ATE13061T1 (de)	1985-05-15	Neue 6alpha-methoxy-penicilline, ihre salze, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel.
DK22983A (da)	1983-07-23	Fremgangsmaade til fremstilling af penicillinderivater
IE43848L (en)	1976-12-02	Pharmaceutical compositions
DE69403606D1 (de)	1997-07-10	Cyclizierte Analoge der Fettsäurenmetaboliten, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen