ATE128450T1 - Neue cyclopropylsqualenderivate und ihre verwendung als inhibitoren der cholesterinsynthese. - Google Patents

Neue cyclopropylsqualenderivate und ihre verwendung als inhibitoren der cholesterinsynthese.

Info

Publication number
ATE128450T1
ATE128450T1 AT91907422T AT91907422T ATE128450T1 AT E128450 T1 ATE128450 T1 AT E128450T1 AT 91907422 T AT91907422 T AT 91907422T AT 91907422 T AT91907422 T AT 91907422T AT E128450 T1 ATE128450 T1 AT E128450T1
Authority
AT
Austria
Prior art keywords
cyclopropylsqualender
inhibitors
derivatives
new
cholesterol synthesis
Prior art date
Application number
AT91907422T
Other languages
English (en)
Inventor
Michael R Angelastro
Norton P Peet
Philippe Bey
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Application granted granted Critical
Publication of ATE128450T1 publication Critical patent/ATE128450T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/18—Ethers having an ether-oxygen atom bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C43/188—Unsaturated ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Steroid Compounds (AREA)
AT91907422T 1990-03-22 1991-03-19 Neue cyclopropylsqualenderivate und ihre verwendung als inhibitoren der cholesterinsynthese. ATE128450T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/497,477 US5051534A (en) 1990-03-22 1990-03-22 Novel cyclopropyl squalene derivatives and their use as inhibitors of cholesterol synthesis

Publications (1)

Publication Number Publication Date
ATE128450T1 true ATE128450T1 (de) 1995-10-15

Family

ID=23977045

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91907422T ATE128450T1 (de) 1990-03-22 1991-03-19 Neue cyclopropylsqualenderivate und ihre verwendung als inhibitoren der cholesterinsynthese.

Country Status (9)

Country Link
US (1) US5051534A (de)
EP (1) EP0521103B1 (de)
JP (1) JP2889697B2 (de)
AT (1) ATE128450T1 (de)
AU (1) AU641008B2 (de)
CA (1) CA2078871C (de)
DE (1) DE69113453T2 (de)
ES (1) ES2080311T3 (de)
WO (1) WO1991014668A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5861496A (en) * 1996-11-07 1999-01-19 Incyte Pharmaceuticals, Inc. Human squalene epoxidase
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7232795B2 (en) * 2005-11-23 2007-06-19 International Flavors & Fragrances Inc. Derivatives of decahydro-cycloprop[e]indene compounds and their use in perfume compositions
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
AR063275A1 (es) * 2006-10-12 2009-01-14 Epix Delaware Inc Compuestos de carboxamida, una composicion farmaceutica que los comprende y su uso en la preparacion de un medicamento para el tratamiento de enfermedades mediadas por la activacion de ccr2.
CN101663262B (zh) 2006-12-01 2014-03-26 百时美施贵宝公司 用于治疗动脉粥样硬化和心血管疾病的作为cetp抑制剂的n-(3-苄基)-2,2-(二苯基)-丙-1胺衍生物
WO2009076404A1 (en) * 2007-12-10 2009-06-18 Epix Delaware, Inc. Carboxamide compounds and their use as antagonists of the chemokine ccr2 receptor
BRPI0820701A2 (pt) 2007-12-11 2015-06-16 Cytopathfinder Inc Composto de carboxamida e seu uso como agonistas do receptor de quimiocina
US20130072519A1 (en) 2010-05-21 2013-03-21 Edward Lee Conn 2-phenyl benzoylamides
EP2680874A2 (de) 2011-03-04 2014-01-08 Pfizer Inc Edn3-ähnliche peptide und ihre verwendung
EP2986599A1 (de) 2013-04-17 2016-02-24 Pfizer Inc. N-piperidin-3-ylbenzamid-derivate zur behandlung von herz-kreislauf-erkrankungen
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
BR112021013807A2 (pt) 2019-01-18 2021-11-30 Astrazeneca Ab Inibidores de pcsk9 e seus métodos de uso

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2330979A (en) * 1940-01-09 1943-10-05 Jr John C Krantz Cyclopropyl ether and method of preparing same
US4891367A (en) * 1987-04-22 1990-01-02 Merrell Dow Pharmaceuticals Inc. 17β-(cyclopropyloxy)androst-5-en-3β-ol and related compounds useful as C17-20 lyase inhibitors

Also Published As

Publication number Publication date
AU7669391A (en) 1991-10-21
AU641008B2 (en) 1993-09-09
CA2078871A1 (en) 1991-09-23
JPH05506023A (ja) 1993-09-02
EP0521103A1 (de) 1993-01-07
DE69113453D1 (de) 1995-11-02
JP2889697B2 (ja) 1999-05-10
ES2080311T3 (es) 1996-02-01
DE69113453T2 (de) 1996-03-07
US5051534A (en) 1991-09-24
WO1991014668A1 (en) 1991-10-03
EP0521103B1 (de) 1995-09-27
EP0521103A4 (en) 1993-03-10
CA2078871C (en) 2001-06-26

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee