ATE136884T1 - Neue 2-mercaptomethylen-tetrahydronaphthalin- und -indan-2-carboxamide als enkephalinaseinhibitoren - Google Patents
Neue 2-mercaptomethylen-tetrahydronaphthalin- und -indan-2-carboxamide als enkephalinaseinhibitorenInfo
- Publication number
- ATE136884T1 ATE136884T1 AT92107464T AT92107464T ATE136884T1 AT E136884 T1 ATE136884 T1 AT E136884T1 AT 92107464 T AT92107464 T AT 92107464T AT 92107464 T AT92107464 T AT 92107464T AT E136884 T1 ATE136884 T1 AT E136884T1
- Authority
- AT
- Austria
- Prior art keywords
- mercaptomethylene
- indaneous
- tetrahydronaphthaline
- carboxamides
- new
- Prior art date
Links
- DFPSGYPEHNZUEZ-UHFFFAOYSA-N C1C=CC=C2CC(=CS)CCC21 Chemical compound C1C=CC=C2CC(=CS)CCC21 DFPSGYPEHNZUEZ-UHFFFAOYSA-N 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 239000002792 enkephalinase inhibitor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/20—Esters of monothiocarboxylic acids
- C07C327/32—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69563591A | 1991-05-03 | 1991-05-03 | |
| US07/860,572 US5252601A (en) | 1991-05-03 | 1992-04-03 | 2-mercaptomethylene-tetrahydronaphthalene and indane-2-carboxamide derivatives as enkephalinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE136884T1 true ATE136884T1 (de) | 1996-05-15 |
Family
ID=27105626
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92107464T ATE136884T1 (de) | 1991-05-03 | 1992-04-30 | Neue 2-mercaptomethylen-tetrahydronaphthalin- und -indan-2-carboxamide als enkephalinaseinhibitoren |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5252601A (de) |
| EP (1) | EP0516980B1 (de) |
| JP (1) | JP3291631B2 (de) |
| KR (1) | KR100237949B1 (de) |
| AT (1) | ATE136884T1 (de) |
| AU (1) | AU649807B2 (de) |
| CA (1) | CA2067408C (de) |
| DE (1) | DE69209892T2 (de) |
| DK (1) | DK0516980T3 (de) |
| ES (1) | ES2089281T3 (de) |
| FI (1) | FI111252B (de) |
| GR (1) | GR3019685T3 (de) |
| HU (1) | HU211730B (de) |
| IE (1) | IE72082B1 (de) |
| IL (1) | IL101743A (de) |
| NO (1) | NO178334C (de) |
| NZ (1) | NZ242521A (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2183314C (en) * | 1994-02-14 | 1999-08-31 | Gary A. Flynn | Novel 2-substituted indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ace |
| CA2183313C (en) * | 1994-02-14 | 2001-01-02 | Gary A. Flynn | Novel indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase |
| JPH09508906A (ja) * | 1994-02-14 | 1997-09-09 | メレル ファーマスーティカルズ インコーポレーテッド | エンケファリナーゼ及びａｃｅの阻害剤として有用な新規なメルカプトアセチルアミド１，３，４，５−テトラヒドロベンゾ［ｃ］アゼピン−３−オンジスルフィド誘導体類 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2480747A1 (fr) * | 1980-04-17 | 1981-10-23 | Roques Bernard | Derives d'acides amines et leur application therapeutique |
| DE3467754D1 (de) * | 1983-10-03 | 1988-01-07 | Squibb & Sons Inc | Enkephalinase inhibitors |
| US4973585A (en) * | 1986-06-13 | 1990-11-27 | Merrell Dow Pharmaceuticals | Tricyclic lactams active as antihypertensive agents |
| KR880007441A (ko) * | 1986-12-11 | 1988-08-27 | 알렌 제이.스피겔 | 스피로-치환된 글루타르아미드 이뇨제 |
| JPH02231464A (ja) * | 1988-02-26 | 1990-09-13 | Tanabe Seiyaku Co Ltd | インダンオキシ酢酸誘導体 |
| EP0361365A1 (de) * | 1988-09-30 | 1990-04-04 | E.R. SQUIBB & SONS, INC. | Derivate von Aminobenzoesäure und Aminocyclohexancarbonsäure, Zusammensetzungen und ihre Verwendung |
| ZA902661B (en) * | 1989-04-10 | 1991-01-30 | Schering Corp | Mercapto-acyl amino acids |
| US5407960A (en) * | 1989-12-22 | 1995-04-18 | Schering Corporation | Mercaptocycloacyl aminoacid endopeptidase inhibitors |
-
1992
- 1992-04-03 US US07/860,572 patent/US5252601A/en not_active Expired - Fee Related
- 1992-04-27 AU AU15168/92A patent/AU649807B2/en not_active Ceased
- 1992-04-28 NZ NZ242521A patent/NZ242521A/en not_active IP Right Cessation
- 1992-04-28 CA CA002067408A patent/CA2067408C/en not_active Expired - Fee Related
- 1992-04-30 DE DE69209892T patent/DE69209892T2/de not_active Expired - Fee Related
- 1992-04-30 ES ES92107464T patent/ES2089281T3/es not_active Expired - Lifetime
- 1992-04-30 EP EP92107464A patent/EP0516980B1/de not_active Expired - Lifetime
- 1992-04-30 DK DK92107464.7T patent/DK0516980T3/da active
- 1992-04-30 AT AT92107464T patent/ATE136884T1/de not_active IP Right Cessation
- 1992-04-30 NO NO921706A patent/NO178334C/no unknown
- 1992-04-30 HU HU9201474A patent/HU211730B/hu not_active IP Right Cessation
- 1992-04-30 IL IL10174392A patent/IL101743A/en not_active IP Right Cessation
- 1992-04-30 FI FI921948A patent/FI111252B/fi not_active IP Right Cessation
- 1992-05-01 JP JP13763192A patent/JP3291631B2/ja not_active Expired - Fee Related
- 1992-05-01 KR KR1019920007436A patent/KR100237949B1/ko not_active Expired - Fee Related
- 1992-07-01 IE IE921408A patent/IE72082B1/en not_active IP Right Cessation
-
1996
- 1996-04-19 GR GR960401064T patent/GR3019685T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO921706L (no) | 1992-11-04 |
| AU1516892A (en) | 1992-11-05 |
| NO921706D0 (no) | 1992-04-30 |
| DE69209892D1 (de) | 1996-05-23 |
| EP0516980A1 (de) | 1992-12-09 |
| HU211730B (en) | 1995-12-28 |
| AU649807B2 (en) | 1994-06-02 |
| GR3019685T3 (en) | 1996-07-31 |
| IL101743A0 (en) | 1992-12-30 |
| DE69209892T2 (de) | 1996-11-14 |
| US5252601A (en) | 1993-10-12 |
| DK0516980T3 (da) | 1996-05-13 |
| CA2067408A1 (en) | 1992-11-04 |
| IE921408A1 (en) | 1992-11-04 |
| IE72082B1 (en) | 1997-03-12 |
| ES2089281T3 (es) | 1996-10-01 |
| IL101743A (en) | 1996-05-14 |
| NO178334B (no) | 1995-11-27 |
| CA2067408C (en) | 2003-07-15 |
| FI111252B (fi) | 2003-06-30 |
| NZ242521A (en) | 1994-04-27 |
| HUT65256A (en) | 1994-05-02 |
| JPH05208952A (ja) | 1993-08-20 |
| FI921948L (fi) | 1992-11-04 |
| JP3291631B2 (ja) | 2002-06-10 |
| KR920021504A (ko) | 1992-12-18 |
| KR100237949B1 (ko) | 2000-01-15 |
| EP0516980B1 (de) | 1996-04-17 |
| FI921948A0 (fi) | 1992-04-30 |
| HU9201474D0 (en) | 1992-07-28 |
| NO178334C (no) | 1996-03-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |