ATE128704T1 - Substituierte azetidinone als entzündungshemmende und antidegenerative wirkstoffe. - Google Patents
Substituierte azetidinone als entzündungshemmende und antidegenerative wirkstoffe.Info
- Publication number
- ATE128704T1 ATE128704T1 AT89200864T AT89200864T ATE128704T1 AT E128704 T1 ATE128704 T1 AT E128704T1 AT 89200864 T AT89200864 T AT 89200864T AT 89200864 T AT89200864 T AT 89200864T AT E128704 T1 ATE128704 T1 AT E128704T1
- Authority
- AT
- Austria
- Prior art keywords
- inflammatory
- antidegenerative
- active ingredients
- substituted azetidinones
- azetidinones
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Reinforced Plastic Materials (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17968888A | 1988-04-11 | 1988-04-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE128704T1 true ATE128704T1 (de) | 1995-10-15 |
Family
ID=22657566
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT89200864T ATE128704T1 (de) | 1988-04-11 | 1989-04-06 | Substituierte azetidinone als entzündungshemmende und antidegenerative wirkstoffe. |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP0337549B1 (de) |
| JP (1) | JP2736113B2 (de) |
| KR (1) | KR930008223B1 (de) |
| CN (1) | CN1037144A (de) |
| AT (1) | ATE128704T1 (de) |
| AU (1) | AU621865B2 (de) |
| CA (1) | CA1337990C (de) |
| DE (1) | DE68924439T2 (de) |
| DK (1) | DK169329B1 (de) |
| ES (1) | ES2079373T3 (de) |
| FI (1) | FI891689A7 (de) |
| GR (1) | GR3017656T3 (de) |
| HU (1) | HUT50761A (de) |
| IE (1) | IE891140L (de) |
| IL (1) | IL89835A0 (de) |
| LV (1) | LV11459B (de) |
| NO (1) | NO891470L (de) |
| NZ (1) | NZ228600A (de) |
| PT (1) | PT90222B (de) |
| YU (1) | YU71489A (de) |
| ZA (1) | ZA892549B (de) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5229510A (en) * | 1983-12-01 | 1993-07-20 | Merck & Co., Inc. | β-lactams useful in determining the amount of elastase in a clinical sample |
| US5229381A (en) * | 1983-12-01 | 1993-07-20 | Merck & Co., Inc. | Substituted azetidinones as anti-inflammatory and antidegenerative agents |
| KR930700494A (ko) * | 1990-04-10 | 1993-03-15 | 시게루 미즈노 | 신규한 옥사디논 유도체 |
| IL99658A0 (en) * | 1990-10-15 | 1992-08-18 | Merck & Co Inc | Substituted azetidinones and pharmaceutical compositions containing them |
| GB9103654D0 (en) * | 1991-02-21 | 1991-04-10 | Merck Sharp & Dohme | Chemical process |
| US5100880A (en) * | 1991-03-20 | 1992-03-31 | Merck & Co., Inc. | Novel betalactam elastase inhibitors containing phosphorous acid derivatives at the 4-position of the 2-azetidinone |
| US5104862A (en) * | 1991-03-20 | 1992-04-14 | Merck & Co., Inc. | Bethalactam elastase inhibitors containing phosphorous acid derivatives at the 4-position of the 2-azetidinone |
| WO1993000332A1 (en) * | 1991-06-25 | 1993-01-07 | Merck & Co., Inc. | Substituted azetidinones as anti-inflammatory and antidegenerative agents |
| US5348953A (en) * | 1991-06-25 | 1994-09-20 | Merck & Co., Inc. | Substituted azetidinones as anti-inflammatory and antidegenerative agents |
| US5688787A (en) * | 1991-07-23 | 1997-11-18 | Schering Corporation | Substituted β-lactam compounds useful as hypochlesterolemic agents and processes for the preparation thereof |
| TW223059B (de) * | 1991-07-23 | 1994-05-01 | Schering Corp | |
| US5688785A (en) * | 1991-07-23 | 1997-11-18 | Schering Corporation | Substituted azetidinone compounds useful as hypocholesterolemic agents |
| US5229267A (en) * | 1991-08-26 | 1993-07-20 | Merck & Co., Inc. | Assay for evaluating inhibition of PMN elastase by N-substituted azetidinones |
| US5274080A (en) * | 1991-08-26 | 1993-12-28 | Merck & Co., Inc. | Monospecific antibodies useful in evaluating inhibition of polymorphonuclear leukocyte elastase by N-substituted azetidinones |
| US5276139A (en) * | 1991-08-26 | 1994-01-04 | Merck & Co., Inc. | Haptens useful in evaluating inhibition of PNN elastase by N-substituted azetidinones |
| EP0529719A1 (de) * | 1991-08-26 | 1993-03-03 | Merck & Co. Inc. | Test zur Bestimmung der Hemmung der PMN-Elastase durch N-substituierte Azetidinone |
| US5149838A (en) * | 1991-09-20 | 1992-09-22 | Merck & Co., Inc. | Intermediates for substituted azetidinones useful as anti-inflammatory and antidegenerative agents |
| GB2266527A (en) * | 1992-03-17 | 1993-11-03 | Merck & Co Inc | Substituted azetidinones useful in the treatment of leukemia |
| US5250676A (en) * | 1992-03-23 | 1993-10-05 | University Of Notre Dame Du Lac | Process for the preparation of 3-substituted-2-azetidinones |
| CA2108584C (en) * | 1992-10-27 | 1998-11-24 | James B. Doherty | Substituted azetidinones as anti-inflammatory and antidegenerative agents |
| JPH08502752A (ja) * | 1992-10-27 | 1996-03-26 | メルク エンド カンパニー インコーポレーテッド | 抗炎症剤及び抗変性剤としての新規の置換アゼチジノン |
| AU5802894A (en) * | 1992-12-17 | 1994-07-04 | Merck & Co., Inc. | New substituted azetidinones as anti-inflammatory and antidegenerative agents |
| US5591737A (en) * | 1992-12-17 | 1997-01-07 | Merck & Co., Inc. | Substituted azetidinones as anti-inflammatory and antidegenerative agents |
| LT3595B (en) * | 1993-01-21 | 1995-12-27 | Schering Corp | Spirocycloalkyl-substituted azetidinones useful as hypocholesterolemic agents |
| GB9314350D0 (en) * | 1993-07-12 | 1993-08-25 | Zeneca Ltd | Armide derivatives |
| US5420010A (en) * | 1993-07-30 | 1995-05-30 | Merck & Co., Inc. | Assay for evaluating inhibition of polymorphonuclear leukocyte elastase by N-substituted azetidinones |
| US5631365A (en) * | 1993-09-21 | 1997-05-20 | Schering Corporation | Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents |
| US5403952A (en) * | 1993-10-08 | 1995-04-04 | Merck & Co., Inc. | Substituted cyclic derivatives as novel antidegenerative agents |
| JPH09510212A (ja) * | 1994-03-11 | 1997-10-14 | メルク エンド カンパニー インコーポレーテッド | 肺疾患を処置するための組成物 |
| US5627176A (en) * | 1994-03-25 | 1997-05-06 | Schering Corporation | Substituted azetidinone compounds useful as hypocholesterolemic agents |
| US5624920A (en) * | 1994-11-18 | 1997-04-29 | Schering Corporation | Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents |
| US5633246A (en) * | 1994-11-18 | 1997-05-27 | Schering Corporation | Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents |
| US5656624A (en) * | 1994-12-21 | 1997-08-12 | Schering Corporation | 4-[(heterocycloalkyl or heteroaromatic)-substituted phenyl]-2-azetidinones useful as hypolipidemic agents |
| AU5014496A (en) * | 1995-03-23 | 1996-10-08 | Japan Tobacco Inc. | Diphenylmethyl-azetidinone compounds and elastase inhibitor |
| US5747485A (en) * | 1995-04-13 | 1998-05-05 | Merck & Co., Inc. | Substituted azetidiones as anti-inflammatory and antidegenerative agents |
| US5523233A (en) * | 1995-05-03 | 1996-06-04 | Merck & Co., Inc. | Enzymatic hydrolysis of 3,3-diethyl-4-[(4-carboxy)phenoxy]-2-azetidinone esters |
| CN1197452A (zh) * | 1995-07-01 | 1998-10-28 | 史密丝克莱恩比彻姆有限公司 | 用于治疗动脉粥样硬化的氮杂环丁烷酮衍生物 |
| AU7222196A (en) * | 1995-10-09 | 1997-04-30 | Chiroscience Limited | Azetidinones and their therapeutic use as cytokine inhibitors |
| EP0869943A1 (de) * | 1995-12-08 | 1998-10-14 | Smithkline Beecham Plc | Monocyclische beta-lactame zur behandlung von atherosklerose |
| IL126696A0 (en) * | 1996-04-26 | 1999-08-17 | Smithkline Beecham Plc | Azetidinone derivatives for the treatment of atherosclerosis |
| US5756470A (en) * | 1996-10-29 | 1998-05-26 | Schering Corporation | Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents |
| US6903075B1 (en) | 1997-05-29 | 2005-06-07 | Merck & Co., Inc. | Heterocyclic amide compounds as cell adhesion inhibitors |
| PT1021404E (pt) * | 1997-10-07 | 2003-04-30 | Boehringer Ingelheim Ca Ltd | Derivados de azetidinona para o tratamento de infeccoes pelo hcmv |
| DE69808326T2 (de) * | 1997-10-07 | 2003-05-22 | Boehringer Ingelheim (Canada) Ltd., Laval | Azetidinonderivate zur behandlung von hcmv entzündungen |
| CA2301967C (en) * | 1997-10-07 | 2005-05-17 | Boehringer Ingelheim (Canada) Ltd. | Azetidinone derivatives for the treatment of hcmv infections |
| AU8059598A (en) * | 1998-06-11 | 1999-12-30 | Merck & Co., Inc. | Heterocyclic amide compounds as cell adhesion inhibitors |
| US6335324B1 (en) | 1998-06-25 | 2002-01-01 | Bristol-Myers Squibb Co. | Beta lactam compounds and their use as inhibitors of tryptase |
| WO2000005204A1 (en) * | 1998-07-23 | 2000-02-03 | Shionogi & Co., Ltd. | MONOCYCLIC β-LACTAM COMPOUNDS AND CHYMASE INHIBITORS CONTAINING THE SAME |
| AR023463A1 (es) | 1999-04-16 | 2002-09-04 | Schering Corp | Uso de compuestos de azetidinona |
| US6982251B2 (en) | 2000-12-20 | 2006-01-03 | Schering Corporation | Substituted 2-azetidinones useful as hypocholesterolemic agents |
| US7071181B2 (en) | 2001-01-26 | 2006-07-04 | Schering Corporation | Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors |
| PT1355644E (pt) | 2001-01-26 | 2006-11-30 | Schering Corp | Utilização de compostos azetidinona substituídos para o tratamento de sitosterolemia |
| RS20100015A (sr) | 2001-01-26 | 2010-12-31 | Schering Corporation | Kombinacija aktivatora receptora aktiviranog peroksizom- proliferatorom (ppar) fenofibrata sa inhibitorom apsorpcije sterola ezetimibom za vaskularne indikacije |
| IL157552A0 (en) | 2001-03-28 | 2004-03-28 | Schering Corp | Enantioselective synthesis of azetidinone intermediate compounds |
| EP1429756B1 (de) | 2001-09-21 | 2006-11-22 | Schering Corporation | Behandlung von xanthom mittels azetidinon-derivate als hemmer der sterol absorption |
| US7056906B2 (en) | 2001-09-21 | 2006-06-06 | Schering Corporation | Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women |
| US7053080B2 (en) | 2001-09-21 | 2006-05-30 | Schering Corporation | Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors |
| JP2006508188A (ja) | 2002-11-06 | 2006-03-09 | シェーリング コーポレイション | 脱髄の処置のためのコレステロール吸収インヒビター |
| US7459442B2 (en) | 2003-03-07 | 2008-12-02 | Schering Corporation | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof |
| CN1756755A (zh) | 2003-03-07 | 2006-04-05 | 先灵公司 | 取代的2－吖丁啶酮化合物、其制剂及其治疗高胆甾醇血症的用途 |
| DE602004016123D1 (de) | 2003-03-07 | 2008-10-09 | Schering Corp | Substituierte azetidinon-derivate, deren pharmazeutische formulierungen und deren verwendung zur behandlung von hypercholesterolemia |
| CN1756756A (zh) | 2003-03-07 | 2006-04-05 | 先灵公司 | 取代的2－吖丁啶酮化合物、其制剂及其治疗高胆甾醇血症的用途 |
| US8440819B2 (en) * | 2008-02-22 | 2013-05-14 | Allergan, Inc. | Therapeutic substituted beta-lactams |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4680391A (en) * | 1983-12-01 | 1987-07-14 | Merck & Co., Inc. | Substituted azetidinones as anti-inflammatory and antidegenerative agents |
-
1989
- 1989-04-04 IL IL89835A patent/IL89835A0/xx unknown
- 1989-04-04 NZ NZ228600A patent/NZ228600A/en unknown
- 1989-04-06 ES ES89200864T patent/ES2079373T3/es not_active Expired - Lifetime
- 1989-04-06 DE DE68924439T patent/DE68924439T2/de not_active Expired - Fee Related
- 1989-04-06 AT AT89200864T patent/ATE128704T1/de not_active IP Right Cessation
- 1989-04-06 EP EP89200864A patent/EP0337549B1/de not_active Expired - Lifetime
- 1989-04-07 PT PT90222A patent/PT90222B/pt not_active IP Right Cessation
- 1989-04-07 ZA ZA892549A patent/ZA892549B/xx unknown
- 1989-04-07 CA CA000595997A patent/CA1337990C/en not_active Expired - Fee Related
- 1989-04-10 NO NO89891470A patent/NO891470L/no unknown
- 1989-04-10 HU HU891708A patent/HUT50761A/hu unknown
- 1989-04-10 KR KR1019890004702A patent/KR930008223B1/ko not_active Expired - Lifetime
- 1989-04-10 YU YU00714/89A patent/YU71489A/xx unknown
- 1989-04-10 AU AU32630/89A patent/AU621865B2/en not_active Ceased
- 1989-04-10 DK DK170589A patent/DK169329B1/da not_active IP Right Cessation
- 1989-04-10 FI FI891689A patent/FI891689A7/fi not_active Application Discontinuation
- 1989-04-10 IE IE891140A patent/IE891140L/xx not_active IP Right Cessation
- 1989-04-10 CN CN89103271A patent/CN1037144A/zh active Pending
- 1989-04-11 JP JP1091723A patent/JP2736113B2/ja not_active Expired - Fee Related
-
1995
- 1995-10-05 GR GR950402512T patent/GR3017656T3/el unknown
-
1996
- 1996-02-01 LV LVP-96-24A patent/LV11459B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| YU71489A (en) | 1991-10-31 |
| CN1037144A (zh) | 1989-11-15 |
| NO891470D0 (no) | 1989-04-10 |
| KR900016121A (ko) | 1990-11-12 |
| DK170589A (da) | 1989-10-12 |
| IL89835A0 (en) | 1989-12-15 |
| HUT50761A (en) | 1990-03-28 |
| FI891689A7 (fi) | 1989-10-12 |
| DE68924439D1 (de) | 1995-11-09 |
| DE68924439T2 (de) | 1996-05-09 |
| LV11459A (lv) | 1996-08-20 |
| CA1337990C (en) | 1996-01-23 |
| DK169329B1 (da) | 1994-10-10 |
| EP0337549B1 (de) | 1995-10-04 |
| AU3263089A (en) | 1989-10-12 |
| FI891689A0 (fi) | 1989-04-10 |
| DK170589D0 (da) | 1989-04-10 |
| NZ228600A (en) | 1992-02-25 |
| PT90222B (pt) | 1994-07-29 |
| ZA892549B (en) | 1989-11-29 |
| ES2079373T3 (es) | 1996-01-16 |
| JP2736113B2 (ja) | 1998-04-02 |
| PT90222A (pt) | 1989-11-10 |
| AU621865B2 (en) | 1992-03-26 |
| LV11459B (en) | 1996-12-20 |
| JPH026471A (ja) | 1990-01-10 |
| IE891140L (en) | 1989-10-11 |
| GR3017656T3 (en) | 1996-01-31 |
| KR930008223B1 (ko) | 1993-08-27 |
| EP0337549A1 (de) | 1989-10-18 |
| NO891470L (no) | 1989-10-12 |
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