ATE128980T1 - Substituierte imidazol-2-one derivate und verfahren zu deren herstellung. - Google Patents
Substituierte imidazol-2-one derivate und verfahren zu deren herstellung.Info
- Publication number
- ATE128980T1 ATE128980T1 AT92103724T AT92103724T ATE128980T1 AT E128980 T1 ATE128980 T1 AT E128980T1 AT 92103724 T AT92103724 T AT 92103724T AT 92103724 T AT92103724 T AT 92103724T AT E128980 T1 ATE128980 T1 AT E128980T1
- Authority
- AT
- Austria
- Prior art keywords
- chem
- derivatives
- production
- phenyl
- substituted imidazol
- Prior art date
Links
- WZELXJBMMZFDDU-UHFFFAOYSA-N Imidazol-2-one Chemical class O=C1N=CC=N1 WZELXJBMMZFDDU-UHFFFAOYSA-N 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 abstract 1
- 125000006650 (C2-C4) alkynyl group Chemical group 0.000 abstract 1
- 208000019695 Migraine disease Diseases 0.000 abstract 1
- 206010047700 Vomiting Diseases 0.000 abstract 1
- 239000012190 activator Substances 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000019771 cognition Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 230000010243 gut motility Effects 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 206010027599 migraine Diseases 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Addiction (AREA)
- Rheumatology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB919106571A GB9106571D0 (en) | 1991-03-27 | 1991-03-27 | Derivatives of substituted imidazol-2-one and process for their preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE128980T1 true ATE128980T1 (de) | 1995-10-15 |
Family
ID=10692325
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92103724T ATE128980T1 (de) | 1991-03-27 | 1992-03-05 | Substituierte imidazol-2-one derivate und verfahren zu deren herstellung. |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US5242929A (de) |
| EP (1) | EP0505778B1 (de) |
| JP (1) | JP3315144B2 (de) |
| KR (1) | KR920018030A (de) |
| AT (1) | ATE128980T1 (de) |
| AU (1) | AU644720B2 (de) |
| CA (1) | CA2062271C (de) |
| DE (1) | DE69205312T2 (de) |
| DK (1) | DK0505778T3 (de) |
| ES (1) | ES2080975T3 (de) |
| FI (1) | FI921308A7 (de) |
| GB (1) | GB9106571D0 (de) |
| GR (1) | GR3018342T3 (de) |
| HU (1) | HU208135B (de) |
| IE (1) | IE76918B1 (de) |
| IL (1) | IL101087A (de) |
| MX (1) | MX9201279A (de) |
| MY (1) | MY108681A (de) |
| NZ (1) | NZ241785A (de) |
| RU (1) | RU2056418C1 (de) |
| TW (1) | TW198719B (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9212486D0 (en) * | 1992-06-12 | 1992-07-22 | Erba Carlo Spa | Derivatives of substituted imidazo benzoxazin-1-one and process for their preparation |
| SK94393A3 (en) * | 1992-09-11 | 1994-08-10 | Thomae Gmbh Dr K | Cyclic derivatives of urea, process for their production and their pharmaceutical agents with the content of those |
| GB9224144D0 (en) * | 1992-11-18 | 1993-01-06 | Erba Carlo Spa | Phenyl-imidazolidinone derivatives and process for their preparation |
| DE4332168A1 (de) * | 1993-02-22 | 1995-03-23 | Thomae Gmbh Dr K | Cyclische Derivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| JP3916093B2 (ja) * | 1993-09-17 | 2007-05-16 | 杏林製薬株式会社 | 光学活性イミダゾリジノン誘導体とその製造方法 |
| JP3916092B2 (ja) * | 1993-09-17 | 2007-05-16 | 杏林製薬株式会社 | イミダゾリジノン誘導体とその酸付加塩及び老年性痴呆症の治療薬 |
| GB9410441D0 (en) * | 1994-05-25 | 1994-07-13 | Erba Carlo Spa | Azabicycloakyl derivatives of imidazo (1,5-a) indol-3-one and process for their preparation |
| US6347538B1 (en) * | 2000-11-29 | 2002-02-19 | Gerald J. Doiron | Locking mechanism for weapons |
| US6770655B2 (en) * | 2002-01-18 | 2004-08-03 | Aryx Therapeutics | 5-HT3 receptor antagonists and methods of use |
| MA37975B2 (fr) | 2012-09-11 | 2021-03-31 | Genzyme Corp | Inhibiteurs de synthase de glucosylcéramide |
| US12527776B2 (en) | 2019-02-04 | 2026-01-20 | Genzyme Corporation | Treatment of ciliopathies using inhibitors of glucosylceramide synthase (GCS) |
| EP4100009A1 (de) | 2020-02-03 | 2022-12-14 | Genzyme Corporation | Verfahren zur behandlung neurologischer symptome im zusammenhang mit lysosomalen speicherkrankheiten |
| KR20230043024A (ko) | 2020-07-24 | 2023-03-30 | 젠자임 코포레이션 | 벤글루스타트를 포함하는 제약 조성물 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3702327A (en) * | 1970-12-28 | 1972-11-07 | Aldrich Chem Co Inc | N-beta-1-(3-phenylimidazolidin-2-one)ethyl 4,4-ethylene dioxypiperidines |
| EP0235878A3 (de) * | 1986-01-16 | 1989-06-14 | Beecham Group Plc | Neue Verbindungen |
| DE3785507T2 (de) * | 1986-07-31 | 1993-07-29 | Beecham Group Plc | Azabicyclische verbindungen, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung. |
| IE62231B1 (en) * | 1987-12-24 | 1995-01-11 | Wyeth John & Brother Ltd | Heterocyclic compounds |
| IT1230881B (it) * | 1989-06-20 | 1991-11-08 | Angeli Inst Spa | Derivati del r(-) 3-chinuclidinolo |
| DK443489D0 (da) * | 1989-09-08 | 1989-09-08 | Ferrosan As | Substituerede urinstofforbindelser, deres fremstilling og anvendelse |
| GB8922622D0 (en) * | 1989-10-07 | 1989-11-22 | Wyeth John & Brother Ltd | Aroylureas |
-
1991
- 1991-03-27 GB GB919106571A patent/GB9106571D0/en active Pending
-
1992
- 1992-02-25 AU AU11214/92A patent/AU644720B2/en not_active Ceased
- 1992-02-27 IL IL10108792A patent/IL101087A/en not_active IP Right Cessation
- 1992-02-28 NZ NZ241785A patent/NZ241785A/en unknown
- 1992-02-28 US US07/843,339 patent/US5242929A/en not_active Expired - Lifetime
- 1992-03-04 CA CA002062271A patent/CA2062271C/en not_active Expired - Fee Related
- 1992-03-05 AT AT92103724T patent/ATE128980T1/de active
- 1992-03-05 EP EP92103724A patent/EP0505778B1/de not_active Expired - Lifetime
- 1992-03-05 DE DE69205312T patent/DE69205312T2/de not_active Expired - Fee Related
- 1992-03-05 ES ES92103724T patent/ES2080975T3/es not_active Expired - Lifetime
- 1992-03-05 DK DK92103724.8T patent/DK0505778T3/da active
- 1992-03-07 TW TW081101751A patent/TW198719B/zh active
- 1992-03-23 MX MX9201279A patent/MX9201279A/es not_active IP Right Cessation
- 1992-03-23 MY MYPI92000483A patent/MY108681A/en unknown
- 1992-03-25 FI FI921308A patent/FI921308A7/fi unknown
- 1992-03-26 IE IE920961A patent/IE76918B1/en not_active IP Right Cessation
- 1992-03-26 RU SU925011244A patent/RU2056418C1/ru active
- 1992-03-26 HU HU9200946A patent/HU208135B/hu not_active IP Right Cessation
- 1992-03-26 KR KR1019920004892A patent/KR920018030A/ko not_active Abandoned
- 1992-03-27 JP JP07146692A patent/JP3315144B2/ja not_active Expired - Fee Related
-
1993
- 1993-06-14 US US08/076,153 patent/US5401750A/en not_active Expired - Fee Related
-
1995
- 1995-12-08 GR GR950403461T patent/GR3018342T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MY108681A (en) | 1996-10-31 |
| KR920018030A (ko) | 1992-10-21 |
| US5401750A (en) | 1995-03-28 |
| FI921308A0 (fi) | 1992-03-25 |
| EP0505778A1 (de) | 1992-09-30 |
| AU1121492A (en) | 1992-10-01 |
| DK0505778T3 (da) | 1995-12-11 |
| JP3315144B2 (ja) | 2002-08-19 |
| GR3018342T3 (en) | 1996-03-31 |
| RU2056418C1 (ru) | 1996-03-20 |
| IE920961A1 (en) | 1992-10-07 |
| HU9200946D0 (en) | 1992-05-28 |
| HUT61021A (en) | 1992-11-30 |
| NZ241785A (en) | 1994-01-26 |
| DE69205312T2 (de) | 1996-03-14 |
| TW198719B (de) | 1993-01-21 |
| US5242929A (en) | 1993-09-07 |
| IL101087A0 (en) | 1992-11-15 |
| ES2080975T3 (es) | 1996-02-16 |
| IL101087A (en) | 1996-01-31 |
| MX9201279A (es) | 1992-10-01 |
| JPH0570457A (ja) | 1993-03-23 |
| HU208135B (en) | 1993-08-30 |
| CA2062271A1 (en) | 1992-09-28 |
| FI921308A7 (fi) | 1992-09-28 |
| CA2062271C (en) | 2003-04-08 |
| AU644720B2 (en) | 1993-12-16 |
| GB9106571D0 (en) | 1991-05-15 |
| DE69205312D1 (de) | 1995-11-16 |
| IE76918B1 (en) | 1997-11-05 |
| EP0505778B1 (de) | 1995-10-11 |
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