ATE129013T1 - Steroid 5-alpha-reduktase. - Google Patents

Steroid 5-alpha-reduktase.

Info

Publication number
ATE129013T1
ATE129013T1 AT91909339T AT91909339T ATE129013T1 AT E129013 T1 ATE129013 T1 AT E129013T1 AT 91909339 T AT91909339 T AT 91909339T AT 91909339 T AT91909339 T AT 91909339T AT E129013 T1 ATE129013 T1 AT E129013T1
Authority
AT
Austria
Prior art keywords
preparation
steroid
alpha
disclosed
sequences
Prior art date
Application number
AT91909339T
Other languages
English (en)
Inventor
Stefan Andersson
David W Russell
Original Assignee
Univ Texas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas filed Critical Univ Texas
Application granted granted Critical
Publication of ATE129013T1 publication Critical patent/ATE129013T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/001—Oxidoreductases (1.) acting on the CH-CH group of donors (1.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C12Q1/32—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving dehydrogenase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y103/00—Oxidoreductases acting on the CH-CH group of donors (1.3)
    • C12Y103/01—Oxidoreductases acting on the CH-CH group of donors (1.3) with NAD+ or NADP+ as acceptor (1.3.1)
    • C12Y103/01022—3-Oxo-5alpha-steroid 4-dehydrogenase (NADP+) (1.3.1.22), i.e. cortisone alpha-reductase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT91909339T 1990-04-30 1991-04-25 Steroid 5-alpha-reduktase. ATE129013T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US51766190A 1990-04-30 1990-04-30

Publications (1)

Publication Number Publication Date
ATE129013T1 true ATE129013T1 (de) 1995-10-15

Family

ID=24060703

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91909339T ATE129013T1 (de) 1990-04-30 1991-04-25 Steroid 5-alpha-reduktase.

Country Status (8)

Country Link
US (2) US5422262A (de)
EP (1) EP0528906B1 (de)
JP (1) JP3294844B2 (de)
AT (1) ATE129013T1 (de)
AU (1) AU642501B2 (de)
CA (1) CA2079454C (de)
DE (1) DE69113795T2 (de)
WO (1) WO1991017251A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991017251A1 (en) * 1990-04-30 1991-11-14 Board Of Regents, The University Of Texas System STEROID 5α-REDUCTASES
US5576191A (en) * 1994-06-17 1996-11-19 Immunex Corporation Cytokine that binds ST2
US5656613A (en) * 1995-01-04 1997-08-12 Merck & Co., Inc. Treatment of hyperandrogenic conditions
US5968770A (en) * 1995-02-10 1999-10-19 Millennium Pharmaceuticals, Inc. Compositions and methods for the treatment and diagnosis of cardiovascular disease using rchd523 as a target
US6359194B1 (en) * 1995-02-10 2002-03-19 Millennium Pharmaceuticals, Inc. Compositions and methods for the treatment and diagnosis of cardiovascular disease
US20020170077A1 (en) * 1995-02-10 2002-11-14 Millennium Pharmaceuticals, Inc. Compositions and methods for the treatment and diagnosis of cardiovascular disease
IT1276662B1 (it) * 1995-04-04 1997-11-03 Uni Degli Studi Camerino Vaccini polinucleotidici
JP2000501603A (ja) * 1995-12-07 2000-02-15 ベイラー・カレッジ・オブ・メディスン 尿生殖洞由来増殖因子のヌクレオチドおよびアミノ酸配列
CA2247246A1 (en) 1996-02-16 1997-08-21 Millennium Pharmaceuticals, Inc. Compositions and methods for the treatment and diagnosis of cardiovascular disease
AU2666797A (en) * 1996-04-15 1997-11-07 Dyad Pharmaceutical Corporation Combination therapy for androgenic alopecia with antisense oligonucleotides and minoxidil
US6143950A (en) * 1996-04-18 2000-11-07 The Salk Institute For Biological Studies Plant steroid 5α reductase, DET2
DE69733947T2 (de) * 1996-05-15 2006-06-14 Altana Pharma Ag Verfahren zur trennung und bestimmung von hydrophoben proteinen durch dünnschichtchromatographie
AU2238499A (en) 1998-01-23 1999-08-09 University Of Southern California Androgen-metabolic gene mutations and prostate cancer risk
US6372712B1 (en) 1998-05-22 2002-04-16 The Board Of Trustees Of The Leland Stanford Jr. University Synthetic bifunctional molecules containing a drug moiety and presenter protein ligand
EP1280915A1 (de) * 2000-04-13 2003-02-05 Millennium Pharmaceuticals, Inc. Menschliche 5-alpha reductase und deren anwendungen
US6469150B1 (en) * 2000-05-22 2002-10-22 Pharmacopeia, Inc. Cloning and characterization of genes encoding bradykinin B1 receptor homologues from five mammalian species
WO2002046386A2 (en) 2000-10-30 2002-06-13 Pharmacia Corporation Aspergillus ochraceus 11 alpha hydroxylase and oxidoreductase
DE60129838T2 (de) * 2000-11-09 2008-04-30 Astrazeneca Ab Orale pharmazeutische zusammensetzung mit einem blockcopolymer
JP2002236307A (ja) * 2001-02-09 2002-08-23 Asahi Optical Co Ltd ズームストロボ装置
US7635598B2 (en) * 2004-07-08 2009-12-22 Biosearch Technologies, Inc. Inducible fluorescence assay
US20070036740A1 (en) * 2004-10-06 2007-02-15 Reed Kenneth C Modulation of hair growth
EP2671508B1 (de) 2005-04-28 2020-09-16 Proteus Digital Health, Inc. Pharma-Informatiksystem
US9062126B2 (en) 2005-09-16 2015-06-23 Raptor Pharmaceuticals Inc. Compositions comprising receptor-associated protein (RAP) variants specific for CR-containing proteins and uses thereof
FR2903999B1 (fr) * 2006-07-19 2008-09-05 Galderma Res & Dev S N C Snc Modulateurs de sc4mol dans le traitement de l'acne ou de l'hyperseborrhee
ES2919563T3 (es) 2009-02-20 2022-07-27 Enhanx Biopharm Inc Sistema de administración de medicamentos a base de glutatión
CA2759098A1 (en) * 2009-04-14 2010-10-21 Smith Holdings, Llc Methods and compositions for the treatment of medical conditions involving cellular programming
KR20180114970A (ko) 2009-05-06 2018-10-19 라보라토리 스킨 케어, 인크. 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
EP4092103A4 (de) * 2020-01-16 2024-05-15 Keio University Zusammensetzung zum produzieren von gallensäuren
CN115247189A (zh) * 2022-05-17 2022-10-28 南京启真基因工程有限公司 一种表达人源II型5α-还原酶的脱发模型猪核移植供体细胞的构建方法
CN117630382A (zh) * 2023-11-25 2024-03-01 温州医科大学附属第二医院（温州医科大学附属育英儿童医院） 大鼠睾丸Leydig祖细胞标志蛋白及其筛选方法和应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991017251A1 (en) * 1990-04-30 1991-11-14 Board Of Regents, The University Of Texas System STEROID 5α-REDUCTASES

Also Published As

Publication number Publication date
CA2079454C (en) 2002-02-26
AU7857991A (en) 1991-11-27
WO1991017251A1 (en) 1991-11-14
US5679521A (en) 1997-10-21
JP3294844B2 (ja) 2002-06-24
EP0528906A1 (de) 1993-03-03
US5422262A (en) 1995-06-06
AU642501B2 (en) 1993-10-21
EP0528906B1 (de) 1995-10-11
DE69113795T2 (de) 1996-03-28
JPH05507405A (ja) 1993-10-28
CA2079454A1 (en) 1991-10-31
DE69113795D1 (de) 1995-11-16

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