ATE130009T1 - Antitumor-aminosäuren und peptid-derivate von 1,4-bis((aminoalkyl und hydroxyaminoalkyl)amino>5,8- dihydroxyanthraquinonen. - Google Patents

Antitumor-aminosäuren und peptid-derivate von 1,4-bis((aminoalkyl und hydroxyaminoalkyl)amino>5,8- dihydroxyanthraquinonen.

Info

Publication number: ATE130009T1
Authority: AT; Austria
Prior art keywords: amino; hydroxyaminoalkyl; dihydroxyanthraquinones; aminoalkyl; antitumor
Prior art date: 1986-06-13

Application number

AT87108677T

Other languages

English (en)

Inventor

Thomas Lynn Fields

Keith Chadwick Murdock

Martin Leon Sassiver

Janis Upeslacis

Original Assignee

American Cyanamid Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-06-13

Filing date

1987-06-16

Publication date

1995-11-15

1987-06-16 Application filed by American Cyanamid Co filed Critical American Cyanamid Co

1995-11-15 Application granted granted Critical

1995-11-15 Publication of ATE130009T1 publication Critical patent/ATE130009T1/de

Links

150000001413 amino acids Chemical class 0.000 title abstract 2
230000000259 anti-tumor effect Effects 0.000 title abstract 2
108090000765 processed proteins & peptides Chemical class 0.000 title abstract 2
125000004103 aminoalkyl group Chemical group 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06043—Leu-amino acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0815—Tripeptides with the first amino acid being basic
- C07K5/0817—Tripeptides with the first amino acid being basic the first amino acid being Arg
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0819—Tripeptides with the first amino acid being acidic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1021—Tetrapeptides with the first amino acid being acidic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Hematology (AREA)
Oncology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Indole Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT87108677T 1986-06-13 1987-06-16 Antitumor-aminosäuren und peptid-derivate von 1,4-bis((aminoalkyl und hydroxyaminoalkyl)amino>5,8- dihydroxyanthraquinonen. ATE130009T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/874,195 US4732970A (en)	1986-06-13	1986-06-13	Antitumor amino acid and peptide derivatives of 1,4-bis(aminoalkyl and hydroxy-aminoalkyl)amino)-5,8-dihydroxyanthraquinones

Publications (1)

Publication Number	Publication Date
ATE130009T1 true ATE130009T1 (de)	1995-11-15

Family

ID=25363206

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT87108677T ATE130009T1 (de)	1986-06-13	1987-06-16	Antitumor-aminosäuren und peptid-derivate von 1,4-bis((aminoalkyl und hydroxyaminoalkyl)amino>5,8- dihydroxyanthraquinonen.

Country Status (8)

Country	Link
US (1)	US4732970A (de)
EP (1)	EP0295316B1 (de)
JP (1)	JP2512482B2 (de)
AT (1)	ATE130009T1 (de)
CA (1)	CA1298035C (de)
DE (1)	DE3751586T2 (de)
ES (1)	ES2081797T3 (de)
GR (1)	GR3018038T3 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3629175A1 (de) *	1986-08-28	1988-03-17	Behringwerke Ag	Chromogene verbindungen, verfahren zu deren herstellung und ihre verwendung
US4980343A (en) *	1988-10-27	1990-12-25	Bayer Aktiengesellschaft	Aminooxodihydroisoindoloquinazoline carcinostatic agents
AU7044994A (en) *	1993-05-24	1994-12-20	Nycomed Pharma	Hemoregulatory peptides
GB9320191D0 (en) *	1993-09-30	1993-11-17	Univ Napier	Compounds
EP0768317B1 (de) *	1995-10-16	1999-01-27	Kyowa Hakko Kogyo Co., Ltd.	UCK14-Verbindungen
DE19635557C2 (de) *	1996-09-02	1998-09-03	Baykut Goekhan Dr	Neue Hydroxyanthrachinon-Derivate
GB9929801D0 (en) *	1999-12-16	2000-02-09	Btg Int Ltd	Anti-cancer agents iii
RU2245143C2 (ru) *	2002-12-27	2005-01-27	Хохлов Александр Петрович	Аминокислотный препарат, обладающий противоопухолевым действием, и способ его получения
CN104788333B (zh) *	2015-03-19	2017-03-22	中国医科大学	2‑取代‑9,10‑蒽醌类化合物、制备方法及其用途
WO2019056098A1 (en) *	2017-09-19	2019-03-28	The Governors Of The University Of Alberta	BIOREDUCTION-ACTIVATED COMPOUNDS, THEIR PRODRUGS, RADIOPHARMACEUTICAL PRODUCTS, COMPOSITIONS AND THEIR APPLICATIONS IN THE MULTIMODAL THERANOSTIC MANAGEMENT OF HYPOXIA, INCLUDING CANCER

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4197249A (en)	1977-08-15	1980-04-08	American Cyanamid Company	1,4-Bis(substituted-amino)-5,8-dihydroxyanthraquinones and leuco bases thereof
US4310666A (en) *	1978-04-10	1982-01-12	United States Of America	Anti-neoplastic 1,4-bis-(substituted aminoalkyl amino)-anthraquinones
US4526989A (en) *	1978-07-11	1985-07-02	American Cyanamid Company	1,4-Bis (substituted-amino)-5,8-dihydroxy-anthraquinones and leuco bases thereof
US4296030A (en) *	1980-04-09	1981-10-20	American Cyanamid Company	Metal chelates of 1,4-bis(substituted-amino-5,8-dihydroxy-anthraquinones
US4298523A (en) *	1980-06-17	1981-11-03	Ortho Pharmaceutical Corporation	Methods and compositions for preparation of H-ARG-X-Z-Y-TYR-R
IL76002A0 (en) *	1984-08-03	1985-12-31	Boehringer Biochemia Srl	Amino-anthracenediones-platinum complexes useful as anti-cancer compounds
EP0182135A3 (de) *	1984-11-19	1987-08-05	American Cyanamid Company	Bis-(substituierte Amino)-anthrachinone

1986
- 1986-06-13 US US06/874,195 patent/US4732970A/en not_active Expired - Lifetime
1987
- 1987-06-12 CA CA000539591A patent/CA1298035C/en not_active Expired - Fee Related
- 1987-06-16 EP EP87108677A patent/EP0295316B1/de not_active Expired - Lifetime
- 1987-06-16 AT AT87108677T patent/ATE130009T1/de not_active IP Right Cessation
- 1987-06-16 ES ES87108677T patent/ES2081797T3/es not_active Expired - Lifetime
- 1987-06-16 DE DE3751586T patent/DE3751586T2/de not_active Expired - Fee Related
- 1987-07-11 JP JP62172118A patent/JP2512482B2/ja not_active Expired - Fee Related
1995
- 1995-11-09 GR GR950402166T patent/GR3018038T3/el unknown

Also Published As

Publication number	Publication date
JPS6416753A (en)	1989-01-20
DE3751586D1 (de)	1995-12-14
US4732970A (en)	1988-03-22
JP2512482B2 (ja)	1996-07-03
EP0295316A2 (de)	1988-12-21
EP0295316B1 (de)	1995-11-08
EP0295316A3 (en)	1990-03-14
DE3751586T2 (de)	1996-06-13
ES2081797T3 (es)	1996-03-16
GR3018038T3 (en)	1996-02-29
CA1298035C (en)	1992-03-24

Legal Events

Date	Code	Title	Description
1996-06-15	UEP	Publication of translation of european patent specification
2006-03-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
FI906438A0 (fi)	1990-12-28	Menetelmä uusien, terapeuttisesti käyttökelpoisten A-nor-steroidi-3-karboksyylihappojohdannaisten valmistamiseksi
FI920023A0 (fi)	1992-01-03	Heteroarylpiperazinfoereningar som antipsykotiska aemnen.
GR3004139T3 (de)	1993-03-31
ES2043609T3 (es)	1994-01-01	Composiciones de interleucina-2.
FI871406A7 (fi)	1987-10-02	Foerfarande foer framstaellning av nya aminosyraderivat.
DE3751586D1 (de)	1995-12-14	Antitumor-Aminosäuren und Peptid-Derivate von 1,4-bis[(Aminoalkyl und Hydroxyaminoalkyl)amino]5,8-Dihydroxyanthraquinonen.
AU1634388A (en)	1988-11-24	Cyclic anticoagulant peptides
AU1634288A (en)	1988-11-24	Cyclic anticoagulant peptides
PT86233A (fr)	1987-12-01	Procede de preparation d:une variant de l:hirudine
DE3787657D1 (de)	1993-11-11	Aminosäure-Derivate.
AU5901490A (en)	1991-01-17	Hemoregulatory peptides
ATE41773T1 (de)	1989-04-15	4,5-dihydro-4-oxo-2((2-transphenylcyclopropyl)amino>-3-furancarbonsaeuren und derivate davon.
ES2053809T3 (es)	1994-08-01	Derivados de ciclopropano.
FI862336A0 (fi)	1986-06-02	Nytt foerfarande foer framstaellning av 7-aca-derivat.
DE68921051D1 (de)	1995-03-23	Pyridin-3-percarboxylsäure monopersulfat.
FR2580636B1 (fr)	1987-05-15	Nouveaux derives acryliques de l'uree
FI913161A7 (fi)	1991-06-28	Menetelmä N-(3',4'-dimetoksikinnamoyyli)antraniilihapon valmistamiseks i
ZA841534B (en)	1984-10-31	New 3-alkylthio-2-o-carbamoyl-propan-1.2-diol-1-0-phosphocholines,and processes for their preparation
ATE95518T1 (de)	1993-10-15	Aminosaeure-derivate.