PT88603A - Immunomodulatory azapiranes - Google Patents

Immunomodulatory azapiranes

Info

Publication number: PT88603A
Authority: PT; Portugal
Prior art keywords: immunomodulatory; azapiranes; azaspiranes; formulae; chem
Prior art date: 1987-09-28

Application number

PT88603A

Other languages

English (en)

Other versions

PT88603B (pt

Inventor

Alison Mary Badger

Elaine Nicholas Cheesemann

Michael John Dimartino

Christopher Kevin Mirabelli

Donald Harold Picker

David Aaron Schwartz

Original Assignee

Smithkline Beckman Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-09-28

Filing date

1988-09-27

Publication date

1988-10-01

1988-09-27 Application filed by Smithkline Beckman Corp filed Critical Smithkline Beckman Corp

1988-10-01 Publication of PT88603A publication Critical patent/PT88603A/pt

1992-12-31 Publication of PT88603B publication Critical patent/PT88603B/pt

Links

230000002519 immonomodulatory effect Effects 0.000 title abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/20—Spiro-condensed ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/01—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics
- C04B35/45—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics based on copper oxide or solid solutions thereof with other oxides
- C04B35/4504—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics based on copper oxide or solid solutions thereof with other oxides containing rare earth oxides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/54—Spiro-condensed
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/96—Spiro-condensed ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Ceramic Engineering (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Immunology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Structural Engineering (AREA)
Materials Engineering (AREA)
Manufacturing & Machinery (AREA)
Biomedical Technology (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Transplantation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Indole Compounds (AREA)
Saccharide Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

PT88603A 1987-09-28 1988-09-27 Processo para a preparacao de composicoes farmaceuticas contendo derivados de azaspiranos e de preparacao de alguns derivados de azaspiranos PT88603B (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US10170487A	1987-09-28	1987-09-28
US07/244,229 US4963557A (en)	1987-09-28	1988-09-13	Immunomodulatory azaspiranes

Publications (2)

Publication Number	Publication Date
PT88603A true PT88603A (pt)	1988-10-01
PT88603B PT88603B (pt)	1992-12-31

Family

ID=26798539

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT88603A PT88603B (pt)	1987-09-28	1988-09-27	Processo para a preparacao de composicoes farmaceuticas contendo derivados de azaspiranos e de preparacao de alguns derivados de azaspiranos

Country Status (23)

Country	Link
US (1)	US4963557A (pt)
EP (1)	EP0310321B1 (pt)
JP (1)	JP2582888B2 (pt)
KR (1)	KR0166336B1 (pt)
CN (1)	CN1031618C (pt)
AT (1)	ATE114463T1 (pt)
AU (1)	AU619780B2 (pt)
CA (1)	CA1313189C (pt)
CY (1)	CY1955A (pt)
DE (1)	DE3852266T2 (pt)
DK (1)	DK170042B1 (pt)
ES (1)	ES2064356T3 (pt)
FI (1)	FI93006C (pt)
GR (1)	GR3014931T3 (pt)
HU (1)	HU208809B (pt)
IE (1)	IE67891B1 (pt)
IL (1)	IL87908A (pt)
MX (1)	MX9203765A (pt)
NO (1)	NO173824C (pt)
NZ (1)	NZ226354A (pt)
PT (1)	PT88603B (pt)
WO (1)	WO1989002889A1 (pt)
ZW (1)	ZW12388A1 (pt)

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ATE166228T1 (de) *	1990-08-10	1998-06-15	Anormed Inc	Immunosuppressive zusammensetzungen
US6051596A (en) *	1990-08-10	2000-04-18	Anormed, Inc.	Immunosuppressive compositions
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ZA921120B (en) *	1991-02-19	1993-01-27	Smithkline Beecham Corp	Cytokine inhibitors
PT100566B (pt) *	1991-06-07	1999-06-30	Smithkline Beecham Corp	Azaspiranos imunomoduladores, composicoes farmaceuticas que os contem, sua preparacao e seu uso
US5591748A (en) *	1991-06-07	1997-01-07	Smithkline Beecham Corporation	Immunomodulatory azaspiranes
US5455247A (en) *	1991-10-25	1995-10-03	Smithkline Beecham Corporation	Methods for the treatment of hyperlipidemia using azaspiranes
GB9122735D0 (en) *	1991-10-25	1991-12-11	Smithkline Beecham Corp	Methods
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DK0717987T3 (da) *	1991-12-18	2001-11-12	Minnesota Mining & Mfg	Suspension-aerosol-formuleringer
US7101534B1 (en)	1991-12-18	2006-09-05	3M Innovative Properties Company	Suspension aerosol formulations
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US5482959A (en) *	1992-01-28	1996-01-09	Smithkline Beecham Corporation	Method for delaying aids in an HIV infected individual by administration of substituted azaspirane compounds
GB9201803D0 (en) *	1992-01-28	1992-03-11	Smithkline Beecham Corp	Methods
DE4222459C2 (de) *	1992-07-08	1995-09-14	Sigma Tau Ind Farmaceuti	3,9-disubstituierte-Spiro[5.5]undecane, ein Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, die diese enthalten
GB9217121D0 (en) *	1992-08-13	1992-09-23	Smithkline Beecham Corp	Methods
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JPH09502699A (ja) *	1993-03-26	1997-03-18	ベス、イスラエル、ホスピタル、アソシエーション	バスピロン又はその誘導体の局部的及び全身投与に依る免疫反応性病体の治療
US5631017A (en) *	1993-03-26	1997-05-20	Beth Israel Deaconess Medical Center, Inc.	Topical application of buspirone for treatment of pathological conditions associated with immune responses
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US5708019A (en) *	1993-04-28	1998-01-13	Smithkline Beecham Corporation	Methods of treating hyperlipidemia using azaspirane derivatives
US5505948A (en) *	1993-06-01	1996-04-09	Dermatology Home Products, Inc.	Home skin peel composition for producing healthy and attractive skin
GB9315271D0 (en) *	1993-07-23	1993-09-08	Smithkline Beecham Corp	Methods
GB9315351D0 (en) *	1993-07-23	1993-09-08	Smithkline Beecham Corp	Methods
GB9315298D0 (en) *	1993-07-23	1993-09-08	Smithkline Beecham Corp	Methods
GB9315340D0 (en) *	1993-07-23	1993-09-08	Smithkline Beecham Corp	Methods
GB9315341D0 (en) *	1993-07-23	1993-09-08	Smithkline Beecham Corp	Methods
GB9315306D0 (en) *	1993-07-23	1993-09-08	Smithkline Beecham Corp	Methods
US5461054A (en) *	1993-12-09	1995-10-24	Bayer Aktiengesellschaft	Anthracene-spiro-pyrrolindines
GB9325854D0 (en) *	1993-12-17	1994-02-23	Smithkline Beecham Corp	Porcess
GB9414902D0 (en) *	1994-07-23	1994-09-14	Smithkline Beecham Corp	Methods
US5786376A (en) *	1994-07-23	1998-07-28	Smithkline Beecham Corporation	Methods of treating opportunistic infections with azaspiranes
GB9414901D0 (en) *	1994-07-23	1994-09-14	Smithkline Beecham Corp	Methods
US5734061A (en) *	1994-12-07	1998-03-31	Smithkline Beecham Corporation	Process for preparing spirocyclic lactams
US5637314A (en) *	1995-06-07	1997-06-10	Beth Israel Deaconess Medical Center, Inc.	Topical and systemic application of buspirone or derivatives thereof for treating atopic dermatitis
JP2001519754A (ja) *	1995-07-13	2001-10-23	アノーメッド・インコーポレイテッド	２−［２−（ジメチルアミノ）エチル］−８，８−ジプロピル−２−アザスピロ［４．５］デカンジマレイン酸塩
BR9601909A (pt) *	1995-07-13	1999-10-13	Smithkline Beecham Corp	N,n-dietil-8,8-dipropil-2-azaspiro(4,5)decano-2-propan amina dimaleato
SG43383A1 (en) *	1995-07-13	1997-10-17	Smithkline Beecham Corp	N n-diethyl-8,8-dipropyl-2-azaspiro[4.5]decane-2- propanamine dimaleate
EP0837678A1 (en) *	1995-07-13	1998-04-29	Smithkline Beecham Corporation	N,n-dimethyl-8,8-dipropyl-2-azaspiro 4,5]decane-2-propanamine dimaleate
BR9709007A (pt) *	1996-05-17	2000-01-04	Anormed Inc	Uso de azaspirano substituìdo no tratamento da asma.
US5843936A (en) *	1996-06-28	1998-12-01	Bernstein; Lawrence R.	Topical administration of azaspiranes to prevent or treat skin conditions associated with hyperproliferation of keratinocytes
GB0208742D0 (en)	2002-04-17	2002-05-29	Bradford Particle Design Ltd	Particulate materials
US7582284B2 (en)	2002-04-17	2009-09-01	Nektar Therapeutics	Particulate materials
JP4458514B2 (ja)	2002-07-18	2010-04-28	第一三共株式会社	高純度のエナミン類の製造方法
MXPA05009708A (es) *	2003-03-10	2006-05-25	Callisto Pharmaceuticals Inc	Metodo para el tratamiento de cancer con composiciones de azaspirina.
EP1768662A2 (en)	2004-06-24	2007-04-04	Novartis Vaccines and Diagnostics, Inc.	Small molecule immunopotentiators and assays for their detection
WO2006010379A1 (en)	2004-07-29	2006-02-02	Actelion Pharmaceuticals Ltd.	Novel thiophene derivatives as immunosuppressive agents
AU2005287037A1 (en) *	2004-09-20	2006-03-30	Targacept, Inc.	Azaspiroalkene and azaspiroalkane compounds with nicotinic cholinergic receptor activity
JP5047941B2 (ja)	2005-03-23	2012-10-10	アクテリオンファーマシューティカルズリミテッド	免疫調節物質としての水素付加されたベンゾ（ｃ）チオフェン誘導体
AR057894A1 (es)	2005-11-23	2007-12-26	Actelion Pharmaceuticals Ltd	Derivados de tiofeno
CN101370805B (zh)	2006-01-24	2011-04-27	埃科特莱茵药品有限公司	吡啶衍生物
EP1989297B1 (en)	2006-02-13	2015-03-25	The Board of Trustees of The Leland Stanford Junior University	Blockade of gamma-secretase activity to promote myelination by oligodendrocytes
PL2425820T3 (pl)	2007-02-11	2015-08-31	Map Pharmaceuticals Inc	Sposób terapeutycznego stosowania dhe w celu umożliwienia szybkiego złagodzenia migreny przy jednoczesnym zminimalizowaniu profilu działań niepożądanych

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1988
- 1988-09-13 US US07/244,229 patent/US4963557A/en not_active Expired - Lifetime
- 1988-09-21 ZW ZW123/88A patent/ZW12388A1/xx unknown
- 1988-09-25 IL IL87908A patent/IL87908A/xx not_active IP Right Cessation
- 1988-09-26 DE DE3852266T patent/DE3852266T2/de not_active Expired - Lifetime
- 1988-09-26 EP EP88308914A patent/EP0310321B1/en not_active Expired - Lifetime
- 1988-09-26 AT AT88308914T patent/ATE114463T1/de not_active IP Right Cessation
- 1988-09-26 ES ES88308914T patent/ES2064356T3/es not_active Expired - Lifetime
- 1988-09-27 HU HU885889A patent/HU208809B/hu not_active IP Right Cessation
- 1988-09-27 NZ NZ226354A patent/NZ226354A/xx unknown
- 1988-09-27 KR KR1019890700907A patent/KR0166336B1/ko not_active Expired - Fee Related
- 1988-09-27 PT PT88603A patent/PT88603B/pt not_active IP Right Cessation
- 1988-09-27 CA CA000578528A patent/CA1313189C/en not_active Expired - Lifetime
- 1988-09-27 AU AU25333/88A patent/AU619780B2/en not_active Expired
- 1988-09-27 JP JP63508105A patent/JP2582888B2/ja not_active Expired - Lifetime
- 1988-09-27 WO PCT/US1988/003323 patent/WO1989002889A1/en not_active Ceased
- 1988-09-28 CN CN88109032A patent/CN1031618C/zh not_active Expired - Lifetime
- 1988-09-28 IE IE292988A patent/IE67891B1/en not_active IP Right Cessation
1990
- 1990-03-23 DK DK077090A patent/DK170042B1/da not_active IP Right Cessation
- 1990-03-27 NO NO901392A patent/NO173824C/no not_active IP Right Cessation
- 1990-03-27 FI FI901530A patent/FI93006C/fi not_active IP Right Cessation
1992
- 1992-06-29 MX MX9203765A patent/MX9203765A/es unknown
1995
- 1995-02-01 GR GR950400195T patent/GR3014931T3/el unknown
1997
- 1997-05-16 CY CY195597A patent/CY1955A/xx unknown

Also Published As

Publication number	Publication date
CY1955A (en)	1997-05-16
PT88603B (pt)	1992-12-31
HUT57722A (en)	1991-12-30
DK77090D0 (da)	1990-03-23
AU2533388A (en)	1989-04-18
HK1006274A1 (en)	1999-02-19
DK77090A (da)	1990-03-23
CN1031618C (zh)	1996-04-24
KR0166336B1 (ko)	1999-01-15
JPH03500290A (ja)	1991-01-24
HU885889D0 (en)	1991-11-28
ES2064356T3 (es)	1995-02-01
ZW12388A1 (en)	1989-01-04
NO901392D0 (no)	1990-03-27
DE3852266D1 (de)	1995-01-12
FI93006C (fi)	1995-02-10
WO1989002889A1 (en)	1989-04-06
EP0310321B1 (en)	1994-11-30
MX9203765A (es)	1992-07-01
CN1032437A (zh)	1989-04-19
KR890701562A (ko)	1989-12-20
HU208809B (en)	1995-06-28
NO901392L (no)	1990-03-27
AU619780B2 (en)	1992-02-06
FI901530A0 (fi)	1990-03-27
DE3852266T2 (de)	1995-05-18
NZ226354A (en)	1991-02-26
IL87908A0 (en)	1989-03-31
US4963557A (en)	1990-10-16
EP0310321A2 (en)	1989-04-05
GR3014931T3 (en)	1995-05-31
DK170042B1 (da)	1995-05-08
IE882929L (en)	1989-03-28
NO173824B (no)	1993-11-01
CA1313189C (en)	1993-01-26
JP2582888B2 (ja)	1997-02-19
IE67891B1 (en)	1996-05-01
NO173824C (no)	1994-02-09
ATE114463T1 (de)	1994-12-15
EP0310321A3 (en)	1991-02-06
FI93006B (fi)	1994-10-31
IL87908A (en)	1993-02-21

Legal Events

Date

Code

Title

Description

1992-12-31

FG3A

Patent granted, date of granting

Effective date: 19920625

2003-03-31

PC3A

Transfer or assignment

Free format text: ANORMED INC. CA

Effective date: 20030116

2008-10-10

MM4A

Annulment/lapse due to non-payment of fees, searched and examined patent

Free format text: MAXIMUM VALIDITY LIMIT REACHED

Effective date: 20080927

Publication	Publication Date	Title
DK77090D0 (da)	1990-03-23	Immunmodulerende azaspiraner
DK353385A (da)	1986-02-04	Fremstilling af 3-acylamino-1-hydroxy-2-azetidinoner og herved forekommende n-hydroxybeskyttelsesgrupper
NZ236589A (en)	1993-02-25	A-nor-steroid-3-carboxylic acid derivatives and pharmaceutical compositions
PT87552A (pt)	1989-05-31	Process for the preparation of novel tetrazole intermediates toantihypertensive compounds
IL84917A0 (en)	1988-06-30	Quinolinone derivative,its preparation and pharmaceutical compositions containing it
DE68914292D1 (de)	1994-05-11	Zusammensetzung zur Behandlung von ischämischen Störungen in Organen.
ZA883444B (pt)	1988-11-16
DK183789A (da)	1989-10-19	2-alkyl-3-benzoylbenzofuraner og laegemidler indeholdende disse
DK74189D0 (da)	1989-02-17	Laegemiddel til behandling af mavesaar
ATE69220T1 (de)	1991-11-15	Sechsgliedrige heterocyclische derivate von n'substituiertenn,n'-diacylhydrazinen.
NO842345L (no)	1984-12-27	Heksahydropyrrolo(2,1-a)isoquinolin-derivater.
NO914192L (no)	1992-04-27	8-azabicyklo(3.2.1)oktylalkylthiazolidinoner, fremgangsmaate for fremstilling og anvendelse som medikamenter
DE3781986D1 (de)	1992-11-05	Substituierte chinoxaline.
ATE38029T1 (de)	1988-11-15	Benz-trisubstituierte 2-aminotetraline.
GR3007498T3 (pt)	1993-07-30
DE3778088D1 (de)	1992-05-14	Substituierte pyrimidochinoxaline.
GR850484B (pt)	1985-06-26