ATE130293T1 - Tamoxifenderivate mit hoher affinität und ihre verwendung. - Google Patents
Tamoxifenderivate mit hoher affinität und ihre verwendung.Info
- Publication number
- ATE130293T1 ATE130293T1 AT91919917T AT91919917T ATE130293T1 AT E130293 T1 ATE130293 T1 AT E130293T1 AT 91919917 T AT91919917 T AT 91919917T AT 91919917 T AT91919917 T AT 91919917T AT E130293 T1 ATE130293 T1 AT E130293T1
- Authority
- AT
- Austria
- Prior art keywords
- tamoxifen
- derivatives
- tamoxifen derivatives
- estrogen
- substituted
- Prior art date
Links
- NKANXQFJJICGDU-QPLCGJKRSA-N Tamoxifen Chemical class C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 NKANXQFJJICGDU-QPLCGJKRSA-N 0.000 abstract 19
- 102000015694 estrogen receptors Human genes 0.000 abstract 6
- 108010038795 estrogen receptors Proteins 0.000 abstract 6
- 229960001603 tamoxifen Drugs 0.000 abstract 6
- 125000001931 aliphatic group Chemical group 0.000 abstract 3
- -1 chloro, bromo, iodo Chemical group 0.000 abstract 3
- 210000000481 breast Anatomy 0.000 abstract 2
- 238000003384 imaging method Methods 0.000 abstract 2
- YYPATXTUOFGPQZ-OCEACIFDSA-N 2-[4-[(e)-1-(3-fluorophenyl)-2-phenylbut-1-enyl]phenoxy]-n,n-dimethylethanamine Chemical class C=1C=CC=CC=1C(/CC)=C(C=1C=C(F)C=CC=1)\C1=CC=C(OCCN(C)C)C=C1 YYPATXTUOFGPQZ-OCEACIFDSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- TXUZVZSFRXZGTL-QPLCGJKRSA-N afimoxifene Chemical class C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=C(O)C=C1 TXUZVZSFRXZGTL-QPLCGJKRSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 125000003636 chemical group Chemical group 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 238000002603 single-photon emission computed tomography Methods 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
- C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
- C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/001—Acyclic or carbocyclic compounds
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/589,928 US5219548A (en) | 1990-10-01 | 1990-10-01 | High affinity halogenated-tamoxifen derivatives and uses thereof |
| US07/722,322 US5192525A (en) | 1990-10-01 | 1991-06-28 | High affinity tamoxifen derivatives and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE130293T1 true ATE130293T1 (de) | 1995-12-15 |
Family
ID=27080697
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT91919917T ATE130293T1 (de) | 1990-10-01 | 1991-09-27 | Tamoxifenderivate mit hoher affinität und ihre verwendung. |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0551434B1 (de) |
| JP (1) | JPH06504522A (de) |
| AT (1) | ATE130293T1 (de) |
| AU (1) | AU664161B2 (de) |
| CA (1) | CA2092996A1 (de) |
| DE (1) | DE69114719T2 (de) |
| WO (1) | WO1992006068A1 (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5491173A (en) * | 1982-06-25 | 1996-02-13 | Orion-Yhtyma Oy | Tri-phenyl alkene derivatives and their preparation and use |
| DE69435137D1 (de) * | 1993-05-13 | 2008-10-16 | Poniard Pharmaceuticals Inc | Prävention und behandlung von pathologien, die mit einer abnormalen proliferationglatter muskelzellen verbunden sind |
| US5650425A (en) * | 1994-04-04 | 1997-07-22 | Pharmos Corporation | Permanently ionic derivatives of steroid hormones and their antagonists |
| US5681835A (en) * | 1994-04-25 | 1997-10-28 | Glaxo Wellcome Inc. | Non-steroidal ligands for the estrogen receptor |
| US6083990A (en) | 1997-04-02 | 2000-07-04 | Pharmos Corporation | Enhanced anti-angiogenic activity of permanently charged derivatives of steroid hormones |
| WO1998046588A2 (en) | 1997-04-11 | 1998-10-22 | Neorx Corporation | Compounds and therapies for the prevention of vascular and non-vascular pathologies |
| CN1275911A (zh) | 1997-08-15 | 2000-12-06 | 杜克大学 | 一种预防或治疗雌激素依赖性疾病及失调的方法 |
| IL146284A0 (en) | 1999-05-04 | 2002-07-25 | Strakan Ltd | Androgen glycosides and pharmaceutical compositions containing the same |
| TW593256B (en) | 1999-11-16 | 2004-06-21 | Hormos Medical Oy Ltd | Triphenylalkene derivatives and their use as selective estrogen receptor modulators |
| US6613083B2 (en) | 2001-05-02 | 2003-09-02 | Eckhard Alt | Stent device and method |
| US20040248989A1 (en) | 2003-06-05 | 2004-12-09 | Risto Santti | Method for the treatment or prevention of lower urinary tract symptoms |
| CA2538520C (en) * | 2003-07-24 | 2015-02-10 | The Queen's Medical Center | Preparation and use of alkylating agents |
| JP5123935B2 (ja) | 2006-05-22 | 2013-01-23 | ホルモス メディカル リミテッド | 選択的エストロゲン受容体モジュレーターまたはアロマターゼ阻害剤を用いた慢性非細菌性前立腺炎の治療方法 |
| ES2590262T3 (es) | 2007-02-14 | 2016-11-21 | Hormos Medical Ltd. | Método para la preparación de derivados de trifenilbuteno con valor terapéutico |
| WO2008099060A2 (en) | 2007-02-14 | 2008-08-21 | Hormos Medical Ltd | Methods for the preparation of fispemifene from ospemifene |
| US9321712B2 (en) | 2012-10-19 | 2016-04-26 | Fermion Oy | Process for the preparation of ospemifene |
| WO2014173374A1 (en) * | 2013-04-24 | 2014-10-30 | Smart Brain s.r.o. | Tamoxifen derivatives for treatment of neoplastic diseases, especially with high her2 protein level |
| CZ305571B6 (cs) * | 2014-01-29 | 2015-12-16 | Smart Brain s.r.o. | Deriváty tamoxifenu k léčbě neoplastických chorob, zejména s vyšší hladinou proteinu HER2 |
| SG11201702401RA (en) | 2014-10-14 | 2017-04-27 | Novartis Ag | Antibody molecules to pd-l1 and uses thereof |
| CN109563054B (zh) | 2016-06-27 | 2022-08-05 | 大邱庆北尖端医疗产业振兴财团 | 新型芳基乙烯衍生物以及以该新型芳基乙烯为有效成分的药物组合物 |
| CN116969983A (zh) * | 2018-09-12 | 2023-10-31 | 路易斯安那泽维尔大学 | 雌激素受体靶向拮抗剂 |
| CN116113409B (zh) | 2020-08-04 | 2026-02-03 | 诺麦塔制药有限公司 | 细胞因子释放综合征的治疗方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3046719C2 (de) * | 1980-12-11 | 1983-02-17 | Klinge Pharma GmbH, 8000 München | 1,1,2-Triphenyl-but-1-en-Derivate, Verfahren zu ihrer Herstellung und Arzneimittel |
| FI77839C (fi) * | 1982-05-27 | 1989-05-10 | Farmos Oy | Foerfarande foer framstaellning av nya terapeutiskt effektiva trifenylalkan- och alkenderivat. |
| DE3762617D1 (de) * | 1986-09-11 | 1990-06-13 | Nat Res Dev | Tamoxifenderivate. |
-
1991
- 1991-09-27 AT AT91919917T patent/ATE130293T1/de not_active IP Right Cessation
- 1991-09-27 EP EP91919917A patent/EP0551434B1/de not_active Expired - Lifetime
- 1991-09-27 JP JP3518057A patent/JPH06504522A/ja active Pending
- 1991-09-27 CA CA002092996A patent/CA2092996A1/en not_active Abandoned
- 1991-09-27 DE DE69114719T patent/DE69114719T2/de not_active Expired - Fee Related
- 1991-09-27 AU AU88682/91A patent/AU664161B2/en not_active Ceased
- 1991-09-27 WO PCT/US1991/007150 patent/WO1992006068A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU8868291A (en) | 1992-04-28 |
| EP0551434A1 (de) | 1993-07-21 |
| DE69114719T2 (de) | 1996-10-10 |
| JPH06504522A (ja) | 1994-05-26 |
| DE69114719D1 (de) | 1995-12-21 |
| CA2092996A1 (en) | 1992-04-02 |
| AU664161B2 (en) | 1995-11-09 |
| WO1992006068A1 (en) | 1992-04-16 |
| EP0551434B1 (de) | 1995-11-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69114719D1 (de) | Tamoxifenderivate mit hoher affinität und ihre verwendung. | |
| DK0615448T3 (da) | Kønssteroidaktivitetsinhibitorer | |
| PL304496A1 (en) | Novel tricyclic benzazepines, their transient compounds, pharmaceutical agents and methods of obtaining such compounds | |
| DK0393838T3 (da) | Dopaminreceptorligander og imagografimidler | |
| AP2002002634A0 (en) | Malonamic Acids And Derivatives Thereof As Thyroid Receptor Ligands. | |
| GB2101114B (en) | Substituted imidazole derivatives and their preparation and use | |
| KR930700451A (ko) | 항암제로서의 비스-나프탈이미드 | |
| IL83804A (en) | Imidazolylguanidine derivatives, processes for preparing them and pharmaceutical compositions containing them | |
| DE69222757D1 (de) | Imidazol-derivate mit antagonistischer aktivität auf den histamin-h3-receptor | |
| PT877803E (pt) | Receptor da proteina ob e composicoes e metodos afins | |
| ATE48835T1 (de) | Chinolylglycinamidderivate, verfahren zu ihrer herstellung und therapeutische verwendung als psychotrope. | |
| NO165960C (no) | Dimetyloksazolforbindelser. | |
| PT73280A (de) | Neue imidazol-derivate verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praparate | |
| JPS55124758A (en) | Indole derivative and medical composition | |
| PT1226122E (pt) | Agonistas biciclicos da vasopressina | |
| SE7902866L (sv) | 3-0-(beta-d-glukuronopyranosyl)-sojasapogenol b | |
| ATE2423T1 (de) | 1-acyloxyphenyl-1,2-diphenylalken-derivate, verfahren zu deren herstellung und eine diese derivate enthaltende pharmazeutische zusammensetzung. | |
| Höltke et al. | Synthesis, in vitro pharmacology and biodistribution studies of new PD 156707-derived ETA receptor radioligands | |
| KR940021524A (ko) | 1,2,5,6-테트라하이드로피리딘 유도체와 이의 제조 방법 및 치료시 이의 이용방법 | |
| Rybin et al. | The inhibiting effect of pertussis toxin on the exchange of guanyl nucleotides bound to transducin from bovine retinal rod outer segment. | |
| GB2096994B (en) | Aminosulfenyl chloride derivatives and process for preparing carbamate derivatives useful as ins | |
| ES475428A1 (es) | Procedimiento para la obtencion de compuestos heterociclicos | |
| ATE79872T1 (de) | Aromatasehemmende 4(5)-imidazole. | |
| JPS56158743A (en) | Novel aminoalkyl ether derivative | |
| KR900016139A (ko) | 도파민 수용체 리간드와 영상화제 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |