ATE130365T1 - Bakterien transformiert mit expressionsplasmiden, die für den menschlichen neurothrophen wimper faktor (h-cntf) kodieren, ihre verwendung in der herstellung von h-cntf, antikörper gegen h-cntf und die anwendung von h-cntf in medizischer behandlung. - Google Patents

Bakterien transformiert mit expressionsplasmiden, die für den menschlichen neurothrophen wimper faktor (h-cntf) kodieren, ihre verwendung in der herstellung von h-cntf, antikörper gegen h-cntf und die anwendung von h-cntf in medizischer behandlung.

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Publication number
ATE130365T1
ATE130365T1 AT90917018T AT90917018T ATE130365T1 AT E130365 T1 ATE130365 T1 AT E130365T1 AT 90917018 T AT90917018 T AT 90917018T AT 90917018 T AT90917018 T AT 90917018T AT E130365 T1 ATE130365 T1 AT E130365T1
Authority
AT
Austria
Prior art keywords
cntf
nucleic acid
acid sequences
relates
variety
Prior art date
Application number
AT90917018T
Other languages
English (en)
Inventor
Piotr Masiakowski
Vivien Wong
Nikos Panayotatos
Hans Friedrich Erwin Thoenen
Kurt A Stockli-Rippstein
Michael Sendtner
Yoshihiro Arakawa
Patrick Desmond Carroll
Rudolf Georg Gotz
Georg W Kreutzberg
Dan B Lindholm
Friedrich Lottspeich
Nancy Ip
Mark E Furth
Original Assignee
Max Planck Gesellschaft
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27410749&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE130365(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Max Planck Gesellschaft, Regeneron Pharma filed Critical Max Planck Gesellschaft
Application granted granted Critical
Publication of ATE130365T1 publication Critical patent/ATE130365T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1825—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT90917018T 1989-09-15 1990-09-14 Bakterien transformiert mit expressionsplasmiden, die für den menschlichen neurothrophen wimper faktor (h-cntf) kodieren, ihre verwendung in der herstellung von h-cntf, antikörper gegen h-cntf und die anwendung von h-cntf in medizischer behandlung. ATE130365T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40817289A 1989-09-15 1989-09-15
US42951789A 1989-10-31 1989-10-31
US57065190A 1990-08-20 1990-08-20

Publications (1)

Publication Number Publication Date
ATE130365T1 true ATE130365T1 (de) 1995-12-15

Family

ID=27410749

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90917018T ATE130365T1 (de) 1989-09-15 1990-09-14 Bakterien transformiert mit expressionsplasmiden, die für den menschlichen neurothrophen wimper faktor (h-cntf) kodieren, ihre verwendung in der herstellung von h-cntf, antikörper gegen h-cntf und die anwendung von h-cntf in medizischer behandlung.

Country Status (11)

Country Link
US (1) US6602687B1 (de)
EP (1) EP0448707B1 (de)
JP (2) JPH05199879A (de)
AT (1) ATE130365T1 (de)
AU (1) AU705371B2 (de)
CA (1) CA2040404A1 (de)
DE (1) DE69023637T2 (de)
ES (1) ES2084045T3 (de)
IE (1) IE903130A1 (de)
LV (1) LV10308A (de)
WO (1) WO1991004316A2 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT405835B (de) * 1989-01-05 1999-11-25 Synergen Inc Aufgereinigter ziliärer neurotropher faktor
US5141856A (en) * 1989-01-05 1992-08-25 Synergen, Inc. Expression of purified ciliary neurotrophic factor
IL98304A (en) * 1990-06-01 2008-08-07 Regeneron Pharma The ciliary neurotrophic factor receptor
IT1247150B (it) * 1991-01-21 1994-12-12 Fidia Spa Processo per la sintesi e la purificazione del fattore neuronotroficociliare umano (cntf) da escherichia coli.
RU94016525A (ru) * 1991-07-10 1996-06-10 Ридженерон Фармасьютикалз Способы лечения заболеваний двигательных нейронов
WO1993002206A1 (en) * 1991-07-23 1993-02-04 Syntex-Synergen Neuroscience Joint Venture Purification of recombinant ciliary neurotrophic factor and c-terminal truncated ciliary neurotrophic factor and methods for treating peripheral nerve damage
US5593857A (en) * 1991-08-23 1997-01-14 Scios Inc. Production of homogeneous truncated CNTF
EP0607247A1 (de) * 1991-10-01 1994-07-27 Genentech, Inc. Herstellung des gpa neurotrophen faktors
EP0668911A1 (de) * 1991-11-11 1995-08-30 FIDIA S.p.A. Synthese und reinigung von unvollständigen und mutierten formen des humanen ciliaren neurotrophen faktors
AU4995193A (en) * 1992-08-04 1994-03-03 Regeneron Pharmaceuticals, Inc. Method of enhancing differentiation and survival of neuronal precursor cells
ATE404683T1 (de) * 1992-09-25 2008-08-15 Aventis Pharma Sa Adenovirus vektoren für die übertragung fremder gene in zellen des zentralen nervensystems, insbesondere im gehirn
US6472178B1 (en) 1998-02-27 2002-10-29 Regeneron Pharmaceuticals, Inc. Nucleic acids encoding a modified ciliary neurotrophic factor and method of making thereof
AU6169894A (en) * 1993-02-08 1994-08-29 Syntex-Synergen Neuroscience Joint Venture, The Methods for treating amyotrophic lateral sclerosis with cntf
WO1994020125A1 (en) * 1993-03-12 1994-09-15 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Treatment of motor neuron diseases with fibroblast growth factor-5 (fgf-5)
FR2705361B1 (fr) * 1993-05-18 1995-08-04 Centre Nat Rech Scient Vecteurs viraux et utilisation en thérapie génique.
EP0632008B1 (de) 1993-06-01 1998-02-04 Ono Pharmaceutical Co., Ltd. Pentansäurederivate
US6143714A (en) * 1994-10-24 2000-11-07 Regeneron Pharmaceuticals, Inc. Methods of using hepatocyte growth factor to promote survival, growth and differentiation of motor neurons
AU2800797A (en) 1996-04-05 1997-10-29 Chiron Corporation Recombinant alphavirus-based vectors with reduced inhibition of cellular macromolecular synthesis
FR2753379B1 (fr) 1996-09-13 1998-10-30 Rhone Poulenc Rorer Sa Methode de traitement de la sclerose laterale amyotrophique
IT1288388B1 (it) 1996-11-19 1998-09-22 Angeletti P Ist Richerche Bio Uso di sostanze che attivano il recettore del cntf ( fattore neurotrofico ciliare) per la preparazione di farmaci per la terapia
US6313089B1 (en) * 1997-08-20 2001-11-06 Duke University Complexes of apolipoprotein E and ciliary neurotrophic factor (CNTF) and methods of use
EP0999270A1 (de) * 1998-10-09 2000-05-10 Institut National De La Sante Et De La Recherche Medicale (Inserm) Verfahren zur Regulierung der SMN-Genexpression
EP1365785A2 (de) * 2000-05-24 2003-12-03 Regeneron Pharmaceuticals, Inc. Verwendung von ciliary neurotrophic factor
DE60239634D1 (de) * 2001-12-10 2011-05-12 Novartis Ag Verfahren zur behandlung von psychosen und schizophrenie auf der basis eines polymorphismus im cntf gen
JP2005073592A (ja) * 2003-09-01 2005-03-24 Yukiguni Maitake Co Ltd マイタケ由来のレクチンをコードする遺伝子
EP2009103A1 (de) * 2007-03-16 2008-12-31 Ebewe Pharma Ges.m.b.H. Nfg. KG Neurotrophische Peptide
US8592374B2 (en) 2007-03-16 2013-11-26 Research Foundation For Mental Hygiene, Inc. Neurotrophic peptides
JP6495830B2 (ja) * 2013-12-11 2019-04-03 住友化学株式会社 毛様体周縁部様構造体の製造法
CN112566622A (zh) * 2018-06-19 2021-03-26 细胞疗法有限责任公司 用于治疗青光眼或高眼压症的包含眼内压降低剂、cnp化合物、npr-b化合物、tie-2激动剂或神经营养剂的缓释药物递送系统
WO2019246141A1 (en) * 2018-06-19 2019-12-26 Cella Therapeutics, Llc DRUG DELIVERY SYSTEMS COMPRISING A NEUROTROPHIC AGENT, AN APOPTOSIS SIGNALING FRAGMENT INHIBITOR (FAS) OR FAS LIGAND (FASL) INHIBITOR, A TUMOR NECROSIS FACTOR-α (TNF-α) OR TNF RECEPTOR INHIBITOR, A MITOCHONDRIAL PEPTIDE, AN OLIGONUCLEOTIDE, A CHEMOKINE INHIBITOR, OR A CYSTEINE-ASPARTIC PROTEASE
US20230094423A1 (en) * 2019-12-18 2023-03-30 Cella Therapeutics, Llc Drug delivery systems comprising a neurotrophic agent, an apoptosis signaling fragment inhibitor (fas) or fas ligand (fasl) inhibitor, a tumor necrosis factor-alpha (tnf-alpha) or tnf receptor inhibitor, a mitochondrial peptide, an oligonucleotide, a chemokine inhibitor, or a cysteine-aspartic protease inhibitor

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4923696A (en) 1987-05-04 1990-05-08 Baylor College Of Medicine Method to prepare a neurotrophic composition
US4997929A (en) 1989-01-05 1991-03-05 Synergen, Inc. Purified ciliary neurotrophic factor
US5141856A (en) * 1989-01-05 1992-08-25 Synergen, Inc. Expression of purified ciliary neurotrophic factor
US5011914A (en) 1989-01-05 1991-04-30 Collins Franklin D Purified ciliary neurotrophic factor
EP0463082A1 (de) * 1989-03-15 1992-01-02 The Regents Of The University Of California Reinigung von cntf
HUT62033A (en) * 1990-03-14 1993-03-29 Fidia Spa Process for producing human ciliary body neuronotropic factor

Also Published As

Publication number Publication date
US6602687B1 (en) 2003-08-05
EP0448707A4 (en) 1992-11-19
JPH05199879A (ja) 1993-08-10
IE903130A1 (en) 1991-03-27
EP0448707A1 (de) 1991-10-02
AU6740290A (en) 1991-04-18
AU705371B2 (en) 1999-05-20
JP2001354697A (ja) 2001-12-25
WO1991004316A2 (en) 1991-04-04
WO1991004316A3 (en) 1991-04-18
DE69023637D1 (de) 1995-12-21
DE69023637T2 (de) 1996-10-17
EP0448707B1 (de) 1995-11-15
CA2040404A1 (en) 1991-03-16
ES2084045T3 (es) 1996-05-01
LV10308A (lv) 1994-10-20

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REN Ceased due to non-payment of the annual fee