ATE131052T1 - Verwendung von histaminderivaten zur herstellung von arzneimitteln, neue histaminderivate und arzneimittel. - Google Patents

Verwendung von histaminderivaten zur herstellung von arzneimitteln, neue histaminderivate und arzneimittel.

Info

Publication number: ATE131052T1
Authority: AT; Austria
Prior art keywords: medicinal products; compound; histamine derivatives; imidazolyl; drugs
Prior art date: 1991-09-06

Application number

AT92402418T

Other languages

English (en)

Inventor

Jean Charles Schwartz

Monique Garbarg

Jean Michel Arrang

Charon Robin Ganellin

Jeanne Marie Lecomte

Abdellatif Fkyerat

Original Assignee

Bioprojet Soc Civ

Inst Nat Sante Rech Med

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-09-06

Filing date

1992-09-04

Publication date

1995-12-15

1992-09-04 Application filed by Bioprojet Soc Civ, Inst Nat Sante Rech Med filed Critical Bioprojet Soc Civ

1995-12-15 Application granted granted Critical

1995-12-15 Publication of ATE131052T1 publication Critical patent/ATE131052T1/de

Links

NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical class NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 title 2
229940126601 medicinal product Drugs 0.000 title 2
150000001875 compounds Chemical class 0.000 abstract 3
239000003814 drug Substances 0.000 abstract 3
229940079593 drug Drugs 0.000 abstract 3
229940126062 Compound A Drugs 0.000 abstract 1
NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 abstract 1
229940123322 Histamine receptor agonist Drugs 0.000 abstract 1
208000007107 Stomach Ulcer Diseases 0.000 abstract 1
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 1
230000001088 anti-asthma Effects 0.000 abstract 1
229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
239000002260 anti-inflammatory agent Substances 0.000 abstract 1
230000002460 anti-migrenic effect Effects 0.000 abstract 1
239000000924 antiasthmatic agent Substances 0.000 abstract 1
239000002249 anxiolytic agent Substances 0.000 abstract 1
230000000949 anxiolytic effect Effects 0.000 abstract 1
210000000621 bronchi Anatomy 0.000 abstract 1
RXKUYBRRTKRGME-UHFFFAOYSA-N butanimidamide Chemical compound CCCC(N)=N RXKUYBRRTKRGME-UHFFFAOYSA-N 0.000 abstract 1
210000003169 central nervous system Anatomy 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
JNGZXGGOCLZBFB-IVCQMTBJSA-N compound E Chemical compound N([C@@H](C)C(=O)N[C@@H]1C(N(C)C2=CC=CC=C2C(C=2C=CC=CC=2)=N1)=O)C(=O)CC1=CC(F)=CC(F)=C1 JNGZXGGOCLZBFB-IVCQMTBJSA-N 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
201000005917 gastric ulcer Diseases 0.000 abstract 1
239000003453 histamine agonist Substances 0.000 abstract 1
230000000147 hypnotic effect Effects 0.000 abstract 1
239000000411 inducer Substances 0.000 abstract 1
LVTJOONKWUXEFR-FZRMHRINSA-N protoneodioscin Natural products O(C[C@@H](CC[C@]1(O)[C@H](C)[C@@H]2[C@]3(C)[C@H]([C@H]4[C@@H]([C@]5(C)C(=CC4)C[C@@H](O[C@@H]4[C@H](O[C@H]6[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O6)[C@@H](O)[C@H](O[C@H]6[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O6)[C@H](CO)O4)CC5)CC3)C[C@@H]2O1)C)[C@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H](CO)O1 LVTJOONKWUXEFR-FZRMHRINSA-N 0.000 abstract 1
239000000932 sedative agent Substances 0.000 abstract 1
230000001624 sedative effect Effects 0.000 abstract 1
UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 abstract 1
239000003204 tranquilizing agent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pain & Pain Management (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Pulmonology (AREA)
Anesthesiology (AREA)
Ophthalmology & Optometry (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT92402418T 1991-09-06 1992-09-04 Verwendung von histaminderivaten zur herstellung von arzneimitteln, neue histaminderivate und arzneimittel. ATE131052T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/754,914 US5321039A (en)	1990-04-13	1991-09-06	Method of inducing a histamine agonist action on H2 receptors

Publications (1)

Publication Number	Publication Date
ATE131052T1 true ATE131052T1 (de)	1995-12-15

Family

ID=25036925

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92402418T ATE131052T1 (de)	1991-09-06	1992-09-04	Verwendung von histaminderivaten zur herstellung von arzneimitteln, neue histaminderivate und arzneimittel.

Country Status (8)

Country	Link
US (1)	US5321039A (de)
EP (1)	EP0531219B1 (de)
JP (1)	JPH0687742A (de)
AT (1)	ATE131052T1 (de)
DE (1)	DE69206536T2 (de)
DK (1)	DK0531219T3 (de)
ES (1)	ES2080466T3 (de)
GR (1)	GR3018687T3 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6407132B1 (en)	1997-07-25	2002-06-18	James Black Foundation Limited	Substituted imidazole derivatives and their use as histamine H3 receptor ligands
US6028095A (en) *	1998-10-15	2000-02-22	Warner-Lambert Company	Treatment of inflammatory bowel disease using histamine H3 -receptor agonists
JP2002534511A (ja)	1999-01-18	2002-10-15	ノボノルディスクアクティーゼルスカブ	置換型イミダゾール、それらの調製及び使用
US6908926B1 (en)	1999-04-16	2005-06-21	Novo Nordisk A/S	Substituted imidazoles, their preparation and use
US6437147B1 (en)	2000-03-17	2002-08-20	Novo Nordisk	Imidazole compounds
US6610721B2 (en)	2000-03-17	2003-08-26	Novo Nordisk A/S	Imidazo heterocyclic compounds
WO2004087938A1 (ja) *	2003-03-31	2004-10-14	Meiji Seika Kaisha, Ltd.	新規生理活性物質ｐｆ１２７０ａ、ｂおよびｃ物質
JP4765627B2 (ja)	2003-09-22	2011-09-07	Ｍｓｄ株式会社	新規ピペリジン誘導体
CA2622597A1 (en)	2005-09-15	2007-03-22	Banyu Pharmaceutical Co., Ltd.	Histamine h3 agonist for use as therapeutic agent for lipid/glucose metabolic disorder
WO2012048950A1 (en)	2010-10-14	2012-04-19	Unilever Plc	Laundry detergent particles

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3891764A (en) *	1969-10-29	1975-06-24	Smith Kline French Lab	Method of inhibiting histamine activity with amidine derivatives
US3818097A (en) *	1969-10-29	1974-06-18	Smith Kline French Lab	Method of inhibiting histamine activity with isothioureas
BE758145A (fr) *	1969-10-29	1971-04-28	Smith Kline French Lab	Iso-thio-urees et derives
US3759944A (en) *	1970-10-14	1973-09-18	Smith Kline French Lab	Isothioureas and their derivatives
US3954982A (en) *	1972-04-20	1976-05-04	Smith Kline & French Laboratories Limited	Pharmaceutical compositions and method of inhibiting H-1 and H-2 histamine receptors
US4000302A (en) *	1972-04-20	1976-12-28	Smith Kline & French Laboratories Limited	Pharmaceutical compositions and methods of inhibiting H-1 and H-2 histamine receptors
GB8916947D0 (en) *	1989-07-25	1989-09-13	Smith Kline French Lab	Medicaments
FR2660862B1 (fr) *	1990-04-13	1994-09-23	Bioprojet Soc Civ	Application therapeutique de derives de l'histamine, nouveau derive de l'histamine et utilisation de ces derives pour la preparation de medicaments.

1991
- 1991-09-06 US US07/754,914 patent/US5321039A/en not_active Expired - Lifetime
1992
- 1992-09-04 DK DK92402418.5T patent/DK0531219T3/da active
- 1992-09-04 DE DE69206536T patent/DE69206536T2/de not_active Expired - Fee Related
- 1992-09-04 AT AT92402418T patent/ATE131052T1/de not_active IP Right Cessation
- 1992-09-04 EP EP92402418A patent/EP0531219B1/de not_active Expired - Lifetime
- 1992-09-04 ES ES92402418T patent/ES2080466T3/es not_active Expired - Lifetime
- 1992-09-07 JP JP4264298A patent/JPH0687742A/ja active Pending
1996
- 1996-01-17 GR GR960400088T patent/GR3018687T3/el unknown

Also Published As

Publication number	Publication date
JPH0687742A (ja)	1994-03-29
GR3018687T3 (en)	1996-04-30
DE69206536T2 (de)	1996-05-09
EP0531219A1 (de)	1993-03-10
DK0531219T3 (da)	1996-01-08
DE69206536D1 (de)	1996-01-18
EP0531219B1 (de)	1995-12-06
US5321039A (en)	1994-06-14
ES2080466T3 (es)	1996-02-01

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Legal Events

Date	Code	Title	Description
1996-06-15	UEP	Publication of translation of european patent specification
2009-06-15	REN	Ceased due to non-payment of the annual fee